[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"General Hospital of Ningxia Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":545},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,23,0,[8,46,71,97,121,140,164,185,204,227,244,265,289,308,327,359,383,403,425,449,473,500,524],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":26,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644503","phase-4-comparison-of-hemodynamics-and-respiratory-function-between-ciprofol-and-propofol-in-elderly-patients-undergoing-non-intubated-general-anesthesia-100644503",false,"NCT07670923","Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia","Inclusion Criteria:\n\n1. Patients scheduled for elective non-intubated general anesthesia\n2. Age ranging from 65 to 80 years old\n3. American Society of Anesthesiologists (ASA) physical status class I-III\n4. Written informed consent signed by the patient or legal guardian\n\nExclusion Criteria:\n\n1. Confirmed allergy to propofol, ciprofol or their excipients\n2. Severe cardiovascular diseases (uncontrolled hypertension, heart failure, severe arrhythmia, etc.)\n3. Severe respiratory diseases (chronic obstructive pulmonary disease, obstructive sleep apnea syndrome, etc.)\n4. Severe hepatic or renal insufficiency\n5. Long-term regular use of sedatives or opioids\n6. Baseline bradycardia (HR \\\u003C 50 beats\u002Fmin) or hypoxemia (SpO₂ \\\u003C 90%)","ALL","65 Years","80 Years",{"count":19,"type":20},108,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","At the initiation of induction for non-intubated general anesthesia, ciprofol or propofol will be administered intravenously at a rate of 10 mL\u002Fmin. The Modified Observer's Assessment of Alertness\u002FSedation (MOAA\u002FS) scale will be used to evaluate sedation depth. This study aims to assess the effects of ciprofol and propofol on hemodynamics and respiratory function in elderly patients undergoing non-intubated general anesthesia.",[13],[27,28,29,30,31,32],"Ciprofol","Propofol","Aged","Non-intubated general anesthesia","Hemodynamics","Respiratory function","RECRUITING","2026-08-18",{"date":36,"type":37},"2026-08-19","ACTUAL",{"date":39,"type":37},"2026-07-01",{"date":41,"type":20},"2027-04-01",{"name":43,"class":44},"General Hospital of Ningxia Medical University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100649717","remimazolam-for-postoperative-sleep-in-elderly-patients-100649717","NCT07740343","Remimazolam for Postoperative Sleep in Elderly Patients","Remimazolam and Postoperative Sleep in Elderly Patients Undergoing Laparoscopic Colorectal Cancer Resection: A Randomized, Double-Blind, PSG-Based Controlled Trial","Inclusion Criteria:\n\n* Aged between 65 and 80 years.\n* Scheduled for elective laparoscopic radical resection of colorectal cancer.\n* American Society of Anesthesiologists (ASA) physical status class II-III.\n* Able to understand the study protocol and provide written informed consent.\n\nExclusion Criteria:\n\n* Known allergy to any study medications.\n* Preoperative sleep disorder (Pittsburgh Sleep Quality Index \\[PSQI\\] score \\> 10).\n* Regular use of sedatives, antipsychotics or hormonal drugs within the past month.\n* Preoperative cognitive impairment, screened using the education-adjusted Mini-Mental State Examination (MMSE).\n* Preoperative history of neurological or psychiatric disorders, including Alzheimer's disease, Parkinson's disease, depression and anxiety disorders.\n* Severe preoperative comorbidities involving the cardiovascular, cerebrovascular, respiratory, hepatic or renal systems, as follows:New York Heart Association (NYHA) functional class IV; current or recent (within 2 months) congestive heart failure; myocardial infarction or coronary stent implantation within the preceding 3 months; Uncontrolled frequent ventricular premature beats (\\>5 beats per minute), couplets, triplets, paired ventricular arrhythmias, multifocal ventricular premature beats, or R-on-T phenomenon; Second-degree atrioventricular block (Mobitz II type), third-degree atrioventricular block or sick sinus syndrome without pacemaker implantation; Stroke or transient ischemic attack within the preceding 3 months; Severe hypertension (blood pressure ≥ 180\u002F110 mmHg); Severe respiratory tract infection (including common cold), or maximal voluntary ventilation (MMV) \\\u003C 30% of the predicted value; Severe hepatic dysfunction (Child-Pugh score \\> 9); Acute or chronic renal failure without renal replacement therapy: Acute kidney injury was defined as an absolute increase in serum creatinine ≥ 0.3 mg\u002FdL (≥26.5 μmol\u002FL) or a relative increase ≥ 50% from baseline, or urine output \\\u003C 0.5 mL\u002F(kg·h) for more than 6 consecutive hours. Chronic renal failure or uremia was defined as serum creatinine \\> 451 μmol\u002FL and estimated glomerular filtration rate (eGFR) \\\u003C 30 mL\u002Fmin\u002F1.73 m².\n* Severe coagulation disorders.\n* Refusal to participate in the trial.\n* Anticipated postoperative admission to the intensive care unit (ICU).",{"count":54,"type":20},84,[56],"NA","Postoperative sleep disturbance (PSD) is highly prevalent in elderly patients undergoing laparoscopic radical resection of colorectal cancer. Although remimazolam has shown favorable sedative properties and may alleviate perioperative stress, its effects on postoperative sleep architecture remain poorly understood. Polysomnography (PSG), the gold standard for objective sleep assessment, has not been widely used to evaluate these effects in this population. Therefore, this study employs a randomized controlled trial design to verify whether remimazolam is superior to propofol in preserving postoperative sleep quality, thereby offering more evidence-based options for anesthetic management in elderly patients undergoing laparoscopic colorectal cancer surgery.",[59],"Postoperative Sleep",[61],"postoperative sleep","NOT_YET_RECRUITING","2026-07-30",{"date":65,"type":37},"2026-07-31",{"date":67,"type":20},"2026-09-01",{"date":69,"type":20},"2027-02-28",{"name":43,"class":44},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":15,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100648329","phase-1-clinical-study-of-non-invasive-40-hz-audiovisual-stimulation-guided-by-gamma-eeg-monitoring-for-promoting-perioperative-brain-function-recovery-in-children-100648329","NCT07719465","Clinical Study of Non-invasive 40-Hz Audiovisual Stimulation Guided by Gamma EEG Monitoring for Promoting Perioperative Brain Function Recovery in Children","Inclusion Criteria:\n\n* Children aged 3-6 years, irrespective of sex, representing the critical period of brain network development.\n\nClassified as American Society of Anesthesiologists (ASA) Physical Status I or II.\n\nScheduled to undergo elective single-session surgery under general anesthesia (including inhalational anesthesia with agents such as sevoflurane) with an expected anesthesia duration of ≥1 hour, including procedures such as inguinal hernia repair, orchiopexy, and adenoidectomy.\n\nNormal preoperative neurodevelopment as assessed by routine clinical evaluation, with parents or legal guardians able to understand the study protocol and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* A preoperative diagnosis of autism spectrum disorder (ASD), epilepsy, intellectual developmental disorder, attention-deficit\u002Fhyperactivity disorder (ADHD), or any other neurological or psychiatric disorder.\n\nSevere visual impairment (e.g., cataract or amblyopia) or significant hearing impairment that would preclude the administration of synchronized audiovisual stimulation.\n\nA personal or family history of photosensitive epilepsy, owing to safety considerations.\n\nOccurrence of major anesthesia-related complications during surgery, including severe allergic reactions, malignant hyperthermia, prolonged severe hypoxemia, or other serious perioperative adverse events.",true,"3 Years","6 Years",{"count":81,"type":20},80,[83],"PHASE1","Exposure to general anesthesia during early brain development has emerged as an important risk factor for long-term attention-deficit\u002Fhyperactivity disorder (ADHD)-like behaviors and learning difficulties in school-aged children. However, objective biomarkers for perioperative neurofunctional assessment and effective non-invasive physical interventions remain lacking in clinical practice.\n\nThis study adopts a prospective randomized controlled trial (RCT) design to establish a clinical cohort of preschool children undergoing surgery under general anesthesia. Early postoperative intervention will be performed using 40-Hz non-invasive synchronized audiovisual stimulation. Portable electroencephalography (EEG) technology will be employed to quantify prefrontal gamma oscillatory activity by analyzing the relative gamma-band power spectrum and phase-locking index (PLI) during the perioperative period. The study aims to characterize the pathological suppression of gamma oscillations following general anesthesia and to evaluate the restorative effects of 40-Hz stimulation on gamma-band neural activity. Long-term postoperative follow-up, combined with the Conners Rating Scales and the Child Behavior Checklist (CBCL), will be conducted to systematically investigate the association between gamma oscillation restoration and improvements in long-term ADHD-like symptoms.\n\nThe successful completion of this project will establish an integrated pediatric postoperative neurorehabilitation strategy encompassing screening, intervention, and outcome evaluation, thereby providing a novel clinical approach with substantial translational potential and broad prospects for clinical implementation.",[86],"ADHD - Attention Deficit Disorder With Hyperactivity",[88],"ADHD,post-anesthesia,infant,","2026-07-17",{"date":91,"type":37},"2026-07-22",{"date":93,"type":20},"2026-09-15",{"date":95,"type":20},"2027-10-01",{"name":43,"class":44},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":77,"sex":15,"minAge":103,"maxAge":16,"enrollmentInfo":104,"targetDuration":4,"studyType":21,"phases":105,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":45},"100648136","effect-of-pre-injection-of-rocuronium-on-neuromuscular-blockade-onset-time-and-hemodynamics-during-general-anesthesia-induction-100648136","NCT07716891","Effect of Pre-injection of Rocuronium on Neuromuscular Blockade Onset Time and Hemodynamics During General Anesthesia Induction","Inclusion Criteria:\n\n* Aged from 18 to 65 years old\n* American Society of Anesthesiologists (ASA) physical status classification Ⅰ, Ⅱ or Ⅲ\n* Elective surgery requiring general anesthesia with tracheal intubation\n* Able to understand the study and voluntarily sign written informed consent\n* Male or female, no gender restriction\n\nExclusion Criteria:\n\n* Severe hepatic dysfunction (ALT\u002FAST \\> 3 times the upper limit of normal) or renal dysfunction (creatinine \\> 2 times the upper limit of normal)\n* Central nervous system diseases or severe neuromuscular disorders\n* Severe arrhythmia or cardiac dysfunction (NYHA class Ⅲ-Ⅳ, or ejection fraction EF \\\u003C 30%)\n* Known hypersensitivity or allergy to rocuronium, midazolam, propofol or other study-related drugs\n* Refusal to participate in this clinical trial\n* Pregnant or breastfeeding women\n* History of predicted difficult airway requiring awake tracheal intubation\n* Contraindications to rapid sequence induction","18 Years",{"count":19,"type":20},[56],"This is a single-center, prospective, randomized, controlled trial comparing pre-injection versus standard bolus administration of rocuronium bromide for general anesthesia induction. A total of 108 adult patients (18-65 years, ASA I-III) scheduled for elective surgery requiring endotracheal intubation will be enrolled and randomized 1:1 to either the pre-injection group or control group.\n\nThe pre-injection group will receive rocuronium 0.06 mg\u002Fkg as a priming dose followed by 0.54 mg\u002Fkg 3 minutes later. The control group will receive rocuronium 0.6 mg\u002Fkg as a single bolus. All patients will receive standardized anesthesia induction with midazolam and propofol.\n\nThe primary outcome is neuromuscular blockade onset time (seconds). Secondary outcomes include hemodynamic parameters (SBP, DBP, MAP, HR, CO, SV, SVR), injection pain incidence, and adverse events.\n\nThis study aims to investigate whether pre-injection of rocuronium can shorten neuromuscular blockade onset time while maintaining hemodynamic stability compared to standard bolus administration.",[108,109],"General Anesthesia","Elective Surgery",[111,112,31],"Rocuronium bromide","Onset time","2026-07-16",{"date":115,"type":37},"2026-07-21",{"date":117,"type":20},"2026-07",{"date":119,"type":20},"2026-12",{"name":43,"class":44},{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":21,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":139,"locationsCount":45},"100611357","combined-interval-training-and-scenario-simulation-for-als-training-of-medical-students-100611357","NCT07239531","Combined Interval Training and Scenario Simulation for ALS Training of Medical Students","Application of Interval Training Combined With Scenario Simulation Teaching in Advanced Life Support Skill Training for Medical Students","Inclusion Criteria:\n\n* Medical students studying in the Department of Anesthesiology\n* The initial training for \"Advanced Life Support Scenario Simulation Instruction\" required by this study has been successfully completed, and the corresponding pre-test assessment has been passed.\n* Voluntarily participate in this study and sign a written informed consent form, committing to adhere to the entire schedule of the research plan.\n* During the research period, do not participate in any other training that conflicts with this experiment.\n\nExclusion Criteria:\n\n* Individuals who have previously obtained an Advanced Cardiac Life Support (ACLS) provider certificate issued by the American Heart Association (AHA) or an equivalent organization, and whose certificate remains valid.\n* Individuals who have participated in any form of Advanced Cardiac Life Support (ACLS) or Advanced CPR scenario simulation training courses within the past three months.\n* Previously participated as a subject in educational interventions comparing \"spaced learning versus traditional learning.\"\n* Individuals who, for any reason, fail to complete all instructional components during the initial training phase or whose pre-test data is missing.\n* Individuals who are unable to guarantee participation in all scheduled training or testing sessions during the study period (particularly on Days 2, 4, 6, and 7) due to scheduling conflicts, leave requests, or other reasons.",{"count":129,"type":20},48,[56],"This study aims to investigate medical students' mastery of advanced life support skills when using scenario-based simulation combined with intermittent training, compared to traditional teaching methods.",[133],"Advanced Life Support Operational Skills and Theoretical Knowledge Learning and Memorization","2026-07-05",{"date":136,"type":37},"2026-07-08",{"date":67,"type":20},{"date":69,"type":20},{"name":43,"class":44},{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":15,"minAge":103,"maxAge":16,"enrollmentInfo":147,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":45},"100644932","effects-of-preoperative-sleep-disorders-on-perioperative-anesthesia-depth-and-recovery-quality-in-patients-undergoing-noncardiac-surgery-100644932","NCT07675993","Effects of Preoperative Sleep Disorders on Perioperative Anesthesia Depth and Recovery Quality in Patients Undergoing Noncardiac Surgery","Effects of Preoperative Sleep Disorders on Perioperative Anesthesia Depth and Recovery Quality in Patients Undergoing Noncardiac Surgery: A Single-Center, Prospective, Observational Cohort Study","Inclusion Criteria:\n\n1. \\- Aged 18 to 65 years, with American Society of Anesthesiologists (ASA) physical status classification Ⅰ-Ⅲ;\n2. Elective non-cardiac surgery with an expected operative duration longer than 2 hours;\n3. Preoperative Mini-Mental State Examination (MMSE) score ≥ 24;\n4. Completion of the Pittsburgh Sleep Quality Index (PSQI) assessment 1 day before surgery;\n5. Absence of severe cardiac, hepatic, renal or cerebral diseases, and no history of psychiatric or neurological disorders;\n6. Voluntary provision of written informed consent.\n\nExclusion Criteria:\n\n1. Preoperative severe cognitive dysfunction, history of traumatic brain injury or stroke;\n2. Long-term regular use of sedative-hypnotics, antidepressants or antipsychotics;\n3. Intraoperative massive hemorrhage, cardiac arrest, or severe hypoxemia (SpO₂ \\\u003C 90% lasting for more than 5 minutes);\n4. Inability to cooperate with EEG monitoring or scale evaluation;\n5. Pregnancy or breastfeeding status.\n\nDrop-out Criteria :\n\n1. Cancellation of scheduled surgery\u002Fanesthesia or postoperative admission to the intensive care unit (ICU);\n2. Patient withdrawal of study participation;\n3. Intraoperative massive hemorrhage, cardiac arrest, or severe hypoxemia (SpO₂ \\\u003C 90% lasting for more than 5 minutes);\n4. Development of severe postoperative complications;\n5. Incomplete data collection or voluntary trial withdrawal.",{"count":81,"type":20},"OBSERVATIONAL","A Single-Center, Prospective Observational Cohort Study Comparing Perioperative Electroencephalographic Anesthesia Depth Parameters (Electroencephalographic Index, SE\u002FRE Entropy, Burst Suppression Ratio) Between Patients With Preoperative Sleep Disorders and Those Without; To Identify the Independent Effects of Preoperative Sleep Disorders on the Speed of Electroencephalographic Recovery During Emergence, Electroencephalographic Status at Extubation, Intra-PACU Electroencephalographic Fluctuations, and Quality of Emergence.",[151],"Emergence Time",[153,154,155],"sleep disorders","sevoflurane anesthesia","delayed emergence","2026-06-29",{"date":158,"type":37},"2026-06-30",{"date":160,"type":37},"2026-06-16",{"date":162,"type":20},"2027-01-31",{"name":43,"class":44},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":15,"minAge":103,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":21,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":45},"100644805","effect-of-preoxygenation-position-and-examination-position-on-hypoxemia-during-painless-gastrointestinal-endoscopy-100644805","NCT07673042","Effect of Preoxygenation Position and Examination Position on Hypoxemia During Painless Gastrointestinal Endoscopy","Effect of Preoxygenation Position and Examination Position on Hypoxemia During Painless Gastrointestinal Endoscopy: A 2×2 Factorial Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18 to 75 years, regardless of gender\n* Body mass index (BMI): 18.5 - 35 kg\u002Fm²\n* ASA physical status class I, II or III\n* Scheduled for painless gastroscopy, painless colonoscopy, or combined painless gastroenteroscopy\n* Able to understand the study procedure and provide written informed consent\n\nExclusion Criteria:\n\n* Severe cardiopulmonary diseases, including severe COPD, heart failure, severe arrhythmia and pulmonary hypertension\n* Difficult airway identified before anesthesia\n* Severe obstructive sleep apnea (OSA)\n* Spinal or thoracic deformity\n* Preoperative baseline hypoxemia\n* Known allergy to any anesthetic drugs used in this study\n* Pregnant females\n* Unable to cooperate with required intraoperative body position","75 Years",{"count":173,"type":20},208,[56],"To investigate the independent effects and interaction of pre-oxygenation position (left lateral vs left lateral with 30° head-up tilt) and examination position (left lateral vs left lateral with 30° head-up tilt) on hypoxemia during painless gastroscopy and colonoscopy using a 2×2 factorial design.",[177],"Hypoxemia During Surgery","2026-06-24",{"date":156,"type":37},{"date":181,"type":20},"2026-06-23",{"date":183,"type":20},"2026-08-31",{"name":43,"class":44},{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":15,"minAge":103,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":21,"phases":194,"briefSummary":195,"conditions":196,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":203,"locationsCount":45},"100634896","effect-of-lateral-versus-supine-positions-on-postoperative-hypoxemia-100634896","NCT07545642","Effect of Lateral Versus Supine Positions on Postoperative Hypoxemia","Effect of Lateral Versus Supine Positions on Postoperative Hypoxemia in Patients Undergoing Painless Gastroscopy and Colonoscopy: A Prospective Randomized Controlled Study","Inclusion Criteria:\n\n1. Age ≥ 18 years.\n2. Both sexes.\n3. American Society of Anesthesiologists (ASA) physical status classification I-III.\n4. Scheduled for combined painless esophagogastroduodenoscopy\u002Fcolonoscopy or either of the two procedures.\n5. Ability to understand the study protocol and provide written informed consent.\n6. A broad set of inclusion criteria was adopted to enroll a patient population that better reflects routine clinical practice. The study aimed to enhance the generalizability of the findings by including patients with various comorbidities, such as preprocedural hypoxemia (room-air SpO₂ ≤ 90%), history of pulmonary surgery, obstructive sleep apnea (OSA), and other pulmonary conditions (including asthma, COPD, chronic bronchitis, emphysema, and pulmonary bullae).\n\nExclusion Criteria:\n\n1. Severe cardiovascular or cerebrovascular diseases.\n2. Pregnant patients.\n3. History of hypersensitivity to ciprofol.\n\nWithdrawal Criteria:\n\n1. Endotracheal intubation required during the procedure.\n2. Voluntary withdrawal requested by the patient or their legal representative.",{"count":193,"type":20},960,[56],"Using prospective real-world data, this study aims to determine whether the lateral decubitus position reduces the incidence of post-procedure hypoxemia in patients undergoing painless gastroscopy\u002Fcolonoscopy, thereby providing a simple, non-invasive, and low-cost optimization strategy for clinical practice.",[197],"Postoperative Hypoxemia","2026-06-22",{"date":178,"type":37},{"date":201,"type":37},"2026-04-22",{"date":63,"type":20},{"name":43,"class":44},{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":15,"minAge":211,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":21,"phases":214,"briefSummary":215,"conditions":216,"keywords":218,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":226,"locationsCount":45},"100644361","propofol-vs-ciprofol-for-anesthesia-induction-in-frail-elderly-patients-100644361","NCT07663695","Propofol vs. Ciprofol for Anesthesia Induction in Frail Elderly Patients","Comparison of the Effects of Propofol and Ciprofol on the Incidence of Post-induction Hypotension in Frail Elderly Patients Undergoing General Anesthesia","Inclusion Criteria:\n\n* Patients scheduled to undergo major abdominal surgery under general anesthesia.\n* Frailty score \\>= 3\\[cite: 2\\].\n* Age \\>= 60 years\\[cite: 2\\].\n* American Society of Anesthesiologists (ASA) physical status class \\>= II\\[cite: 2\\].\n* Planned invasive blood pressure monitoring\\[cite: 2\\].\n\nExclusion Criteria:\n\n* Severe cardiac arrhythmia\\[cite: 2\\].\n* Severe valvular heart disease\\[cite: 2\\].\n* Poorly controlled hypertension with medication (systolic blood pressure \\>= 180 mmHg and\u002For diastolic blood pressure \\>= 110 mmHg)\\[cite: 2\\].\n* Pre-existing preoperative hypotension (mean arterial pressure \\\u003C 65 mmHg)\\[cite: 2\\].\n* Preoperative renal dysfunction (serum creatinine greater than the upper limit of normal)\\[cite: 2\\].","60 Years",{"count":213,"type":20},96,[56],"Post-induction hypotension (PIH) is a common and critical complication during general anesthesia, particularly in frail elderly patients whose physiological reserves are significantly diminished. PIH is strongly associated with adverse postoperative outcomes, including acute kidney injury (AKI) and myocardial injury. Propofol is the most widely used induction agent but frequently induces circulatory depression. Ciprofol, a novel anesthetic agent developed by optimizing the molecular structure of propofol, has demonstrated improved hemodynamic stability and fewer adverse effects in general populations. However, its specific impact on frail elderly patients remains unestablished.\n\nThe primary purpose of this single-center, randomized, double-blind, controlled trial is to compare the effects of propofol and ciprofol during anesthesia induction on the incidence of PIH in frail elderly patients undergoing major abdominal surgery. The investigator's hypothesis is that ciprofol will significantly lower the incidence of PIH compared to propofol. Additionally, the study will evaluate secondary clinical outcomes, such as postoperative AKI, postoperative cardiac complications, and the overall quality of recovery, to provide an evidence-based clinical guide for selecting optimal induction agents for this vulnerable patient population.",[217],"Hypotension",[28,27,219,220],"Anesthesia Induction","Frail Elderly","2026-06-17",{"date":181,"type":37},{"date":224,"type":20},"2026-06-25",{"date":162,"type":20},{"name":43,"class":44},{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":15,"minAge":103,"maxAge":4,"enrollmentInfo":233,"targetDuration":4,"studyType":21,"phases":235,"briefSummary":236,"conditions":237,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":243,"locationsCount":45},"100641503","effect-of-different-body-positions-on-hypoxemia-during-recovery-in-patients-undergoing-painless-gastroscopy-and-colonoscopy-100641503","NCT07587970","Effect of Different Body Positions on Hypoxemia During Recovery in Patients Undergoing Painless Gastroscopy and Colonoscopy","Effects of Lateral Decubitus Head-up Position, Supine Head-up Position, and Standard Lateral Decubitus Position on Hypoxemia During Recovery in Patients Undergoing Painless Gastroscopy and Colonoscopy: A Multicenter, Three-arm Randomized Controlled Trial",{"count":234,"type":20},1617,[56],"Through a multicenter, three-arm randomized controlled trial design, this study aimed to compare the effects of three positioning strategies-side-lying with elevated head position, supine with elevated head position, and standard side-lying position-on the incidence of hypoxemia during the recovery phase in patients undergoing painless gastroscopy and colonoscopy. The goal was to provide clinicians with a simple, non-invasive, and cost-effective optimization strategy.",[197],"2026-06-15",{"date":221,"type":37},{"date":241,"type":37},"2026-05-08",{"date":162,"type":20},{"name":43,"class":44},{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":11,"sex":15,"minAge":103,"maxAge":16,"enrollmentInfo":251,"targetDuration":4,"studyType":21,"phases":253,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":45},"100642474","effect-of-lidocaine-through-gastric-tube-on-ponv-100642474","NCT07643298","Effect of Lidocaine Through Gastric Tube on PONV","Effect of Lidocaine Applied Via Nasogastric Tube on Postoperative Nausea and Vomiting in Obese Patients Undergoing Bariatric Surgery","Inclusion Criteria:\n\n* Adults aged between 18 and 65 years old;\n* American Society of Anesthesiologists (ASA) physical status classification II - III;\n* Planned to undergo primary elective laparoscopic sleeve gastrectomy with general anesthesia;\n* Capable of giving informed consent.\n\nExclusion Criteria:\n\n* Known allergy, hypersensitivity or contraindication to lidocaine or amide - type local anesthetics;\n* Previous significant liver or kidney dysfunction (e.g., ALT\u002FAST \\> 3 times the upper limit of normal, GFR \\\u003C 30 mL\u002Fmin);\n* History of epilepsy, cardiac conduction abnormalities or previous diagnosis of malignant hyperthermia;\n* Pregnancy or lactation;\n* Patients who received systemic lidocaine treatment during the operation;\n* History of severe postoperative nausea and vomiting (PONV) or motion sickness, requiring multiple prophylactic medications;\n* Emergency or revision bariatric surgery.",{"count":252,"type":20},100,[56],"The goal of this clinical trial is to learn if intragastric administration of lidocaine can reduce postoperative nausea and vomiting in obese patients undergoing laparoscopic sleeve gastrectomy. The main question it aims to answer is:\n\nDoes administering 0.5% lidocaine via an orogastric tube reduce the incidence of postoperative nausea and vomiting (PONV) in the post-anesthesia care unit and within the first 24 hours after surgery compared to a placebo (normal saline)?\n\nResearchers will compare the Lidocaine Group to the Placebo Group to see if the intervention lowers the PONV incidence.\n\nParticipants will:\n\n* Receive the assigned study solution (either 0.5% lidocaine 20ml or normal saline 20ml) through an orogastric tube upon surgery completion and before extubation.\n* Have their gastric tube clamped for 5 minutes to ensure mucosal exposure before removal.\n* Undergo standardized total intravenous anesthesia and perioperative management according to the study protocol.\n* Be assessed for nausea, vomiting, and other outcomes at specified time points postoperatively in the recovery room and at 6, 12, and 24 hours.",[256],"PONV","2026-06-09",{"date":259,"type":37},"2026-06-11",{"date":261,"type":37},"2026-05-20",{"date":263,"type":20},"2027-06-30",{"name":43,"class":44},{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":15,"minAge":211,"maxAge":171,"enrollmentInfo":273,"targetDuration":4,"studyType":21,"phases":274,"briefSummary":275,"conditions":276,"keywords":278,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":45},"100637173","effect-of-bupivacaine-liposome-injection-on-muscle-strength-after-total-knee-arthroplasty-100637173","NCT07616102","Effect of Bupivacaine Liposome Injection on Muscle Strength After Total Knee Arthroplasty","Effect of Bupivacaine Liposome Adductor Canal Block on Muscle Strength After Total Knee Arthroplasty.","TKA","Inclusion Criteria:\n\n1. Patients aged 60-75 years scheduled for elective TKA;\n2. ASA physical status classification II-III;\n3. BMI 18-30 kg\u002Fm²;\n4. Agreement to participate in this study and provision of signed informed consent.\n\nExclusion Criteria:\n\n1. Individuals with communication barriers such as language or hearing impairments;\n2. Patients with contraindications to nerve blocks;\n3. Severe systemic diseases, such as severe renal disease (estimated glomerular filtration rate below 50 mL\u002Fmin), cardiac disease (congestive heart failure New York Heart Association Class III to IV), or severe hepatic disease defined as a current or past diagnosis of acute\u002Fsubacute hepatic necrosis, acute liver failure, chronic liver disease, liver abscess, hepatic coma, or hepatorenal syndrome;\n4. History of long-term opioid use (defined as daily or nearly daily opioid use within the past 3 months).",{"count":81,"type":20},[56],"This study employs a randomized controlled trial to investigate whether bupivacaine liposome injection for adductor canal block can effectively improve lower limb muscle strength after total knee arthroplasty.",[271,277],"Muscle Strength",[279,280,271,277],"Bupivacaine Liposome","Adductor Canal Block","2026-05-26",{"date":283,"type":37},"2026-05-29",{"date":285,"type":20},"2026-06-10",{"date":287,"type":20},"2026-11-03",{"name":43,"class":44},{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":15,"minAge":103,"maxAge":4,"enrollmentInfo":296,"targetDuration":4,"studyType":21,"phases":297,"briefSummary":298,"conditions":299,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":307,"locationsCount":45},"100631085","external-oblique-intercostal-block-versus-transversus-abdominis-plane-combined-with-rectus-sheath-block-on-postoperative-pain-in-laparoscopic-radical-gastrectomy-100631085","NCT07496086","External Oblique Intercostal Block Versus Transversus Abdominis Plane Combined With Rectus Sheath Block on Postoperative Pain in Laparoscopic Radical Gastrectomy","Effects of Ultrasound-guided External Oblique Intercostal Block Versus Transversus Abdominis Plane Combined With Rectus Sheath Block on Postoperative Pain in Laparoscopic Radical Gastrectomy","Inclusion Criteria:\n\n* Patients aged over 18 years\n* Classified as ASA I-III\n* Scheduled for elective laparoscopic radical gastrectomy under general anesthesia\n* Voluntarily participated and provided written informed consent.\n\nExclusion Criteria:\n\n* Chronic opioid dependence or prior use of analgesic medications for \\>3 months;\n* Inability to communicate due to severe dementia, language barriers, or terminal illness;\n* History of central and\u002For peripheral nervous system disorders;\n* Severe renal insufficiency (serum creatinine \\>442 μmol\u002FL or requiring renal replacement therapy) or severe hepatic insufficiency (Child-Pugh class C);\n* Allergy to local anesthetics.\n* Expected to be transferred to ICU after surgery.\n* Refuse patient control agenesia after surgery.",{"count":252,"type":20},[56],"Postoperative pain is highly prevalent following laparoscopic radical gastrectomy. Although Transversus abdominis plane block combined with rectus sheath block(TAP+RSB） can effectively alleviate this pain, it still has many limitations. The external oblique intercostal plane block (EOIB) is a novel nerve block technique that may provide well postoperative analgesia for upper abdominal surgery. Therefore, this study employs a non-inferiority randomized controlled trial design to verify that the analgesic effect of EOIB is not inferior to that of ESPB, thereby offering more options for regional analgesia strategies in laparoscopic radical gastrectomy.",[300],"Postoperative Pain","2026-03-22",{"date":303,"type":37},"2026-03-27",{"date":305,"type":37},"2026-03-20",{"date":287,"type":20},{"name":43,"class":44},{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":11,"sex":15,"minAge":103,"maxAge":4,"enrollmentInfo":315,"targetDuration":4,"studyType":21,"phases":317,"briefSummary":318,"conditions":319,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":324,"leadSponsor":326,"locationsCount":45},"100623431","external-oblique-intercostal-block-versus-erector-spinae-plane-block-on-postoperative-pain-in-laparoscopic-radical-gastrectomy-100623431","NCT07396545","External Oblique Intercostal Block Versus Erector Spinae Plane Block on Postoperative Pain in Laparoscopic Radical Gastrectomy","Effects of Ultrasound-guided External Oblique Intercostal Block Versus Erector Spinae Plane Block on Postoperative Pain in Laparoscopic Radical Gastrectomy","Inclusion Criteria:\n\n* Patients aged over 18 years\n* Classified as ASA I-III\n* Scheduled for elective laparoscopic radical gastrectomy under general anesthesia\n* Voluntarily participated and provided written informed consent.\n\nExclusion Criteria:\n\n* Chronic opioid dependence or prior use of analgesic medications for \\>3 months;\n* Inability to communicate due to severe dementia, language barriers, or terminal illness;\n* History of central and\u002For peripheral nervous system disorders;\n* Severe renal insufficiency (serum creatinine \\>442 μmol\u002FL or requiring renal replacement therapy) or severe hepatic insufficiency (Child-Pugh class C);\n* Allergy to local anesthetics.\n* Expected to be transferred to ICU after surgery.",{"count":316,"type":20},184,[56],"Postoperative pain is highly prevalent following laparoscopic radical gastrectomy. Although the erector spinae plane block (ESPB) can effectively alleviate this pain, it still has many limitations. The external oblique intercostal plane block (EOIB) is a novel nerve block technique that may provide well postoperative analgesia for upper abdominal surgery. Therefore, this study employs a non-inferiority randomized controlled trial design to verify that the analgesic effect of EOIB is not inferior to that of ESPB, thereby offering more options for regional analgesia strategies in laparoscopic radical gastrectomy.",[300],"2026-03-12",{"date":322,"type":37},"2026-03-16",{"date":320,"type":37},{"date":325,"type":20},"2027-02-09",{"name":43,"class":44},{"id":328,"slug":329,"hasResults":11,"nctId":330,"briefTitle":331,"officialTitle":332,"acronym":333,"eligibilityCriteria":334,"healthyVolunteers":77,"sex":15,"minAge":103,"maxAge":16,"enrollmentInfo":335,"targetDuration":4,"studyType":21,"phases":337,"briefSummary":338,"conditions":339,"keywords":343,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":45},"100621148","feasibility-and-safety-of-sciatic-nerve-paraneural-sheath-block-using-a-mid-femoral-lateral-approach-100621148","NCT07366853","Feasibility and Safety of Sciatic Nerve Paraneural Sheath Block Using a Mid-Femoral Lateral Approach","Feasibility and Safety of Intraneural Sciatic Nerve Block Via Lateral Mid-femoral Approach: A Clinical Study","iSNB-LF","Inclusion Criteria:\n\n1. Patients scheduled for elective unilateral surgery below the knee (e.g., internal fixation for ankle, metatarsal, or calcaneal fractures; hallux valgus correction; flatfoot reconstruction).\n2. American Society of Anesthesiologists (ASA) physical status class I or II.\n3. Aged 18 to 65 years.\n4. Ability to understand the study procedure and provide written informed consent.\n\nExclusion Criteria:\n\n1. Contraindications to peripheral nerve block:\n\n   * Known allergy or history of toxicity to local anesthetics.\n   * Pre-existing neuropathy in the operative limb.\n   * Severe coagulopathy.\n   * Infection at the intended needle puncture site.\n   * Systemic infection.\n2. Requirement for simultaneous surgery at a site other than the unilateral lower limb below the knee.\n3. Previous surgery or significant scarring in the area of the planned needle insertion for the sciatic nerve block.\n4. Body mass index (BMI) \\> 35 kg\u002Fm².\n5. Patients receiving chronic pain therapy or with a history of opioid abuse.\n6. Inability to communicate or cooperate with the study assessments (e.g., due to cognitive impairment, language barrier, or psychiatric disorder).\n7. Pregnancy or lactation.",{"count":336,"type":20},200,[56],"This study is designed as a randomized controlled trial aiming to evaluate the feasibility and safety of ultrasound-guided mid-femoral lateral approach sciatic nerve paraneural sheath block, in order to provide a new sciatic nerve block approach for clinical practice that offers greater patient comfort and higher precision, thereby facilitating its use for specific patient populations and less experienced operators.",[340,341,342],"Adverse Effect","Feasibility Study","Safety and Effectiveness",[344,345,346,347,348,349,350],"Sciatic Nerve Block","Subparaneural Block","Lateral Mid-femoral Approach","Popliteal Approach","Ultrasound-guided","Feasibility","Safety","2026-01-16",{"date":353,"type":37},"2026-01-26",{"date":355,"type":20},"2026-01-01",{"date":357,"type":20},"2026-10-01",{"name":43,"class":44},{"id":360,"slug":361,"hasResults":11,"nctId":362,"briefTitle":363,"officialTitle":363,"acronym":4,"eligibilityCriteria":364,"healthyVolunteers":11,"sex":365,"minAge":103,"maxAge":16,"enrollmentInfo":366,"targetDuration":4,"studyType":21,"phases":367,"briefSummary":368,"conditions":369,"keywords":370,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":45},"100613584","the-impact-of-intraperitoneal-spray-combined-with-intravenous-lidocaine-on-postoperative-pain-after-myomectomy-100613584","NCT07268495","The Impact of Intraperitoneal Spray Combined With Intravenous Lidocaine on Postoperative Pain After Myomectomy","Inclusion Criteria:\n\n1. Age:18-65 years old;\n2. ASA physical status classification I - III;\n3. Undergoing laparoscopic hysteromyoma resection under general anesthesia;\n4. The patient has been informed and has signed the informed consent form.\n\nExclusion Criteria:\n\n1. Surgery duration exceeding 3 hours;\n2. Need for additional surgery;\n3. Allergy to the study drugs;\n4. Presence of severe psychological,hepatic,renal,and cardiac diseases;\n5. History of chronic pain or arrhythmia.\n\nElimination Criteria:\n\n1. The patient or their family withdraws from or refuses to participate in the trial during the observation period;\n2. Conversion from laparoscopy to laparotomy or change in surgical approach during the procedure.","FEMALE",{"count":252,"type":20},[56],"The purpose of this study is to determine whether laparoscopic spraying combined with intravenous injection of lidocaine can improve pain in patients undergoing laparoscopic myomectomy under general anesthesia.",[300],[371,372,373,374],"lidocaine","myomectomy","laparoscopic surgery","postoperative pain","2025-11-25",{"date":377,"type":37},"2025-12-05",{"date":379,"type":37},"2024-08-01",{"date":381,"type":20},"2025-12-20",{"name":43,"class":44},{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":390,"targetDuration":4,"studyType":21,"phases":392,"briefSummary":393,"conditions":394,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":402,"locationsCount":4},"100612061","application-of-intermittent-training-in-radial-artery-puncture-and-catheterization-skills-under-ultrasound-guided-line-guidance-100612061","NCT07248683","Application of Intermittent Training in Radial Artery Puncture and Catheterization Skills Under Ultrasound-Guided Line Guidance","Application of Ultrasound-Guided Midline Combined With Spaced Retrieval Training in Radial Artery Puncture and Catheterization for Standardized-Trained Residents：A Randomized Sequential Allocation Study","Inclusion and Exclusion Criteria for Study Participants (Resident Trainees) I. Inclusion Criteria Identity and Qualifications: Resident physicians undergoing standardized training in this department.\n\nTraining Stage: Resident physicians who have not yet independently performed ultrasound-guided radial artery puncture and catheterization procedures.\n\nWillingness to Learn: Voluntary participation in this \"Ultrasound-Guided Radial Artery Catheterization\" training program with full understanding of the research content.\n\nInformed Consent: Have signed a written informed consent form agreeing to participate in this study and comply with protocol requirements.\n\nBasic Requirements: Possess good hand-eye coordination and learning ability, capable of cooperating to complete the entire training course and data collection.\n\nII. Exclusion Criteria Prior Experience: Residents who have previously independently completed more than 5 cases or have systematically studied ultrasound-guided radial artery puncture and catheterization techniques.\n\nSkill Level: Residents who achieved a high pre-test performance score or demonstrated consistent success in performing ultrasound-guided radial artery catheterization prior to the study.\n\nCognitive or Motor Impairment: Residents with severe cognitive dysfunction, motor impairment, or a history of psychiatric disorders that may compromise training efficacy assessment.\n\nTime Commitment and Compliance: Individuals unable to guarantee completion of the prescribed training program, practical exercises, and follow-up evaluations.\n\nOther Conditions: Participants deemed unsuitable for this study by the investigator due to other reasons (e.g., rotation schedule conflicts, inability to coordinate personal time, etc.).\n\nInclusion and Exclusion Criteria for Study Subjects (Patients Undergoing Radial Artery Catheterization)\n\nI. Inclusion Criteria\n\nAge: Generally ≥18 years old. Clinical Indications: Patients requiring invasive arterial pressure monitoring via radial artery puncture and catheterization due to surgical procedures, critical condition monitoring, or blood gas analysis.\n\nVascular Criteria: Palpable radial artery pulse on the puncture side, negative modified Allen test (or adequate ulnar artery compensation as determined by current guidelines).\n\nInformed Consent: Patient or authorized family member fully understands the study purpose and procedures, and has signed a written informed consent form.\n\nCooperation Capacity: Able to cooperate throughout the radial artery puncture and catheterization procedure.\n\nII. Exclusion Criteria Contraindications for Puncture: History of thrombosis, aneurysm, or arteriovenous fistula at the puncture site; skin infection, laceration, burn, or severe scar tissue at the puncture site.\n\nCirculatory Impairment: Severe shock, hypovolemic state, or anticipated difficulty with radial artery puncture.\n\nCoagulation Abnormalities: Significant bleeding tendency, marked thrombocytopenia, or ongoing anticoagulant\u002Fantiplatelet therapy without discontinuation.\n\nAbnormal vascular anatomy: Preliminary ultrasound assessment indicates severe tortuosity, malformation, excessively narrow diameter, or other significant anatomical variations in the radial artery that may compromise puncture success or safety.\n\nSpecial circumstances: Requirement for simultaneous bilateral radial artery catheterization; or other situations deemed unsuitable for this teaching procedure by the investigator.",{"count":391,"type":20},30,[56],"This study aims to investigate medical students' mastery of radial artery puncture and catheterization skills guided by the midline on ultrasound when using scenario simulation combined with intermittent training, and to compare this approach with traditional teaching methods.",[395],"Learning and Memorization of Radial Artery Puncture and Catheterization Guided by Ultrasound Midline","2025-11-18",{"date":375,"type":37},{"date":399,"type":20},"2025-11-20",{"date":401,"type":20},"2026-02-28",{"name":43,"class":44},{"id":404,"slug":405,"hasResults":11,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":4,"eligibilityCriteria":409,"healthyVolunteers":11,"sex":15,"minAge":410,"maxAge":78,"enrollmentInfo":411,"targetDuration":4,"studyType":21,"phases":412,"briefSummary":413,"conditions":414,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":4},"100607745","perioperative-gdnf-as-a-predictive-factor-for-postoperative-delirium-and-adverse-neurological-outcomes-in-pediatric-surgery-100607745","NCT07192549","Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery","Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery:a Single-center, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n* (1) Aged 1-3 years; (2) American Society of Anesthesiologists (ASA) Physical Status Classification I-II; (3) Body Mass Index (BMI) 18-35 kg\u002Fm²; (4) Agreement to participate in the study and signed informed consent form.\n\nExclusion Criteria:\n\n* (1) Surgical duration exceeding 4 hours; (2) Patients with language or hearing impairments hindering effective communication; (3) Patients with postoperative infections or perioperative cardiopulmonary complications; (4) Patients with preoperative psychiatric disorders.","1 Year",{"count":336,"type":20},[56],"To observe the dynamic changes in serum levels of inflammatory cytokines (e.g., IL-6, TNF-α), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell Line-Derived Neurotrophic Factor (GDNF) during the perioperative period in pediatric patients undergoing Scheduled Laparoscopic Hernia Repair surgery, and to investigate their relationship with the occurrence of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD),and to compare the different influence between propofol and sevoflurane . The aim is to provide insights into the neurobiological mechanisms underlying these complications and to identify potential biomarkers for risk stratification.",[415,416],"Postoperative Cognitive Dysfunction","Postoperative Delirium","2025-09-17",{"date":419,"type":37},"2025-09-25",{"date":421,"type":20},"2025-09-15",{"date":423,"type":20},"2030-12-01",{"name":43,"class":44},{"id":426,"slug":427,"hasResults":11,"nctId":428,"briefTitle":429,"officialTitle":430,"acronym":4,"eligibilityCriteria":431,"healthyVolunteers":77,"sex":15,"minAge":432,"maxAge":4,"enrollmentInfo":433,"targetDuration":4,"studyType":21,"phases":434,"briefSummary":435,"conditions":436,"keywords":437,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":448,"locationsCount":45},"100597895","sacral-canal-block-for-hip-replacement-the-efficacy-and-safety-of-controlled-intraoperative-hypotension-100597895","NCT07064434","Sacral Canal Block for Hip Replacement the Efficacy and Safety of Controlled Intraoperative Hypotension","Sacral Canal Block for Hip Replacement the Efficacy and Safety of Controlled Intraoperative Hypotension:a Single-center, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n1. Over 45 years old;\n2. ASA Grade II - III;\n3. BMI 18-35kg\u002F㎡;\n4. Agree to participate in this study and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Those who refuse to participate in the experiment;\n2. Those who suffer from language or hearing impairments and are unable to communicate;\n3. Those with contraindications for sacral canal block.","45 Years",{"count":81,"type":20},[56],"To observe the efficacy and safety of sacral canal block in controlled blood pressure reduction during hip replacement in the elderly, and to provide a better option for controlled blood pressure reduction during clinical hip surgery.",[300],[438,439,440],"Sacral canal block","Hip replacement","Postoperative rehabilitation","2025-07-03",{"date":443,"type":37},"2025-07-14",{"date":445,"type":37},"2024-11-01",{"date":447,"type":20},"2025-10-30",{"name":43,"class":44},{"id":450,"slug":451,"hasResults":11,"nctId":452,"briefTitle":453,"officialTitle":454,"acronym":4,"eligibilityCriteria":455,"healthyVolunteers":11,"sex":15,"minAge":103,"maxAge":211,"enrollmentInfo":456,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":458,"conditions":459,"keywords":461,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":466,"lastUpdatePostDateStruct":467,"startDateStruct":469,"completionDateStruct":471,"leadSponsor":472,"locationsCount":45},"100576875","wearable-device-based-analysis-of-the-relationship-between-sleep-patterns-and-clinical-prognosis-in-patients-with-traumatic-brain-injury-100576875","NCT06790979","Wearable Device-Based Analysis of the Relationship Between Sleep Patterns and Clinical Prognosis in Patients With Traumatic Brain Injury","Wearable Device-Based Analysis of the Relationship Between Sleep Patterns and Clinical Prognosis in Patients With Mild to Moderate Traumatic Brain Injury","Inclusion Criteria:\n\n1. 18\\~60 years old.\n2. The patient had no sleep disturbance problems prior to traumatic brain injury.\n3. The patient has a definite diagnosis of traumatic brain injury and the Glasgow score is \\>8.\n4. The patient had abnormal imaging scans.\n5. It has complete preclinical data.\n\nExclusion Criteria:\n\n1. Patients with a previous history of traumatic brain injury, mental illness, alcohol abuse or sleep disorders.\n2. Patients admitted for surgical intervention.\n3. Patients with a combination of other heavy visceral injuries.\n4. Women during pregnancy and lactation.\n5. The patents' use of medications that interfere with sleep",{"count":457,"type":20},50,"In patients with traumatic brain injury, post-traumatic sleep patterns have the potential to impact clinical prognosis. While some progress has been made in the study of sleep and prognosis in patients with traumatic brain injury, there is still lack of research on the relationship between sleep and clinical prognosis in post-traumatic patients due to differences in study design, patient age, severity of trauma, and definitions of sleep disorders. Additionally, the primary data collection methods employed in most studies have been self-reported sleep assessments, which are subject to potential biases and inaccuracies. Therefore, explore the impact of sleep patterns on clinical prognosis in post-traumatic patients, with potential to advance our comprehension of recovery outcomes in this patient group.",[460],"Traumatic Brain Injury (TBI); Concussion, Initial Encounter",[462,463,464,465],"Traumatic brain injury","Sleep","Prognosis of trauma","Wearable devices","2025-01-18",{"date":468,"type":37},"2025-01-24",{"date":470,"type":37},"2024-10-01",{"date":447,"type":20},{"name":43,"class":44},{"id":474,"slug":475,"hasResults":11,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":4,"eligibilityCriteria":479,"healthyVolunteers":77,"sex":15,"minAge":103,"maxAge":171,"enrollmentInfo":480,"targetDuration":4,"studyType":21,"phases":482,"briefSummary":483,"conditions":484,"keywords":486,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":492,"lastUpdatePostDateStruct":493,"startDateStruct":495,"completionDateStruct":497,"leadSponsor":499,"locationsCount":45},"100558637","ultrasound-guided-hydrodilatation-with-triamcinolone-acetonide-for-adhesive-capsulitis-100558637","NCT06553716","Ultrasound-Guided Hydrodilatation With Triamcinolone Acetonide for Adhesive Capsulitis","Ultrasound-Guided Hydrodilatation With Triamcinolone Acetonide for Adhesive Capsulitis:The Effect of the Rotator Cuff Interval With Posterior Glenohumeral Recess Approaches on the Improvement of Joint Motion and Pain","Inclusion Criteria:\n\n1. Age ≥18 years old, clinical diagnosis of periarthritis of shoulder;\n2. symptom duration \\> 1 month, shoulder ROM limitation in at least two directions, defined as abduction \\\u003C 80°, flexion \\\u003C 130°, and rotation \\\u003C 30°;\n3. Before enrollment, the patients received plain radiographs, ultrasound images, and magnetic resonance imaging to rule out the cause of secondary shoulder capsitis.\n\nExclusion Criteria:\n\n1. Secondary frozen shoulder, such as rotator cuff tear, calcifying tendinitis, osteoarthritis, infection, tuberculosis infection, rheumatic disease, shoulder impingement syndrome;\n2. Previous history of shoulder joint surgery;\n3. Involved cervical nervous system symptoms or abnormal nervous system;\n4. corticosteroid injection in the affected shoulder within 3 months;\n5. Mental illness;\n6. Patients with contraindications to cortisol-hormone use.",{"count":481,"type":20},70,[56],"The purpose of this study was to compare the efficacy of ultrasus-guided hydrodilation of Rotator Cuff Interval combined with Posterior Glenohumeral recess approach and hydrodilation of the Rotator cuff Interval alone in Adhesive Capsulitis.",[485],"Postoperation Pain",[487,488,489,490,491],"Adhesive capsulitis","hydrodilatation","corticosteroid","rotator cuff interval","Posterior Glenohumeral Recess","2024-09-18",{"date":494,"type":37},"2024-09-20",{"date":496,"type":37},"2024-02-05",{"date":498,"type":20},"2024-11-30",{"name":43,"class":44},{"id":501,"slug":502,"hasResults":11,"nctId":503,"briefTitle":504,"officialTitle":505,"acronym":4,"eligibilityCriteria":506,"healthyVolunteers":77,"sex":365,"minAge":103,"maxAge":432,"enrollmentInfo":507,"targetDuration":4,"studyType":21,"phases":509,"briefSummary":510,"conditions":511,"keywords":513,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":523,"locationsCount":45},"100562382","effect-of-epidural-catheter-retention-depth-on-labor-analgesia-performed-in-dpe-combined-with-pieb-model-100562382","NCT06602440","Effect of Epidural Catheter Retention Depth on Labor Analgesia Performed in DPE Combined With PIEB Model","Observations on the Effect of Different Depths of Epidural Catheter Retention on the DPE Technique Combined With the PIEB Mode of Labor Analgesia：a Single-center, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n1. Those aged 18 to 45 years old;\n2. Pregnancy lasts for 37 to 42 weeks;\n3. Single healthy pregnant women with cervical dilation \\\u003C 3.0 cm who wish to use epidural labor analgesia;\n4. The NRS score of uterine contraction pain is \\> 3;\n5. ASA grade I-II;\n6. BMI ≤ 40 kg\u002Fm².\n\nExclusion Criteria:\n\n1. Those with contraindications to intraspinal anesthesia;\n2. Those with a history of allergy to local anesthetics and opioids;\n3. Pregnancy diseases (such as pregnancy-induced hypertension, preeclampsia or gestational diabetes, etc.);\n4. Known fetal abnormalities or situations associated with an increased risk of cesarean section;\n5. Patients who have taken opioids or sedatives within 4 hours before epidural analgesia.",{"count":508,"type":20},102,[56],"The purpose of this study is to observe the appropriate indwelling depth of epidural catheter when labor analgesia is performed in the mode of DPE combined with PIEB, and then shorten the onset time of labor analgesia and reduce the occurrence of catheter-related adverse outcomes.",[512],"Labor Analgesia",[514,515,516],"Uterine contraction pain","Dural puncture epidural technique（DPE）","Programmed intermittent epidural bolus（PIEB）","2024-09-17",{"date":519,"type":37},"2024-09-19",{"date":521,"type":37},"2024-07-01",{"date":470,"type":20},{"name":43,"class":44},{"id":525,"slug":526,"hasResults":11,"nctId":527,"briefTitle":528,"officialTitle":529,"acronym":4,"eligibilityCriteria":530,"healthyVolunteers":77,"sex":15,"minAge":432,"maxAge":17,"enrollmentInfo":531,"targetDuration":4,"studyType":21,"phases":533,"briefSummary":534,"conditions":535,"keywords":536,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":540,"startDateStruct":541,"completionDateStruct":542,"leadSponsor":544,"locationsCount":45},"100556247","effect-of-posterior-femoral-cutaneous-nerve-block-on-postoperative-posterior-lateral-knee-analgesia-in-patients-with-tka-100556247","NCT06522620","Effect of Posterior Femoral Cutaneous Nerve Block on Postoperative Posterior Lateral Knee Analgesia in Patients With TKA","Posterior Femoral Cutaneous Nerve Combined With Proximal Sciatic and Saphenous Nerve Block for Postoperative Posterior Lateral Knee Analgesia in Patients With TKA: a Single-center, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n1. Patients who are \\>45 years of age; intended to undergo elective first TKA under general anesthesia\n2. ASA grade II-III.\n3. Agreed to participate in this study and signed the informed consent form.\n4. BMI less than 28Kg\u002Fm2.\n\nExclusion Criteria:\n\n1. Patients who refuse to participate in the trial\n2. Preoperative inability to communicate due to speech and hearing impairment, etc.\n3. History of allergy to local anesthetics or opioids\n4. Contraindications to nerve block operation.",{"count":532,"type":20},90,[56],"The aim of this study was to observe the effects of posterior femoral cutaneous nerve block combined with sciatic and saphenous nerve block compared with sciatic and saphenous nerve block alone on postoperative posterior side of the knee (popliteal fossa) pain and sleep quality in patients with TKA, and to further alleviate postoperative posterior side of the knee pain in patients with TKA and improve the quality of postoperative sleep.",[300],[537,538,271,539],"Posterior Femoral Cutaneous Nerve","Nerve Block","posterior lateral knee pain",{"date":519,"type":37},{"date":521,"type":37},{"date":543,"type":20},"2024-09-25",{"name":43,"class":44},""]