[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Giorgio Veneziano\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100657529","a-pilot-study-comparison-of-programmed-intermittent-bolus-versus-continuous-infusion-100657529",false,"NCT07839039","A Pilot Study Comparison of Programmed Intermittent Bolus Versus Continuous Infusion","A Pilot Study Comparison of Postoperative Analgesia Using Two Modes of Local Anesthetic Epidural Delivery After Bladder Exstrophy Repair: Programmed Intermittent Bolus Versus Continuous Infusion","Inclusion Criteria:\n\n* Age less than 18 years\n* Kelly procedure or other approximating surgical interventions\n* Expected need for postoperative epidural analgesia of at least 72 hours in duration\n\nExclusion Criteria:\n\n* Spine abnormality or coagulopathy that contraindicates epidural catheter placement\n* Perioperative anticoagulation regimen that is not recommended by the ASRA guidelines on concurrent use with neuraxial anesthesia\n* Surgery is anticipated to require osteotomies\n* Allergy to local anesthetic drug or other pain management drugs listed in protocol\n* Allergy to chlorhexidine, Dermabond, or Tegaderm CHG dressing\n* Opioid consumption within two weeks prior to surgery\n* Infection or rash over the epidural catheter insertion site\n* Systemic bacterial or fungal infection requiring ongoing treatment with antibiotics\n* Epidural pump unable to be initiated in the operating room or within 30 minutes of arrival to PACU.","ALL","18 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to determine whether programmed intermittent epidural bolus (PIEB) offers advantages over continuous epidural infusion (CEI) in this pediatric post-surgical population by randomizing patients to receive either the PIEB or CEI pump modality for postoperative analgesia. The comparative efficacy of the two interventions will be primarily determined by assessing pain scores at frequent intervals in the first three postoperative days. Secondary outcomes examined over this period will include opioid consumption, number of epidural pump interventions, incidence of epidural insertion site leakage and\u002For early catheter discontinuation, time to full diet, and incidence of postoperative hypotension.",[26,27],"Bladder Extrophy","Surgery in Children","NOT_YET_RECRUITING","2026-09-24",{"date":31,"type":32},"2026-09-28","ACTUAL",{"date":34,"type":20},"2026-11",{"date":36,"type":20},"2028-12",{"name":38,"class":39},"Giorgio Veneziano","OTHER",""]