[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"High Point University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":84},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":39,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100648278","acute-effects-of-neurodynamics-on-strength-and-endurance-in-athletes-100648278",false,"NCT07721220","Acute Effects of Neurodynamics on Strength and Endurance in Athletes","Acute Effects of Neurodynamics on Strength and Endurance in Athletes: A Randomized Control Trial","Inclusion Criteria:\n\n* Participants must be between 18 and 30 years of age.\n* Must be able to read, understand, and provide informed consent, in English.\n* Must be currently participating in an organized sport (e.g. collegiate, club, or competitive recreational level) or engaging in structured resistance training and athletic conditioning for recreational sports events (e.g 5k, marathon, Crossfit, Hyrox, etc).\n* Medically stable with no known contraindications to physical exertion.\n* Cleared for participation in strength or maximal-effort isometric testing.\n* Be able to perform lower extremity isometric testing without pain that limits maximal effort.\n* Must have 2 lower extremities capable to producing full range knee flexion and extension range of motion.\n* No medical condition that significantly alters lower extremity neuromuscular performance.\n* No history of lower extremity surgery in the past 12 months.\n\nExclusion Criteria:\n\n* Individuals younger than 18 or older than 30.\n* Acute lower extremity injury in the last 12 weeks.\n* Lower extremity surgery within the last 12 months.\n* Pain in either lower extremity that would limit maximal physical exertion.\n* History of neurological disorders, including but not limited to: Neuropathy, Stoke, MS, Parkinson's Disease, etc.\n* Use of medications that significantly impact neuromuscular performance, strength or fatigue.\n* No supplementation that affects neuromuscular performance, strength, or fatigue.\n* Unable to read and understand English.\n* Not in a vulnerable population: Pregnant, mentally or physically challenged, cognitively impaired.",true,"ALL","18 Years","30 Years",{"count":21,"type":22},45,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population. This study aims to find if these interventions can maintain or promote strength and endurance in the hamstrings. The studies results will help physical therapist better prescribe exercise and hands-on treatment for hamstring and sciatic nerve related conditions and injuries.",[28,29,30,31,32,33,34,35,36,37,38],"Sciatic Leg Pain","Hamstring Muscle Tightness","Hamstring Muscle Strain","Hamstring Muscle Strength","Hamstring Injuries","Hamstring Injury Prevention","Hamstring Rupture","Sciatic Nerve Injury","Sciatic Radiculopathy","Lumbar Disc Herniation With Radiculopathy","Lumbar Disc Herniation",[40,41,42],"hamstring","sciatic nerve","athlete","RECRUITING","2026-07-20",{"date":46,"type":47},"2026-07-22","ACTUAL",{"date":49,"type":47},"2026-06-15",{"date":51,"type":22},"2026-07",{"name":53,"class":54},"High Point University","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":55},"100600404","phase-2-multi-session-transcranial-alternating-current-stimulation-to-improve-dual-task-standing-and-brain-activity-in-older-adults-with-mild-cognitive-impairment-100600404","NCT07097051","Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment","Inclusion Criteria:\n\n* Age 65+\n* Who have been diagnosed with cognitive impairment (based in MoCA or TICS and Clinical Dementia Rating: CDR 0.5)\n* Ability to stand and walk independently\n* Willing and capable to give informed consent for the participation in the study after it has been thoroughly explained\n* Cut off of MOCA score \\>18 will be applied\n* Able and willing to comply with all study requirements informed consent form was signed\n* Understanding of the ICF will be assessed by asking the participant to answer the following three questions: 1) What is the purpose of this study? 2) What are the risks of study involvement? 3) If you decide to participate, are you allowed to withdraw from the study at any time? Answers will be recorded by study personnel on the \"Assessment of Protocol Understanding\" form (see attached). Insufficient understanding will be defined by one or more incorrect answers, as determined at the discretion of the investigator.\n\nExclusion Criteria:\n\n* Cut off of MOCA score \\\u003C18 will be applied\n* Major psychiatric co-morbidity including major depressive disorder, schizophrenia or psychosis\n* Blindness or other disabilities that prevent task performance\n* Self-reported history of stroke or neurodegenerative disorders other than MCI.\n* Self-reported active cancer for which chemo-\u002Fradiation therapy is being received.\n* Contraindications to tACS, as recorded on a standardized screening questionnaire, which include a reported seizure within the past two years, use of neuro-active drugs, self-reported presence of specific implanted medical devices (e.g., deep brain stimulator, medication infusion pump, cochlear implant, pacemaker, etc.), or the presence of any active dermatological condition, such as eczema, on the scalp.","65 Years","85 Years",{"count":65,"type":22},20,[67],"PHASE2","Older adults with Mild Cognitive Impairment (MCI) often show less brain activity in a specific range (8-13 Hz, known as alpha power) compared to healthy older adults. Those with lower alpha activity, especially in the front part of the brain, usually have problems with executive functions like planning and multitasking. Our research has shown that older adults with lower alpha power in these areas also struggle more with balance when they have to do two things at once (like standing and performing a cognitive task simultaneously).\n\nThe investigators believe that increasing alpha power in older adults with MCI could improve their balance and executive function, helping them stay independent longer. In early studies, the investigators found that using transcranial alternating current stimulation (tACS) at 10 Hz on the front part of the brain can boost alpha power and balance immediately after a single session in older adults with MCI. The effect was stronger in those whose natural brain activity was close to the 10 Hz stimulation.\n\nBased on these findings, the investigators plan to conduct a pilot study with older adults aged 65-85 years with MCI. Participants will be randomly assigned to receive either real tACS or a sham (placebo) treatment. Our main hypothesis is that real tACS will improve balance when multitasking, and these improvements will last for 1 to 3 months after the treatment. The investigators also believe that tACS will enhance other aspects of executive function and mobility and that these improvements will be linked to increased alpha activity in the brain.\n\nThrough this study, we aim to gather strong evidence that tailored tACS is a promising treatment to improve cognitive and motor functions and overall brain activity in older adults with MCI.",[70],"Mild Cognitive Impairment (MCI)",[72,73,74,75],"brain stimulation","balance","cognition","executive function","2025-07-30",{"date":78,"type":47},"2025-07-31",{"date":80,"type":47},"2025-05-13",{"date":82,"type":22},"2026-12-31",{"name":53,"class":54},""]