[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Hospital Universitario de Gran Canaria Doctor Negrín\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":66},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100646384","postoperative-analgesia-in-thoracic-surgery-100646384",false,"NCT07694141","Postoperative Analgesia in Thoracic Surgery","Postoperative Analgesia in Patients Undergoing Thoracic Surgery","ARP-TS","Inclusion Criteria:\n\n* Patients undergoing thoracic surgery between July 1 and October 31, 2020.\n* Age over 18.\n* ASA I-III.\n* Signed informed consent\n\nExclusion Criteria:\n\n* ASA IV-V.\n* Chronic opioid treatment or treatment in the Chronic Pain Unit.\n* Intravenous drug abuse.\n* Local anesthetic allergy.\n* Language barrier, cognitive impairment, or inability to participate in clinical assessment during the study.\n* BMI \\\u003C18 or \\>35 kg\u002Fm2","ALL","18 Years",{"count":20,"type":21},160,"ESTIMATED","OBSERVATIONAL","Analgesic management in thoracic surgery presents a particular challenge for the anesthesiologist, given the intensity of postoperative pain associated with thoracotomy, a surgical procedure that can impact respiratory function and the patient's subsequent recovery. Epidural analgesia is the gold standard. When epidural catheter placement is not feasible, erector spinae plane block is a safe alternative. The ultrasound target is easily visualized, and the injection site is far from the neuraxis, pleura, and major vascular structures. Consequently, this block has been incorporated into standard clinical practice as a treatment option for patients with complex cases or as an alternative approach when epidural catheter placement is not feasible. The primary objective of this study is to assess the effectiveness of postoperative analgesia in patients undergoing elective thoracic surgery.\n\nStudy Population Design A prospective observational follow-up study will be conducted. ASA I-III patients undergoing scheduled thoracic surgery between November 1 and December 31, 2025, will be included. Their analgesic management will be based on standard clinical practice.",[25],"Postoperative Pain Management",[27,28,29],"thoracic surgery","pain","epidural analgesia","RECRUITING","2026-07-16",{"date":33,"type":34},"2026-07-20","ACTUAL",{"date":36,"type":34},"2025-11-15",{"date":38,"type":21},"2027-01-30",{"name":40,"class":41},"Hospital Universitario de Gran Canaria Doctor Negrín","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":4},"100603031","changes-in-portal-vein-pulsatility-variability-during-a-tidal-volume-challenge-can-predict-fluid-tolerance-100603031","NCT07131228","Changes in Portal Vein Pulsatility Variability During a Tidal Volume Challenge Can Predict Fluid Tolerance","SERLU","Inclusion Criteria:\n\nParticipants must meet all of the following:\n\nAge ≥ 18 years at the time of enrollment.\n\nReceiving controlled mechanical ventilation with a baseline tidal volume of 6 mL\u002Fkg of predicted body weight.\n\nClinical indication for assessment of fluid responsiveness.\n\nAdequate acoustic window for ultrasound visualization of the portal vein.\n\nExclusion Criteria:\n\nParticipants will be excluded if they have any of the following:\n\nLiver cirrhosis.\n\nRight heart failure, defined as any of the following on prior echocardiography:\n\nTricuspid annular plane systolic excursion (TAPSE) \\\u003C 16 mm\n\nS' wave \\\u003C 10 cm\u002Fs\n\nRight ventricular fractional area change \\\u003C 35%\n\nLeft heart failure (left ventricular ejection fraction \\\u003C 50%).\n\nIntra-abdominal hypertension.\n\nAtrial fibrillation or other significant cardiac arrhythmias.\n\nTricuspid regurgitation.\n\nPoor echogenic window preventing adequate ultrasound assessment.\n\nPresence of spontaneous breathing activity.",{"count":51,"type":21},60,"In critically ill patients, appropriate fluid administration is one of the cornerstones of hemodynamic management, as both hypovolemia and fluid overload can negatively impact clinical outcomes.\n\nFor years, fluid responsiveness-defined as an increase in cardiac output following volume administration-has guided decision-making in the postoperative ICU. However, fluid responsiveness alone does not guarantee fluid tolerance, which refers to the venous system's ability to accommodate volume without developing venous congestion or adverse effects such as pulmonary edema, renal or hepatic dysfunction.\n\nThe tidal volume challenge (TVC)-which consists of a transient increase in tidal volume from 6 to 8 mL\u002Fkg-has been shown to predict fluid responsiveness by enhancing the hemodynamic interaction between the heart and lungs during the cardiac cycle, as measured through dynamic arterial indices such as pulse pressure variation (PPV) or stroke volume variation (SVV). However, these indices do not provide information about fluid tolerance or the state of venous congestion.\n\nDoppler ultrasound of the portal vein, specifically the portal pulsatility index (which under normal conditions presents as a continuous waveform due to the damping effects of the hepatic parenchyma and venous compliance), has been proposed as a non-invasive marker of systemic venous congestion. Studies have shown that an increase in the portal pulsatility index following volume loading may indicate the development of venous congestion and, therefore, poor fluid tolerance.\n\nSince the tidal volume challenge transiently increases intrathoracic pressure and allows dynamic evaluation of cardiovascular responses, we propose that this interaction be assessed not only through arterial dynamic indices (which assess responsiveness) but also through changes in venous flow patterns-specifically, variations in portal pulsatility-so that both fluid responsiveness and tolerance can be predicted with the same test.",[54],"Venous Congestion",[56],"Fluid Responsiveness Fluid Tolerance","NOT_YET_RECRUITING","2026-07-02",{"date":60,"type":34},"2026-07-06",{"date":62,"type":21},"2026-11-01",{"date":64,"type":21},"2027-11-30",{"name":40,"class":41},""]