[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Instituto Nacional de Cancerologia, Columbia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100656262","quad-shot-versus-split-course-radiotherapy-in-incurable-head-and-neck-cancer-100656262",false,"NCT07823309","Quad Shot Versus Split Course Radiotherapy in Incurable Head and Neck Cancer","Comparison of Two Hypofractionated Radiotherapy Regimens for the Palliative Management of Patients With Head and Neck Cancers: Quad Shot Versus Split Course","QSSC-HN","Inclusion Criteria:\n\n* Adult patients (18 years and older) with a histopathological diagnosis of incurable squamous cell carcinoma of the head and neck, not candidates for curative-intent treatment.\n* Metastatic or locally advanced unresectable disease, in a strictly palliative setting.\n* Medical indication for palliative radiotherapy.\n* Performance status: Karnofsky 50 or higher or ECOG 3 or lower.\n* Clinical capacity to receive radiotherapy in an outpatient setting.\n* Estimated life expectancy greater than 3 months.\n* Presence of at least one measurable lesion according to RECIST 1.1 criteria.\n* Logistical capacity and willingness to adhere to follow-up clinical and radiological controls up to 6 months post-treatment.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* History of previous radiotherapy to the same anatomical region to be treated.\n* Diagnosis of a second active malignancy that could interfere with the evaluation of oncological outcomes.\n* Presence of clinical instability or severe comorbidities that contraindicate radiotherapy treatment.\n* Severe cognitive or psychiatric alterations that prevent the understanding of the nature of the study, signing the consent form, or adherence to the protocol.\n* Women who are pregnant or breastfeeding","ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","Head and neck cancer in its advanced, incurable stage causes severe symptoms such as pain, trouble swallowing, and bleeding. Palliative radiation therapy is frequently used to relieve these symptoms and improve the patient's quality of life. Currently, a standard treatment approach is the \"Split Course\" regimen, which takes several weeks and can cause side effects that are difficult for patients to tolerate. This study aims to evaluate a shorter, alternative radiation treatment called \"Quad Shot.\"\n\nThe hypothesis of this study is that the Quad Shot regimen will be as effective as the Split Course regimen in shrinking the tumor and controlling local symptoms, but will offer a better quality of life by reducing the overall treatment time and the severity of side effects. To test this, researchers will assign participants by chance to receive either the Quad Shot or the Split Course regimen. The research team will closely monitor tumor response, treatment side effects, and patients' quality of life for up to six months.",[27,28],"Head and Neck Neoplasms","Squamous Cell Carcinoma of Head and Neck",[30,31,32,33,34,35],"Palliative Radiotherapy","Radiation Dose Hypofractionation","Quad Shot","Split Course","Quality of Life","Cancer Pain","NOT_YET_RECRUITING","2026-09-29",{"date":39,"type":40},"2026-10-02","ACTUAL",{"date":42,"type":21},"2027-01-01",{"date":44,"type":21},"2028-12-31",{"name":46,"class":47},"Instituto Nacional de Cancerologia, Columbia","OTHER_GOV",""]