[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Irene Latorre Rueda\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100649659","a-step-forward-for-unraveling-the-immune-mechanisms-and-tools-for-tuberculosis-spectrum-management-100649659",false,"NCT07735754","A Step Forward for Unraveling the Immune Mechanisms and Tools for Tuberculosis Spectrum Management","TB-SPECTRUM","Inclusion Criteria:\n\n* Age between 5 and 65 years\n* Willing and able to provide informed consent (or legal guardian consent) \\*GROUP 1: Active pulmonary TB\\*\n* Bacteriologically confirmed TB\n* Pulmonary TB\n* Anti-TB treatment ≤ 14 days \\*GROUP 2: Close contacts of active pulmonary TB\\*\n* Close contact with confirmed pulmonary TB case\n* Exposure ≥6 hours\u002Fday for ≥5 days\u002Fweek\n* Positive TST and\u002For IGRA\n* NOT receiving TB preventive therapy \\*GROUP 3: Other respiratory diseases (non-TB)\\*\n* Diagnosis of ARI (Acute Respiratory Infection) and\u002For sarcoidosis and\u002For lung cancer\n* Clinical\u002Fradiological findings consistent with non-TB disease\n* NO clinical suspicion compatible with active TB \\*GROUP 4: Healthy uninfected controls\\*\n* No symptoms suggestive of active TB\n* Not known prior exposure to active TB\n* Negative TST and\u002For IGRA\n\nExclusion Criteria:\n\n* Known or suspected immunodeficiency (including HIV or immunosuppressive therapy)\n* Known or suspected pregnancy",true,"ALL","5 Years","65 Years",{"count":21,"type":22},940,"ESTIMATED","2 Years","OBSERVATIONAL","Tuberculosis (TB) is a significant infectious disease worldwide, with millions of people infected and major impact on mortality and public health. TB-SPECTRUM project will conduct a clinical study to characterize better clinically, microbiologically, and immunologically the spectrum of TB across the different stages of infection, including incipient and asymptomatic\u002Fsubclinical TB, active disease, and post treatment phases. Passive and active case-finding (ACF) clinical approaches will be implemented, recruiting TB patients through public and private healthcare facilities and targeted community outreach, as well as their close contacts. This approach will allow the study of biomarker profiles associated with infection risk, disease progression and response to treatment. The specific objectives of the study will be:\n\n* To unravel immune mechanisms underlying the TB spectrum through a multidisciplinary approach.\n* To perform a clinical study (passive and ACF) for recruiting patients and their contacts for the enrolment of incipient\u002Fsubclinical TB forms and the subsequent immune characterization and management.\n* To characterize host systemic and local immune responses on different TB immune states (with special focus on incipient, subclinical and cured TB) to better understand host-pathogen interactions and the established cellular\u002Fhumoral immune mechanisms.\n* To stratify host immunity according to patient's clinical strain characterization and disease severity.\n* To develop and evaluate innovative tools for better management of all phases of the TB spectrum.",[27],"Tuberculosis",[29,30,31,32,33,34,35],"Pulmonary tuberculosis","tuberculosis spectrum","close contacts","Active Case Finding","host-pathogen interactions","asymptomatic tuberculosis","incipient tuberculosis","NOT_YET_RECRUITING","2026-07-24",{"date":39,"type":40},"2026-07-30","ACTUAL",{"date":42,"type":22},"2026-09",{"date":44,"type":22},"2029-12",{"name":46,"class":47},"Irene Latorre Rueda","OTHER",""]