[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Júnea Regina Pires Drews\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100659789","effect-of-dietary-fiber-supplementation-on-systemic-inflammation-and-clinical-parameters-in-copd-a-randomized-double-blind-placebo-controlled-clinical-trial-100659789",false,"NCT07868211","Effect of Dietary Fiber Supplementation on Systemic Inflammation and Clinical Parameters in COPD: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","Efeito Da Suplementação Dietética De Fibras Sobre Inflamação Sistêmica E Parâmetros Clínicos Na DPOC: Ensaio Clínico Randomizado, Duplo-Cego E Controlado Por Placebo","Inclusion Criteria:\n\n* Inclusion Criteria:\n* Diagnosis of COPD with no exacerbation episodes in the last 3 months\n* Aged 18 to 75 years\n* Patient at the Interstitial Lung Diseases Outpatient Clinic of Hospital das Clínicas da UFMG\n* Ability to perform spirometry\n* Ability to perform the 6-minute walk test (6MWT)\n* Willingness to participate in the study and signed Informed Consent Form (ICF)\n* Ability to read and write\n* Daily dietary fiber intake between 10 and 20 grams\n\nExclusion Criteria:\n\n* End-stage COPD (GOLD stage 4)\n* Primary diagnosis of asthma\n* Interstitial lung disease\n* Lung transplant recipients\n* Severe comorbidities impacting outcomes (severe pancreatic, hepatic, renal, or cardiac disease; inflammatory bowel disease; active neoplasm with prognostic impact; human immunodeficiency virus\u002FAIDS; active pulmonary tuberculosis; multiple sclerosis)\n* Any other condition identified during the screening visit by the investigator or nurse that could interfere with the study or patient safety\n* Diagnosed COPD exacerbation (ECOPD) within the 3 months prior to study start\n* Recent acute respiratory infection\n* Unwillingness or inability to comply with study procedures (e.g., inability to record dietary intake, attend visits, or manage oral supplementation)\n* Pregnant, breastfeeding, or planning to become pregnant\n* Change in smoking habits within the last 6 months\n* Major changes in COPD maintenance therapy within 3 months prior to screening\n* Requirement for other nutritional supplements or parenteral nutrition\n* Daily dietary fiber intake exceeding 28 grams for women or 34 grams for men\n* Use of a short course of oral corticosteroids within 4 weeks prior to Day 1 of the study","ALL","18 Years","75 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent respiratory symptoms and systemic inflammation. Dietary fiber intake has been associated with beneficial effects on gut microbiota composition and systemic inflammatory markers. This study aims to evaluate the effects of dietary fiber supplementation on systemic inflammation and clinical parameters in patients with COPD through a randomized, double-blind, placebo-controlled trial.",[27,28,29],"Pulmonary Disease, Chronic Obstructive (COPD)","Pulmonary Diseases","Pulmonary Diseases, Obstructive",[31,32,33,34,35,36],"Dietary Fiber","Systemic Inflammation","Nutritional Status","Gut Microbiota","Randomized Controlled Trial","Fibras alimentares","NOT_YET_RECRUITING","2026-10-05",{"date":40,"type":41},"2026-10-09","ACTUAL",{"date":43,"type":21},"2026-11",{"date":45,"type":21},"2027-07",{"name":47,"class":48},"Júnea Regina Pires Drews","OTHER_GOV",""]