[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"JYAMS PET Research & Development Limited\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":62},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100650796","phase-3-evaluate-the-concordance-between-pet-imaging-of-18f-apn-1607-injection-and-postmortem-brain-tissue-tau-pathology-in-individuals-with-hv-and-mci-or-ad-100650796",false,"NCT07752784","Evaluate the Concordance Between PET Imaging of [18F]-APN-1607 Injection and Postmortem Brain Tissue Tau Pathology in Individuals With HV and MCI or AD.","A Clinicopathological Study to Evaluate the Concordance Between [18F]-APN-1607 Injection PET Imaging and Post-mortem Brain Tau Protein Pathological Changes in Cognitively Normal (HV) Subjects and Patients With AD-derived Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) Dementia.","Inclusion Criteria:\n\n1. Able to understand and voluntarily sign a written informed consent form (ICF).\n2. Age≥50 years, male or female.\n3. Charlson Comorbidity Index (CCI)≥5.\n4. Able to tolerate imaging procedures.\n5. For MCI or AD subjects: clinically diagnosed as AD-derived cognitive impairment or Alzheimer's dementia.\n6. For HV subjects: no known personal or family history of AD-derived dementia.\n\nExclusion Criteria:\n\n1. Confirmed brain structural abnormalities that may affect PET reading, e.g., large stroke (infarct area\\>4 cm) or intracranial space-occupying lesion.\n2. Currently having clinically significant infectious diseases: HIV, hepatitis, etc.\n3. Currently participating in any investigational clinical trial.\n4. Previous participation in clinical studies of amyloid or tau-targeting agents.\n5. Suspected hepatic encephalopathy.\n6. Allergy to the investigational drug or any of its components.\n7. Currently pregnant or breastfeeding.\n8. Currently having a disease or condition that prolongs the QT interval.",true,"ALL","50 Years",{"count":20,"type":21},12,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","1. To evaluate the diagnostic performance of \\[18F\\]-APN-1607 injection PET imaging in detecting uptake patterns consistent with AD neuropathological changes as defined by the National Institute on Aging-Alzheimer's Association (NIA-AA) criteria.\n2. To assess the association between \\[18F\\]-APN-1607 injection and Alzheimer's disease (AD)-related tau neurofibrillary pathology (as determined by post-mortem brain tissue histopathology), and detect the uptake pattern corresponding to neurofibrillary tangle (NFT) scores.\n3. To evaluate the safety of \\[18F\\]-APN-1607 injection.",[27],"Alzheimer's Disease","RECRUITING","2026-08-14",{"date":31,"type":32},"2026-08-17","ACTUAL",{"date":34,"type":21},"2026-08-15",{"date":36,"type":21},"2027-08-15",{"name":38,"class":39},"JYAMS PET Research & Development Limited","INDUSTRY",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":5},"100625455","phase-3-evaluate-the-use-of-18f-apn-1607-pet-in-subjects-with-ad-related-cognitive-impairment-and-subjects-with-normal-cognitive-function-100625455","NCT07422857","Evaluate the Use of [18F]-APN-1607 PET in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function","Phase III Multicenter Clinical Trial Evaluating the Use of [18F]-APN-1607 Injection in Positron Emission Tomography in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function","Inclusion Criteria:\n\n1. Subjects must be able to understand and voluntarily sign a written informed consent form (ICF);\n2. Age ≥ 50 years, regardless of gender;\n3. Subjects with HV, MCI, and AD should meet the clinical diagnostic criteria\n4. Can tolerate brain MRI and PET imaging examinations;\n5. For women of potential fertility (not yet menopausal or within 2 years of menopause), effective contraception must be used during the study and for 3 months after the study (effective contraception refers to sterilization, intrauterine hormonal devices, condoms, birth control pills, abstinence, or partner vasectomy, etc.); male participants should agree to use contraception during the study and for 3 months after the study.\n\nExclusion Criteria:\n\n1. Specific clinical phenotypes of atypical AD as defined in the 2014 IWG-2 criteria\n2. Possible presence of frontotemporal degeneration (FTLD), characterized by progressive psych behavioral abnormalities and executive dysfunction，Characterized primarily by impairment and language function, progressive aphasia\n3. The core symptoms of Lewy body dementia include fluctuating cognitive changes accompanied by significant attention and arousal abnormalities, recurrent typical visual hallucinations, and spontaneous symptoms of Parkinson's syndrome;\n4. Currently suffering from significant mental illness. Subjects with accompanying psychiatric symptoms need to be carefully evaluated by the researchers to determine whether they can complete the imaging process;\n5. Brain structural abnormalities confirmed by MRI, such as large strokes (infarct area greater than 4 cm) or intracranial space-occupying lesions;\n6. Suffering from claustrophobia or unable to tolerate imaging procedures for other reasons;\n7. History of alcohol or drug abuse\u002Fdependency;\n8. Hypersensitivity to the investigational drug or any of its components;\n9. Currently pregnant or breastfeeding;\n10. Received non-vaccine investigational treatment for Alzheimer's disease or other dementia within 3 months prior to screening, or received passive immunotherapy (antibody) for the treatment of Alzheimer's disease or other dementia within 6 months prior to screening, or previously received a vaccine for the treatment of Alzheimer's disease or other dementia; or participated in other new drug clinical trials within 30 days prior to enrollment;\n11. At present, the researcher suffers from serious diseases, such as infectious diseases, infectious diseases, endocrine or metabolic diseases, as well as serious cardiac function, liver function, lung function, and kidney function damage, and believes that participation in this study will have adverse effects on the subject or the research results\n12. Currently suffering from a disease or factor that causes QT interval prolongation, including torsades de pointes, QT prolongation syndrome, hyperkalemia, hypocalcemia, or taking medications that can prolong the QT interval, such as quinidine, amiodarone, or sotalol\n13. There are other situations that researchers consider unsuitable for participating in the experiment.",{"count":49,"type":21},316,[24],"This study is to evaluate the efficacy and safety of \\[18F\\]-APN-1607 Injection in PET imaging for detecting AD-related cognitive impairment.",[53],"Subjects With Mild Cognitive Impairment (MCI) of AD, Alzheimer's Disease (AD) Dementia","2026-02-13",{"date":56,"type":32},"2026-02-20",{"date":58,"type":32},"2026-01-22",{"date":60,"type":21},"2027-02-01",{"name":38,"class":39},""]