[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jan Kochanowski University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":112},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100647961","endoscopic-assessment-in-acute-pancreatitis-study-endopan-study-100647961",false,"NCT07714850","ENDoscopic Assessment in Acute PANcreatitis Study (ENDOPAN Study)","Early Upper Gastrointestinal Endoscopic Findings as Predictors of Disease Course and Severity in Acute Pancreatitis: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Age 18 years or older.\n* Diagnosis of acute pancreatitis according to the revised Atlanta criteria, defined by the presence of at least two of the following three features:\n\ntypical abdominal pain consistent with acute pancreatitis; serum amylase and\u002For lipase activity at least three times the upper limit of normal; imaging findings consistent with acute pancreatitis.\n\n* Hospital admission due to acute pancreatitis to the study center.\n* Admission during the early phase of acute pancreatitis, allowing planned upper gastrointestinal endoscopy within 24-48 hours from hospital admission.\n* Ability to undergo diagnostic upper gastrointestinal endoscopy according to the investigator's and treating physician's assessment.\n* Ability to provide written informed consent before enrollment and before any study-specific procedure.\n\nExclusion Criteria:\n\n* Age below 18 years.\n* Lack of written informed consent.\n* Inability to provide informed consent before enrollment.\n* Clinical condition precluding safe diagnostic upper gastrointestinal endoscopy, including hemodynamic instability, severe respiratory failure, or other unstable life-threatening condition.\n* Need for emergency therapeutic upper gastrointestinal endoscopy before planned study endoscopy, for example due to active upper gastrointestinal bleeding.\n* Known or suspected gastrointestinal perforation.\n* Previous gastric or duodenal surgery significantly altering upper gastrointestinal anatomy and preventing reliable assessment of gastric or duodenal mucosa.\n* Known advanced upper gastrointestinal malignancy affecting the stomach or duodenum.\n* Pregnancy.\n* Contraindication to upper gastrointestinal endoscopy or sedation according to the treating physician's or investigator's assessment.\n* Any condition that, in the investigator's opinion, would make participation unsafe or would prevent completion of study procedures.","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","30 Days","OBSERVATIONAL","This is a prospective observational cohort study designed to evaluate early upper gastrointestinal endoscopic findings in adult patients hospitalized with acute pancreatitis. The study aims to determine whether gastric and duodenal mucosal abnormalities detected during early hospitalization are associated with the severity and clinical course of acute pancreatitis.\n\nAdult patients diagnosed with acute pancreatitis according to the revised Atlanta criteria will be enrolled after providing informed consent. Upper gastrointestinal endoscopy will be performed within 24-48 hours from hospital admission. In patients with moderately severe or severe acute pancreatitis, a follow-up endoscopy may be performed before discharge. Clinical, laboratory, imaging, microbiological, and endoscopic data will be collected prospectively during the index hospitalization.\n\nThe primary objective is to assess the association between early endoscopic mucosal abnormalities and acute pancreatitis severity according to the revised Atlanta classification. Secondary objectives include evaluation of the relationship between endoscopic findings and organ failure, local or systemic complications, inflammatory markers, nutritional tolerance, length of hospital stay, need for invasive interventions, and in-hospital mortality.\n\nThe study has received a positive opinion from the Bioethics Committee of Jan Kochanowski University in Kielce, Collegium Medicum, resolution no. 27\u002F2026 dated May 20, 2026.",[25],"Acute Pancreatitis (AP)",[27,28,29,30,31,32],"Acute pancreatitis","Upper gastrointestinal endoscopy","Gastroscopy","Disease severity","Gastroduodenal mucosal injury","Helicobacter pylori","NOT_YET_RECRUITING","2026-07-20",{"date":36,"type":37},"2026-07-22","ACTUAL",{"date":39,"type":20},"2026-09-01",{"date":41,"type":20},"2029-09-30",{"name":43,"class":44},"Jan Kochanowski University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},"100641833","genetic-microbiological-and-behavioral-factors-in-obesity-100641833","NCT07650149","Genetic, Microbiological and Behavioral Factors in Obesity","OPTIMIZE GEN - Outcomes of Persistence and Treatment With tIrzepatide deterMined by Genetic, mIcrobiological & bEhavioral Factors in obEsity","OPTIMIZE-GEN","Inclusion criteria\n\n* Age 18-60 years\n* Consent to participate in the study and providing informed written consent\n* Overweight or obese with a BMI \\>27\n\nExclusion criteria\n\n* Contraindications to tirzepatide use:\n* Type 1 or type 2 diabetes\n* Pregnancy or breastfeeding\n* Cancer\n* Heart failure\n* Expected lack of patient compliance\n* Taking immunosuppressive medications, steroids, NSAIDs, antibiotics (within 2 weeks prior to sample collection),\n* Autoimmune and inflammatory diseases, acute infectious diseases, AIDS, tuberculosis\n* Mental illness\n* Alcohol dependence syndrome\n* Liver cirrhosis\n* Post-myocardial infarction or stroke","60 Years",{"count":19,"type":20},"This study will assess the impact of genetic markers, microbiological (microbiome) and behavioral factors on tolerance, adherence and effectiveness of dual GLP1\u002FGIP RA in the treatment of obesity.\n\n200 consecutive patients who meet all inclusion and none of the exclusion criteria will be enrolled.",[57,58,59],"Obesity & Overweight","Obesity","Genetics",[61,62,63,64,65,66,67],"tirzepatide","obesity","genetics","microbiom","adherence","compliance","gene","RECRUITING","2026-06-15",{"date":71,"type":37},"2026-06-16",{"date":73,"type":37},"2026-05-23",{"date":75,"type":20},"2028-05",{"name":43,"class":44},2,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":88,"conditions":89,"keywords":96,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},"100578786","prevention-of-postoperative-hernias-in-emergency-surgery-100578786","NCT06815822","Prevention of Postoperative Hernias in Emergency Surgery","PROPHECY","Inclusion criteria:\n\n* Patient age \\> 18 years.\n* Emergency or urgent surgery.\n* Specific surgical indications (acute appendicitis, acute cholecystitis, incarcerated hernia, gastrointestinal perforation, and obstruction).\n\nExclusion criteria:\n\n* Lack of patient consent.\n* Open abdomen technique applied.","100 Years",{"count":87,"type":20},500,"The aim of this observational study is to understand the risk factors and incidence of postoperative hernias among patients undergoing emergency surgery. The main question it aims to answer is:\n\nWhat is the incidence of postoperative hernias in this group of patients?\n\nA brief telephone interview will be conducted with participants who will be included in this study one year after the surgery. If the presence of a postoperative hernia is suspected, the patient will be invited to a follow-up visit to the surgical clinic, where the diagnosis will be confirmed by imaging tests.",[90,91,92,93,94,95],"Incarcerated Hernia","Appendicitis Acute","Cholecystitis, Acute","Ileus","Perforated Gastro-duodenal Ulcers","Perforated Bowel",[97,98,99,100,101,102],"postoperative hernia","trocar site hernia","parastomal hernia","incisional hernia","outcomes","emergency surgery","2025-06-12",{"date":105,"type":37},"2025-06-15",{"date":107,"type":37},"2025-06-01",{"date":109,"type":20},"2026-12-31",{"name":43,"class":44},1,""]