[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jiangsu Taizhou People's Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":263},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,44,67,83,112,133,158,180,200,220,242],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100649858","medical-large-language-model-assisted-diagnosis-and-treatment-in-primary-care-chronic-disease-management-100649858",false,"NCT07740044","Medical Large Language Model-Assisted Diagnosis and Treatment in Primary Care Chronic Disease Management","Verification and Application Study of Medical Large Language Model-Assisted Diagnosis and Treatment in Primary Care Chronic Disease Management: A Randomized Controlled Study","Inclusion Criteria:\n\n1. Work experience of 3 years or more;\n2. Able to complete the case assessment tasks required by the study;\n3. Have a practicing doctor qualification;\n4. Work at a township health center or community health service center;\n5. Voluntarily participate in the study and sign the informed consent form.\n\nExclusion Criteria:\n\nN\u002FA","ALL","18 Years","65 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to explore the feasibility of using medical large language models to assist in chronic disease management. By setting up experimental and control group interventions and having experts blindly evaluate anonymized cases, it compares different management approaches in chronic disease care, verifying the scientific basis, effectiveness, and potential for broader use of medical large language models in supporting chronic disease management.",[27,28,29,30],"Coronary Artery Disease","Atrial Fibrillation (AF)","Heart Failure","Stroke","NOT_YET_RECRUITING","2026-07-27",{"date":34,"type":35},"2026-07-31","ACTUAL",{"date":37,"type":21},"2026-08-17",{"date":39,"type":21},"2026-11-30",{"name":41,"class":42},"Jiangsu Taizhou People's Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},"100630811","novel-model-of-integrated-care-of-older-patients-with-atrial-fibrillation-and-heart-failure-in-rural-china-miracle-afhf-100630811","NCT07492524","Novel Model of Integrated Care of Older Patients With Atrial Fibrillation and Heart Failure in Rural China (MIRACLE-AFHF)","1\\. The village clinics need to be willing and able to provide integrated care to their patients with atrial fibrillation; 2. The village doctors from one village clinic serves all AF patients from 3-5 nearby villages; 3. The village doctors are trained to have a fundamental understanding of telemedicine; 4. Patients are eligible for participation if 1)they aged 65-80 years. 2) Electrocardiogram (ECG) confirmation of AF or possession of a diagnostic certificate for AF issued by a specialist. 3) A documented history of HF or a diagnosis of HF based on echocardiography and\u002For NT-proBNP screening, defined by the presence of typical HF symptoms and\u002For signs, together with one of the following: reduced left ventricular ejection fraction (HFrEF; LVEF \\\u003C 40%), mildly reduced left ventricular ejection fraction (HFmrEF; LVEF 40-49%), or preserved left ventricular ejection fraction with elevated NT-proBNP and structural heart disease changes (HFpEF; LVEF ≥ 50%, meeting at least one of the following criteria: LAV 40 ml\u002Fm², E\u002Fe' ≥ 15, or TRV \\> 2.8 m\u002Fs). 4) Management by a village clinic near the participant's place of residence. 5) Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n1. Expected life expectancy of less than 12 months.\n2. Severe renal insufficiency (Ccr \\\u003C 30ml\u002Fmin) or ongoing dialysis treatment.\n3. Cardiac insufficiency secondary to correctable causes, including hyperthyroid heart disease, anemic heart disease, or uncorrected congenital heart disease.\n4. Indications for pacemaker implantation without having undergone implantation.\n5. Chronic obstructive pulmonary disease (COPD) complicated by type II respiratory failure.\n6. Special populations, including patients with mental illnesses.","80 Years",{"count":52,"type":21},942,[24],"This cluster randomization study aims to compare village-doctor led integrated care versus usual care to improve heart failure risk management, guideline-directed medical therapy, self-management adherence, and clinical outcomes for older patients with atrial fibrillation and heart failure in rural China.",[56,29],"Atrial Fibrillation","RECRUITING","2026-07-25",{"date":60,"type":35},"2026-07-28",{"date":62,"type":21},"2026-08-01",{"date":64,"type":21},"2029-12-30",{"name":41,"class":42},3,{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":50,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":78,"startDateStruct":79,"completionDateStruct":80,"leadSponsor":82,"locationsCount":66},"100630809","novel-model-of-integrated-care-of-older-patients-with-atrial-fibrillation-to-prevent-heart-failure-in-rural-china-100630809","NCT07492498","Novel Model of Integrated Care of Older Patients With Atrial Fibrillation to Prevent Heart Failure in Rural China","Inclusion Criteria:\n\n1\\. The village clinics need to be willing and able to provide integrated care to their patients with atrial fibrillation; 2. The village doctors from one village clinic serves all AF patients from 3-5 nearby villages; 3. The village doctors are trained to have a fundamental understanding of telemedicine; 4. Patients are eligible for participation if 1)they aged 65-80 years.\n\n2)Availability of an electrocardiogram confirming atrial fibrillation, or an official diagnosis certificate of atrial fibrillation issued by a specialist.\n\n3)Receiving healthcare management from a primary medical institution near the place of residence.\n\n4)Able to understand and sign the informed consent form.\n\nExclusion Criteria:\n\n1. A definite history of heart failure, or confirmed cardiac dysfunction or heart failure based on echocardiography and\u002For NT-proBNP screening. Diagnostic criteria include typical heart failure symptoms or signs with reduced left ventricular ejection fraction (HFrEF, LVEF \\\u003C40%), mildly reduced left ventricular ejection fraction (HFmrEF, LVEF 40-49%), or preserved left ventricular ejection fraction with elevated NT-proBNP and structural heart disease evidence (HFpEF, LVEF ≥50%, with at least one of the following: LAVI \\>40 mL\u002Fm², E\u002Fe' ≥15, or TRV \\>2.8 m\u002Fs).\n2. Expected survival of less than 12 months.\n3. Severe renal insufficiency, defined as creatinine clearance \\\u003C30 mL\u002Fmin, or currently receiving dialysis treatment.\n4. Cardiac dysfunction caused by reversible secondary causes, including hyperthyroid heart disease, anemic heart disease, or uncorrected congenital heart disease.\n5. Indication for pacemaker implantation but without pacemaker placement.\n6. Chronic obstructive pulmonary disease complicated by type II respiratory failure.\n7. Special populations, such as patients with mental illness.",{"count":74,"type":21},1356,[24],"This cluster randomized study aims to compare village doctor-led integrated care versus usual care to improve cardiovascular health, atrial fibrillation management, self-management adherence, and heart failure prevention among older rural patients with atrial fibrillation in China.",[56,29],{"date":60,"type":35},{"date":62,"type":21},{"date":81,"type":21},"2030-07-01",{"name":41,"class":42},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":101,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":43},"100646035","mri-dti-assessment-of-urethral-internal-sphincter-ring-and-prostate-base-morphology-100646035","NCT07694752","MRI-DTI Assessment of Urethral Internal Sphincter Ring and Prostate Base Morphology","An Observational Study of the Relationship Between the Urethral Internal Sphincter Ring and Prostate Base Morphology Using MRI-DTI Fiber Tracking","Inclusion Criteria:\n\n1. Male participants undergoing clinically indicated pelvic, seminal vesicle, or prostate-related MRI-DTI examination.\n2. Participants with adequate T2-weighted MRI and DTI data for post-processing and quantitative assessment of the bladder neck, prostate base, and proximal urethral region.\n3. Participants in the cross-sectional imaging cohort may include men undergoing MRI for suspected cryptorchidism, suspected seminal vesiculitis, benign prostatic enlargement, or other clinically indicated pelvic or prostate-related evaluations.\n4. Participants in the ADT paired follow-up cohort must have prostate cancer and be scheduled to receive androgen deprivation therapy, with MRI-DTI planned before treatment and during follow-up after ADT.\n5. Participants must be able to comply with MRI examination procedures.\n6. Written informed consent will be obtained when required by the approved study protocol.\n\nExclusion Criteria:\n\n1. Contraindications to MRI, including but not limited to incompatible metallic implants, severe claustrophobia, or other conditions preventing MRI examination.\n2. Known neurogenic bladder dysfunction, including spinal cord injury, multiple sclerosis, Parkinson disease, or other neurological disorders that may significantly affect lower urinary tract function.\n3. History of pelvic radiotherapy.\n4. History of urethral reconstruction, sphincter surgery, or other prior surgery that substantially alters the bladder neck, proximal urethra, or prostate base anatomy.\n5. Severe cardiopulmonary dysfunction, cognitive impairment, psychiatric disorder, or other conditions preventing cooperation with MRI examination or study procedures.\n6. Use of medications or treatments within the previous 3 months that may substantially affect neuromuscular function of the lower urinary tract, as judged by the investigators.\n7. Poor image quality or failed post-processing that prevents reliable visualization or measurement of the urethral internal sphincter ring.","MALE","15 Years","90 Years",{"count":94,"type":21},80,"OBSERVATIONAL","This is a single-center, observational imaging study designed to evaluate the in vivo morphology of the male urethral internal sphincter ring using magnetic resonance diffusion tensor imaging (MRI-DTI) fiber tracking and to investigate its relationship with prostate base morphology.\n\nMale participants undergoing clinically indicated pelvic, seminal vesicle, or prostate-related MRI-DTI examinations will be included. The study population may include patients with benign prostatic enlargement, younger men undergoing MRI for suspected cryptorchidism or suspected seminal vesiculitis, and patients with prostate cancer scheduled to receive androgen deprivation therapy (ADT). All participants will undergo T2-weighted imaging and DTI. T2WI-DTI image registration, dual-region-of-interest fiber tracking, and three-dimensional reconstruction will be used to visualize ring-like muscle fiber structures in the bladder neck, prostate base, and proximal urethral region.\n\nThe cross-sectional imaging cohort will be used to assess the associations between prostate-side morphological parameters, including prostate volume, prostate base diameter or area, and intravesical prostatic protrusion, and sphincter-ring parameters, including ring inner diameter and ring area. The ADT paired cohort will undergo MRI-DTI before treatment and during follow-up after ADT to evaluate whether reduction in prostate volume and prostate base morphology is accompanied by corresponding changes in the urethral internal sphincter ring.\n\nThis study will not alter the participants' existing clinical diagnostic or treatment pathways. Imaging data will be analyzed using standardized post-processing and quantitative measurement procedures. The results may provide in vivo imaging evidence for age- and prostate-related displacement and morphological remodeling of the male urethral internal sphincter and may inform future surgical strategies for identifying, preserving, or reconstructing proximal urinary continence-related structures.",[98,99,100],"Urethral Internal Sphincter Morphology","Benign Prostatic Hyperplasia","Prostate Cancer",[102,103,100],"Diffusion Tensor Imaging","Urethral Internal Sphincter","2026-07-17",{"date":106,"type":35},"2026-07-20",{"date":108,"type":21},"2026-07-15",{"date":110,"type":21},"2028-06-01",{"name":41,"class":42},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":119,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":130,"leadSponsor":132,"locationsCount":4},"100645220","llm-assisted-diabetes-and-hypertension-management-by-village-doctors-100645220","NCT07678658","LLM-Assisted Diabetes and Hypertension Management by Village Doctors","Large Language Model-Assisted Decision Support for Improving Village Doctors' Integrated Management of Patients With Type 2 Diabetes and Hypertension: A Randomized Controlled Study","Inclusion Criteria:\n\n1. Certified village doctors or primary care physicians practicing in rural primary healthcare institutions;\n2. At least 1 year of experience in the management of chronic diseases, including type 2 diabetes mellitus and hypertension;\n3. Able to complete the case assessment tasks required by the study;\n4. Willing to participate in the study and provide informed consent.\n\nExclusion Criteria:\n\nNone.",true,{"count":20,"type":21},[24],"This is a prospective, assessor-blinded, randomized controlled study designed to evaluate whether large language model (LLM)-assisted decision support can improve village doctors' abilities in the comprehensive management of patients with type 2 diabetes mellitus and hypertension.\n\nFor each standardized clinical case, two village doctors will independently review the same patient information and develop management plans. An independent statistician will randomly assign one doctor to receive LLM-assisted decision support, while the other will complete the assessment without assistance. All management plans and questionnaire responses will be de-identified and evaluated by an independent expert panel blinded to group allocation. The study will compare the quality of clinical decision-making, risk assessment, treatment recommendations, and follow-up planning between the LLM-assisted and control groups.",[124,125],"Type 2 Diabetes Mellitus","Hypertension","2026-06-25",{"date":128,"type":35},"2026-07-01",{"date":128,"type":21},{"date":131,"type":21},"2026-07-14",{"name":41,"class":42},{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":142,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":43},"100635557","auricular-acupuncture-therapy-administered-by-village-doctors-improves-sleep-quality-in-elderly-patients-with-comorbid-diabetes-mellitus-and-hypertension-100635557","NCT07554235","Auricular Acupuncture Therapy Administered by Village Doctors Improves Sleep Quality in Elderly Patients With Comorbid Diabetes Mellitus and Hypertension","Auricular Acupuncture Therapy Administered by Village Doctors Improves Sleep Quality in Elderly Patients With Comorbid Diabetes and Hypertension","Inclusion Criteria:\n\n1. Age ≥65 years;\n2. Patients with comorbid diabetes mellitus and hypertension:\n3. Sleep disturbance: Pittsburgh Sleep Quality Index (PSQI) total score ≥8;\n4. Willing to participate in this study and sign the informed consent form;\n5. Has resided in this village for at least six months.\n\nExclusion Criteria:\n\n1. Stroke;\n2. Severe mental illness or cognitive impairment;\n3. Severe organ failure (e.g., end-stage renal disease);\n4. Ear infection, eczema, breakage, or deformity;\n5. Currently receiving regular other acupuncture treatments;\n6. Use of any hypnotic medications within the past month\n7. Bleeding disorders or use of anticoagulants (increased bleeding risk);\n8. History of fainting during acupuncture;\n9. Life expectancy less than six months.",{"count":141,"type":21},320,[24],"This study aims to apply traditional auricular press-needle acupuncture to treat sleep disturbances in elderly patients (aged ≥65 years) with comorbid diabetes mellitus and hypertension in rural areas of China. Given the complex bidirectional relationship between diabetes mellitus with hypertension and sleep disturbances, this cluster randomized trial is designed to test whether a village doctor-led intervention model supported by telemedicine can improve sleep disturbances in patients with comorbid diabetes mellitus and hypertension, compared to sham auricular press-needle acupuncture. Participants will be recruited by local village doctors according to the inclusion and exclusion criteria. The protocol is based on Traditional Chinese Medicine theory for core point selection: Heart, Liver, Kidney, Shenmen, and Forehead area, along with optimized medication regimens supported by remote cardiovascular specialists. The investigators will evaluate the overall improvement in sleep disturbances using the Pittsburgh Sleep Quality Index (PSQI) at the end of the 6-week treatment period, and assess sleep disturbances, anxiety, depression, daytime sleepiness, and fatigue at 12 weeks.",[145,146,125],"Insomnia Disorder","Diabetes",[148,149,125,146,150],"Village Doctors","Acupuncture needles","insomnia",{"date":152,"type":35},"2026-06-29",{"date":154,"type":35},"2026-04-22",{"date":156,"type":21},"2027-02-20",{"name":41,"class":42},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":22,"phases":168,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":43},"100642618","transcranial-focused-ultrasound-neuromodulation-for-post-stroke-motor-dysfunction-100642618","NCT07637825","Transcranial Focused Ultrasound Neuromodulation for Post-Stroke Motor Dysfunction","Transcranial Focused Ultrasound Neuromodulation in Post-Stroke Motor Dysfunction","Inclusion Criteria:\n\n* (1) Patients with a confirmed imaging diagnosis of first-ever ischemic stroke; (2) Unilateral limb motor involvement; (3) Modified Ashworth Scale (MAS) grade ≤3 for the upper extremity, Brunnstrom stage II-V, and upper extremity Fugl-Meyer Assessment (FMA-UE) score between 15 and 60 (inclusive); (4) Age 18-75 years, onset within 21 days to 6 months, in the subacute or recovery phase; (5) Stable vital signs, no consciousness impairment, informed consent provided, ability to cooperate with clinical assessments, and approval obtained from the institutional ethics committee.\n\nExclusion Criteria:\n\n* (1) Contraindications to MRI; (2) Infarction involving the thalamus; (3) Risk of intracranial hemorrhage; (4) Presence of intracranial metallic foreign bodies, cardiac pacemakers, or cochlear implants; (5) Unstable medical condition, severe cognitive impairment or psychiatric disorders rendering the patient unable to comprehend the study or cooperate with assessments; (6) Conditions affecting limb motor function, including fractures, joint contractures, or severe limb spasticity; (7) Current use of medications that alter cortical excitability.","75 Years",{"count":167,"type":21},60,[24],"This study aims to evaluate how transcranial focused ultrasound (tFUS) technology can promote neural network remodeling and functional recovery after stroke. By integrating signals from electroencephalography (EEG) and magnetic resonance imaging (MRI), the study will investigate how activating or inhibiting specific brain regions affects motor and cognitive recovery. The goal is to improve patients' motor and cognitive functions, reduce long-term disability, and enhance quality of life. The study also seeks to optimize stimulation parameters to maximize rehabilitation outcomes and explore the mechanisms underlying neuroprotection and functional reconstruction after stroke.\n\nThis is a case-control study involving a total of 60 participants. Participants will be ischemic stroke survivors aged 18-75 years, with first-ever stroke onset between 21 days and 6 months, stable vital signs, no consciousness disorders, and the ability to provide informed consent and cooperate with assessments. Eligible participants must have unilateral limb motor impairment, with an upper extremity modified Ashworth score ≤3, Brunnstrom stage II-V, and an upper extremity Fugl-Meyer Assessment (FMA-UE) score between 15 and 60.\n\nParticipants will be assigned to either a neuromodulation group (receiving multi-modal neuromodulation targeting specific brain regions) or a control group (receiving sham stimulation or conventional treatment). Primary outcome measures include changes in FMA-UE scores, neuroimaging data (CT\u002FMRI), EEG measurements (resting-state and task-state spectral power, functional connectivity), and laboratory markers (complete blood count, CRP, IL-6, S100β, BDNF). Secondary outcome measures include Brunnstrom stage, Ashworth grade, muscle strength, and patient comfort ratings. Safety will be monitored through blood routine tests, blood biochemistry, and coagulation function.\n\nStatistical analysis will compare key indicator changes between the neuromodulation and control groups before and after intervention. Independent t-tests (for two groups) or ANOVA (for multiple groups) will be used to assess between-group differences, with non-parametric tests applied for data not following a normal distribution.",[171],"Ischemic Stroke","2026-06-05",{"date":174,"type":35},"2026-06-10",{"date":176,"type":21},"2026-06",{"date":178,"type":21},"2028-03-31",{"name":41,"class":42},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":50,"enrollmentInfo":186,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":188,"conditions":189,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":43},"100640360","construction-of-a-cohort-of-elderly-patients-with-atrial-fibrillation-in-rural-china-100640360","NCT07611084","Construction of a Cohort of Elderly Patients With Atrial Fibrillation in Rural China","Inclusion Criteria:\n\n1. Permanent residents with local household registration in rural China.\n2. Aged 65-80 years.\n3. Electrocardiogram confirmation of AF or possession of a diagnostic certificate for AF issued by a specialist.\n4. Willing to participate in HF screening.\n5. Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n1. Expected life expectancy of less than 3 months.\n2. Severe renal insufficiency (Ccr \\\u003C 30ml\u002Fmin) or ongoing dialysis treatment.\n3. Cardiac insufficiency secondary to correctable causes, including hyperthyroid heart disease, anemic heart disease, or uncorrected congenital heart disease.\n4. Indications for pacemaker implantation without having undergone implantation.\n5. Chronic obstructive pulmonary disease complicated by type II respiratory failure.\n6. Special populations, including patients with mental illnesses.",{"count":187,"type":21},2500,"Atrial fibrillation (AF) is a common arrhythmia in aging populations and is strongly associated with an increased risk of heart failure (HF) and adverse cardiovascular outcomes. However, early detection of HF among patients with AF remain inadequate in rural settings. This study aims to screen for HF among older adults with AF in rural China and to conduct long-term follow-up in order to observe the disease progression in patients with AF.\n\nThis study will recruit at least 2,500 elderly individuals aged between 65 and 80 years, with confirmed diagnoses of AF, residing in rural areas. Participants will undergo HF screening using NT-proBNP testing and echocardiographic assessment. Additionally, data will be collected on electrocardiographic signals, seismocardiography, voice, and demographic characteristics. Following data collection, participants will be followed up every three months to monitor the incidence and progression of HF as well as the occurrence of adverse cardiovascular events.",[28,29,190,191],"Screening","Progression","2026-05-22",{"date":194,"type":35},"2026-05-28",{"date":196,"type":35},"2026-03-14",{"date":198,"type":21},"2029-12-31",{"name":41,"class":42},{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":22,"phases":209,"briefSummary":210,"conditions":211,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":43},"100513086","cohort-study-of-chronic-heart-failure-100513086","NCT05960890","Cohort Study of Chronic Heart Failure","CHF","Inclusion Criteria:\n\n1. Age ≥18 years;\n2. Fulfill at least one of the following criteria：①History of chronic heart failure;②New-onset heart failure with LVEF \\\u003C50%；③New-onset heart failure with LVEF≧50%，E\u002Fe'≧15 and BNP\\>400 pg\u002FmL\u002FNT-proBNP(\\\u003C50 years, \\>450 pg\u002FmL; 50\\~75 years, \\>900 pg\u002FmL; \\>75 years, \\>1800 pg\u002FmL)\n3. Etiology: dilated cardiomyopathy, hypertensive heart disease, ischaemic cardiomyopathy, Non-severe valvular heart disease；\n4. Primary post-discharge therapy: oral medication;\n5. Sign the informed consent form.\n\nExclusion Criteria:\n\n1. Patients with renal failure (Ccr\\\u003C30ml\u002Fmin) or patients on dialysis therapy;\n2. Various correctable secondary causes of cardiac insufficiency including hyperthyroid heart disease, anaemic heart disease, uncorrected congenital heart disease; severe valvular heart disease (including severe stenosis or closure of organic aortic and mitral valves);\n3. Patients with indications for pacemaker implantation but have not received a pacemaker implant;\n4. Patients with chronic obstructive pulmonary disease accompanied by type II respiratory failure.\n5. Patients who cannot understand and sign an informed consent form.\n6. Patients with mental illness, pregnant women, and other special populations.",{"count":208,"type":21},1000,[24],"The goal of this observational study is to learn about the influencing factors of chronic heart failure prognosis in heart failure patients. The main question it aims to answer is that what are the influencing factors of clinical outcomes in chronic heart failure. Participants will be collected multiple omics data such as phenotype group, environmental exposure group, intestinal microbiome, genome, metabolome, and noninvasive biomarkers.",[29],"2026-05-18",{"date":214,"type":35},"2026-05-20",{"date":216,"type":35},"2023-06-08",{"date":218,"type":21},"2028-12",{"name":41,"class":42},{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":119,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":229,"conditions":230,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":43},"100633865","survey-of-knowledge-practice-and-recommendation-behaviors-regarding-healthy-lifestyles-among-healthcare-workers-100633865","NCT07532239","Survey of Knowledge, Practice, and Recommendation Behaviors Regarding Healthy Lifestyles Among Healthcare Workers","Investigation of Healthy Lifestyle Knowledge, Practice, and Recommendation Behaviors Among Healthcare Workers Across Different Levels of Healthcare Institutions","Inclusion Criteria:\n\n* Healthcare workers employed at participating healthcare institutions\n\nExclusion Criteria:\n\n* Individuals unwilling or unable to provide informed consent",{"count":228,"type":21},150,"This cross-sectional observational study aims to assess healthy lifestyle knowledge, personal health practices, and lifestyle recommendation behaviors among healthcare workers across different levels of healthcare institutions. The study will also collect clinical examination and biochemical indicators to evaluate the health status of participants and explore their associations with lifestyle-related knowledge and behaviors.\n\nHealthcare workers play a critical role in promoting healthy lifestyles among patients; however, their own health behaviors and recommendations may vary depending on training background and institutional settings. This study seeks to better understand these differences and identify potential gaps between knowledge and practice.\n\nThe findings of this study may help inform targeted training strategies and support the development of effective health promotion programs for healthcare professionals, ultimately improving the quality of lifestyle guidance provided to patients.",[231,232,233],"Healthy Lifestyle","Health Knowledge","Health Behavior","2026-04-08",{"date":236,"type":35},"2026-04-15",{"date":238,"type":21},"2026-04-10",{"date":240,"type":21},"2026-04-20",{"name":41,"class":42},{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":119,"sex":16,"minAge":248,"maxAge":4,"enrollmentInfo":249,"targetDuration":250,"studyType":95,"phases":4,"briefSummary":251,"conditions":252,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":4},"100558029","construction-of-a-cohort-for-pan-vascular-disease-among-employees-of-taizhou-peoples-hospital-100558029","NCT06545799","Construction of a Cohort for Pan-Vascular Disease Among Employees of Taizhou People's Hospital","Inclusion Criteria:\n\n1. Employed or retired individuals aged 45 years or older;\n2. Willing to sign an informed consent form and voluntarily participate in health examinations and related data collection.\n\nExclusion Criteria:\n\n1. History of myocardial infarction, ischemic or hemorrhagic stroke, or revascularization of coronary, carotid, or peripheral arteries;\n2. Employees with severe psychological disorders who are unable to cooperate with the study;\n3. Pregnant or breastfeeding women.","45 Years",{"count":208,"type":21},"10 Years","1. Participant Recruitment During the annual health check-ups for hospital staff, potential participants are recruited. Those who express interest are provided with a detailed explanation of the study's objectives, content, and procedures, and are required to sign an informed consent form.\n2. Screening Phase Medical history is collected, including any previous occurrences of myocardial infarction, ischemic or hemorrhagic stroke, or history of coronary, carotid, or peripheral arterial revascularization.\n3. Baseline Data Collection\n\n1\\. Health Questionnaire Survey: Collect demographic information, medical history, and data on nutrition, physical activity, and smoking habits through a questionnaire.\n\n2\\. Clinical Assessments: Conduct the following assessments for all enrolled participants:\n\n* High-sensitivity cardiac troponin I and NT-proBNP testing\n* Non-invasive arterial stiffness testing\n* Measurement of visceral and subcutaneous fat content\n* Fundus photography\n* Body composition analysis\n\n  4 Regular Follow-Up\n\nAnnual follow-up for a total of 10 years. The follow-up includes:\n\n1. . Collection of updated demographic information and medical history, as well as repeated questionnaires on nutrition, physical activity, and smoking habits.\n2. . Reassessment of the following items:\n\n   * High-sensitivity cardiac troponin I and NT-proBNP testing\n   * Non-invasive arterial stiffness testing\n   * Measurement of visceral and subcutaneous fat content\n   * Fundus photography\n   * Body composition analysis\n\n     5 Outcome Evaluation\n\n1）. Primary Outcomes: Cardiovascular mortality, non-fatal myocardial infarction, or non-fatal stroke events.\n\n2）. Secondary Outcomes: All vascular events, changes in cardiovascular biomarkers, and degree of arterial stiffness.",[253,254,30],"Cardiovascular Death","Myocardial Infarction","2024-08-05",{"date":257,"type":35},"2024-08-09",{"date":259,"type":21},"2024-09-01",{"date":261,"type":21},"2034-09-01",{"name":41,"class":42},""]