[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Jinnah Medical & Dental College\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100655098","phase-4-metformin-in-parkinsons-disease-safety-and-efficacy-100655098",false,"NCT07806019","Metformin in Parkinson's Disease: Safety and Efficacy","Clinical Efficacy and Safety Profile of Metformin in Parkinson's Disease","MET-PD","Inclusion Criteria: :\n\nMale and female patients diagnosed with primary PD age 50-70 years receiving levodopa + carbidopa. Diagnosis will be made in accordance with movement disorder society clinical diagnostic criteria for Parkinson's disease\n\nExclusion Criteria:\n\nSecondary Parkinsonism co-morbid (such as Diabetes mellitus, Cardio-vascular diseases, Senile tremors, Wilson's disease, Cancers etc.) Pregnant and lactating mothers Sensitivity to metformin Lactic acidosis History of alcohol use","ALL","50 Years","70 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This study will evaluate whether metformin when it will be given to patients with Parkinson's disease along with standard therapy (levodopa carbidopa) will improve motor symptoms and decreases levels of alpha synuclein and MDA in patients with PD as compare to PD patients receiving only standard therapy (levodopa carbidopa)",[28],"Parkinsons Disease (PD)",[30,31,32,33,34,35],"Parkinson's disease","Neuroinflamation","Metformin","Alpha synuclein","MDA levels","MDS-UPDRS","NOT_YET_RECRUITING","2026-09-07",{"date":39,"type":40},"2026-09-09","ACTUAL",{"date":42,"type":22},"2026-08-28",{"date":44,"type":22},"2027-02-01",{"name":46,"class":47},"Jinnah Medical & Dental College","OTHER",""]