[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Josip Juraj Strossmayer University of Osijek\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":192},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,52,76,96,123,145,172],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100648961","endothelial-extracellular-vesicles-as-biomarkers-of-endothelial-activation-in-pregnant-women-with-hypertensive-disorders-of-pregnancy-100648961",false,"NCT07728656","Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy","Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy","HYPER-endoEV-p","Inclusion Criteria:\n\n* Pregnant women aged ≥18 years.\n* Singleton pregnancy.\n* Ability to provide written informed consent.\n* Normotensive pregnancy or diagnosis of gestational hypertension or preeclampsia according to current clinical guidelines.\n* Ability to comply with study procedures.\n\nExclusion Criteria:\n\n* Chronic hypertension diagnosed before pregnancy.\n* Multiple pregnancy.\n* Pre-existing diabetes mellitus.\n* Chronic kidney disease.\n* Autoimmune disease.\n* Known cardiovascular disease.\n* Active infection or inflammatory disease.\n* Malignancy.\n* Inability or unwillingness to provide informed consent.","FEMALE","18 Years",{"count":20,"type":21},80,"ESTIMATED","OBSERVATIONAL","Hypertensive disorders of pregnancy are associated with endothelial dysfunction and increased maternal and fetal morbidity. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their relationship with blood pressure and endothelial function during pregnancy remains incompletely understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive pregnant women and pregnant women with hypertensive disorders of pregnancy. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury during pregnancy and support the development of non-invasive biomarkers for early detection and monitoring of hypertensive disorders of pregnancy.",[25,26,27],"Hypertensive Disorder of Pregnancy","Gestational Hypertension","Preeclampsia",[29,26,27,30,31,32,33,34,35,36,37,38],"Hypertensive Disorders of Pregnancy","Pregnancy","Endothelial Dysfunction","Endothelial Extracellular Vesicles","Extracellular Vesicles","Endothelial Activation","Biomarkers","Microvascular Function","Laser Doppler Flowmetry","Cardiovascular Risk","RECRUITING","2026-07-22",{"date":42,"type":43},"2026-07-27","ACTUAL",{"date":45,"type":43},"2026-04-01",{"date":47,"type":21},"2029-09-30",{"name":49,"class":50},"Josip Juraj Strossmayer University of Osijek","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":75,"locationsCount":51},"100648895","endothelial-extracellular-vesicles-as-biomarkers-of-endothelial-activation-in-adults-with-newly-diagnosed-hypertension-100648895","NCT07728630","Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Adults With Newly Diagnosed Hypertension","Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Adults With Newly Diagnosed Untreated Hypertension","HYPER-endoEV-a","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Ability and willingness to provide written informed consent.\n* Normotensive individuals or individuals with newly diagnosed, previously untreated primary hypertension, classified according to the European Society of Hypertension (ESH) guidelines.\n* Ability to comply with all study procedures.\n\nExclusion Criteria:\n\n* Secondary hypertension.\n* Previous treatment with antihypertensive medication.\n* History of cardiovascular disease (except newly diagnosed primary hypertension in the hypertensive group).\n* Diabetes mellitus.\n* Chronic kidney disease.\n* Cerebrovascular disease.\n* Peripheral arterial disease.\n* Acute or chronic inflammatory or infectious disease.\n* Active malignancy.\n* Pregnancy or breastfeeding.\n* Current use of oral contraceptives, hormone replacement therapy, or medications known to affect endothelial function.\n* Inability or unwillingness to provide informed consent.",true,"ALL",{"count":20,"type":21},"Hypertension is associated with endothelial dysfunction, an early event in the development of cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation and vascular injury; however, their relationship with blood pressure and microvascular endothelial function in untreated hypertension remains insufficiently understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive adults and adults with newly diagnosed, untreated primary hypertension. In addition, the study will investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and established circulating biomarkers of endothelial activation. The findings may improve understanding of the role of EEVs in early hypertension and support their potential use as non-invasive biomarkers of endothelial dysfunction and cardiovascular risk.",[65,66],"Hypertension","Endothelial Function",[65,68,31,32,33,34,35,36,37,69,70],"Primary Hypertension","Post-Occlusive Reactive Hyperemia","Vascular Function",{"date":42,"type":43},{"date":73,"type":43},"2026-05-01",{"date":47,"type":21},{"name":49,"class":50},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":60,"sex":61,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":92,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":95,"locationsCount":51},"100648844","endothelial-extracellular-vesicles-as-biomarkers-of-endothelial-activation-in-children-with-newly-diagnosed-hypertension-100648844","NCT07728643","Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension","Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Children With Newly Diagnosed Untreated Primary Hypertension","HYPER-endoEV-c","Inclusion Criteria:\n\n* Children and adolescents aged 6-17 years.\n* Written informed consent from a parent or legal guardian and assent from the participant when appropriate.\n* Normotensive status or newly diagnosed, previously untreated primary hypertension according to current pediatric hypertension guidelines.\n* Ability to comply with study procedures.\n\nExclusion Criteria:\n\n* Secondary hypertension.\n* Previous antihypertensive treatment.\n* Congenital heart disease or other significant cardiovascular disease.\n* Diabetes mellitus.\n* Chronic kidney disease.\n* Autoimmune or chronic inflammatory disease.\n* Acute infection at the time of enrollment.\n* Malignancy.\n* Use of medications known to affect endothelial function.\n* Inability to comply with study procedures.","6 Years","17 Years",{"count":20,"type":21},"Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their role in pediatric hypertension remains poorly understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive children and children with newly diagnosed, untreated primary hypertension. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury in pediatric hypertension and support the development of non-invasive biomarkers for early cardiovascular risk assessment.",[89,68,31],"Pediatric Hypertension",[89,91,68,32,31,34,35,36,37,38],"Childhood Hypertension",{"date":42,"type":43},{"date":45,"type":43},{"date":47,"type":21},{"name":49,"class":50},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":122,"locationsCount":51},"100627687","glycocalyx-and-oxidative-stress-in-endothelial-function-part-2-100627687","NCT07451873","Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)","The Role of Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)","GlikoOxEND","Inclusion Criteria:\n\n* adult patients of both sexes over 18 years of age\n* Caucasian\n* undergoing elective coronary artery bypass grafting (CABG)\n* provided written informed consent\n\nExclusion Criteria:\n\n* emergency surgery\n* sepsis or severe systemic inflammation before surgery\n* severe renal or hepatic insufficiency\n* immunosuppression\n* serious comorbidities (e.g., active cancer)\n* therapies that could affect oxidative stress (e.g., high doses of corticosteroids)",{"count":105,"type":21},35,"The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CVD, as well as identify new biomarkers for CVD.",[108],"Coronary Heart Disease",[110,111,112,113,114,115],"Glycocalyx","Inflammation","Oxidative stress","Endothelium","Coronary Artery Disease","Myocardial Revascularization","2026-03-05",{"date":118,"type":43},"2026-03-09",{"date":120,"type":43},"2025-10-01",{"date":47,"type":21},{"name":49,"class":50},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":102,"eligibilityCriteria":129,"healthyVolunteers":60,"sex":61,"minAge":18,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":143,"leadSponsor":144,"locationsCount":51},"100626599","glycocalyx-and-oxidative-stress-in-endothelial-function-part-1-100626599","NCT07437729","Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)","The Role of Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)","Inclusion Criteria:\n\n* patients with CKD of hypertensive etiology (grades 1-2 and 3-5; eGFR CKD-EPI GFR ≥ 90 ml\u002Fmin\u002F1.73 m², i.e. \\\u003C 60 mL\u002Fmin\u002F1.73 m2), non-diabetics, non-smokers\n* patients with hypertension (according to ESH2023 Guidelines) without kidney damage (eGFR CKD-EPI \\>90 mL\u002Fmin\u002F1.73 m2) non-diabetics, non-smokers\n* healthy volunteer subjects as controls\n\nExclusion Criteria:\n\n* kidney disease of any other etiology except hypertension\n* endocrine, autoimmune or inflammatory diseases that could affect kidney function.\n* smoking\n* diabetes",{"count":131,"type":21},105,"The primary research objective of the project is to determine the role of eGC in microvascular reactivity in CKD (cross-sectional study 1).\n\nThe main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CKD, as well as identify new biomarkers for CKD.",[134],"Chronic Kidney Disease Patients",[110,136,113,111,137,138],"Microcirculation","Oxidative Stress","Renal Insufficiency, Chronic","2026-02-26",{"date":141,"type":43},"2026-03-02",{"date":120,"type":43},{"date":47,"type":21},{"name":49,"class":50},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":60,"sex":61,"minAge":18,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":155,"conditions":156,"keywords":158,"overallStatus":163,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":51},"100540395","mirna-in-chronic-kidney-diseases-100540395","NCT06316284","miRNA in Chronic Kidney Diseases","The Role of miRNAs in the Regulation of Oxidative Stress and Microvascular Reactivity in Chronic Kidney Disease","Inclusion Criteria:\n\n* healthy normotensive adults (eGFR CKD-EPI \\>90 mL\u002Fmin\u002F1.73 m2, BP \\\u003C140\u002F90 mmHg)\n* hypertensive adults (eGFR CKD-EPI \\>90 mL\u002Fmin\u002F1.73 m2, BP \\>140\u002F90 mmHg)\n* patients with chronic kidney disease stage 3-5 (eGFR CKD-EPI\\\u003C 60 mL\u002Fmin\u002F1.73 m2)\n\nExclusion Criteria:\n\n* cardiovascular diseases, but hypertension\n* diabetes\n* cerebrovascular diseases\n* peripheral artery disease","69 Years",{"count":154,"type":21},90,"Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in both acute kidney injury and chronic kidney disease (CKD). Oxidative stress in the kidneys promotes renal vascular remodeling and increases preglomerular resistance. These are key elements in hypertension, acute and chronic kidney injury, as well as diabetic nephropathy. Chronic renal hypoxia is highlighted as the final common pathway to end-stage renal disease (ESRD). MicroRNA molecules (miRNA) also play an important role in these processes. MicroRNAs (miRNAs) are regulators of gene expression and play a role in the progression of renal ischemia-reperfusion injury. Although the pathophysiological contribution of microRNAs (miRNAs) to kidney damage has also been highlighted, the effect of miRNAs on kidney damage under conditions of oxidative and ER stress remains understudied.",[157],"Chronic Kidney Diseases",[159,160,161,162],"chronic kidney diseases","miRNA","oxidative stress","hypertension","NOT_YET_RECRUITING","2024-03-11",{"date":166,"type":43},"2024-03-18",{"date":168,"type":21},"2024-04-01",{"date":170,"type":21},"2026-12-31",{"name":49,"class":50},{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":60,"sex":61,"minAge":18,"maxAge":152,"enrollmentInfo":179,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":180,"conditions":181,"keywords":183,"overallStatus":163,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":188,"startDateStruct":189,"completionDateStruct":190,"leadSponsor":191,"locationsCount":51},"100540394","endothelial-function-in-prehypertension-100540394","NCT06316271","Endothelial Function in Prehypertension","Endothelial Dysfunction and Cardiovascular Remodeling in Pathophyisiology of Prehypertension","Inclusion Criteria:\n\n* adults of both sexes with normotensive, prehypertensive and grade I hypertension blood pressure values\n\nExclusion Criteria:\n\n* cardiovascular diseases, but grade I hypertension (BP 140-150\u002F90-100 mmHg)\n* diabetes\n* kidney disease\n* cerebrovascular diseases\n* peripheral artery disease\n* taking oral contraceptives or any drugs that could affect the endothelium",{"count":154,"type":21},"In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and macrocirculation, reduces re-endothelialization potential of human endothelial progenitor cells (EPCs) and increases the level of endothelial extracellular vesicles (EVs), which are accompanied by increased oxidative stress level. Furthermore, initial vascular and left ventricle (LV) remodeling contributes to changes in systemic hemodynamics and may be influenced by altered regulatory role of renin-angiotensin system (RAS) and autonomic nervous system (ANS) in PreHT but otherwise healthy individuals. To distinguish high normal blood pressure effect from those considered normal or high, study will be performed in three groups of individuals: prehypertensive (BP 130-139\u002F85-89 mmHg), hypertensive (stage I, BP 140-150\u002F90-100 mmHg), and controls (BP less than or equal to 129\u002F85 mmHg). Altogether, the impairment of normal vascular relaxation mechanisms, endothelial activation as well as vascular and LV remodeling could play crucial role in increased cardiovascular risk and CVDs incidence in PreHT individuals. Moreover, the prognostic significance of assessing endotehlial dysfunction in hypertension (as well as in PreHT) is yet to be established.",[182],"Hypertension,Essential",[162,184,185,186,187],"prehypertension","endothelium","left ventricle","hemodynamics",{"date":166,"type":43},{"date":168,"type":21},{"date":170,"type":21},{"name":49,"class":50},""]