[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"King George's Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":72},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100638486","phase-3-comparison-of-rabeprazole-and-vonoprazan-in-the-prevention-of-post-endoscopic-variceal-ligation-ulcer-in-patients-with-cirrhosis-100638486",false,"NCT07608536","Comparison of Rabeprazole and Vonoprazan in the Prevention of Post-endoscopic Variceal Ligation Ulcer in Patients With Cirrhosis","Inclusion Criteria:\n\n* Age 18 years and above\n* Diagnosis of portal hypertension and esophageal varix should be established by endoscopy.\n* Who are willing to participate in the study\n\nExclusion Criteria:\n\n* Negative consent\n* Diagnosed with HCC\n* Already taking PPI\u002FVonoprazan for other indications\n* Using anticoagulants and antiplatelets","ALL","18 Years",{"count":18,"type":19},300,"ESTIMATED","INTERVENTIONAL",[22],"PHASE3","The study aims to to evaluate Vonoprazan effectiveness in prevention of post endoscopic variceal ligation (EVL) ulcer and its related bleed in comparison to Rabeprazole.\n\nAll patients who are eligible for the study will be screened from outpatient department and endoscopy lab. Patients who are diagnosed to have oesophageal varices and requiring EVL will be enrolled after fulfilling inclusion and exclusion criteria.\n\nPatient clinical and demographic data will be collected in proforma. Patients who are willing to participate in the study will be randomized into two arms in 1:1 ratio. One arm is Vonoprazan 20 mg once a day group and second arm will be rabeprazole 20 mg once a day. Duration of therapy will be 2 weeks. Patients will also be advised to take nonselective beta blockers (NSBB) as per standard of care.\n\nPatients will undergo upper GI endoscopy after 2 weeks to evaluate varices and ulcers, ulcer will be classified according to Jamwal \\& Sarin classification system.",[25],"Endoscopic Variceal Band Ligation",[27,28,29],"Post endoscopic variceal ligation (EVL) ulcer","Vonoprazan","Rabeprazole","NOT_YET_RECRUITING","2026-05-26",{"date":33,"type":34},"2026-05-27","ACTUAL",{"date":36,"type":19},"2026-05-01",{"date":38,"type":19},"2026-07-31",{"name":40,"class":41},"King George's Medical University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":20,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":42},"100623323","phase-3-albumin-in-acute-variceal-bleeding-100623323","NCT07395141","Albumin in Acute Variceal Bleeding","Albumin in Acute Variceal Bleeding: A Randomized Controlled Trial: ALB-AVB Trial","ALB-AVB","Inclusion Criteria:\n\n* All adult patients with acute variceal bleeding and cirrhosis presenting to Medical Gastroenterology department at KGMU, Lucknow, U.P. India.\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years and \\> 70 years\n2. Patients with portal vein thrombosis\n3. Hepatocellular carcinoma\n4. Non-cirrhotic portal fibrosis\n5. Extrahepatic portal vein thrombosis\n6. Patients who received albumin in the last one month\n7. Patients who require fresh frozen plasma\n8. Patients with heart failure\n9. Patients with chronic kidney disease\n10. Volume overload state","70 Years",{"count":53,"type":19},60,[22],"The objective of this randomized control clinical trial is to learn the role of albumin in patients with acute variceal bleed. The trial will include all adult patients with acute variceal bleeding and cirrhosis presenting to Medical Gastroenterology department at KGMU, Lucknow, U.P. India, will include patients with age between 18-70 years and all gender.\n\nThe primary endpoint will be re-bleeding during hospitalization and at 6 weeks. Participants will be randomized in two groups, the intervention group will receive albumin for 3 days along with standard treatment and comparison group will receive on standard treatment.",[57,58],"Acute Variceal Bleeding","Cirrhosis",[60,61,62,63],"albumin","acute variceal bleed","cirrhosis","Albumin in acute variceal bleeding","2026-02-03",{"date":66,"type":34},"2026-02-09",{"date":68,"type":19},"2026-03-01",{"date":70,"type":19},"2026-05-31",{"name":40,"class":41},""]