[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Klinik Valens\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":101},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100658404","cooling-during-inpatient-rehabilitation-in-persons-with-ms-100658404",false,"NCT07852156","Cooling During Inpatient Rehabilitation in Persons With MS","Optimizing Inpatient Rehabilitation - Investigating the Effects of Cooling During Intensive Active Training Sessions on Fatigue in Persons With Multiple Sclerosis","CoolEx","Inclusion Criteria:\n\n* FSMC total score ≥ 43;\n* Adult age (≥ 18 years);\n* A definite MS diagnosis according to the 2024 revised McDonald criteria with relapsing-remitting, primary or secondary progressive phenotypes;\n* Disease severity according to Expanded disability status scale (EDSS) score 3.0-6.0;\n* Subjective perceived heat sensitivity (Yes).\n\nExclusion Criteria:\n\n* Inability to follow the study procedures (i.e. participant not fluent in oral and written German language);\n* Cognitive impairment (Montreal Cognitive Assessment, MoCA score \\\u003C 26);\n* Severe concomitant disease states (i.e. orthopaedic, cardiovascular, metabolic, psychiatric (e.g., substance abuse), other neurological disease states, other serious medical conditions) impairing the ability to participate;\n* Participation in another study;\n* Pregnant or lactating women;\n* Intention to become pregnant during this study;\n* Suspected non-compliance;\n* Previous enrolment into this study;\n* Sudden severe disease progression or falling sick (e.g. bacterial or viral infections) during the study;\n* Subjective perceived cold sensitivity (Yes).","ALL","18 Years",{"count":20,"type":21},42,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to shed light on the use of cooling during intensive active training sessions during a three-week multidisciplinary inpatient rehabilitation stay in persons with Multiple Sclerosis. The objectives of this study are:\n\n* to investigate the effects of one week of using a cooling vest during intensive active training sessions compared with one week of not using a cooling vest during inpatient rehabilitation on the state fatigue in persons with Multiple Sclerosis.\n* to investigate the effects of one week of using a cooling vest during intensive active training sessions compared with one week of not using a cooling vest during inpatient rehabilitation on the walking capacity, functional lower limb muscle strength, balance and cognition in persons with Multiple Sclerosis.\n* to investigate the effects of the three-week inpatient rehabilitation on the cardiorespiratory fitness, muscle strength and trait fatigue in persons with Multiple Sclerosis.\n\nResearchers will compare the effects of one week of using a cooling vest during intensive active training sessions with one week of not using a cooling vest during intensive active training sessions during three weeks of inpatient rehabilitation.\n\nParticipants will\n\n* Wear a cooling vest during intensive active training sessions for one week\n* Attend the assessment appointments during study participation\n* Keep a diary recording their use of a cooling vest during intensive active training sessions",[27,28,29],"Multiple Sclerosis","Heat Tolerance","Fatigue Symptom",[31,32,33,34],"cooling","exercise training","Multiple sclerosis","multidisciplinary rehabilitation","RECRUITING","2026-09-25",{"date":38,"type":39},"2026-10-01","ACTUAL",{"date":41,"type":39},"2026-07-28",{"date":43,"type":21},"2028-09-30",{"name":45,"class":46},"Klinik Valens","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100654843","monitoring-intensity-during-balance-training-in-persons-with-multiple-sclerosis---a-randomized-feasibility-study-100654843","NCT07805850","Monitoring Intensity During Balance Training in Persons With Multiple Sclerosis","Monitoring Intensity During Balance Training in Persons With Multiple Sclerosis - a Randomized Feasibility Study","BALANCE-MS","Inclusion Criteria:\n\n* Patients with a definite MS diagnosis according to 2024 revised McDonald criteria;\n* Hold an Expanded disability status (EDSS) between 2.0-6.5;\n* An inpatient stay of at least three weeks at the ;\n* Aged 18 years and older;\n* Have sufficient knowledge of the German language (spoken and written).\n\nExclusion Criteria:\n\n* Cognitive impairment indicated by a score of \\\u003C21 on the Montreal Cognitive Assessment (MoCA);\n* Severe osteoporosis;\n* Fractures and\u002For other surgical interventions;\n* Presence of any other condition that would substantially influence balance;\n* Alcoholism;\n* Participation in another study;\n* Pregnancy.",{"count":57,"type":21},60,[24],"Balance training is recommended to improve gait stability and mobility. However, there are currently no clearly defined methods for controlling the intensity (challenge) of balance training. This research project aims to determine whether balance training for individuals with multiple sclerosis (MS), individually tailored to the level of difficulty and exertion, is feasible and possible within an inpatient rehabilitation setting. Participants will be randomly assigned to one of two groups: either they will complete group training focusing on strength, endurance, and balance in addition to their regular therapy program, or they will receive individually tailored balance training. Both groups will undergo an initial assessment followed by seven training sessions, each lasting approximately 45-60 minutes. Before discharge, the initial assessments will be repeated. These assessments include completing questionnaires, performing gait tests, balance tests, and a short cognitive test. Interviews will also be conducted with patients and therapists. These are intended to help better assess the feasibility of the training and to gain more insight into the experiences with the training.",[27,61],"Balance",[61,63,64,27,65,66,67],"Postural Control","Intensity","Walking","Gait","Training","2026-09-14",{"date":70,"type":39},"2026-09-17",{"date":72,"type":39},"2026-05-06",{"date":74,"type":21},"2027-12",{"name":45,"class":46},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":95,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":47},"100654700","does-hippotherapy-have-an-effect-on-mobility-gait-balance-and-perceived-health-related-quality-of-life-in-persons-with-parkinsons-disease-100654700","NCT07802509","Does Hippotherapy Have an Effect on Mobility, Gait, Balance and Perceived Health-related Quality of Life in Persons With Parkinson's Disease?","HIHA","Inclusion Criteria:\n\n* Confirmed diagnosis of Parkinson's diagnosis\n* Age \\> 18 Years;\n* Hoehn \\& Yahr stage ≤ 4;\n* Category 3 in the Functional Ambulation Categories\n* Climbing stairs is possible (with support).\n\nExclusion Criteria:\n\n* Severe cognitive impairment, defined by a score below 26 on the Montreal Cognitive Assessment (MoCa)\n* Body weight \\> 90kg;\n* Horse hair allergy;\n* Other acute and subacute cardiovascular, respiratory, musculoskeletal or neurological disorders that constitute a contraindication to hippotherapy (i.e. a recent fracture);\n* Pregnancy.",{"count":84,"type":21},30,[24],"The goal of this pilot randomized controlled trial is to investigate the effects of hippotherapy (horse assisted therapy) (intervention group) compared to usual care (control group) on mobility, gait, balance and perceived health-related quality of life in persons with Parkinson's disease. The main objectives of this study are:\n\n* The primary objective is to investigate the effects of hippotherapy on mobility of pwPD, walking speed and the ability to perform daily movements.\n* The secondary objective is to investigate the effects of hippotherapy on (a) balance, (b) self-perceived physical and mental health and (c) specific gait parameters.\n* Furthermore this study, aims to gather critical information that will inform about the design and implementation of a larger, more definitive randomized controlled trial.\n\nIn addition to the three-week, multidisciplinary rehabilitation program the intervention group will receive hippotherapy (20 minutes) three times a week (7 sessions in total) and the control group will receive additional physiotherapy sessions (30 minutes) two times a week.",[88],"Parkinson Disease",[90,91,92,93,94],"Parkinson","Hippotherapy","Equine assisted therapy","Physiotherapy","Rehabilitation",{"date":70,"type":39},{"date":97,"type":39},"2025-01-01",{"date":99,"type":21},"2027-01-01",{"name":45,"class":46},""]