[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Koşuyolu Kartal Heart Training and Research Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":94},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100654509","flow-controlled-vs-pressure-controlled-ventilation-in-cabg-effects-on-lung-aeration-and-diaphragm-function-100654509",false,"NCT07800741","Flow-Controlled vs. Pressure-Controlled Ventilation in CABG: Effects on Lung Aeration and Diaphragm Function","Comparison of Flow-Controlled Ventilation and Pressure-Controlled Ventilation on Lung Aeration and Diaphragm Function in Patients Undergoing Elective Isolated On-Pump Coronary Artery Bypass Graft Surgery: A Single-Centre Prospective Randomised Controlled Trial","FCV-PCV-DTI-LU","Inclusion Criteria:\n\n* Age ≥18 years\n* Planned elective isolated on-pump coronary artery bypass graft (CABG) surgery\n* ASA Physical Status Classification II-IV\n* Written informed consent obtained\n* Technically adequate acoustic window for lung and diaphragm ultrasonography\n\nExclusion Criteria:\n\n* Emergency surgery\n* Combined surgical procedures (e.g., valve repair\u002Freplacement + CABG)\n* Preoperative requirement for invasive or non-invasive mechanical ventilation\n* Known diaphragm paralysis or neuromuscular disease\n* Severe COPD exacerbation or active pneumonia at time of surgery\n* Body mass index ≥40 kg\u002Fm²\n* Inability to obtain standard lung or diaphragm ultrasound images due to pleural effusion, thoracic deformity, or prior thoracic surgery","ALL","18 Years",{"count":20,"type":21},154,"ESTIMATED","INTERVENTIONAL",[24],"NA","Pulmonary atelectasis and loss of lung aeration are common complications following cardiac surgery with cardiopulmonary bypass (CPB) and are associated with impaired oxygenation and prolonged mechanical ventilation. Diaphragm dysfunction occurring in the perioperative period may further delay extubation and prolong intensive care unit (ICU) stay. Flow-Controlled Ventilation (FCV) is a novel ventilation modality that provides continuous, flow-based delivery of tidal breaths with a triangular flow profile, potentially offering superior dynamic compliance optimisation compared to conventional Pressure-Controlled Ventilation (PCV).",[27,28,29,30,31],"Coronary Artery Disease","Postoperative Pulmonary Complications","Pulmonary Atelectasis, Postoperative","Diaphragm Dysfunction","Respiratory Insufficiency",[33,34,35,36,37,38,39,40,41,42,43],"Flow-Controlled Ventilation","Pressure-Controlled Ventilation","Lung Ultrasound","Diaphragm Ultrasonography","Diaphragm Excursion","Diaphragm Thickening Fraction","Lung-Protective Ventilation","Point-of-Care Ultrasound","Perioperative Pulmonary Complications","Cardiopulmonary Bypass","Cardiac Surgery","NOT_YET_RECRUITING","2026-08-30",{"date":47,"type":48},"2026-09-02","ACTUAL",{"date":50,"type":21},"2026-09-30",{"date":52,"type":21},"2028-12-30",{"name":54,"class":55},"Koşuyolu Kartal Heart Training and Research Hospital","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":68,"conditions":69,"keywords":77,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":90,"startDateStruct":91,"completionDateStruct":92,"leadSponsor":93,"locationsCount":56},"100654406","selective-antegrade-cerebral-perfusion-and-perioperative-optic-nerve-sheath-diameter-in-ascending-aortic-surgery-100654406","NCT07800806","Selective Antegrade Cerebral Perfusion and Perioperative Optic Nerve Sheath Diameter in Ascending Aortic Surgery","Selective Antegrade Cerebral Perfusion as a Cerebral Protection Strategy in Ascending Aortic Surgery: Perioperative Changes in Ultrasonographic Optic Nerve Sheath Diameter. A Single-Center Prospective Observational Cohort Study","SACP-ONSD","Inclusion Criteria:\n\n* Age 18 years or older\n* Planned or urgent, hemodynamically stable ascending aortic surgery, including supracoronary ascending aortic replacement, aortic root replacement (Bentall procedure) or valve-sparing root surgery (David procedure), limited to cases involving the ascending aortic segment\n* Perfusion planned through axillary artery cannulation\n* Written informed consent\n\nExclusion Criteria:\n\n* History of intracranial procedure or intracranial pathology\n* Previous carotid intervention, or carotid artery stenosis of 50 percent or more on preoperative Doppler ultrasonography\n* Advanced chronic obstructive pulmonary disease, defined clinically as advanced stage disease with long-term oxygen therapy or a history of frequent exacerbations\n* Baseline arterial carbon dioxide tension of 55 mmHg or higher on preoperative arterial blood gas analysis\n* Ocular pathology, ocular surgery or ocular trauma that could affect measurement of the optic nerve sheath or optic nerve, including glaucoma and retinal detachment or fibrosis\n* Severe preoperative neurological deficit, including major stroke or severe dementia, or active psychiatric illness\n* Hemodynamic instability, or a requirement for extracorporeal membrane oxygenation or intra-aortic balloon counterpulsation, of a degree that prevents measurements during the first 24 postoperative hours\n* Known contraindication to any component of the protocol-specified anesthesia regimen",{"count":66,"type":21},134,[24],"In ascending aortic surgery the distal anastomosis may be constructed with the aortic cross-clamp maintained, or, where the extent of the aortic pathology and the geometry of the graft require it, after release of the cross-clamp during a period of systemic circulatory arrest. Both are established surgical approaches. Where the cross-clamp is released, selective antegrade cerebral perfusion (SACP) is an established cerebral protection technique and is applied for that purpose. Where release of the cross-clamp is not required, systemic circulatory arrest is avoided and SACP is not applied. Optic nerve sheath diameter (ONSD) measured by ocular ultrasonography is a non-invasive marker of raised intracranial pressure. Cardiopulmonary bypass may increase blood-brain barrier permeability through hypoperfusion, non-pulsatile flow, hemodilution and systemic inflammation, predisposing to cerebral edema. Perioperative increases in ONSD have been reported after open heart surgery and have been associated with postoperative delirium. Data on how SACP influences perioperative ONSD dynamics in ascending aortic surgery, and whether such changes relate to postoperative delirium, are limited.",[70,71,72,73,74,75,76],"Aortic Diseases","Cardiac Surgical Procedures","Aortic Aneurysm, Thoracic","Delirium - Postoperative","Postoperative Complications (Cardiopulmonary)","Postoperative Complications","Cerebrovascular Circulation",[78,79,80,81,82,83,84,85,86,87,88,89],"Optic nerve sheath diameter","Selective antegrade cerebral perfusion","Ascending aortic surgery","Circulatory arrest","Cardiopulmonary bypass","Postoperative delirium","Nursing Delirium Screening Scale","Transcranial Doppler ultrasonography","Middle cerebral artery mean flow velocity","Near-infrared spectroscopy","Suppression ratio","Cerebral protection",{"date":47,"type":48},{"date":50,"type":21},{"date":52,"type":21},{"name":54,"class":55},""]