[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Koite Health Oy\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":99},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100517459","antibacterial-photodynamic-therapy-in-the-management-of-peri-implantitis-100517459",false,"NCT06017817","Antibacterial Photodynamic Therapy in the Management of Peri-implantitis","Regular Home-use of Antibacterial Photodynamic Therapy in the Management of Peri-implantitis","Inclusion Criteria:\n\n* PPD ≥6 mm and marginal bone loss \\>3 mm\n* Dental implants collected and clinically characterized according to Lähteenmäki et al. CEDR-22\n* Agreement to participate in the study and to sign a written consent form\n* Able to co-operate with the treatment protocol and avoid any other oral hygiene measures outside of the study protocol\n\nExclusion Criteria:\n\n* Presence of any physical limitation or restriction that might restrict Lumoral use\n* Unwilling to participate in the study\n* Pregnancy or lactation\n* Active smoking\n* Medicated diabetes mellitus (DM)\n* Any systemic disease (e.g., wound healing dysfunctions) that could alter the progression of peri-implantitis\n* Use of antibiotics and doxycycline, chlorhexidine, and bisphosphonates, within 4 weeks week prior to study participation\n* Peri-implant and periodontal treatment within 3 months prior to study participation\n* Removable major prosthesis or major orthodontic appliance","ALL","18 Years","85 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","This early-stage study is designed to determine the efficacy of the Lumoral method in periimplantitis. Improved supragingival plaque control can help to also sustain subgingival plaque management in the long term. In addition, the device might have a photobiomodulation effect on periodontal tissues, thus impacting osseointegration.",[27,28],"Peri-Implantitis","Plaque, Dental",[30,31,32,33,34],"Lumoral","Lumorinse","Antibacterial photodynamic therapy (aBPT)","aMMP-8","Plaque control","RECRUITING","2026-08-04",{"date":38,"type":39},"2026-08-07","ACTUAL",{"date":41,"type":39},"2024-05-13",{"date":43,"type":21},"2026-12-31",{"name":45,"class":46},"Koite Health Oy","INDUSTRY",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":5},"100560355","antibacterial-photodynamic-therapy-as-an-adjunctive-treatment-on-oral-hygiene-in-elderly-persons-100560355","NCT06576063","Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly Persons","Effects of the Regular Use of Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly Persons Living at Home or at Care Homes","Inclusion Criteria:\n\n* An elderly (age ≥ 65 years) person living at home or at care home, with a possibility to regular dental care appointments\n* Ability to understand and sign the informed consent\n* At least 10 teeth in the mouth, including implants\n* Ability to understand and follow the study protocol, including tooth brushing and following the instructions for the use of Lumoral Treatment, based on the assessment of the investigator\n\nExclusion Criteria:\n\n* Uncontrolled diabetes mellitus (DM)\n* Severe dementia or other similar conditions that may restrict understanding of the study information and protocol\n* Presence of any physical limitation or restriction that might restrict Lumoral use\n* Active smoking and use of other tobacco products\n* Use of antibiotics within 4 weeks week prior study\n* Oral thrush\n* Known sensitivity to near-infrared or antibacterial blue light.",true,"65 Years",{"count":58,"type":21},100,[24],"On average, the dental condition of elderly people is poor due to various reasons. The importance of oral health maintenance of the ageing population has been recognized by the World Health Organization (WHO), as oral health plays a key role in reaching the global goal of the \"Decade of Healthy Ageing 2021-2030\".\n\nNew measures for maintaining good oral health are welcome. The use of antibacterial photodynamic therapy (aPDT) and antibacterial blue light (aBL) has been studied and found to reduce the amount of plaque in the mouth. The Lumoral device is a CE-marked home medical device combining aPDT and aBL, and it is effective in reducing the development of plaque and harmful bacteria in the plaque. The device has also been shown to be easy and safe to use. In this study, a combination of regular dental appointments with the importance of enhanced dental self-care, will be tested as one regional solution for reaching the global goal set by WHO.",[62,63,64],"Dental Plaque","Bleeding of Subgingival Space","Oral Complication",[30,66,32,33,34,67],"Preventive oral care","Oral hygiene","2025-08-05",{"date":70,"type":39},"2025-08-07",{"date":72,"type":39},"2025-01-02",{"date":74,"type":21},"2027-06",{"name":45,"class":46},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":47},"100582173","efficacy-of-adjunctive-at-home-photodynamic-therapy-apdt-in-the-treatment-of-peri-implant-mucositis-100582173","NCT06859866","Efficacy of Adjunctive At-Home Photodynamic Therapy (aPDT) in the Treatment of Peri-Implant Mucositis","Efficacy of Adjunctive At-Home Photodynamic Therapy (aPDT) in the Treatment of Peri-Implant Mucositis: A Post-Marketing Interventional Pilot Study With a Medical Device","Inclusion Criteria:\n\n* Presence of at least 20 teeth within the oral cavity.\n* Diagnosis of peri-implant mucositis: bleeding or suppuration upon gentle probing with or without increased probing depth compared to previous evaluations, and no bone loss beyond the changes in the crestal bone level resulting from initial bone remodeling.\n* Patients willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy.\n* Patients with a history of periodontitis.\n* Use of medications that could affect soft tissues within the past 6 months (e.g., antibiotics, anti-inflammatories, anticonvulsants, immunosuppressants, or calcium channel blockers, including doxycycline and bisphosphonates).\n* Allergy to the photosensitizer.\n* Patients with removable major prostheses or orthodontic appliances.\n* Patients with untreated carious lesions.",{"count":84,"type":21},30,[24],"The study aims to establish a validated protocol enabling an alternative approach for bacterial biofilm control through the application of a novel at-home photodynamic\u002Fantibacterial blue light therapy in addition to non-surgical professional treatment (NST) for peri-implant mucositis. The primary outcomes will include reductions in plaque and bleeding scores, decreases in probing pocket depth, and lower aMMP-8 levels in PISF. Secondary outcomes will include changes in keratinized peri-implant mucosa (KPIM) and patient-reported outcome measures (PROMs).",[88],"Peri-implant Mucositis",[90,33,91],"APDT","antibacterial","2025-08-04",{"date":68,"type":39},{"date":95,"type":39},"2025-04-29",{"date":97,"type":21},"2027-02",{"name":45,"class":46},""]