[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Li Juan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":58},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100657199","effect-of-stellate-ganglion-block-on-sleep-quality-in-patients-with-depression-100657199",false,"NCT07836738","Effect of Stellate Ganglion Block on Sleep Quality in Patients With Depression","Inclusion Criteria:\n\n1. Aged 18-65 years of both genders. Alert and capable of normal communication. Voluntarily sign informed consent, complete the whole experimental procedure, and meet ethical and compliance requirements.\n2. Hamilton Depression Rating Scale (HAMD) score ≥ 8.\n3. Insomnia Severity Index (ISI) score ≥ 7 or Pittsburgh Sleep Quality Index (PSQI) score ≥ 7.\n4. No contraindications to stellate ganglion block (SGB); no cervical deformity, trauma, or infection; and no severe cervical spine disease, such as cervical fracture or cervical disc herniation with nerve compression.\n5. No use of sedative-hypnotics, anxiolytics, antidepressants, or other medications that may affect sleep within the past month, and no acupuncture, massage, nerve block, or other sleep-related interventions during the same period.\n6. Stable vital signs; normal liver and renal function, complete blood count, and coagulation function; and no severe organic diseases of the heart, brain, lungs, liver, or kidneys.\n7. Able to strictly follow the required sleep-wake schedule and cooperate with polysomnography (PSG) monitoring and completion of sleep diaries, with good study compliance.\n\nExclusion Criteria:\n\n* 1: Age \\\u003C18 or \\>65 years; pregnant or lactating women; subjects with psychiatric disorders (schizophrenia, mania, etc.) or cognitive impairment who cannot cooperate with the study, to prevent missing data and experimental bias.\n\n  2: Presence of contraindications to stellate ganglion block, such as coagulation disorders, local skin infection, severe cervical spine disease, hyperthyroidism, glaucoma, or increased intracranial pressure.\n\n  3: Allergy to ropivacaine, epinephrine, or other drugs used for the block, or a history of drug allergy.\n\n  4: Use of sedative-hypnotics, anxiolytics, antidepressants, hormonal medications, or other treatments that may affect sleep within the past month.\n\n  5: Severe cardiovascular or cerebrovascular disease, hepatic or renal insufficiency, hematologic disease, respiratory disease, or other serious organic diseases, or a recent history of surgery or trauma.\n\n  6: Alcohol dependence or drug dependence, or daily consumption of coffee, strong tea, or other stimulating beverages with inability to abstain during the study period.\n\n  7: Inability to maintain a fixed sleep-wake schedule during the study or inability to complete the full monitoring and intervention procedures because of work, daily life, or other reasons.\n\n  8: Voluntary withdrawal during the study, or inability to complete the study because of adverse reactions, poor compliance, or other reasons.",true,"ALL","18 Years","65 Years",{"count":20,"type":21},42,"ESTIMATED","INTERVENTIONAL",[24],"NA","\\# Brief Summary\n\nThis clinical research study looks at whether stellate ganglion block (SGB) can improve sleep quality for people with depression. Poor sleep often goes together with depression. Medicines used for these conditions may cause side-effects or dependency. Researchers want to learn if SGB, a minimally-invasive nerve treatment, can help sleep and mood without those medicine-related downsides.\n\nThis study uses a self-controlled design. Every person who joins will receive the study treatment. No separate comparison group is enrolled. Researchers will collect sleep data from each participant before treatment and again after treatment, then compare these two sets of information.\n\nAbout 42 participants will take part in this study.\n\nKey requirements to join the study:\n\n* Aged 18 to 65 years old\n* Have depression-related symptoms and sleep trouble\n* Able to understand and sign an informed consent form\n* No medical conditions that make SGB unsafe\n* Have not taken sleep-affecting medicines or received other sleep-focused treatments in the past one month\n* Can follow study schedules and complete all study assessments\n\nPeople cannot join if they:\n\n* Are younger than 18 years or older than 65 years\n* Are pregnant or breastfeeding\n* Have known allergies to study-used medicines\n* Have unstable serious organ diseases, uncontrolled substance or alcohol dependence\n* Cannot keep fixed daily routines or finish all study visits\n\nStudy procedures for each participant:\n\n1. On study day zero (D0): Study staff will explain the study fully. Participants will sign informed consent. Staff will run physical checks and blood tests. Participants will fill out several simple questionnaires about mood and sleep. Sleep will be measured overnight with a multi-channel sleep recording device called polysomnography (PSG). Participants also keep a short sleep diary.\n2. From study day one (D1) to day five (D5): Participants get one SGB treatment each day, for a total of five treatments. During SGB, a doctor uses ultrasound guidance to inject small-dose local anesthetic near nerves in the neck. Participants keep completing their sleep diary every day. Study staff watch for any unwanted reactions during each treatment.\n3. On the night of D5 through early morning of D6: PSG sleep recording will be repeated after the final SGB treatment.\n4. On study day six (D6): Participants finish the final set of mood-and-sleep questionnaires. Study staff collect all safety information.\n\nResearchers will compare sleep measurements taken before treatment versus after five-day SGB treatment. Collected data includes objective sleep readings from PSG and self-reported sleep information from sleep diaries. Questionnaires will show changes in depression and insomnia symptoms.\n\nPossible benefits: SGB may make participants' sleep better and may ease depression-related symptoms. No benefit is guaranteed for every participant.\n\nPossible risks: SGB is generally safe. Rare unwanted reactions may include temporary hoarseness, local neck-site infection, or drug allergic responses. Study doctors will watch participants closely. If serious problems happen, immediate medical help will be provided.\n\nAll participants' private personal information will be protected. Participants can choose to stop taking part in this research at any time without penalty.",[27],"Sleep and Circadian Problems","NOT_YET_RECRUITING","2026-10-08",{"date":31,"type":32},"2026-10-13","ACTUAL",{"date":34,"type":21},"2026-09-20",{"date":36,"type":21},"2026-12-30",{"name":38,"class":39},"Li Juan","OTHER_GOV",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":4,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":55,"completionDateStruct":56,"leadSponsor":57,"locationsCount":4},"100659340","perioperative-sleep-recovery-trajectories-in-patients-of-different-sexes-undergoing-laparoscopic-cholecystectomy-100659340","NCT07863804","Perioperative Sleep Recovery Trajectories in Patients of Different Sexes Undergoing Laparoscopic Cholecystectomy","A Prospective Observational Study of Perioperative Sleep Recovery Trajectories in Patients of Different Sexes Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n1. Aged 18-65 years of both genders. Alert and capable of normal communication. Voluntarily sign informed consent, complete the whole experimental procedure, and meet ethical and compliance requirements.\n2. Patients scheduled to undergo laparoscopic cholecystectomy under general anesthesia.\n3. No history of severe needle or blood phobia, and able to tolerate repeated venous blood sampling during the perioperative period.\n4. No long-term use of sedative-hypnotics, anxiolytics, antidepressants, or glucocorticoids within the past month, except for short-term use for acute illness for no more than 3 days; no other interventions that may affect sleep, such as transcranial magnetic stimulation or cognitive behavioral therapy.\n5. Stable vital signs, essentially normal function of major organs, including the heart, brain, lungs, liver, and kidneys, and no severe organic disease; able to tolerate surgery and the study procedures.\n6. Able to strictly follow the required sleep-wake schedule during the study period and cooperate with completion of sleep diaries, questionnaires, and all assessments, with good compliance.\n\nExclusion Criteria:\n\n* 1: Aged \\\u003C18 years or \\>65 years; pregnant or breastfeeding women; patients with psychiatric disorders, such as schizophrenia, mania, or depression, cognitive impairment, or inability to cooperate with the study, in order to avoid missing data or study bias due to poor cooperation.\n\n  2: Severe coagulation disorders, skin infection at the puncture site, or other conditions unsuitable for repeated blood sampling, to ensure the safety of blood collection procedures.\n\n  3: Use of sedative-hypnotics, anxiolytics, antidepressants, hormonal medications, or other sleep-related interventions within the past month that may affect the study outcomes, in order to minimize confounding factors and ensure the accuracy of the results.\n\n  4: Severe cardiovascular or cerebrovascular disease, severe hepatic or renal insufficiency, severe respiratory disease, or other conditions that may affect perioperative recovery or sleep assessment.\n\n  5: Major surgery or severe trauma within the past 3 months that may interfere with the perioperative stress response.\n\n  6: Alcohol or drug dependence, or consumption of more than three cups of coffee, strong tea, or other stimulant beverages per day with an inability to maintain relatively stable consumption habits during the study period, as substances such as caffeine may interfere with sleep.\n\n  7: Voluntary withdrawal from the study before completion, or inability to complete the study due to adverse reactions, poor compliance, or other reasons.",{"count":48,"type":21},58,"OBSERVATIONAL","This is an observational clinical study. It does not give new treatments to participants. Researchers want to learn how sleep gets better or worse after laparoscopic gallbladder removal surgery. Sleep problems are common after surgery. Some people may recover their sleep faster than others. Researchers will look at whether sleep recovery differs between women and men. They will also check how sex-related hormone levels connect with sleep changes.\n\nAbout 58 participants will join this study.\n\nKey requirements to take part:\n\n* Aged 18 to 65 years old\n* Scheduled for laparoscopic gallbladder removal under general anesthesia\n* Able to give informed consent and finish all study tasks\n* Can tolerate repeated blood draws\n* No long-term sleep-affecting medicine use in the past one month\n* Major organs work normally\n\nPeople cannot join if they:\n\n* Are younger than 18 years or older than 65 years\n* Are pregnant or breastfeeding\n* Have mental health or cognitive conditions that stop study participation\n* Have problems that make repeated blood collection unsafe\n* Have severe organ diseases or recent major injury or surgery\n* Have alcohol or drug dependence\n\nWhat happens for each participant:\n\n1. Before surgery: Participants sign consent forms. Staff collect basic health information. Participants wear a sleep-recording device called polysomnography (PSG) overnight. Participants fill out a short sleep diary each morning. Fasting blood samples are collected the next morning to measure hormone levels.\n2. On surgery day: Standard hospital care goes forward. Staff record surgery-related information. PSG sleep recording, sleep diary, and morning blood draw are repeated.\n3. First and second days after surgery: The same sleep recording, sleep diary, and morning fasting blood collection continue for two more nights.\n\nResearchers compare sleep measurements across four nights. These measurements come from both PSG machine readings and participants' self-reported sleep diaries. Researchers also compare hormone level changes between female and male participants.\n\nPossible benefits: Participants receive objective feedback on their own sleep and hormone results. If test values show clear concerns, researchers share these findings with their clinical care team. No direct treatment benefit is guaranteed.\n\nPossible risks: This is a low-risk study. Small risks may include mild pain, bruising at blood draw sites, or temporary light-headedness from blood collection. Filling out short diaries may bring minor tiredness. All personal data will be kept private. Participants can leave the study at any time with no penalty.",[27],"2026-10-04",{"date":54,"type":32},"2026-10-07",{"date":34,"type":21},{"date":36,"type":21},{"name":38,"class":39},""]