[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Mansoura University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":687},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,114,0,25,[9,50,76,102,129,151,188,224,251,273,300,327,352,381,402,428,454,481,509,544,567,588,614,643,668],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100652831","passive-fit-of-implant-supported-frameworks-digital-vs-conventional-impressions-100652831",false,"NCT07778199","Passive Fit of Implant-Supported Frameworks: Digital vs Conventional Impressions","Passive Fit Evaluation of Full-Arch Implant-supported Frameworks Using Digital and Conventional Impression Techniques: Crossover Study","Inclusion Criteria:\n\n* Completely edentulous patients requiring full-arch implant-supported fixed prosthesis\n* Age 35-70 years\n* Adequate mandibular bone to place at least four implants without major grafting\n* Ability to undergo digital scanning and radiographic evaluation\n* Signed informed consent\n\nExclusion Criteria:\n\n* Systemic conditions affecting healing (uncontrolled diabetes, immunosuppression)\n* History of head\u002Fneck radiotherapy or bisphosphonate therapy\n* Active oral infection or severe bruxism\n* Strong gag reflex preventing accurate scanning\n* Poor compliance or unwillingness to attend follow-up visits","ALL","35 Years","70 Years",{"count":21,"type":22},8,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized crossover clinical trial compares the passivity of fit of complete-arch mandibular implant-supported frameworks fabricated using three impression techniques: a non-calibrated splinted digital scan body system (IO-Connect), a Reverse Scan Body (RSB) digital impression technique, and a conventional splinted open-tray impression technique. Eight completely edentulous patients each receiving four mandibular implants will be included. Passivity of fit will be evaluated clinically using the Sheffield one-screw test and radiographically using intraoral periapical radiographs obtained with the parallel technique.",[28,29,30],"Dental Implants","Edentulous Jaw","Passive Fit",[32,33,34,35,36],"Passive fit","Implant-supported framework","Digital impression","Full-arch implant prosthesis","Crossover study","RECRUITING","2026-08-20",{"date":40,"type":41},"2026-08-21","ACTUAL",{"date":43,"type":41},"2026-01-25",{"date":45,"type":22},"2027-01-25",{"name":47,"class":48},"Mansoura University","OTHER",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":12,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":49},"100649873","posterior-resin-bite-turbos-effect-on-maxillary-expansion-using-a-hyrax-expander-in-early-adolescents-100649873","NCT07739498","Posterior Resin Bite Turbos Effect on Maxillary Expansion Using a HYRAX Expander in Early Adolescents","Effect of Posterior Disarticulatory Resin Bite Turbos on the Rate of Maxillary Expansion Using HYRAX Expander in Early Adolescent Patients: Randomized Controlled Clinical Trial","HYRAX_ RME_SME","Inclusion Criteria:\n\n1. Patients aged 10-14 years.\n2. Bilateral posterior cross bite.\n3. Functional lateral cross bite.\n4. Good general and oral health.\n5. Normal to decreased vertical height )average FMA 29.7 °± 4.2 °).23\n\nExclusion Criteria:\n\n1. Patients with cleft lip and palate.\n2. Severe facial asymmetry.\n3. Anterior open bite.\n4. Systemic conditions affecting tooth movement (e.g., diabetes, bone disorders).\n5. Previous orthodontic treatment.","10 Years","14 Years",{"count":61,"type":22},22,[25],"This randomized controlled clinical trial aims to evaluate the effect of posterior disarticulatory resin bite turbos on the rate of maxillary expansion using a HYRAX expander in early adolescent patients. Participants will be randomly assigned to receive either maxillary expansion with posterior resin bite turbos or conventional expansion without bite turbos. The study will assess and compare the rate and effectiveness of maxillary expansion between the two groups during the treatment period. Clinical measurements will be recorded to evaluate skeletal and dental changes associated with the intervention.",[65],"Maxillary Transverse Deficiency (Posterior Crossbite) in Early Adolescent Patients",[67],"Maxillary transverse deficiency - Rapid maxillary expansion - HYRAX expander - Bite turbos - Orthodontics - Intraoral scanning - RCT","2026-08-13",{"date":70,"type":41},"2026-08-17",{"date":72,"type":41},"2026-02-15",{"date":74,"type":22},"2027-06",{"name":47,"class":48},{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":49},"100648314","ultrasound-guided-retrolaminar-block-versus-transverse-abdominis-plane-block-in-laparoscopic-upper-abdominal-surgeries-100648314","NCT07720817","Ultrasound Guided Retrolaminar Block Versus Transverse Abdominis Plane Block in Laparoscopic Upper Abdominal Surgeries","Safety and Efficacy of Ultrasound Guided Retrolaminar Block Versus Transverse Abdominis Plane Block on Quality of Recovery in Laparoscopic Upper Abdominal Surgeries: A Randomized Comparative Clinical Trial","Inclusion Criteria:\n\n* Age between 21 and 65 years.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Body mass index (BMI) less than 30 kg\u002Fm².\n* Scheduled for elective laparoscopic upper abdominal surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Refusal to participate in the study.\n* Known allergy or hypersensitivity to any of the study drugs.\n* Infection at the planned block insertion site.\n* Severe uncontrolled cardiac, renal, hepatic, neurological, or respiratory disease.\n* Pre-existing chronic pain.\n* Immunodeficiency.\n* Coagulation abnormalities, anticoagulant therapy, or platelet count less than 80,000\u002FµL.\n* Emergency surgery.","21 Years","65 Years",{"count":86,"type":22},164,[25],"This study aims to compare and evaluate the safety and efficacy of ultrasound guided retrolaminar block versus transverse abdominis plane block in laparoscopic upper abdominal surgeries. Both RLB and TAP blockade are hypothesized to reduce analgesic consumption, manage pain effectively and minimize side effects but their comparative effectiveness has not yet to be thoroughly explored.",[90,91,92],"Retrolaminar Block","TAP Block","Laparoscopic Abdominal Surgeries","NOT_YET_RECRUITING","2026-08-08",{"date":96,"type":41},"2026-08-11",{"date":98,"type":22},"2026-07-15",{"date":100,"type":22},"2027-02",{"name":47,"class":48},{"id":103,"slug":104,"hasResults":12,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":109,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":49},"100651126","effectiveness-of-epigallocatechin-3-gallate-green-tea-extract-as-adjunctive-locally-delivered-nanotherapeutic-in-the-treatment-of-stage-ii-periodontitis-100651126","NCT07754253","Effectiveness of Epigallocatechin-3-Gallate (Green Tea Extract) as Adjunctive Locally Delivered Nanotherapeutic in the Treatment of Stage II Periodontitis","Effectiveness of Epigallocatechin-3-Gallate (Green Tea Extract) as Adjunctive Locally Delivered Nanotherapeutic in the Treatment of Stage II Periodontitis (A Randomized Controlled Clinical Trial)Man","Inclusion Criteria:\n\nHealthy patients diagnosed with stage II and grade B periodontitis (pocket depth ≤ 5mm and CAL = 3-4 mm).\n\n* Patients within the age range of 25-60 years.\n* Good compliance with the plaque control instructions following initial therapy. 9\n* Patients willing to participate in the study and will give written informed consent.\n\nExclusion Criteria:\n\n* Patients with active systemic disease.\n* Periodontal treatment during the last 6 months.\n* Patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study.\n* Pregnant and lactating females.\n* Smokers",true,"25 Years","60 Years",{"count":113,"type":22},30,[115],"PHASE1","The main objective of the current study is to clinically and biochemically evaluate the effectiveness of epigallocatechin-3-gallate-loaded chitosan nanoparticulate gel as a local drug delivery system, when used in conjunction with mechanical debridement, for treating periodontal pockets in patients with stage II periodontitis.\n\nThe primary endpoint will be the assessment of pocket depth reduction after 3 months of therapy, whereas the secondary endpoints include the changes in clinical attachment gain, bleeding on probing, plaque and gingival indices and gingival crevicular fluid level of tumor necrosis factor alpha (TNF-α).",[118],"Peridontitis",[120],"gum","2026-08-04",{"date":123,"type":41},"2026-08-10",{"date":125,"type":41},"2026-03-16",{"date":127,"type":22},"2026-12-20",{"name":47,"class":48},{"id":130,"slug":131,"hasResults":12,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":137,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":147,"completionDateStruct":148,"leadSponsor":150,"locationsCount":4},"100649534","phase-1-evaluation-of-nipsa-using-alloplastic-bone-graft-and-cross-linked-hyaluronic-acid-in-thetreatment-of-intrabony-defects-100649534","NCT07737678","Evaluation of NIPSA Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in theTreatment of Intrabony Defects","Evaluation of Non-Incised Papillae Surgical Approach Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in the Treatment of Intrabony Defects (A Randomized Controlled Clinical Trial)","RCT","Inclusion Criteria:\n\n1. Age range: 35 to 65 years old.\n2. Patients diagnosed with stage III. Periodontitis\n3. Presence of isolated intrabony defect with PPD ≥ 6 mm, CAL ≥ 6 mm\n4. Intrabony defect depth ≥3 mm.\n5. Contained an intrabony defect, 3-wall intrabony defect.\n6. No periodontal treatment has been administered in the previous six months.\n7. Full-mouth plaque score ≤ 10%.\n8. Full-mouth bleeding score ≤ 10%. -\n\nExclusion Criteria:\n\n1. Smokers ≥ 10 cigarettes per day\n2. Patient with systemic disease.\n3. Pregnant or lactating patients.\n4. Patient who has traumatic occlusion.\n5. Noncompliant patient.\n6. Patient with multi-rooted teeth with class II \\& III furcation involvement.",{"count":138,"type":22},60,[115,140],"PHASE2","Sixty patients will be selected from the outpatient clinic in the Oral Medicine and Periodontology Department, Faculty of Dentistry, Mansoura University, Egypt, according to preoperative clinical and radiographic data that will be used to evaluate the bone destruction pattern.",[143,144],"Intrabony Periodontal Defect","Periodontal Disease","2026-08-01",{"date":121,"type":41},{"date":145,"type":22},{"date":149,"type":22},"2027-03-01",{"name":47,"class":48},{"id":152,"slug":153,"hasResults":12,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":12,"sex":17,"minAge":159,"maxAge":160,"enrollmentInfo":161,"targetDuration":4,"studyType":23,"phases":163,"briefSummary":164,"conditions":165,"keywords":171,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":185,"leadSponsor":187,"locationsCount":49},"100650065","virtual-reality-for-pain-and-fear-in-children-with-burns-100650065","NCT07740980","Virtual Reality for Pain and Fear in Children With Burns","Does Virtual Reality Reduce Pain, Fear, and Behavioral Distress in Children During Burn Dressing Changes? A Randomized Controlled Trial","VR-PFB","Inclusion Criteria:\n\n* Children aged 6 to 12 years\n* Acute burn injury requiring a routine dressing change, either during inpatient hospitalization or during a scheduled outpatient clinic visit\n* Able to communicate verbally and follow simple instructions\n* Medically stable as determined by attending physician (no acute respiratory distress, hemodynamic instability, or active sepsis)\n* Written informed consent from parent\u002Fguardian\n* Verbal child assent (for children aged 7 years and older)\n\nExclusion Criteria:\n\n* Burns involving the face, head, or ears that prevent safe VR headset placement\n* Cognitive, motor, visual, or hearing impairments interfering with study participation\n* History of motion sickness, seizure disorder, or migraines triggered by visual stimuli\n* Inability to maintain sitting or semi-upright position during the procedure\n* Burns greater than 60% Total Body Surface Area (TBSA) or requiring intensive care admission","6 Years","12 Years",{"count":162,"type":22},80,[25],"Burn injuries are very painful for children, especially during dressing changes when the wound is cleaned and re-bandaged. This procedure, while necessary, can cause pain, fear, and distress that may make children afraid of future treatments. Virtual reality (VR) is a technology that uses a headset to show an immersive, interactive 3D world. It can distract children from painful medical procedures.\n\nThis study aims to find out if using VR during burn dressing changes can reduce pain, fear, and behavioral distress in children aged 6 to 12 years. Half of the children will receive standard burn care plus VR distraction during their dressing change. The other half will receive standard care only.\n\nThe study will take place at the Burns and Plastic Surgery Center, Mansoura University, Egypt. Children will be recruited from both inpatient wards and outpatient clinics. Pain will be measured using a number scale, fear using a faces scale, and distress will be observed throughout the procedure.\n\nIt is expected that children who use VR will report less pain, show less fear, and display less distress during their dressing changes compared to children who receive standard care alone.",[166,167,168,169,170],"Burns","Pain, Procedural","Pain, Acute","Fear","Stress, Psychological",[172,173,174,175,176,177,178,179,180],"Virtual Reality","VR","Distraction","Burn Dressing Change","Pediatric Pain","Procedural Pain","Child Fear","Behavioral Distress","Randomized Controlled Trial","2026-07-31",{"date":183,"type":41},"2026-08-03",{"date":145,"type":22},{"date":186,"type":22},"2026-11-30",{"name":47,"class":48},{"id":189,"slug":190,"hasResults":12,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":12,"sex":17,"minAge":196,"maxAge":19,"enrollmentInfo":197,"targetDuration":4,"studyType":23,"phases":199,"briefSummary":201,"conditions":202,"keywords":206,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":223},"100636899","phase-2-colchicine-for-autoimmune-and-subacute-thyroiditis-100636899","NCT07571681","Colchicine for Autoimmune and Subacute Thyroiditis","Colchicine as a Novel Anti-Inflammatory Strategy in Autoimmune and Subacute Thyroiditis: A Prospective Three-Arm Randomized Controlled Trial","COLTHYR","Inclusion Criteria:\n\n* Age 18 to 70 years\n* Newly diagnosed Hashimoto's thyroiditis or Subacute thyroiditis\n* Diagnosis confirmed clinically, biochemically, and ultrasonographically\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Severe renal impairment\n* Severe hepatic disease\n* Cytopenia\n* Active serious infection\n* Known hypersensitivity to colchicine\n* Chronic corticosteroid use within previous 30 days\n* Participation in another interventional trial\n* Any condition affecting safety or protocol adherence","18 Years",{"count":198,"type":22},300,[140,200],"PHASE3","Thyroiditis includes inflammatory thyroid disorders such as Hashimoto's thyroiditis and subacute thyroiditis. These conditions may cause thyroid pain, neck tenderness, elevated inflammatory markers, thyroid dysfunction, fatigue, and recurrence. Current management includes observation, symptomatic treatment, nonsteroidal anti-inflammatory drugs, and corticosteroids. Although corticosteroids may be effective, relapse after tapering and treatment-related adverse effects remain limitations. Colchicine is hypothesized to reduce inflammatory activity and may improve biochemical and clinical recovery. This study will evaluate the efficacy and safety of low-dose colchicine compared with corticosteroid therapy and supportive care in adults with autoimmune or subacute thyroiditis.",[203,204,205],"Hashimoto Thyroiditis","Subacute Thyroiditis","Thyroiditis",[207,208,209,210,211,212,213,214],"Colchicine","Prednisolone","Autoimmune Thyroiditis","Inflammation","C-reactive protein","ESR","Thyroid Pain","Randomized Trial","2026-07-27",{"date":217,"type":41},"2026-07-29",{"date":219,"type":41},"2026-06-15",{"date":221,"type":22},"2027-09",{"name":47,"class":48},2,{"id":225,"slug":226,"hasResults":12,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":12,"sex":17,"minAge":196,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":23,"phases":234,"briefSummary":235,"conditions":236,"keywords":238,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":4},"100648932","evaluation-of-enamel-matrix-derivative-in-immediate-dental-implants-in-the-mandibular-molar-region-100648932","NCT07727655","Evaluation of Enamel Matrix Derivative in Immediate Dental Implants in the Mandibular Molar Region","Evaluation of Enamel Matrix Derivative in Management of Jumping Gaps Around Immediate Dental Implants in Mandibular Molar Region. A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Patients with non-restorable mandibular molar requiring dental extraction.\n2. Patient medically free from systemic diseases that absolutely contraindicate implant surgery.\n3. Age range: from (18 to 45) years.\n4. Adequate inter-arch relation and inter-occlusal space to accommodate the prosthetic restoration (8-12mm).\n5. Extraction sockets with intact bony walls and interradicular bone.\n6. Jumping gap more than 2mm.\n7. Patients with good oral hygiene.\n8. Patients willing to participate in the study's follow-up intervals.\n\nExclusion Criteria:\n\n1. Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site impaired the immediate implant placement.\n2. smoker patients.\n3. Pregnant patients.\n4. Patients with para-functional habits (bruxism and clenching)","45 Years",{"count":233,"type":22},24,[25],"This randomized clinical trial will evaluate the effect of using an enamel matrix derivative during immediate dental implant placement in the mandibular molar region. Patients who require extraction of a non-restorable mandibular molar and immediate implant placement will be randomly assigned to receive an implant placed with enamel matrix derivative or without enamel matrix derivative. Clinical and radiographic outcomes, including implant stability and peri-implant bone changes, will be assessed over a follow-up period of six months. The results of this study aim to determine whether the use of enamel matrix derivative improves osseointegration and healing around immediate dental implants.",[237],"Tooth Loss",[239,240,241,242,243],"Immediate dental implant","Enamel matrix derivative","Emdogain","Mandibular molar","Osseointegration","2026-07-22",{"date":215,"type":41},{"date":247,"type":22},"2026-06",{"date":249,"type":22},"2026-09",{"name":47,"class":48},{"id":252,"slug":253,"hasResults":12,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":12,"sex":17,"minAge":258,"maxAge":160,"enrollmentInfo":259,"targetDuration":4,"studyType":23,"phases":261,"briefSummary":262,"conditions":263,"keywords":265,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":269,"completionDateStruct":270,"leadSponsor":272,"locationsCount":4},"100632121","conventional-palatal-crib-versus-bonded-spurs-for-anterior-open-bite-treatment-100632121","NCT07509567","Conventional Palatal Crib Versus Bonded Spurs for Anterior Open Bite Treatment","Conventional Palatal Crib Versus Bonded Spurs in the Treatment of Anterior Open Bite: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Children aged 7 to 12 years\n* Skeletal Class I relationship\n* Angle Class I dental relationship\n* Dental anterior open bite ≥ 1 mm\n* Open bite limited to the anterior segment (incisors and canines)\n* Presence of tongue thrusting habit with anterior tongue posture\n* Patients in mixed dentition stage\n* Fully erupted upper and lower central incisors\n* Fully erupted maxillary first permanent molars\n* Good oral hygiene\n* No gender restrictions\n* Upper arch with no or mild crowding\n\nExclusion Criteria:\n\n* Mouth breathing\n* Skeletal anterior open bite\n* Presence of posterior crossbite\n* Congenitally missing teeth\n* Dental anomalies\n* Presence of any systemic disease","7 Years",{"count":260,"type":22},20,[25],"This randomized clinical trial aims to compare the effectiveness and patient acceptance of two orthodontic appliances-conventional palatal crib and bonded spurs-in the treatment of anterior open bite in children.Twenty children aged 7 to 12 years with anterior open bite and Class I skeletal and dental relationships will be randomly assigned to one of two groups The first group will receive a conventional palatal crib appliance fixed to the upper molars, while the second group will receive bonded spurs attached to the palatal surfaces of the upper incisors , All participants will be followed for 6 months. Clinical and digital measurements, including overbite ,The results of this study are expected to help determine which appliance provides better clinical outcomes and higher patient acceptance in the early treatment of anterior open bite.",[264],"Anterior Open Bite",[266],"Anterior Open Bite , Palatal Crib , Bonded Spurs","2026-07-20",{"date":244,"type":41},{"date":267,"type":22},{"date":271,"type":22},"2026-10-01",{"name":47,"class":48},{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":12,"sex":17,"minAge":196,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":23,"phases":282,"briefSummary":283,"conditions":284,"keywords":287,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":299,"locationsCount":223},"100648000","impact-of-a-mobile-application-based-medication-reminder-on-treatment-adherence-among-patients-with-chronic-diseases-and-memory-impairment-a-nursing-leadership-perspective-100648000","NCT07718334","Impact of a Mobile Application-Based Medication Reminder on Treatment Adherence Among Patients With Chronic Diseases and Memory Impairment: A Nursing Leadership Perspective","Impact of a Mobile Application-Based Medication Reminder on Treatment Adherence Among Patients With Chronic Diseases and Memory Impairment: A Nursing Leadership Perspective - A Quasi Experimental Study","Inclusion Criteria:\n\n* Patients diagnosed with one or more chronic diseases requiring regular long-term medication.\n* Patients exhibiting mild-to-moderate memory impairment or cognitive decline as screened by the Mini-Mental State Examination (MMSE).\n* Patients who personally own and are capable of operating a smartphone or have a primary caregiver willing to manage the mobile application.\n* Patients aged 18 years and older.\n* Patients who provide voluntary informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with severe cognitive impairment or advanced dementia who cannot interact with mobile technology even with caregiver assistance.\n* Patients with severe acute clinical complications or unstable psychiatric conditions.\n* Patients participating in another concurrent clinical trial or study targeting medication adherence",{"count":281,"type":22},193,[25],"This study aims to evaluate the impact of using a mobile application-based medication reminder on medication adherence among patients diagnosed with chronic diseases and memory impairment. Adherence to prescribed therapy is a significant challenge for this patient population, often leading to poor health outcomes and increased healthcare costs. From a nursing leadership perspective, innovative digital solutions can play a crucial role in supporting patient self-management. Using a quasi-experimental design, the study will investigate whether a customized mobile reminder system can effectively improve adherence rates and support patients in managing their therapeutic regimens.",[285,286],"Chronic Disease","Memory Impairment",[288,289,290,291,292],"medication adherence","mobile application","medication reminder","nursing leadership","quasi-experimental study","2026-07-18",{"date":295,"type":41},"2026-07-21",{"date":297,"type":41},"2026-05-10",{"date":249,"type":22},{"name":47,"class":48},{"id":301,"slug":302,"hasResults":12,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":12,"sex":17,"minAge":308,"maxAge":309,"enrollmentInfo":310,"targetDuration":4,"studyType":23,"phases":312,"briefSummary":313,"conditions":314,"keywords":316,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":326,"locationsCount":49},"100647540","remineralizing-effect-of-nano-eggshell-casein-phosphopeptide-amorphous-calcium-phosphate-cpp-acp-and-sodium-fluoride-on-initial-enamel-caries-100647540","NCT07711132","Remineralizing Effect of Nano-eggshell, Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), and Sodium Fluoride on Initial Enamel Caries","Remineralizing Effect of Nano-eggshell, Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), and Sodium Fluoride on Initial Enamel Caries: Randomized Controlled Trial","CPP-ACP","Inclusion Criteria:\n\nPatients' ages should be 15-20 years. Patients should have at least three to four teeth with ICDAS II scores of 1-2. Patients should have moderate-to-high caries risk.\n\nExclusion Criteria:\n\nKnown hypersensitivity to one of the components of the material under study. Systemic disorders or medication interfering with normal salivary flow.","15 Years","20 Years",{"count":311,"type":22},90,[25],"This randomized controlled clinical trial aims to evaluate and compare the remineralizing effect of nano-eggshell varnish, CPP-ACP paste (GC Tooth Mousse), and sodium fluoride varnish on initial enamel caries among adolescents aged 15-20 years.\n\nParticipants will be randomly allocated into three groups. Remineralization and caries activity will be assessed using DIAGNOdent readings, International Caries Classification and Management System (ICCMS) criteria, and the decayed, missed, and filled surfaces (DMFS) index over a 12-month follow-up period.",[315],"Initial Dental Caries",[317,318,319],"Remineralization","Nano eggshell","initial enamel caries","2026-07-14",{"date":322,"type":41},"2026-07-17",{"date":324,"type":41},"2025-12-20",{"date":127,"type":22},{"name":47,"class":48},{"id":328,"slug":329,"hasResults":12,"nctId":330,"briefTitle":331,"officialTitle":332,"acronym":4,"eligibilityCriteria":333,"healthyVolunteers":12,"sex":17,"minAge":196,"maxAge":231,"enrollmentInfo":334,"targetDuration":4,"studyType":23,"phases":336,"briefSummary":337,"conditions":338,"keywords":340,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":351,"locationsCount":49},"100645494","hyaluronic-acid-and-i-prf-mixture-for-tmj-disc-displacement-management-100645494","NCT07683650","Hyaluronic Acid and I-PRF Mixture for TMJ Disc Displacement Management","Evaluation of Hyaluronic Acid and I-PRF Mixture for Intra-articular Injection Following Arthrocentesis in The Management of TMJ Reducible Disc Displacement: A Four Arm Comparative Trial","Inclusion Criteria:\n\n1. Age: 18 - 45 years.\n2. Patients with disc displacement with reduction in any of the TMJs.\n3. arthralgia.\n4. Limited unassisted mouth opening.\n5. Co-operative patients.\n\nExclusion Criteria:\n\n1. Patients with previous history of TMJ minimally invasive interventions.\n2. Patients with autoimmune or connective tissue diseases affecting the joints.\n3. Patients with neurological disorders.\n4. Patients with a history of condylar fractures or ankylosis.\n5. Patients with psychological problems.\n6. Patients receiving non-steroidal anti-inflammatory drugs within 48 hours preoperatively, or systemic use of corticosteroids within 2 weeks.\n7. Patients on anticoagulants, suffering from platelet function disorders or fibrinogen deficiency.\n8. Patients with moderate to severe myogenic pain.",{"count":335,"type":22},72,[25],"The aim of this study is to evaluate the efficacy of hyaluronic acid and I-PRF mixture for intra-articular injection following arthrocentesis in the management of TMJ reducible disc displacement.",[339],"TMJ Disc Displacement With Reduction",[341,342,343,344,345],"TMJ","Disc Displacement With Reduction","Arthrocentesis","Hyaluronic Acid","I-PRF","2026-07-10",{"date":320,"type":41},{"date":349,"type":41},"2026-01-06",{"date":100,"type":22},{"name":47,"class":48},{"id":353,"slug":354,"hasResults":12,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":12,"sex":17,"minAge":359,"maxAge":19,"enrollmentInfo":360,"targetDuration":4,"studyType":23,"phases":361,"briefSummary":362,"conditions":363,"keywords":366,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":380,"locationsCount":49},"100646357","jaw-tracking-impact-on-occlusion-and-patient-outcomes-in-maxillary-implant-restorations-100646357","NCT07693946","Jaw Tracking Impact on Occlusion and Patient Outcomes in Maxillary Implant Restorations","Jaw Tracking Impact on Occlusion and Patient Outcomes in Maxillary Implant Restorations: Randomized Clinical Trial","Inclusion Criteria:\n\n* Male or female patients aged 50 to 70 years.\n* Completely edentulous maxillary arch opposing natural mandibular dentition.\n* Skeletal Class I maxillomandibular relationship with normal occlusion.\n* Acceptable oral hygiene.\n* Willing and able to provide written informed consent and comply with study procedures.\n\nExclusion Criteria:\n\n* Systemic diseases affecting bone healing, such as uncontrolled diabetes mellitus or osteoporosis.\n* Harmful oral habits, including smoking, clenching, or bruxism.\n* Uncooperative patients or patients unable to comply with study procedures.","50 Years",{"count":260,"type":22},[25],"This randomized clinical trial aims to evaluate the effect of integrating digital jaw tracking into the workflow for fabrication of full-arch maxillary implant-supported screw-retained restorations. Twenty completely edentulous maxillary patients opposing natural mandibular dentition will be randomly assigned to either a conventional workflow group or a digital jaw-tracking workflow group. The study will compare patient satisfaction and occlusal accuracy between the two groups. Patient satisfaction will be assessed using a visual analogue scale (VAS), while occlusal accuracy will be evaluated using the OccluSense system.",[364,365],"Edentulism","Complete Maxillary Edentulism",[367,368,369,370,371,372,373],"Digital jaw tracking","Maxillary implant-supported prosthesis","Screw-retained prosthesis","Occlusal accuracy","Patient satisfaction","OccluSense","Randomized clinical trial","2026-07-03",{"date":376,"type":41},"2026-07-09",{"date":378,"type":41},"2025-12-25",{"date":45,"type":22},{"name":47,"class":48},{"id":382,"slug":383,"hasResults":12,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":4,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":17,"minAge":359,"maxAge":84,"enrollmentInfo":388,"targetDuration":4,"studyType":23,"phases":390,"briefSummary":391,"conditions":392,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":4},"100646918","rigid-versus-non-rigid-digitally-fabricated-telescopic-double-crown-prosthesis-100646918","NCT07682623","Rigid Versus Non-Rigid Digitally Fabricated Telescopic Double Crown Prosthesis","Rigid Versus Non-Rigid Digitally Fabricated Telescopic Double Crown Prosthesis Connecting Teeth and Implants: A Crossover Study of Soft Tissue Health and Patient Satisfaction","* Inclusion Criteria:\n\nPatients requiring telescopic overdenture prosthesis.\n\nExclusion Criteria:\n\nPatients with systemic conditions affecting periodontal or prosthetic treatment.\n\nPatients unable to attend follow-up visits\n\n\\-",{"count":389,"type":22},10,[25],"This study aims to compare the clinical and patient satisfaction outcomes of rigid versus non-rigid digitally fabricated telescopic double crown prostheses supported by teeth and implants. The study evaluates the effect of different attachment designs on prosthetic performance and patient satisfaction.\"",[393],"Tooth Loss and Rehabilitation With Telescopic Crown Prostheses","2026-06-28",{"date":396,"type":41},"2026-07-06",{"date":398,"type":22},"2026-12-22",{"date":400,"type":22},"2027-05-14",{"name":47,"class":48},{"id":403,"slug":404,"hasResults":12,"nctId":405,"briefTitle":406,"officialTitle":407,"acronym":4,"eligibilityCriteria":408,"healthyVolunteers":12,"sex":17,"minAge":309,"maxAge":231,"enrollmentInfo":409,"targetDuration":4,"studyType":23,"phases":410,"briefSummary":411,"conditions":412,"keywords":414,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":49},"100645193","custom-made-peek-versus-ptfe-membranes-in-maxillary-alveolar-ridge-augmentation-100645193","NCT07679451","Custom-Made PEEK Versus PTFE Membranes in Maxillary Alveolar Ridge Augmentation","Custom-Made Polyether Ether Ketone Membrane Versus Polytetrafluoroethylene Membrane in Maxillary Alveolar Ridge Augmentation: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\nAge between 20 and 45 years. Male or female participants. Presence of single or multiple missing teeth associated with vertical alveolar defects (vertical bone height less than 8 mm), horizontal alveolar defects (ridge width less than 6 mm), or combined defects in the maxillary esthetic zone requiring alveolar ridge augmentation before implant placement.\n\nGood oral hygiene.\n\nExclusion Criteria:\n\nUncontrolled medical disorders contraindicating surgical intervention. Systemic diseases or medications affecting bone metabolism. Current or previous bisphosphonate therapy. History of radiotherapy. History of chemotherapy. Smokers.",{"count":113,"type":22},[25],"This randomized controlled clinical study aims to evaluate and compare the effectiveness of custom-made polyether ether ketone (PEEK) membranes versus polytetrafluoroethylene (PTFE) membranes in guided bone regeneration for maxillary alveolar ridge augmentation in the esthetic zone. Thirty patients requiring ridge augmentation prior to dental implant placement will be enrolled and randomly allocated into two equal groups. Group A will receive customized PEEK membranes, while Group B will be treated with PTFE membranes. Clinical and radiographic assessments, including cone beam computed tomography (CBCT), will be performed immediately postoperatively, at 6 months, and at 12 months to evaluate volumetric, horizontal, and vertical bone gain as well as soft tissue healing and complication rates.",[413],"Alveolar Ridge Deficiency",[415,416,417,418,419],"Guided Bone Regeneration","PEEK membrane","PTFE membrane","Ridge augmentation","Maxillary ridge augmentation","2026-06-25",{"date":422,"type":41},"2026-07-01",{"date":424,"type":41},"2026-01-01",{"date":426,"type":22},"2027-02-01",{"name":47,"class":48},{"id":429,"slug":430,"hasResults":12,"nctId":431,"briefTitle":432,"officialTitle":433,"acronym":4,"eligibilityCriteria":434,"healthyVolunteers":109,"sex":17,"minAge":309,"maxAge":435,"enrollmentInfo":436,"targetDuration":4,"studyType":23,"phases":437,"briefSummary":439,"conditions":440,"keywords":442,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":49},"100644467","early-phase-1-comparison-of-the-efficacy-of-conventional-versus-minimally-invasive-non-surgical-periodontal-therapy-in-periodontitis-patients-100644467","NCT07671274","Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients","Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients (Randomized Controlled Clinical Trial)","Inclusion Criteria:\n\n* • Patients with stage III pericdontitis, according to the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) periodontal classification system .\n\n  * Medically free patients.\n  * Non-smokers\n  * Patients with good oral hygiene.\n\nExclusion Criteria:\n\n* Pregnant or lactating females.\n\n  * Patients with systemic diseases that might affect periodontal health\n  * previous periodontal treatment within 6 months before baseline examination.\n  * prior antibiotic regimen use within 1 month before baseline examination","40 Years",{"count":113,"type":22},[438],"EARLY_PHASE1","the aim of this study is to investigate the clinical outcomes of Minimally Invasive Non-Surgical Therapy(MINST) compared to Conventional non-surgical periodontal therapy (CNST)",[144,441],"Stage III Periodontitis",[443,444,445],"periodontitis","stage III","mechanical debridement","2026-06-24",{"date":448,"type":41},"2026-06-26",{"date":450,"type":41},"2025-08-05",{"date":452,"type":22},"2026-08-05",{"name":47,"class":48},{"id":455,"slug":456,"hasResults":12,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":4,"eligibilityCriteria":460,"healthyVolunteers":12,"sex":461,"minAge":196,"maxAge":462,"enrollmentInfo":463,"targetDuration":4,"studyType":23,"phases":465,"briefSummary":466,"conditions":467,"keywords":469,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":473,"lastUpdatePostDateStruct":474,"startDateStruct":476,"completionDateStruct":478,"leadSponsor":480,"locationsCount":4},"100641414","effect-of-marital-adjustment-strategies-on-emotional-divorce-among-married-women-100641414","NCT07652411","Effect of Marital Adjustment Strategies on Emotional Divorce Among Married Women","Appling Marital Adjustment Strategies for Emotionally Divorced Wives","Inclusion criteria:\n\n* Free from any medical and psychological disorders.\n* couples are committed to staying in one house despite emotional divorce or not.\n* wives married for 2 years, the family had children who were both spouses and not children of either spouse.\n\nExclusion criteria:\n\n* Age ≤ (18 or ≥ 55) years.\n* Illegal marriage.","FEMALE","55 Years",{"count":464,"type":22},320,[25],"Aim: The current study aims to evaluate the impact of marital adjustment strategies on emotional divorce among married women.\n\nDesign: A mixed design consisting of a cross-sectional study and a quasi-experimental one-group pre-test\u002Fpost-test design.\n\nSample: A purposive sample of 320 married women.\n\nSetting: Antenatal Outpatient Clinics at the New Obstetrics and Gynecology Hospital, Mansoura University Hospitals, Egypt.\n\nTools: Data will be collected using three tools: a structured interview questionnaire, the Emotional Divorce Scale, and the Marital Adjustment Strategies Scale.\n\nIntervention: Participants will receive a structured marital adjustment strategies program delivered through educational sessions designed to address communication, coping, emotional expression, problem-solving, and marital adjustment strategies.\n\nOutcome Measures: Emotional divorce levels and marital adjustment strategies will be assessed at baseline and after completion of the intervention according to the study protocol.",[468],"Marital Relationship",[470,471,472],"Emotional Divorce","Marital Relations","Marital Adjustment Strategies","2026-06-16",{"date":475,"type":41},"2026-06-17",{"date":477,"type":22},"2026-12-11",{"date":479,"type":22},"2027-11-11",{"name":47,"class":48},{"id":482,"slug":483,"hasResults":12,"nctId":484,"briefTitle":485,"officialTitle":486,"acronym":487,"eligibilityCriteria":488,"healthyVolunteers":12,"sex":17,"minAge":196,"maxAge":4,"enrollmentInfo":489,"targetDuration":4,"studyType":23,"phases":491,"briefSummary":492,"conditions":493,"keywords":495,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":504,"completionDateStruct":506,"leadSponsor":508,"locationsCount":49},"100609456","phase-2-sglt2-inhibitors-in-adult-primary-nephrotic-syndrome-100609456","NCT07214818","SGLT2 Inhibitors in Adult Primary Nephrotic Syndrome","Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Adult Patients With Nephrotic Syndrome: A Randomized Controlled Trial","SGLT2-NS","Inclusion Criteria:\n\nAdult patients (≥18 years). Biopsy-confirmed primary nephrotic syndrome (e.g., idiopathic membranous nephropathy, minimal change disease, focal segmental glomerulosclerosis).\n\nEstimated glomerular filtration rate (eGFR) ≥25 mL\u002Fmin\u002F1.73m² using CKD-EPI formula.\n\nOn stable dose of immunosuppressive therapy and renoprotective agents for ≥4 weeks prior to randomization.\n\nAble to signed informed consent.\n\nExclusion Criteria:\n\nDiagnosis of secondary nephrotic syndrome as : diabetes mellitus, lupus nephritis, and amyloidosis.\n\n* Impaired liver functions (ALT or AST values exceeding 3 folds upper limit of normal (ULN) at the screening visit).\n* Glomerular hematuria (red blood cells more than ten cells per high power field (HPF) after routine urinalysis for more than three times in the last 2 weeks).\n* History of severe hypersensitivity or contraindications to dapagliflozin or empagliflozine.\n* Pregnancy or breastfeeding.",{"count":490,"type":22},75,[140,200],"This randomized controlled clinical trial aims to evaluate the efficacy and safety of sodium-glucose cotransporter 2 (SGLT2) inhibitors (dapagliflozin and empagliflozin) in adult patients with primary nephrotic syndrome. The study will compare three groups: dapagliflozin plus standard therapy, empagliflozin plus standard therapy, and standard therapy alone.\n\nThe primary objective is to assess whether SGLT2 inhibitors reduce proteinuria, maintain remission, and prevent relapse. Secondary objectives include evaluating effects on kidney function (eGFR, serum creatinine) and monitoring safety outcomes.\n\nParticipants will continue their baseline standard care and will be followed for 6 months with regular clinical evaluations, laboratory tests, and adverse event monitoring.",[494],"Nephrotic Syndrome",[496,497,498,499,500],"SGLT2 inhibitors","Dapagliflozin","Empagliflozin","Proteinuria","Primary Nephrotic Syndrome","2026-06-08",{"date":503,"type":41},"2026-06-09",{"date":505,"type":41},"2025-11-15",{"date":507,"type":22},"2026-09-06",{"name":47,"class":48},{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":515,"eligibilityCriteria":516,"healthyVolunteers":12,"sex":461,"minAge":196,"maxAge":231,"enrollmentInfo":517,"targetDuration":4,"studyType":23,"phases":519,"briefSummary":521,"conditions":522,"keywords":527,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":537,"lastUpdatePostDateStruct":538,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":543,"locationsCount":49},"100643446","phase-4-carbetocin-monotherapy-versus-carbetocin-plus-oxytocin-infusion-in-elective-cesarean-delivery-a-non-inferiority-trial-100643446","NCT07636421","Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial","Comparative Efficacy of Carbetocin Monotherapy Versus Carbetocin With Supplemental Oxytocin Infusion in Maintaining Uterine Tone and Preventing Blood Loss in Elective Cesarean Delivery: A Randomized, Double-Blind, Non-Inferiority Controlled Trial","CARBOXY-RCT","Inclusion Criteria:\n\n* Adult women aged 18 to 45 years\n* Scheduled for elective non-emergency cesarean delivery\n* Spinal anesthesia planned and administered as the sole anesthetic technique\n* Singleton pregnancy at gestational age of 37 completed weeks or more\n* ASA physical status II\n* Preoperative hemoglobin of 9 g\u002FdL or more\n* Able to provide written informed consent in Arabic or English\n\nExclusion Criteria:\n\n* Emergency or crash cesarean delivery\n* Placenta previa, placenta accreta spectrum disorder, or other abnormal placentation\n* Known uterine anomalies likely to impair contractility including fibroids greater than 5 cm, bicornuate or unicornuate uterus\n* Grand multiparity defined as 5 or more previous deliveries\n* Multiple gestation including twins or higher order\n* Polyhydramnios defined as amniotic fluid index greater than 24 cm\n* Prior oxytocin augmentation in current pregnancy for more than 6 hours\n* Known hypersensitivity to carbetocin, oxytocin, or any formulation excipient\n* Severe preeclampsia, eclampsia, or HELLP syndrome\n* Cardiovascular disease including arrhythmia, valvular disease, cardiomyopathy, or ischemic heart disease\n* Known coagulopathy or thrombocytopenia with platelets less than 100 x 10\\^9\u002FL\n* Hepatic or renal impairment\n* Body mass index greater than 40 kg\u002Fm2 at time of delivery\n* Enrollment in another interventional clinical trial",{"count":518,"type":22},332,[520],"PHASE4","Background: Carbetocin is an established single-dose uterotonic agent for postpartum hemorrhage prophylaxis at elective cesarean delivery. Despite its proven efficacy, many clinicians routinely add a supplemental oxytocin infusion following carbetocin administration without evidence-based justification. Concurrent oxytocin receptor stimulation may be redundant, counterproductive through receptor desensitization, or incrementally beneficial - a mechanistic uncertainty that remains unresolved in the published literature.\n\nObjectives: To determine whether carbetocin monotherapy (100 micrograms IV bolus plus placebo infusion) is non-inferior to carbetocin plus supplemental oxytocin infusion (10 IU over 4 hours) in preventing the need for additional uterotonic agents within 24 hours of elective cesarean delivery.\n\nStudy Design: Prospective, randomized, double-blind, placebo-controlled, non-inferiority trial with an integrated pilot phase. Phase 1 (Pilot, n=60) establishes local feasibility and event rate. Phase 2 (Full trial, n=332) provides the definitive non-inferiority analysis.\n\nParticipants: Women aged 18-45 years undergoing elective cesarean delivery under spinal anesthesia at Qassim University Medical City, singleton pregnancy at or beyond 37 weeks, ASA physical status II, preoperative hemoglobin 9 g\u002FdL or more.\n\nInterventions: Group C (Monotherapy): Carbetocin 100 micrograms IV bolus plus placebo saline infusion 500 mL over 4 hours. Group C+O (Combination): Carbetocin 100 micrograms IV bolus plus oxytocin 10 IU in 500 mL saline over 4 hours.\n\nPrimary Outcome: Proportion of patients requiring at least one additional uterotonic agent within 24 hours of delivery.\n\nSecondary Outcomes: Quantitative intraoperative blood loss by gravimetric measurement; total 24-hour blood loss; actual blood loss by Gross formula; hemoglobin and hematocrit changes; uterine tone scores by verbal numerical rating scale (0-10) at 2, 5, and 10 minutes; incidence of postpartum hemorrhage; blood transfusion requirement; hemodynamic profiles; adverse effects.\n\nSample Size: 332 patients (166 per group), non-inferiority margin 10 percentage points, one-sided alpha 0.025, 80% power, estimated baseline event rate 10%, with 15% dropout allowance.",[523,524,525,526],"Postpartum Hemorrhage","Uterine Atony","Cesarean Section","Blood Loss, Surgical",[528,529,530,531,532,533,534,535,536],"Carbetocin","Oxytocin","Uterotonic","Elective Cesarean Delivery","Non-Inferiority Trial","Uterine Tone","Gravimetric Blood Loss","Obstetric Anesthesia","Spinal Anesthesia","2026-06-04",{"date":503,"type":41},{"date":540,"type":22},"2026-08",{"date":542,"type":22},"2028-08",{"name":47,"class":48},{"id":545,"slug":546,"hasResults":12,"nctId":547,"briefTitle":548,"officialTitle":549,"acronym":4,"eligibilityCriteria":550,"healthyVolunteers":109,"sex":17,"minAge":196,"maxAge":18,"enrollmentInfo":551,"targetDuration":4,"studyType":23,"phases":552,"briefSummary":553,"conditions":554,"keywords":556,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":49},"100640918","impact-of-finishingpolishing-systems-on-ormocer-vs-methacrylate-based-bulk-fill-flowable-composite-in-class-v-100640918","NCT07627295","Impact of Finishing\u002FPolishing Systems on Ormocer VS Methacrylate Based Bulk Fill Flowable Composite in Class V","Impact of Finishing\u002FPolishing Systems on Ormocer Versus Methacrylate Based Bulk Fill Flowable Composite in Class V Restorations: Clinical Study and Laboratory Investigations","Inclusion Criteria:\n\n* Three pairs of buccal cervical supragingival carious lesions in anterior teeth\n* Complete and normal occlusion\n* Good oral hygiene\n* Willingness to attend follow-up and recall visits for 2 years\n\nExclusion Criteria:\n\n* Teeth requiring direct pulp capping\n* Poor oral hygiene or failure to complete the oral hygiene phase\n* Chronic periodontitis\n* Pulpitis or non-vital teeth\n* Current orthodontic treatment\n* Presence of parafunctional habits\n* Systemic diseases\n* Previous or ongoing bleaching procedures\n* Smoking patients",{"count":7,"type":22},[25],"The goal of this clinical trial is to evaluate and compare. Impact of finishing\u002Fpolishing systems on ormocer versus methacrylate-based bulk-fill flowable composite in Class V restorations: The main question it aims to answer is the following:\n\nAre there any differences between finishing\u002Fpolishing systems on Ormocer versus methacrylate-based bulk-fill flowable composite?",[555],"Class V Restorations",[557,558,559],"Class V restorations;","finishing and polishing;","resin composite","2026-05-31",{"date":537,"type":41},{"date":563,"type":41},"2026-05-12",{"date":565,"type":22},"2028-05",{"name":47,"class":48},{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":571,"acronym":572,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":574,"minAge":196,"maxAge":435,"enrollmentInfo":575,"targetDuration":4,"studyType":23,"phases":577,"briefSummary":578,"conditions":579,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":587,"locationsCount":49},"100635562","efficacy-of-targeted-pelvic-floor-muscle-exercises-for-treatment-of-men-with-primary-post-micturition-dribbling-a-randomized-controlled-trial-100635562","NCT07554300","Efficacy of Targeted Pelvic Floor Muscle Exercises for Treatment of Men With Primary Post Micturition Dribbling: a Randomized Controlled Trial.","PMD","Inclusion Criteria:\n\n* Primary post micturition dribbling\n\nExclusion Criteria:\n\n* Patients with secondary post micturition dribbling (BPH, urethral stricture, urethral diverticulum).\n* Patients with urethral or penile malformations, neurological or chronic major systemic disease.","MALE",{"count":576,"type":22},120,[25],"The goal of this clinical trial is to evaluate the effect of pelvic floor muscle exercises on primary post-micturition dribbling (PMD) in male patients aged 18 to 40 years. The main questions it aims to answer are:\n\n1. Does pelvic floor muscle training reduce the severity and frequency of PMD as measured by the Hallym Post-Micturition Dribble Questionnaire (HPMDQ)?\n2. Does pelvic floor muscle training reduce the amount of post-void residual urine as measured by a post-voiding pad test?\n\nResearchers will compare patients undergoing pelvic floor muscle training (Group A) with those performing non-targeted exercises (Group B) to see if targeted pelvic floor training is more effective in managing PMD symptoms and reducing urine leakage.\n\nParticipants will:\n\n* Undergo random assignment to either pelvic floor muscle training or non-targeted exercise for 12 weeks\n* Complete baseline and follow-up assessments including:\n* Medical history and physical exam\n* Urine analysis and post-void residual measurement\n* International Prostate Symptom Score (IPSS)\n* Post-voiding pad test\n* Hallym Post-Micturition Dribble Questionnaire (HPMDQ)",[580],"Post Micturition Dribble","2026-04-21",{"date":583,"type":41},"2026-04-28",{"date":585,"type":41},"2024-07-01",{"date":422,"type":22},{"name":47,"class":48},{"id":589,"slug":590,"hasResults":12,"nctId":591,"briefTitle":592,"officialTitle":593,"acronym":4,"eligibilityCriteria":594,"healthyVolunteers":12,"sex":461,"minAge":196,"maxAge":4,"enrollmentInfo":595,"targetDuration":4,"studyType":23,"phases":597,"briefSummary":598,"conditions":599,"keywords":602,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":607,"lastUpdatePostDateStruct":608,"startDateStruct":609,"completionDateStruct":611,"leadSponsor":613,"locationsCount":49},"100629333","phase-4-low-intensity-shockwave-therapy-versus-solifenacin-for-the-treatment-of-overactive-bladder-in-women-100629333","NCT07473310","Low-intensity Shockwave Therapy Versus Solifenacin for the Treatment of Overactive Bladder in Women","Low-intensity Shockwave Therapy Versus Solifenacin for the Treatment of Overactive Bladder in Women: A Randomized Controlled Trial","Inclusion Criteria:\n\n* OAB symptoms persisting for ≥3 months.\n* OAB Symptom Score (OABSS) ≥7.\n* Ability and willingness to provide informed consent\n\nExclusion Criteria:\n\n* Active urinary tract infection.\n* Stress urinary incontinence as primary diagnosis.\n* Pelvic organ prolapse stage ≥II.\n* History of pelvic radiation or surgery within 6 months.\n* Use of anticholinergics or β3-agonists for the past 4 weeks who are unwilling to undergo washout.\n* Pregnancy or breast feeding.\n* Neuropathic diseases or psychological disorders.\n* History of urogenital malignancy.\n* Uncontrolled DM (HbA1c \\> 6.8)\n* Uncorrected coagulopathy or severe cardiovascular disease.\n* Contraindication to solifenacin e.g.: closed angle glaucoma)",{"count":596,"type":22},70,[520],"The goal of this clinical trial is to evaluate the effectiveness and safety of low-intensity shockwave therapy (Li-SWT) for the treatment of overactive bladder (OAB) in adult women.\n\nThe main questions this study aims to answer are whether Li-SWT improves overactive bladder symptoms and quality of life, and whether these improvements are sustained over a 12-month follow-up period, compared with standard medical therapy.\n\nResearchers will compare Li-SWT with oral solifenacin succinate, a commonly used antimuscarinic medication for OAB.\n\nParticipants will be randomly assigned to receive either Li-SWT once weekly for 8 weeks or solifenacin 5 mg taken orally once daily for 12 months. All participants will complete symptom questionnaires and three-day voiding diaries and will undergo uroflowmetry, post-void residual measurement, and filling cystometry at specified time points during follow-up.",[600,601],"Overactive Bladder (OAB)","Urge Incontinence",[603,604,605,606],"OAB","overactive bladder","low intensity shockwave","solifenacin","2026-03-10",{"date":125,"type":41},{"date":610,"type":41},"2025-11-11",{"date":612,"type":22},"2027-12",{"name":47,"class":48},{"id":615,"slug":616,"hasResults":12,"nctId":617,"briefTitle":618,"officialTitle":619,"acronym":620,"eligibilityCriteria":621,"healthyVolunteers":12,"sex":461,"minAge":196,"maxAge":18,"enrollmentInfo":622,"targetDuration":4,"studyType":23,"phases":624,"briefSummary":625,"conditions":626,"keywords":631,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":636,"lastUpdatePostDateStruct":637,"startDateStruct":638,"completionDateStruct":640,"leadSponsor":642,"locationsCount":49},"100620187","effect-of-oketani-breast-massage-on-promoting-breastfeeding-100620187","NCT07354360","Effect of Oketani Breast Massage on Promoting Breastfeeding","Effect of Oketani Massage on Successful Breastfeeding","OKETANI-BF","inclusion criteria:\n\n1. Age between 18 and 35 years\n2. Singleton pregnancy\n3. Term gestation (\\>37-40 weeks).\n4. Women willing to breast feed\n5. The woman will deliver by cesarean section and has relative with her\n6. Absence of maternal physical and\u002F or mental illness that prevents breastfeeding.\n\nThe exclusion criteria include:\n\n1. Women with breast problems such as breast tumors, breast surgery and nipple problems\n2. Women have obstetric complications as postpartum hemorrhage.\n3. Neonatal problems",{"count":623,"type":22},100,[25],"Breastfeeding is essential for infant survival and maternal health; however, many primipara women experience breastfeeding difficulties in the early postpartum period, particularly, latching difficulties, ineffective milk transfer, low breastfeeding self-efficacy and breast engorgement, which may compromise successful breastfeeding. Oketani massage is a non-pharmacological, cost-effective breast massage technique developed to enhance milk flow, improve maternal comfort during breastfeeding and reduce breast engorgement. This study aims to evaluate effect of Oketani massage on successful breastfeeding. Successful breastfeeding will be assessed through indicators of maternal latching technique, successful breastfeeding behavior and maternal breastfeeding self-efficacy. The findings of this study may support the use of Oketani massage as a supportive nursing intervention to promote successful breastfeeding outcomes in the early postpartum period",[627,628,629,630],"Breastfeeding","Breastfeeding Self-Efficacy","Oketani Massage","Latching",[627,632,633,634,635],"Oketani massage","breastfeeding self-efficacy","breast engorgement","Feeding Behavior","2026-03-07",{"date":607,"type":41},{"date":639,"type":22},"2026-02",{"date":641,"type":22},"2026-12",{"name":47,"class":48},{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":649,"eligibilityCriteria":650,"healthyVolunteers":12,"sex":461,"minAge":309,"maxAge":111,"enrollmentInfo":651,"targetDuration":4,"studyType":23,"phases":652,"briefSummary":653,"conditions":654,"keywords":658,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":661,"lastUpdatePostDateStruct":662,"startDateStruct":664,"completionDateStruct":666,"leadSponsor":667,"locationsCount":49},"100612953","effect-of-an-educational-session-for-abortive-women-on-maternity-nurses-practices-100612953","NCT07260279","Effect of an Educational Session for Abortive Women on Maternity Nurses' Practices","Effect of Educational Sessions for Abortive Care on Maternity Nurses' Performance","EESAW-MNP","Inclusion Criteria:\n\nRegistered maternity nurses working in obstetrics or gynecology departments.\n\nHaving at least one year of clinical experience in maternity or reproductive health units.\n\nWilling to participate and provide informed consent.\n\nAble to read and understand the educational materials provided.\n\nPresent at the workplace during the study and follow-up periods.\n\nNot previously involved in similar abortion care training programs.\n\nExclusion Criteria:\n\nNurses on maternity or annual leave during the study period.\n\nAdministrative or non-clinical nursing staff.\n\nNurses with less than one year of professional experience.\n\nRefusal to participate or withdrawal at any stage of the study.\n\nAttendance of any concurrent external training on abortion or reproductive health during the study.\n\nIncomplete participation in the educational intervention sessions.",{"count":138,"type":22},[25],"The goal of this study is to evaluate the effect of structured educational sessions for abortive women on the practices of maternity nurses.\n\nThe study aims to enhance nurses' clinical skills and patient care related to abortion management.\n\nParticipants will:\n\nAttend educational sessions designed to improve nursing practices\n\nParticipate in activities and discussions led by experienced instructors\n\nBe observed before and after the sessions to assess changes in clinical practices\n\nThe study will compare nursing practices before and after the intervention to determine the overall impact of the educational sessions on professional performance and patient care quality.",[655,656,657],"Abortion","Practice","Maternity",[655,659,660],"Maternity nurses","Practices","2026-02-28",{"date":663,"type":41},"2026-03-03",{"date":665,"type":22},"2026-02-01",{"date":641,"type":22},{"name":47,"class":48},{"id":669,"slug":670,"hasResults":12,"nctId":671,"briefTitle":672,"officialTitle":673,"acronym":4,"eligibilityCriteria":674,"healthyVolunteers":109,"sex":461,"minAge":309,"maxAge":18,"enrollmentInfo":675,"targetDuration":4,"studyType":23,"phases":676,"briefSummary":677,"conditions":678,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":661,"lastUpdatePostDateStruct":681,"startDateStruct":682,"completionDateStruct":684,"leadSponsor":686,"locationsCount":49},"100612055","emergency-obstetric-care-protocol-100612055","NCT07248605","Emergency Obstetric Care Protocol","Effect of Applying Emergency Obstetric Care Protocol on Maternity Nurses' Practices","Inclusion Criteria:\n\n* of maternity nurses who are works in Obstetric departments , Emergency obstetric operating room and delivery unit\n\nExclusion Criteria:\n\n* nurses who are on long vocations at the time of data collection or have administrative work.",{"count":138,"type":22},[25],"This study aims to investigate the effect of applying emergency obstetric care protocol on maternity nurses' practices.",[679,680],"Emergency Care","Obstetric",{"date":663,"type":41},{"date":683,"type":22},"2026-03-01",{"date":685,"type":22},"2027-01-01",{"name":47,"class":48},""]