[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Mary Phillips, MD MD (Cantab)\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100658476","examination-of-transcranial-focused-ultrasound-on-brain-activity-in-adults-with-cocaine-use-disorder-100658476",false,"NCT07852923","Examination of Transcranial Focused Ultrasound on Brain Activity in Adults With Cocaine Use Disorder","Modulating Ventral Striatal Activity and Connectivity With Transcranial Focused Ultrasound as a Putative Novel Intervention for Cocaine Use Disorder","Inclusion Criteria:\n\n* Between 18-45 years of age\n* Uses cocaine as a primary drug at a minimum frequency of 1x\u002Fmo; any period of abstinence within the past month does not exceed 1 week\n\nExclusion Criteria:\n\n* Not between 18-45 years of age\n* Cocaine is not used as a primary drug, is used at a frequency of less than 1x\u002Fmo, and\u002For a period of abstinence lasting longer than 1 week has occurred within past month\n* Present\u002Flifetime history of primary psychosis or Bipolar Disorder (DSM-5 criteria, SCID-5, SCID-5-PD, YMRS\\>10), present suicidal ideation, or current depressive episode\n* History of head injury, neurological (e.g., epilepsy), pervasive developmental disorder (e.g., autism), systemic medical disease and treatment (medical records, participant report)\n* Family history of epilepsy\n* Use of substances with seizure risk (e.g., stimulants), benzodiazepines, and dopaminergic psychotropic medications in the past month\n* Mini-Mental State Examination (MMSE) score (cognitive state) \\\u003C24\n* Premorbid NAART IQ estimate \\\u003C85\n* Visual disturbance: \\\u003C20\u002F40 Snellen visual acuity\n* Left\u002Fmixed handedness (Annett criteria)\n* Binge drinking (as defined by NIAA criteria: consuming 5 or more drinks (male), or 4 or more drinks (female), in about 2 hours.) in the week before, and\u002For \\>3 drinks\u002Fday for the 3 days before, and\u002For alcohol in the last 12 hrs before, any alcohol on tFUS scan day, confirmed at screening and scan days (to avoid tFUS during alcohol withdrawal). Alcohol\u002Fnicotine\u002Fcaffeine\u002Fcannabis use (below SCID-5 SUD and binge levels) will be allowed\n* MRI exclusion criteria: e.g., surgical implants; claustrophobia; positive pregnancy test for females (performed at the MRRC)\u002Fself-report pregnancy\n* Unable to understand English\n* Any implanted neural device since it is not known whether tFUS would interfere with other implanted neural devices\n* Color blind","ALL","18 Years","45 Years",{"count":20,"type":21},57,"ESTIMATED","INTERVENTIONAL",[24],"NA","The investigators aim to examine the effect of transcranial focused ultrasound (tFUS) on brain activity and cocaine craving in adults with cocaine use disorder.",[27],"Cocaine Use Disorder (CUD)",[29,30,31],"transcranial focused ultrasound","Magnetic Resonance Imaging","Reward","NOT_YET_RECRUITING","2026-09-25",{"date":35,"type":36},"2026-10-01","ACTUAL",{"date":38,"type":21},"2026-12-15",{"date":40,"type":21},"2028-12-15",{"name":42,"class":43},"Mary Phillips, MD MD (Cantab)","OTHER",""]