[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Medical Research Council Cognition and Brain Sciences Unit\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":80},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100659421","a-grief-support-app-for-adults-experiencing-bereavement-100659421",false,"NCT07862244","A Grief Support App for Adults Experiencing Bereavement","DayBreak: A Pilot Randomised Trial of a Grief Support App for Adults Experiencing Bereavement","Inclusion Criteria:\n\n* Aged 18+\n* Fluent in English (reading and writing)\n* GP in the UK\n* Capable of giving informed consent\n* Loss of a loved one at least three months ago\n* Smartphone with access to apple store or google play store\n\nExclusion Criteria:\n\n* High risk of suicidal intent or self-harm\n* Current psychiatric inpatient stay\n* Current psychological treatment for grief\n* Diagnosis of PGD or PTSD - If loss less than 6 months ago needs to score below clinical cut-off on PG-13-R\n* Severe cognitive impairment or learning difficulties","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","Losing a loved one is a difficult experience. Some people may require psychological support, but even for those who do not, grief can often feel overwhelming. Many bereaved adults report there not being enough support that is easily available for them. Some researchers have suggested that online interventions, such as phone applications (apps) could be a good way to make support easier to access. Apps can also allow people to access support anonymously. Apps can also help by prompting people to practice different skills. This means that they can test them out in their real life and learn how to best integrate them. This type of app might be particularly helpful for grief as grief does not always stay consistent but rather changes in intensity throughout the day and year.\n\nThe investigators have developed a grief app called Daybreak. The app was developed together with grief experts and bereaved adults. The app includes information about grief, writing exercises, short exercises, a registry of resources for grief support and a place to store memories of the deceased person. In addition, the app prompts twice daily to answer two questions about the grief and do a small exercise.\n\nThe investigators now wish to see how well the app works. To achieve this, each participant will be randomly sorted into two groups. Both groups will have access to the app for four weeks. One group will immediately access the app for four weeks and then have a four-week waiting period (eight weeks in total), while the other group start with the waiting period and then gets access to the app for four weeks (also eight weeks). Different grief-related symptoms will be measured at the beginning, middle and end of the experiment, as well as asking all participants to rate the feasibility and acceptability of the app itself. The researchers can also see how often the app was used and if people responded to the questions in the app. In the end, researchers would inspect if participants liked the app, if they used the app regularly and if the app changed any of the grief-related difficulties.",[26],"Grief",[26,28,29,30,31],"Loss","Ecological Momentary Intervention","App","Grief Support","NOT_YET_RECRUITING","2026-10-06",{"date":35,"type":36},"2026-10-09","ACTUAL",{"date":38,"type":20},"2026-10-05",{"date":40,"type":20},"2027-03-30",{"name":42,"class":43},"Medical Research Council Cognition and Brain Sciences Unit","OTHER_GOV",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":63,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":44},"100659494","group-transdiagnostic-cognitive-behavioural-therapy-for-intolerance-of-uncertainty-versus-applied-relaxation-100659494","NCT07866794","Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty Versus Applied Relaxation","Outcomes and Behavioural Signatures of Coping With Uncertainty-Related Anxiety (OBSCURA) Trial","OBSCURA","Inclusion Criteria:\n\n* Normal or corrected-to-normal vision\n* Fluency in English\n* Capable of giving informed consent\n* Live locally\u002F within commutable distance to Cambridge\n* Intolerance of Uncertainty Scale - Short form (IUS-12) score \\> 28\n* Generalized Anxiety Disorder scale (GAD-7) score \\>= 8\n* Medication-free, or on a stable medication regimen prior to and throughout the study\n\nExclusion Criteria:\n\n* High risk of suicidal intent or self-harm (defined as an affirmative response on item 9 of the PHQ-9 above the clinical threshold, and\u002For corresponding clinical risk indicators during the SCID-5 interview)\n* Engagement with any other psychological treatment within the 3 months prior to the study or during the study period\n* Current diagnosis of obsessive-compulsive disorder (OCD)\n* Current substance use disorder\n* Acute psychosis\n* History of traumatic brain injury\n* Learning disability\n* Epilepsy\u002Fseizures\n* Severe cognitive impairment","65 Years",{"count":55,"type":20},135,[23],"Many people find uncertainty distressing, but for some, it may become overwhelming and drive persistent anxiety, worry, and avoidance. This tendency is called intolerance of uncertainty (IU), and appears across many mental health conditions, including generalised anxiety, social anxiety, depression, and obsessive-compulsive disorder, which is why researchers describe it as a transdiagnostic feature.\n\nA type of therapy called Cognitive Behavioural Therapy for Intolerance of Uncertainty (CBT-IU) has been shown to reduce anxiety in previous trials. What remains to be known is how uncertainty changes when targeted directly, and whether the same mechanism applies across diagnoses. IU has mostly been measured using questionnaires, which indicate whether people find uncertainty difficult, but not what is actually happening when they encounter it. Recent research suggests that IU is not a single trait but a set of differences in how people estimate different kinds of uncertainty. Therefore, in addition to standard questionnaires, computer-based tasks will be used to explore an \"uncertainty fingerprint\" for each participant, capturing different aspects of uncertainty processing in a way that self-report measures cannot.\n\nIn this study, the investigators are comparing CBT-IU, adapted to work across disorders, against Applied Relaxation. Applied relaxation is a well-established therapy that teaches people to notice and release physical tension but does not focus on uncertainty. Adults with high IU and anxiety symptoms (regardless of formal diagnosis) will be randomly allocated to one of the two 12-session group therapies. The investigators will measure anxiety and IU using standard questionnaires as the primary outcomes. Additionally, cognitive tasks will be used to measure the uncertainty fingerprint before therapy, immediately after, and three months later. The aim is to test whether reductions in IU are specific to CBT-IU rather than shared with an equally credible therapy that does not target uncertainty. Going beyond self-reports, the trial will then begin to resolve which specific aspects of uncertainty processing change, so that future treatments can be more precisely targeted and better matched to each person.",[59,60,61,62],"Mental Disorders","Mood Disorders","Anxiety Disorders","Generalized Anxiety Disorder",[64,65,66,67,68,69,70,71,72],"Uncertainty","Cognitive Behavioural Therapy","Relaxation Therapy","Behaviour and Behaviour Mechanisms","Anxiety","Cognitive Science","Clinical Psychology","Group Psychotherapy","Intolerance of Uncertainty",{"date":74,"type":36},"2026-10-08",{"date":76,"type":20},"2026-09-21",{"date":78,"type":20},"2030-04-30",{"name":42,"class":43},""]