[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Medipol University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":650},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,72,0,25,[9,48,74,108,135,164,190,210,237,257,273,295,316,343,370,392,419,448,475,507,533,552,587,604,628],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100618872","royal-jelly-supplementation-in-unexplained-male-infertility-100618872",false,"NCT07337265","Royal Jelly Supplementation in Unexplained Male Infertility","Effect of Oral Royal Jelly Supplementation on Sperm DNA Fragmentation Index and Pregnancy in Couples With Unexplained Infertility: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Study","Inclusion Criteria:\n\n* Men aged 18-45 years. History of infertility for at least 1 year despite unprotected intercourse.\n\nDiagnosis of unexplained infertility with Normozoospermia according to WHO 2021 (6th Ed.) criteria:\n\nConcentration ≥ 16 million\u002FmL Total Motility ≥ 42% Progressive Motility ≥ 30% Normal Morphology (Kruger) ≥ 4% Female partner with normal gynecological evaluation (regular ovulation, normal ovarian reserve, and proven tubal patency via HSG).\n\nNormal serum hormone levels (Testosterone, FSH, LH)\n\nExclusion Criteria:\n\n* Any abnormality in spermiogram (Oligo-, Asteno-, or Teratozoospermia). Presence of clinical varicocele. Leukocytospermia (\\>1 million\u002FmL) or active infection. History of smoking (\\>5 cigarettes\u002Fday) or BMI \\> 30 kg\u002Fm². Use of any antioxidant supplementation within the last 3 months.","MALE","18 Years","45 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized, double-blind, placebo-controlled clinical trial investigates the effects of oral Royal Jelly supplementation on sperm DNA fragmentation and pregnancy rates in couples with unexplained infertility. While routine semen analysis appears normal (normozoospermia) in these patients, underlying Sperm DNA Fragmentation (SDF) and oxidative stress are believed to contribute to reproductive failure.\n\nParticipants will be randomized to receive either 750 mg of lyophilized Royal Jelly or a placebo daily for a period of 3 months (90 days). The study aims to evaluate whether the antioxidant properties of Royal Jelly can improve sperm chromatin integrity, reduce oxidative stress markers, and increase spontaneous pregnancy rates compared to the control group",[28,29,30],"Unexplained Infertility","Male Infertility","Sperm DNA Fragmentation",[32,33,34],"royal jelly","unexplained male infertility","sperm dna fragmentation","RECRUITING","2026-08-16",{"date":38,"type":39},"2026-08-19","ACTUAL",{"date":41,"type":39},"2026-02-01",{"date":43,"type":22},"2026-12-01",{"name":45,"class":46},"Medipol University","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100652191","deep-subgluteal-block-vs-peng-combined-with-lfcn-block-for-analgesia-after-hip-arthroplasty-100652191","NCT07770932","Deep Subgluteal Block vs PENG Combined With LFCN Block for Analgesia After Hip Arthroplasty","Comparison of Deep Subgluteal Block and Pericapsular Nerve Group Block Combined With Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia After Hip Arthroplasty: A Randomized Prospective Study","DSG-PENG","Inclusion Criteria:\n\n* Patients scheduled for elective total or partial hip arthroplasty under general anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Aged between 18 and 80 years\n* Able to understand the study procedures, give voluntary written informed consent, and operate a patient-controlled analgesia (PCA) device\n\nExclusion Criteria:\n\n* Patient refusal or inability to provide informed consent\n* Pre-existing peripheral neuropathy, cognitive impairment, or psychiatric disorders\n* History of significant severe renal or hepatic failure\n* Allergy or hypersensitivity to amide-type local anesthetics or opioids\n* Infection, severe anatomic distortion, or previous surgery at the proposed block injection sites\n* History of substance abuse or chronic opioid use (defined as daily opioid use for \\> 3 months prior to surgery)","ALL","80 Years",{"count":59,"type":22},60,[25],"This randomized, prospective study aims to compare the clinical efficacy of ultrasound-guided Deep Subgluteal Block (DSGB) versus Pericapsular Nerve Group (PENG) block combined with Lateral Femoral Cutaneous Nerve (LFCN) block for postoperative analgesia management in patients undergoing hip arthroplasty.\n\nA total of 60 patients scheduled for hip arthroplasty under general anesthesia will be randomly allocated into two equal groups of 30: Group DSG and Group PENG+LFCN. Total local anesthetic volume (30 mL) and active drug dose (75 mg bupivacaine) will be standardized across both groups to ensure rigorous blinding and high methodological quality.\n\nThe primary outcome of the study is to compare total postoperative opioid (fentanyl) consumption within the first 24 hours. Secondary outcomes include postoperative pain scores evaluated via the Numerical Rating Scale (NRS) at rest and during movement, the presence and degree of quadriceps motor block, and opioid-related adverse effects (e.g., nausea, vomiting, pruritus).",[63],"Postoperative Pain",[65],"Deep Subgluteal Block PENG Block Lateral Femoral Cutaneous Nerve Block Hip Arthroplasty Nerve Block Opioid Consumption","2026-08-13",{"date":68,"type":39},"2026-08-18",{"date":70,"type":22},"2026-08-01",{"date":72,"type":22},"2027-01-30",{"name":45,"class":46},{"id":75,"slug":76,"hasResults":12,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":56,"minAge":18,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100651288","effects-of-electrotherapy-on-muscle-properties-in-forward-head-posture-100651288","NCT07758530","Effects of Electrotherapy on Muscle Properties in Forward Head Posture","Acute Effects of Electrotherapy Modalities on Muscle Mechanical Properties in Individuals With Altered Head-Neck Posture","Inclusion Criteria:\n\n* Aged 18-30 years\n* Craniovertebral angle (CVA) \\\u003C 55°\n* Male and female\n* Voluntary participation\n\nExclusion Criteria:\n\n* Cervical instability\n* Diagnosed inflammatory joint disease\n* History of accident, trauma, or surgery\n* Cervical pain treatment within the last 6 months\n* Presence of cervical implant\n* Skin irritation at measurement\u002Felectrode sites\n* Diagnosed epilepsy\n* Presence of cardiac\u002Fbrain pacemaker\n* Unwillingness to participate",true,"30 Years",{"count":84,"type":22},75,[25],"This randomized controlled trial investigates the acute effects of three electrotherapy modalities (therapeutic ultrasound, interferential current, and TENS) on the mechanical and viscoelastic properties of neck muscles in young adults with forward head posture. Seventy-five participants will be randomly allocated to one of three groups. Muscle stiffness, oscillation frequency, and craniovertebral angle will be assessed before and immediately after a single treatment session.",[88],"Forward Head Posture",[90,91,92,93,94,95,96,97,98],"Forward head posture","Craniovertebral angle","Electrotherapy","Therapeutic ultrasound","Interferential current","TENS","myotonometry","muscle stiffness","cervical muscles","NOT_YET_RECRUITING","2026-08-08",{"date":102,"type":39},"2026-08-11",{"date":104,"type":22},"2026-10-01",{"date":106,"type":22},"2027-11-01",{"name":45,"class":46},{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":82,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100651020","acute-effects-of-foot-orthoses-on-muscle-mechanical-properties-in-individuals-with-pes-planus-100651020","NCT07755215","Acute Effects of Foot Orthoses on Muscle Mechanical Properties in Individuals With Pes Planus","Acute Effects of Orthosis Use on Muscle Mechanical Properties in Individuals With Pes Planus: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18-30 years\n* Diagnosed with unilateral or bilateral pes planus\n* Willing to participate voluntarily in the study\n\nExclusion Criteria:\n\n* History of lower-extremity injury or surgery within the past 6 months\n* Diagnosis of a rheumatologic or neurological condition that may affect foot joint alignment\n* Skin lesions or damage that may prevent the measurements from being performed\n* Current use of an orthosis, such as an insole or wedge, to support pes planus\n* Body mass index (BMI) ≥25 kg\u002Fm² or ≤18.5 kg\u002Fm²\n* Unwilling to participate in the study",{"count":116,"type":22},90,[25],"This randomized controlled study will examine the acute effects of a medial arch support and a prefabricated insole on lower-limb muscle mechanical properties and pain in young adults with pes planus. Ninety participants will be allocated in a 1:1:1 ratio to a medial arch support group, an insole group, or a control group. Muscle mechanical and viscoelastic properties will be assessed with MyotonPRO, and pain will be assessed with a visual analog scale.",[120],"Flatfoot",[122,123,124,125,126],"flatfoot","pes planus","foot orthoses","muscle mechanical properties","myotonPRO","2026-08-05",{"date":129,"type":39},"2026-08-10",{"date":131,"type":22},"2026-09-01",{"date":133,"type":22},"2027-02-28",{"name":45,"class":46},{"id":136,"slug":137,"hasResults":12,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":151,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":47},"100592108","effects-of-orthosis--exercise-on-spondylolisthesis-100592108","NCT06989138","Effects of Orthosis & Exercise on Spondylolisthesis","The Effect of Orthosis and Exercise Training on Pain, Physical Function and Quality of Life in Patients With Spondylolisthesis","Inclusion Criteria:\n\n* Individuals aged 18-65\n* Individuals without indication for surgery\n* Individuals diagnosed with grade 1-2 spondylolysis\n* Individuals without neurological deficits\n* Individuals diagnosed with radicular pain or non-specific chronic low back pain for more than 3 months\n\nExclusion Criteria:\n\n* Surgery recommended after diagnosis\n* History of lumbar surgery\n* Presence of rheumatic inflammatory diseases or diabetic polyneuropathy\n* Individuals with symptoms of cauda equina or ischemic heart disease\n* Presence of back pain with non-mechanical causes or non-radicular neuropathic pain\n* Having received this type of exercise therapy before","65 Years",{"count":144,"type":22},48,[25],"In the treatment of spondylolisthesis, conservative methods are initially preferred unless severe neurological symptoms are present; surgical treatment is only performed in refractory cases lasting at least 3-6 months. Conservative treatment consists of orthotic use, activity restriction, pain control, physiotherapy and exercise. Orthotics may promote healing by restricting movement; however, there are not enough studies on this subject. Exercise is the intervention with the highest level of evidence in chronic low back pain. The efficacy of stabilisation exercises in providing positive and long-lasting effects on pain and functional disability in patients with spondylolisthesis has been demonstrated. However, studies evaluating the effect of exercise on spinal stability and radiological findings are limited. Therefore, this study aims to compare the effects of stabilization and conventional exercises with orthosis on radiographic findings, pain, physical function and quality of life.",[148,149,150],"Spondylolisthesis","Orthosis","Exercise Training",[148,149,152,153,154,155],"Exercise","Stabilization","Physical function","Kinesiophobia","2026-07-31",{"date":158,"type":39},"2026-08-03",{"date":160,"type":39},"2025-07-26",{"date":162,"type":22},"2027-02",{"name":45,"class":46},{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":81,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":171,"targetDuration":4,"studyType":23,"phases":173,"briefSummary":174,"conditions":175,"keywords":179,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":187,"leadSponsor":189,"locationsCount":47},"100609442","development-and-investigation-of-the-apneatheraplay-100609442","NCT07214636","Development and Investigation of the ApneaTheraPlay","Development and Investigation of the Effectiveness of a Digital Video-Based Game Exercise System (ApneaTheraPlay) for Individuals With Obstructive Sleep Apnea Syndrome","Inclusion Criteria:\n\n* 18-65 years of age\n* Individuals diagnosed with mild, moderate, or severe OSAS (AHI 5-30 events\u002Fhour) based on laboratory diagnostic polysomnography assessments\n* Individuals diagnosed by a pulmonologist within the last year and who have started CPAP therapy for at most 12 months and who are regular users\n* Those with habitual snoring\n* All participants in the exercise group must have or have access to a phone, tablet, or computer compatible with SMART technologies using the exercise system app\n* Participants must have sufficient physical function to follow the exercise instructions\n* Familiarity with mobile health applications, as assessed by the VAS, and a willingness to participate in these exercises of \\>7\n* Not having participated in physiotherapy-based interventions targeting OSAS in the last 3 months\n* A score of 68 or higher on the System Usability Scale (SUS)\n\nExclusion Criteria:\n\n* • BMI \\> 40 kg\u002Fm2\n\n  * Serious drug or alcohol abuse\n  * Regular use of sedatives, muscle relaxants, or opioids that may affect sleep patterns or exercise performance\n  * Pregnancy or postpartum (\\\u003C6 months) due to hormonal effects on sleep and respiratory function\n  * Any medical contraindication to physical activity (unstable coronary disease, decompensated heart failure) according to the American College of Sports Medicine (ACSM) exercise guidelines (American College of Sports Medicine, 2021)\n  * History of stroke\n  * Presence of any significant respiratory, neuromuscular, or other disorder causing hypercapnia\n  * Systemic disease associated with an inflammatory entity (e.g., arthritis, sarcoidosis, vasculitis, lupus)\n  * Craniofacial deformity\n  * Presence of secondary respiratory diseases such as severe upper airway obstruction or COPD\n  * Presence of dysphagia\n  * Presence of a frenulum restricting tongue movement",{"count":172,"type":22},54,[25],"Obstructive Sleep Apnea Syndrome (OSAS) is commonly treated with CPAP devices, but adherence rates are low. Exercise has been shown to strengthen respiratory muscles, improve upper airway function, and enhance sleep quality. However, most studies have examined only single or dual exercise protocols, and there is little evidence regarding integrated programs with four exercise types or their effects when performed directly before sleep.\n\nThis project aims to develop and evaluate ApneaTheraPlay (ATP), a digital gamified video-based exercise platform combining respiratory, aerobic, strengthening, and oropharyngeal exercises. The randomized controlled, double-blind study will allocate participants into three groups: ATP, a structured pre-sleep exercise group (SPEG), and a control group (CG). Intervention groups will exercise three times per week for 12 weeks, while the control group will only keep a physical activity diary.",[176,177,178],"Apnea, Obstructive","Exercise Addiction","Physiotherapy and Rehabilitation",[180,152,181,178,182],"Apnea","Exergame","CPAP","2026-07-27",{"date":185,"type":39},"2026-07-28",{"date":185,"type":22},{"date":188,"type":22},"2027-12-01",{"name":45,"class":46},{"id":191,"slug":192,"hasResults":12,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":197,"targetDuration":4,"studyType":23,"phases":198,"briefSummary":199,"conditions":200,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":47},"100634038","sacral-erector-spinae-plane-block-in-pilonidal-sinus-surgery-100634038","NCT07534488","Sacral Erector Spinae Plane Block in Pilonidal Sinus Surgery","Evaluation of the Efficacy of Ultrasound-Guided Sacral Erector Spinae Plane Block in Postoperative Analgesia Management in Patients Undergoing Pilonidal Sinus Surgery","Inclusion Criteria:\n\n* Patients scheduled for elective pilonidal sinus surgery.\n* ASA physical status I and II\n\nExclusion Criteria:\n\n* Allergy or sensitivity to local anesthetics or opioid drugs.\n* Infection at the block site.\n* Alcohol or drug addiction.\n* Use of anticoagulant agents.\n* Patient refusal.",{"count":59,"type":22},[25],"This study aims to evaluate the efficacy of ultrasound-guided Sacral Erector Spinae Plane (ESP) block for postoperative analgesia management in patients undergoing pilonidal sinus surgery under general anesthesia",[201,202],"Sacral Erector Spinae Plane Block","Pilonidal Sinus","2026-07-24",{"date":183,"type":39},{"date":206,"type":39},"2026-04-20",{"date":208,"type":22},"2026-09-15",{"name":45,"class":46},{"id":211,"slug":212,"hasResults":12,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":217,"targetDuration":4,"studyType":23,"phases":219,"briefSummary":220,"conditions":221,"keywords":225,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":232,"startDateStruct":233,"completionDateStruct":234,"leadSponsor":236,"locationsCount":47},"100634037","venous-tourniquet-vs-arterial-tourniquet-for-seizure-monitoring-in-ect-100634037","NCT07534475","Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT","Comparison of Venous Tourniquet Method With Isolated Forearm Technique in Electroconvulsive Therapy in Terms of Efficacy and Safety","Inclusion Criteria:\n\n* Patients scheduled for elective Electroconvulsive Therapy (ECT).\n* ASA (American Society of Anesthesiologists) physical status I to III.\n\nExclusion Criteria:\n\n* Known neuromuscular diseases (e.g., Myasthenia Gravis).\n* Known allergy or hypersensitivity to sugammadex, rocuronium, ketamine, dexmedetomidine, or propofol.\n* Presence of venous insufficiency, lymphedema, or active infection in the upper extremities.\n* Severe cardiovascular instability.",{"count":218,"type":22},20,[25],"This prospective, open-label clinical trial aims to compare a novel \"Venous Tourniquet with Regional Low-Dose Sugammadex\" method against the gold standard \"Arterial Tourniquet\" (Isolated Forearm Technique - IFT) for monitoring motor seizure activity during Electroconvulsive Therapy (ECT). Using a within-subject (intra-individual) design, each of the 40 enrolled patients will receive an arterial tourniquet on one arm and a venous tourniquet on the other arm simultaneously. The study will evaluate clinical efficacy in observing motor seizures, comparing the duration and visibility between the two limbs of the same patient, as well as assessing overall patient comfort and hemodynamics.",[222,223,224],"Major Depressive Disorder","Bipolar Disorder","Schizophrenia",[226,227,228,229,230,231],"Electroconvulsive Therapy","Isolated Forearm Technique","Sugammadex","Neuromuscular Blockade","Seizure Monitoring","Tourniquet",{"date":183,"type":39},{"date":206,"type":39},{"date":235,"type":22},"2026-12-20",{"name":45,"class":46},{"id":238,"slug":239,"hasResults":12,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":12,"sex":17,"minAge":244,"maxAge":245,"enrollmentInfo":246,"targetDuration":4,"studyType":23,"phases":248,"briefSummary":249,"conditions":250,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":252,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":256,"locationsCount":47},"100625758","comparison-of-posterior-qlb-and-qipb-in-pediatric-undescended-testis-surgery-100625758","NCT07426796","Comparison of Posterior QLB and QIPB in Pediatric Undescended Testis Surgery.","Comparison of the Effects of Posterior Quadratus Lumborum Block and Quadroiliac Plane Block on Analgesic Consumption in Postoperative Pain Management in Pediatric Patients Undergoing Undescended Testis Surgery","Inclusion Criteria:\n\n* Male pediatric patients aged 1-7 years.\n* ASA physical status I or II.\n* Scheduled for unilateral undescended testis surgery.\n* Written informed consent obtained.\n\nExclusion Criteria:\n\n* History of neurological deficit or developmental delay.\n* Bleeding diathesis or known coagulopathy.\n* History of allergy to local anesthetics.\n* Infection or skin lesion at the block injection site.\n* Congenital spinal anomaly.\n* Mental retardation or psychiatric history.\n* Liver or kidney dysfunction.","1 Year","7 Years",{"count":247,"type":22},70,[25],"This randomized, double-blind study compares the postoperative analgesic efficacy of ultrasound-guided Posterior Quadratus Lumborum Block (QLB) versus Quadroiliac Plane Block (QIPB) in pediatric patients aged 1-7 years undergoing unilateral undescended testis surgery.",[63,251],"Cryptorchidism",{"date":183,"type":39},{"date":254,"type":39},"2026-02-13",{"date":43,"type":22},{"name":45,"class":46},{"id":258,"slug":259,"hasResults":12,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":12,"sex":17,"minAge":244,"maxAge":245,"enrollmentInfo":264,"targetDuration":4,"studyType":23,"phases":265,"briefSummary":266,"conditions":267,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":269,"startDateStruct":270,"completionDateStruct":271,"leadSponsor":272,"locationsCount":47},"100625753","comparison-of-sacral-esp-block-and-dorsal-penile-nerve-block-in-pediatric-hypospadias-surgery-100625753","NCT07426731","Comparison of Sacral ESP Block and Dorsal Penile Nerve Block in Pediatric Hypospadias Surgery","Comparison of the Effects of Sacral Erector Spinae Plane Block and Dorsal Penile Nerve Block on Postoperative Pain Management in Pediatric Patients Undergoing Hypospadias Surgery","Inclusion Criteria:\n\n* Pediatric male patients aged 1-7 years.\n* ASA (American Society of Anesthesiologists) physical status I or II.\n* Scheduled for elective hypospadias surgery.\n* Written informed consent obtained from parents\u002Fguardians\n\nExclusion Criteria:\n\n* History of neurological deficit or developmental delay.\n* Bleeding diathesis or known coagulopathy.\n* History of allergy to local anesthetics.\n* Infection or skin lesion at the block injection site.\n* Congenital spinal anomaly.\n* Mental retardation or history of psychiatric disease.\n* Liver or kidney dysfunction",{"count":247,"type":22},[25],"This randomized controlled trial aims to compare the postoperative analgesic efficacy of ultrasound-guided Sacral Erector Spinae Plane (ESP) block versus Dorsal Penile Nerve Block (DPNB) in pediatric patients aged 1-7 years undergoing hypospadias surgery. The primary outcome is the pain score assessed by the FLACC scale at the 12th postoperative hour",[63,268],"Hypospadias",{"date":183,"type":39},{"date":254,"type":39},{"date":43,"type":22},{"name":45,"class":46},{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":57,"enrollmentInfo":280,"targetDuration":4,"studyType":23,"phases":281,"briefSummary":282,"conditions":283,"keywords":286,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":289,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":47},"100581532","comparing-thoracolumbar-interfascial-and-quadro-iliac-plane-blocks-on-postoperative-opioid-use-following-lumbar-microsurgery-100581532","NCT06851533","Comparing Thoracolumbar Interfascial and Quadro Iliac Plane Blocks on Postoperative Opioid Use Following Lumbar Microsurgery","Comparison of the Effects of Thoracolumbar Interfascial Plane Block and Quadro Iliac Plane Block on Postoperative Opioid Consumption After Lumbar Microsurgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18 to 80 years\n* American Society of Anesthesiologists (ASA) physical status I to III\n* scheduled for lumbar microdiscectomy surgery\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics\n* Any other significant drug allergies related to the study interventions\n* Pregnancy\n* Pre-existing psychiatric or neurological disorders\n* Inability to provide informed consent",{"count":116,"type":22},[25],"Lumbar microdiscectomy is a commonly used surgical procedure for treating herniated discs. Effective postoperative analgesia is crucial for early mobilization and functional recovery. Uncontrolled postoperative pain can delay recovery, increase the risk of opioid dependence, and lead to respiratory complications.\n\nAlthough opioid analgesics effectively reduce pain, they can cause side effects such as nausea, vomiting, respiratory depression, and dependency. Therefore, non-opioid analgesic methods are preferred for patient safety and comfort. Recently, regional anesthesia techniques such as the Thoracolumbar Interfascial Plane (TLIP) block and the Quadro Iliac Plane Block have been introduced for postoperative pain management in lumbar surgeries. However, there are not enough studies comparing the superiority of these two methods.\n\nStudy Objective: The primary aim of this study is to evaluate the effects of ultrasound-guided TLIP and Quadro Iliac Plane Blocks on postoperative opioid consumption after lumbar microsurgery. The secondary aim is to compare opioid-related side effects (such as nausea, vomiting, respiratory depression, etc.) and postoperative NRS pain scores between the groups.",[284,285],"Lumbar Microdiscectomy","Nerve Block",[287,288],"Postoperative pain","Ultrasound-guided nerve block",{"date":183,"type":39},{"date":291,"type":39},"2025-03-10",{"date":293,"type":22},"2026-12-10",{"name":45,"class":46},{"id":296,"slug":297,"hasResults":12,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":302,"enrollmentInfo":303,"targetDuration":4,"studyType":23,"phases":304,"briefSummary":305,"conditions":306,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":311,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":315,"locationsCount":47},"100575553","transcatheter-aortic-valve-implantation-comparison-of-the-effects-of-ultrasound-guided-pericapsular-nerve-group-block-and-fascia-iliaca-block-on-postoperative-analgesia-management-100575553","NCT06773780","Transcatheter Aortic Valve Implantation: Comparison of the Effects of Ultrasound-Guided Pericapsular Nerve Group Block and Fascia Iliaca Block on Postoperative Analgesia Management","Transcatheter Aortic Valve Implantation: Comparison of the Effects of Ultrasound-Guided Pericapsular Nerve Group Block and Fascia Iliaca Block on Postoperative Analgesia Management - A Randomized, Prospective Study","Inclusion Criteria:\n\n* Patients scheduled for TAVİ\n* aged between 18 and 85 years,\n* American Society of Anesthesiology (ASA) physical status II-IV\n\nExclusion Criteria:\n\n* History of bleeding diathesis.\n* Use of anticoagulant therapy.\n* History of chronic pain prior to surgery.\n* Multiple trauma.\n* Conditions where pain assessment cannot be performed (e.g., dementia).\n* Patients operated under spinal or epidural anesthesia.\n* Presence of infection in the region where the block will be applied.\n* Refusal to consent to the procedure","85 Years",{"count":59,"type":22},[25],"Aortic Stenosis (AS) is the most common valvular pathology, particularly prevalent in advanced age, and Transcatheter Aortic Valve Implantation (TAVI) has become a crucial treatment option for high-risk patients who are not suitable for surgery. This minimally invasive approach has demonstrated successful clinical outcomes in patients deemed ineligible for surgical procedures.\n\nPatient selection criteria and advancements in operative techniques are critical for achieving successful TAVI outcomes. While the transfemoral approach is the most commonly used method, alternative techniques such as transapical, transaxillary, transcarotid, and transaortic approaches are also available.\n\nThe Pericapsular Nerve Group Block (PENG) targets the femoral and accessory obturator nerves, providing analgesia to the anterior hip without causing motor block. The Fascia Iliaca Block (FIB), on the other hand, provides broader analgesic coverage by affecting the lateral femoral cutaneous, obturator, and femoral nerves.\n\nThis study aims to compare PENG block, FIB, and local infiltration anesthesia in TAVI patients regarding sedation requirements during the procedure and postoperative analgesia management. Additionally, pain scores, motor block presence, opioid consumption, and side effects will be assessed. The study seeks to identify optimal strategies to enhance patient comfort and safety during TAVI procedures.",[307,308,309,310],"Aortic Valve Stenosis","Transcatheter Aortic Valve Implantation","Pericapsular Nerve Group Block","Fascia Iliaca Block",{"date":183,"type":39},{"date":313,"type":39},"2025-01-10",{"date":43,"type":22},{"name":45,"class":46},{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":320,"acronym":4,"eligibilityCriteria":321,"healthyVolunteers":12,"sex":56,"minAge":245,"maxAge":322,"enrollmentInfo":323,"targetDuration":4,"studyType":23,"phases":325,"briefSummary":326,"conditions":327,"keywords":331,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":339,"completionDateStruct":340,"leadSponsor":342,"locationsCount":47},"100648575","structured-task-focused-occupational-therapy-in-the-school-environment-to-support-academic-performance-fine-motor-and-visual-motor-skills-100648575","NCT07723092","Structured Task-Focused Occupational Therapy in the School Environment to Support Academic Performance: Fine Motor and Visual-Motor Skills","Inclusion Criteria:\n\n* Being between 7 and 9 years of age\n* Being enrolled in the second or third grade\n* Demonstrating basic literacy skills\n* Being identified as high risk for handwriting and\u002For manual dexterity difficulties based on standardized assessments and teacher observations\n* Being expected to maintain regular school attendance throughout the study period\n* Written informed consent provided by a parent or legal guardian\n\nExclusion Criteria:\n\n* A diagnosed neurodevelopmental disorder, including autism spectrum disorder or attention-deficit\u002Fhyperactivity disorder\n* Significant visual or hearing impairment\n* An orthopedic or neurological condition affecting the upper extremity\n* Current receipt of occupational therapy or special education services","9 Years",{"count":324,"type":22},24,[25],"This randomized controlled trial will evaluate the effects of a structured, task-focused occupational therapy program delivered in the school environment on handwriting performance, fine motor skills, visual-motor integration, and academic performance in primary school children. Second- and third-grade students identified as being at risk for handwriting and manual dexterity difficulties will be randomly assigned to an intervention group or a control group. The intervention group will receive a 10-week school-based occupational therapy program consisting of two 30-minute sessions per week, for a total of 20 sessions. The control group will continue routine classroom activities without therapist-led occupational therapy. Handwriting, manual dexterity, visual-motor integration, visual perception, and motor coordination will be assessed at baseline and after the intervention. Academic grades will also be recorded, and individualized goal attainment will be evaluated in the intervention group.",[328,329,330],"Visual Perception","Visual-Motor Integration","Handwriting",[332,333,330,334,329,335,336],"School-Based Occupational Therapy","Task-Focused Occupational Therapy","Fine Motor Skills","Academic Performance","Primary School Children","2026-07-23",{"date":203,"type":39},{"date":183,"type":22},{"date":341,"type":22},"2026-10-12",{"name":45,"class":46},{"id":344,"slug":345,"hasResults":12,"nctId":346,"briefTitle":347,"officialTitle":348,"acronym":4,"eligibilityCriteria":349,"healthyVolunteers":81,"sex":56,"minAge":350,"maxAge":351,"enrollmentInfo":352,"targetDuration":4,"studyType":23,"phases":354,"briefSummary":355,"conditions":356,"keywords":359,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":369,"locationsCount":47},"100643425","effects-of-a-vision-focused-occupational-therapy-program-on-visual-skills-in-primary-school-children-100643425","NCT07635706","Effects of a Vision-Focused Occupational Therapy Program on Visual Skills in Primary School Children","The Effect of a Vision-Focused Occupational Therapy Program on Visual Perception and School-Based Visual-Motor Functions in Primary School Children","Inclusion Criteria:\n\n* Children aged 8 to 10 years\n* Enrollment in 3rd or 4th grade of primary school\n* Ability to understand and follow study instructions\n* Written informed consent obtained from parent or legal guardian\n* Willingness to participate in all assessment and intervention sessions\n\nExclusion Criteria:\n\n* Diagnosed neurological, psychiatric, developmental, or intellectual disorder\n* Uncorrected visual impairment that may affect assessment results\n* Musculoskeletal condition affecting upper extremity function\n* Participation in another structured visual training or rehabilitation program during the study period\n* Inability to complete study assessments or intervention sessions","8 Years","10 Years",{"count":353,"type":22},32,[25],"This randomized controlled trial aims to investigate the effects of a structured visual skills-based occupational therapy program on visual perception and school-based visual-motor functions in typically developing primary school students aged 8-10 years. Participants will be randomly assigned to either an intervention group receiving a 6-week visual skills program or a control group receiving routine school activities and home-based assignments. Outcomes including visual perception, visual-motor performance, convergence ability, and motor proficiency will be assessed before and after the intervention.",[357,358],"Visual Deficiencies","Visual Attention",[360,328,329,361,362,332],"Visual Skills","Oculomotor Training","Occupational Therapy","2026-07-21",{"date":365,"type":39},"2026-07-22",{"date":367,"type":39},"2026-06-08",{"date":156,"type":22},{"name":45,"class":46},{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":374,"acronym":4,"eligibilityCriteria":375,"healthyVolunteers":12,"sex":376,"minAge":4,"maxAge":4,"enrollmentInfo":377,"targetDuration":4,"studyType":23,"phases":379,"briefSummary":380,"conditions":381,"keywords":383,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":389,"completionDateStruct":390,"leadSponsor":391,"locationsCount":4},"100647476","the-effect-of-web-based-counselling-on-breastfeeding-experiences-and-infant-care-competence-among-mothers-of-preterm-babies-100647476","NCT07709663","The Effect of Web-Based Counselling on Breastfeeding Experiences and Infant Care Competence Among Mothers of Preterm Babies","Inclusion Criteria:\n\n* To be a first-time mother (primipara).\n* To have had a preterm birth at 30 weeks or more of gestation.\n* For the baby to be hospitalized in the neonatal intensive care unit.\n* For the newborn to have no medical condition that prevents breastfeeding.\n* To be able to read and understand Turkish.\n* To be willing to participate in the study.\n\nExclusion Criteria:\n\n* Mothers with a medical condition contraindicating breastfeeding.\n* Infants with a major congenital anomaly or medical condition preventing breast milk feeding.\n* Withdrawal of consent or inability to complete follow-up assessments.","FEMALE",{"count":378,"type":22},56,[25],"Breast milk is of great importance for preterm infants in terms of optimal growth, immune system development, and neurodevelopment. However, mothers who give birth prematurely may face various challenges during the breastfeeding process due to their infants' need for monitoring in the neonatal intensive care unit, mother-infant separation, and the need to pump breast milk. This situation can negatively affect the experience of expressing breast milk and the mother's perception of her competence in caring for her baby.\n\nThe aim of this randomized controlled trial is to evaluate the effect of web-based breastfeeding counseling on the breast milk expression experience and the competence in caring for a preterm infant among mothers of preterm infants. A total of 56 mothers who gave birth preterm at 30 weeks of gestation or later and whose infants are being monitored in the neonatal intensive care unit will be included in the study. Participants will be randomly assigned to the intervention and control groups.\n\nMothers in the intervention group will have access to a Moodle-based training program that includes video training on breastfeeding counseling and care for premature infants, as well as the opportunity to ask the researcher questions online. Mothers in the control group, on the other hand, will continue to receive the hospital's routine education and care services.\n\nThe primary outcome measures of the study will be assessed using the Breastfeeding Experience Scale and the Premature Infant Care Competence Assessment Tool. Measurements will be taken at the start of the study, following the training, and at the end of the one-month follow-up period to examine the effect of web-based counseling on mothers' breastfeeding experience and care competence.",[382],"Preterm Birth",[384,385,386],"Web-based consulting","breast milk pumping","infant care","2026-07-17",{"date":363,"type":39},{"date":131,"type":22},{"date":133,"type":22},{"name":45,"class":46},{"id":393,"slug":394,"hasResults":12,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":398,"eligibilityCriteria":399,"healthyVolunteers":12,"sex":17,"minAge":19,"maxAge":400,"enrollmentInfo":401,"targetDuration":4,"studyType":23,"phases":402,"briefSummary":403,"conditions":404,"keywords":406,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":416,"leadSponsor":418,"locationsCount":47},"100647314","intracavernosal-exosomes-vs-rectal-ozone-for-post-rarp-erectile-dysfunction-100647314","NCT07707505","Intracavernosal Exosomes vs. Rectal Ozone for Post-RARP Erectile Dysfunction","Intracavernosal Exosomes Versus Rectal Ozone Therapy for Erectile Dysfunction Following Robotic-Assisted Radical Prostatectomy","REHAB-RARP","Inclusion Criteria:\n\n* History of Robotic-Assisted Radical Prostatectomy (ns-RARP) for localized prostate cancer.\n* Normal preoperative erectile function (retrospective IIEF-5 score \\> 21).\n* Presence of a stable, sexually active heterosexual relationship.\n* Inadequate response or intolerance to maximum dose, on-demand oral Phosphodiesterase type 5 inhibitors (PDE5i).\n\nExclusion Criteria:\n\n* History of adjuvant or salvage pelvic radiotherapy \u002F androgen deprivation therapy (ADT).\n* Presence of severe anatomical penile deformities (e.g., active phase Peyronie's disease).\n* Uncontrolled endocrinological (e.g., HbA1c \\> 8.5%) or cardiovascular comorbidities.\n* History of major cardiovascular events (myocardial infarction, stroke) within the preceding 6 months.\n* Current use of systemic anticoagulants (excluding low-dose prophylactic aspirin).\n* Concomitant use of any intraurethral alprostadil, vacuum erection devices (VED), or testosterone replacement therapy during the study period.","75 Years",{"count":59,"type":22},[25],"This prospective, randomized, controlled trial aims to evaluate and compare the therapeutic efficacy of intracavernosal urine-derived exosomes and systemic rectal ozone therapy in patients experiencing erectile dysfunction (ED) post-robotic-assisted radical prostatectomy (RARP). Patients will be randomized into two distinct intervention arms. The primary objective is to assess the functional recovery of the erectile tissue via the International Index of Erectile Function (IIEF-5) over a 6-month follow-up period. Secondary endpoints include penile hemodynamic alterations and overall health-related quality of life.",[405],"Erectile Dysfunction Following Radical Prostatectomy",[407,408,409,410,411],"Exosomes","Rectal Ozone Insufflation","Robotic-Assisted Radical Prostatectomy","Penile Rehabilitation","Extracellular Vesicles","2026-07-11",{"date":414,"type":39},"2026-07-16",{"date":70,"type":22},{"date":417,"type":22},"2027-04-01",{"name":45,"class":46},{"id":420,"slug":421,"hasResults":12,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":4,"eligibilityCriteria":425,"healthyVolunteers":12,"sex":376,"minAge":18,"maxAge":4,"enrollmentInfo":426,"targetDuration":4,"studyType":428,"phases":4,"briefSummary":429,"conditions":430,"keywords":433,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":445,"leadSponsor":447,"locationsCount":47},"100647167","early-kidney-injury-biomarkers-in-gynecologic-laparoscopic-surgery-100647167","NCT07704242","Early Kidney Injury Biomarkers in Gynecologic Laparoscopic Surgery","Comparative Analysis of Urinary NGAL and KIM-1 Levels in Predicting Subclinical Acute Kidney Injury Secondary to Pneumoperitoneum and Deep Trendelenburg Position in Gynecological Laparoscopic Surgery","Inclusion Criteria: Female participants aged 18 years or older. Scheduled for elective gynecological laparoscopic surgery. Expected duration of pneumoperitoneum of at least 90 minutes. Planned intraoperative Trendelenburg position of approximately 30° or 45°. Ability to provide written informed consent. -\n\nExclusion Criteria: Age younger than 18 years. Pre-existing chronic kidney disease (estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73 m² or serum creatinine above the institutional upper limit of normal).\n\nAcute kidney injury before surgery. History of kidney transplantation or renal replacement therapy. Active urinary tract infection. Pregnancy. Conversion from laparoscopic to open surgery. Intraoperative conditions requiring major deviation from the standardized anesthetic or surgical protocol.\n\nInability to provide written informed consent.\n\n\\-",{"count":427,"type":22},50,"OBSERVATIONAL","This prospective observational study aims to evaluate early subclinical acute kidney injury associated with pneumoperitoneum and Trendelenburg positioning during gynecological laparoscopic surgery. Urinary neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) levels will be measured and normalized to urinary creatinine. Biomarker changes will be compared between patients undergoing surgery in 30° and 45° Trendelenburg positions. The study seeks to determine whether these biomarkers can detect early renal injury before clinically significant changes in serum creatinine occur.",[431,432],"Acute Kidney Injury","Subclinical Acute Kidney Injury",[434,435,436,437,438,431,439,440],"NGAL","KIM-1","Gynecologic Laparoscopy","Pneumoperitoneum","Trandelenburg Position","Biomarker","Renal Injury","2026-07-09",{"date":443,"type":39},"2026-07-15",{"date":70,"type":22},{"date":446,"type":22},"2027-03-01",{"name":45,"class":46},{"id":449,"slug":450,"hasResults":12,"nctId":451,"briefTitle":452,"officialTitle":453,"acronym":4,"eligibilityCriteria":454,"healthyVolunteers":12,"sex":56,"minAge":455,"maxAge":57,"enrollmentInfo":456,"targetDuration":4,"studyType":23,"phases":458,"briefSummary":459,"conditions":460,"keywords":462,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":467,"lastUpdatePostDateStruct":468,"startDateStruct":470,"completionDateStruct":472,"leadSponsor":474,"locationsCount":47},"100646935","l-theanine-and-mediterranean-diet-on-rbd-gi-function-and-inflammation-in-parkinsons-disease-100646935","NCT07682532","L-THEANINE AND MEDITERRANEAN DIET ON RBD, GI FUNCTION, AND INFLAMMATION IN PARKINSON'S DISEASE","THE EFFECT OF L-THEANINE SUPPLEMENTATION ON REM SLEEP BEHAVIOR DISORDER, GASTROINTESTINAL FUNCTION, AND INFLAMMATORY MARKERS IN PARKINSON'S DISEASE","Inclusion Criteria:\n\nPatients diagnosed with Parkinson's Disease and classified as stage 1 according to the Hoehn-Yahr Staging (HYA), Patients without communication impairment (aphasia) Participants who sign the Informed Consent Form and volunteer to participate in the study Absence of dementia and Mini Mental State Examination (MMSE) score \\> 24 Living in the same household with a healthy spouse\u002Fpartner Not taking prebiotic, fiber, probiotic, herbal, or high-dose vitamin or mineral supplements that may affect inflammation during the pre-onset period and throughout the study protocol\n\nExclusion Criteria:\n\nPatients with a history of severe heart, lung, liver, or kidney failure, primary psychiatric, developmental, or other neurological disease Patients using sedative\u002Fhypnotic medications Individuals consuming more than 200 mg of caffeine per day (approximately 2-3 cups of tea or 1 cup of coffee) Patients who smoke and consume alcohol Having undergone surgery related to bowel health Having a chronic infectious bowel disease Having a congenital bowel anomaly Using probiotics, antifungals, and\u002For antibiotics within the last three months Individuals with an autoimmune disease or weakened immune system Self-reported alcohol or drug use within the last 3 months Current use of over-the-counter medications, supplements, foods, and\u002For beverages that may affect stress, sleep, cognition, and\u002For mood Inability to swallow the study supplement due to swallowing anxiety Receiving treatment for a GI disease or condition diagnosed by a doctor other than constipation, gastroparesis, gastroesophageal reflux disease, or diverticular disease Positive results for human immunodeficiency virus (HIV) or Hepatitis B\u002FC. Current history of active conditions of inflammatory bowel disease, irritable bowel syndrome, colitis, celiac disease, short bowel syndrome, colostomy, colectomy, gastrointestinal fistula, or strictures.\n\nRecent or current use of any antibiotic (within 4 weeks prior to the start of the study) Use of enemas or suppositories to relieve constipation Good adherence to the Mediterranean diet in the pre-start period according to the 14-item Mediterranean Diet Assessment Tool (score \\>6)","50 Years",{"count":457,"type":22},52,[25],"Parkinson's disease is a progressive neurological disorder associated with severe dopaminergic neuron loss in the substantia nigra pars compacta. The decrease in dopamine cells in the gut in Parkinson's disease negatively affects bowel movements, and constipation is a common condition. Impairment of the intestinal barrier increases inflammation. Reactive oxygen species increase, and intestinal homeostasis changes. Alpha-synuclein levels increase in the gut. L-theanine is the most abundant amino acid in green tea leaves. Parkinson's patients exhibit increased oxidative stress along with decreased activity of glutathione peroxidase, superoxide dismutase, and catalase. L-theanine is believed to increase the activity of these enzymes and reduce oxidative stress. L-theanine administration has been found to increase total short-chain fatty acids in stool. Furthermore, it is suggested that L-theanine inhibits imbalances in oxidative stress and inflammatory responses by reducing inflammatory factors such as TNF-α, IL-6, and IL-1β. REM sleep disturbance is also a common problem in Parkinson's disease. Studies have shown that following L-theanine treatment, participants' Pittsburgh Sleep Quality Index (PSQI) scale scores improved. The gut microbiota regulates sleep and neurological states via the microbiota-gut-brain axis. L-theanine supplementation appears to be able to regulate gut bacterial composition to suppress neurotransmitters, cytokines, and other metabolites to regulate sleep. The protective effects of L-theanine administration on increased dopamine and other neurotransmitters, microbiota, sleep, and antioxidant enzymes may offer a glimmer of hope regarding its beneficial role in Parkinson's disease.",[461],"Parkinson Disease (PD)",[463,464,465,466],"Parkinson's disease","REM sleep behavior disorder","inflammation","nutrition","2026-06-28",{"date":469,"type":39},"2026-07-06",{"date":471,"type":39},"2026-05-02",{"date":473,"type":22},"2026-10-20",{"name":45,"class":46},{"id":476,"slug":477,"hasResults":12,"nctId":478,"briefTitle":479,"officialTitle":480,"acronym":4,"eligibilityCriteria":481,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":482,"targetDuration":4,"studyType":23,"phases":484,"briefSummary":485,"conditions":486,"keywords":492,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":506},"100644753","time-restricted-eating-after-bariatric-surgery-100644753","NCT07672821","Time-Restricted Eating After Bariatric Surgery","Comparison of Time-Restricted Intermittent Fasting Diet in Individuals With and Without Bariatric Surgery","Inclusion Criteria:\n\n* Adults aged 18-65 years with obesity who have not undergone bariatric surgery\n* Adults aged 18-65 years with obesity who have undergone bariatric surgery and experienced insufficient weight loss (IWL) within 18 months post-surgery, -defined as %EWL \\\u003C50% at 18 months\n* Adults aged 18-65 years with obesity who have undergone bariatric surgery and experienced weight regain (WR), defined as \\>25% increase in %EWL from the lowest recorded weight\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding individuals\n* Acute illness, active infection, or comorbid conditions limiting treatment efficacy and safety, including: cancer, type 1 diabetes, renal or hepatic failure, recent stroke or myocardial infarction, nephrolithiasis, drug or alcohol abuse, eating disorders, severe depression or other psychiatric disorders, inflammatory bowel disease (IBD), neoplasia, arrhythmic heart disease, heart failure, respiratory failure, or corticosteroid therapy\n* Professional athletes",{"count":483,"type":22},40,[25],"This study aims to compare the effects of time-restricted eating (TRE, 16\u002F8) in adults with obesity who have and have not undergone bariatric surgery (BS). The study will include adults aged 18-65 years: those with obesity who have not undergone BS, and those who have experienced insufficient weight loss (IWL) or weight regain (WR) following BS. Both groups will follow a 16:8 time-restricted eating protocol for 6 weeks, with an 8-hour eating window recommended between 10:00 AM and 6:00 PM, though participants may adjust to other 16-hour fasting windows. Participants will be evaluated before and after the intervention in terms of anthropometric measurements, biochemical parameters, and dietary habits. The study is being conducted at a private hospital in Bursa, Turkey, and is planned to be completed with a total of 40 participants (20 per group).",[487,488,489,490,491],"Obesity & Overweight","Bariatric Surgery","Weight Regain","Weight Regain Post Bariatric Surgery","Time Restricted Feeding",[493,494,488,495,489,496,497],"Time-Restricted Eating","Intermittent Fasting","Obesity","Anthropometric Measurements","Nutritional Assessment","2026-06-26",{"date":500,"type":39},"2026-06-29",{"date":502,"type":39},"2025-07-12",{"date":504,"type":22},"2026-07-12",{"name":45,"class":46},2,{"id":508,"slug":509,"hasResults":12,"nctId":510,"briefTitle":511,"officialTitle":512,"acronym":4,"eligibilityCriteria":513,"healthyVolunteers":81,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":514,"targetDuration":4,"studyType":23,"phases":515,"briefSummary":516,"conditions":517,"keywords":521,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":532,"locationsCount":47},"100644596","antibacterial-efficacy-of-bioceramic-and-calcium-hydroxide-intracanal-medicaments-100644596","NCT07671326","Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments","Antibacterial Efficacy of Bioceramic and Calcium Hydroxide-Based Intracanal Medicaments in Endodontic Treatment","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* Being systemically healthy (ASA I or ASA II)\n* Mandibular molar teeth with a radiographically detectable radiolucent lesion in the periapical region\n* Willingness of the volunteer or their legal representative to participate in the study by signing the Informed Consent Form\n\nExclusion Criteria:\n\n* Patients who have received antibiotics or corticosteroids within the last 3 months\n* Patients with systemic diseases\n* Teeth that cannot be properly isolated with a rubber dam\n* Teeth with periodontal pockets \\>4 mm and teeth with crown\u002Froot fractures\n* Individuals who are undergoing or planning to start orthodontic treatment during the study period\n* Pregnant or breastfeeding individuals",{"count":324,"type":22},[25],"This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis. Intracanal bacterial load is assessed before and after root canal preparation, after intracanal medicament removal, and after final irrigation using droplet digital PCR.",[518,519,520],"Periapical Periodontitis","Root Canal Infection","Intracanal Medicaments",[522,523,524,525],"intracanal medicament","bioceramic medicament","ultrasonic activation","ddPCR","2026-06-25",{"date":500,"type":39},{"date":529,"type":39},"2025-10-15",{"date":531,"type":22},"2026-12",{"name":45,"class":46},{"id":534,"slug":535,"hasResults":12,"nctId":536,"briefTitle":537,"officialTitle":538,"acronym":539,"eligibilityCriteria":540,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":541,"targetDuration":4,"studyType":428,"phases":4,"briefSummary":542,"conditions":543,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":547,"completionDateStruct":549,"leadSponsor":551,"locationsCount":4},"100644074","preoperative-central-sensitization-and-postoperative-outcomes-after-arthroscopic-rotator-cuff-repair-100644074","NCT07667257","Preoperative Central Sensitization and Postoperative Outcomes After Arthroscopic Rotator Cuff Repair","Effect of Central Sensitization on Postoperative Clinical Outcomes in Patients Undergoing Arthroscopic Rotator Cuff Repair","ARCS","Inclusion Criteria:\n\n* Inclusion Criteria:\n* Age between 18 and 65 years\n* Diagnosis of rotator cuff tear confirmed by clinical examination and magnetic resonance imaging (MRI)\n* Scheduled to undergo arthroscopic rotator cuff repair\n* Ability to understand and complete study questionnaires\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Previous surgery on the affected shoulder.\n* Concomitant shoulder disorders requiring additional surgical procedures (e.g., fracture, instability, advanced glenohumeral osteoarthritis).\n* History of inflammatory rheumatic disease, active infection, or malignancy affecting the shoulder.\n* Neurological disorders that may influence pain perception or upper extremity function.\n* Severe psychiatric illness or cognitive impairment preventing completion of the questionnaires.\n* Pregnancy.\n* Inability or unwillingness to provide written informed consent.\n* Inability to attend the postoperative 3-month follow-up evaluation.",{"count":427,"type":22},"This prospective observational study aims to investigate the effect of preoperative central sensitization on postoperative clinical outcomes in patients undergoing arthroscopic rotator cuff repair. Central sensitization, characterized by an increased responsiveness of the central nervous system to pain stimuli, has been associated with persistent pain and poor functional recovery in various musculoskeletal disorders. However, its impact on outcomes following arthroscopic rotator cuff repair has not been fully elucidated.\n\nAdult patients diagnosed with a rotator cuff tear by clinical examination and magnetic resonance imaging (MRI) and scheduled for arthroscopic repair will be enrolled. Preoperative central sensitization will be assessed using the Central Sensitization Inventory (CSI), while pain intensity and shoulder function will be evaluated using the Visual Analog Scale (VAS) and the Shoulder Pain and Disability Index (SPADI), respectively. Clinical assessments will be performed preoperatively and at postoperative 3 months. The study aims to determine whether preoperative central sensitization is associated with postoperative pain and functional recovery after arthroscopic rotator cuff repair.",[544],"Rotator Cuff Tear","2026-06-20",{"date":526,"type":39},{"date":548,"type":22},"2026-06-30",{"date":550,"type":22},"2026-12-30",{"name":45,"class":46},{"id":553,"slug":554,"hasResults":12,"nctId":555,"briefTitle":556,"officialTitle":557,"acronym":558,"eligibilityCriteria":559,"healthyVolunteers":12,"sex":56,"minAge":4,"maxAge":4,"enrollmentInfo":560,"targetDuration":4,"studyType":428,"phases":4,"briefSummary":562,"conditions":563,"keywords":572,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":579,"lastUpdatePostDateStruct":580,"startDateStruct":582,"completionDateStruct":584,"leadSponsor":585,"locationsCount":586},"100625308","mechanical-insufflation-exsufflation-in-critically-ill-patients-100625308","NCT07420946","Mechanical Insufflation-Exsufflation in Critically Ill Patients","Mechanical Insufflation-Exsufflation in Critically Ill Patients: An International DELphi Consensus (DELMI-E)","DELMI-E","Inclusion Criteria:\n\n* Healthcare professionals with documented clinical experience in critical care medicine, pulmonology, anesthesiology, respiratory therapy, or physiotherapy with involvement in airway clearance strategies.\n* Demonstrated experience or recognized expertise in the clinical use of MI-E, either in critically ill patients or in patients with complex respiratory conditions.\n* A minimum of 5 years of clinical experience in their respective field, or a proven academic or clinical contribution related to MI-E.\n* Willingness to participate in multiple Delphi rounds and to provide informed consent.\n* Ability to complete the questionnaires in English.\n\nExclusion Criteria:\n\n* Lack of direct clinical or academic experience related to MI-E or airway clearance techniques.\n* Inability or unwillingness to provide informed consent.\n* Failure to complete the first Delphi round after formal invitation and consent.\n* Withdrawal of consent at any stage of the Delphi process.",{"count":561,"type":22},30,"Mechanical insufflation-exsufflation (MI-E) is an established airway clearance technique for patients with chronic conditions like neuromuscular diseases. However, its use in critically ill ICU patients remains inconsistent and lacks standardized guidelines. Despite growing research, current practices vary widely in patient selection, treatment protocols, and safety management, with limited high-quality evidence to support clear recommendations. To address this gap, an international, multidisciplinary Delphi consensus study is needed to establish expert-based best practices and feasible guidelines for the safe and effective implementation of MI-E in the intensive care setting.",[564,565,566,567,568,569,570,571],"Airway Clearance","Mechanical Insufflation-exsufflation","Mechanical Insufflation-exsufflation Session ( With Cough Assist)","Delphi Study","Consensus","Critical Illness","Critical Care","Critical Care, Intensive Care",[573,574,575,568,576,577,578],"mechanical insufflation-exsufflation","Airway clearance","Delphi study","Cough assist","MI-E","critical care","2026-06-15",{"date":581,"type":39},"2026-06-17",{"date":583,"type":39},"2026-06-10",{"date":43,"type":22},{"name":45,"class":46},4,{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":593,"eligibilityCriteria":594,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":595,"targetDuration":4,"studyType":428,"phases":4,"briefSummary":596,"conditions":597,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":601,"completionDateStruct":602,"leadSponsor":603,"locationsCount":4},"100642010","effect-of-preoperative-kinesiophobia-on-clinical-outcomes-following-arthroscopic-meniscus-surgery-100642010","NCT07654894","Effect of Preoperative Kinesiophobia on Clinical Outcomes Following Arthroscopic Meniscus Surgery","Effect of Preoperative Kinesiophobia on Clinical Success in Patients Undergoing Arthroscopic Surgery for Meniscal Tears","MEN-KIN","Inclusion Criteria:\n\nAdults aged 18 to 65 years. Diagnosis of meniscal tear confirmed by clinical examination and magnetic resonance imaging (MRI).\n\nPatients scheduled to undergo arthroscopic meniscal surgery. Ability to understand and complete the study questionnaires. Willingness to participate and provide written informed consent. Availability for both preoperative assessment and postoperative 3-month follow-up.\n\nExclusion Criteria:\n\nPrevious surgery on the affected knee. Concomitant anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), or collateral ligament injuries requiring surgical treatment.\n\nAdvanced knee osteoarthritis (e.g., Kellgren-Lawrence grade 3 or 4). History of inflammatory rheumatic disease or active joint infection. Neurological disorders affecting lower extremity function or balance. Severe psychiatric disorders or cognitive impairment preventing completion of questionnaires.\n\nPregnancy. Inability or unwillingness to provide written informed consent. Inability to attend the 3-month postoperative follow-up.",{"count":427,"type":22},"Meniscal tears are among the most common knee injuries and frequently require arthroscopic surgical treatment when conservative management fails or mechanical symptoms persist. Although surgical techniques have improved clinical outcomes, postoperative recovery is influenced not only by structural pathology but also by psychological factors. Kinesiophobia, defined as an excessive and debilitating fear of movement due to pain or the expectation of reinjury, may negatively affect rehabilitation adherence, functional recovery, and pain perception.\n\nThis prospective observational study aims to investigate the effect of preoperative kinesiophobia on postoperative clinical outcomes in patients undergoing arthroscopic surgery for meniscal tears. Adult patients diagnosed with a meniscal tear by clinical examination and magnetic resonance imaging and scheduled for arthroscopic surgery will be enrolled. Preoperative demographic and clinical characteristics, pain intensity, functional status, and kinesiophobia levels will be assessed using validated outcome measures. Postoperative evaluations will be performed three months after surgery to determine changes in pain and functional outcomes. The relationship between preoperative kinesiophobia and postoperative clinical success will be analyzed. The findings of this study may help identify patients at risk for suboptimal recovery and support the development of individualized rehabilitation strategies.",[598],"Meniscal Tear","2026-06-12",{"date":581,"type":39},{"date":526,"type":22},{"date":550,"type":22},{"name":45,"class":46},{"id":605,"slug":606,"hasResults":12,"nctId":607,"briefTitle":608,"officialTitle":608,"acronym":4,"eligibilityCriteria":609,"healthyVolunteers":12,"sex":56,"minAge":610,"maxAge":142,"enrollmentInfo":611,"targetDuration":4,"studyType":23,"phases":612,"briefSummary":613,"conditions":614,"keywords":616,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":620,"lastUpdatePostDateStruct":621,"startDateStruct":623,"completionDateStruct":625,"leadSponsor":627,"locationsCount":506},"100599942","effectiveness-of-robot-assisted-structured-foot-ankle-sensorimotor-training-in-stroke-patients-100599942","NCT07091045","Effectiveness of Robot-Assisted Structured Foot-Ankle Sensorimotor Training in Stroke Patients","The inclusion criteria are as follows:\n\n1. Age 40-65 years,\n2. Able to understand and follow study instructions,\n3. Able to communicate coherently and oriented in time and place,\n4. Provided written informed consent,\n5. Stroke ≥6 months prior to enrollment (chronic stroke),\n6. Ankle plantarflexor spasticity ≤2 on the Modified Ashworth Scale,\n7. Ankle dorsiflexor strength ≥ grade 2 on the Medical Research Council (MRC) scale,\n8. Passive ankle dorsiflexion to neutral (90°; 0°) without a plantarflexion contracture,\n9. Moderate or mild lower-extremity impairment based on the Fugl-Meyer Assessment-Lower Extremity (FMA-LE) score (21-27 moderate; 28-34 mild\u002Fgood),\n10. Able to sit for at least 1 hour,\n11. Able to walk at least 10 meters with or without an assistive device,\n12. Completed all conventional lower-extremity physical therapy and rehabilitation programs.\n\nThe exclusion criteria are as follows:\n\n1. Cognitive impairment (Mini-Mental State Test score ≤ 24),\n2. Conditions affecting walking or balance (e.g., orthopedic complications, lower extremity amputation, osteoporosis),\n3. Insufficient visual acuity to view a screen (e.g., diplopia),\n4. Severe visual deficits (e.g., hemianopia) or vestibular disorders34,\n5. Sensory deficits such as hemisensory neglect,\n6. Acute musculoskeletal or cardiovascular disorders,\n7. Intrathecal baclofen pump use or botulinum toxin injections within the past 5 months,\n8. Fixed or painful contracture of the paretic ankle,\n9. Uncontrolled systemic diseases (e.g., diabetes, hypertension, debilitating or immunosuppressive diseases),\n10. history of a non-stroke neurological disease\u002Fdisorder that may impair comprehension of instructions,\n11. Concurrent participation in other lower-extremity physical therapy, robotic rehabilitation, or neurological exercise programs.","40 Years",{"count":561,"type":22},[25],"Introduction: Stroke is a leading cause of long-term disability worldwide. Persistent lower-extremity motor and somatosensory impairments after stroke commonly limit walking and balance despite rehabilitation. Virtual reality (VR)-integrated robotic rehabilitation may support structured, goal-directed ankle-foot practice; however, there is limited evidence for ankle-foot-focused sensorimotor protocols. In particular, approaches that combine robot-assisted motor training with a plantar tactile localization task and VR-supported joint position sense (JPS) training to target plantar sensory and proprioceptive function are scarce. Therefore, this study aims to evaluate the effectiveness of a structured, VR-integrated, robot-assisted ankle-foot sensorimotor rehabilitation protocol in individuals with chronic stroke and to examine its effects on clinical and sensorimotor outcomes.\n\nMethods and analysis: This is an assessor-blinded, two-arm, parallel-group randomized controlled trial. Thirty individuals with chronic stroke will be randomized 1:1 to the Robot-assisted Training Group (RTG) or the Manual Training Group (MTG). All participants will receive conventional rehabilitation; in addition, RTG will receive a structured robot-assisted ankle-foot training program integrated with virtual reality and assist-as-needed control, whereas MTG will receive the same structured ankle-foot training protocol delivered manually by a physiotherapist. Interventions will be delivered three times per week for 6 weeks (18 sessions), and total session duration will be time-matched between groups (50-60 min per session). The primary outcome will be the change in walking speed, derived from the 10-Meter Walk Test, from baseline to 6 weeks. Secondary outcomes will include 2-Minute Walk Test distance, ankle range of motion, joint position sense, plantar tactile sensation, muscle tone, motor performance, static and dynamic balance, and stroke-specific quality of life.",[615],"Stroke",[617,618,619],"stroke","rehabilitation medicine","virtual reality","2026-05-24",{"date":622,"type":39},"2026-05-28",{"date":624,"type":39},"2026-03-01",{"date":626,"type":22},"2027-05-15",{"name":45,"class":46},{"id":629,"slug":630,"hasResults":12,"nctId":631,"briefTitle":632,"officialTitle":633,"acronym":4,"eligibilityCriteria":634,"healthyVolunteers":12,"sex":56,"minAge":18,"maxAge":142,"enrollmentInfo":635,"targetDuration":4,"studyType":23,"phases":636,"briefSummary":637,"conditions":638,"keywords":641,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":643,"lastUpdatePostDateStruct":644,"startDateStruct":646,"completionDateStruct":647,"leadSponsor":649,"locationsCount":47},"100639430","comparison-of-qlb-and-tfp-block-for-postoperative-analgesia-in-laparoscopic-inguinal-hernia-100639430","NCT07604259","Comparison of QLB and TFP Block for Postoperative Analgesia in Laparoscopic Inguinal Hernia","Comparison of the Effects of Ultrasound-Guided Lateral Quadratus Lumborum Block and Transversalis Fascia Plane Block on Postoperative Analgesia in Patients Undergoing Laparoscopic Inguinal Hernia Repair: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Scheduled for elective laparoscopic inguinal hernia repair.\n* American Society of Anesthesiologists (ASA) physical status I, II, or III.\n* Age between 18 and 65 years.\n* Provided written informed consent.\n\nExclusion Criteria:\n\n* History of allergy to local anesthetics.\n* Presence of coagulopathy.\n* Signs of infection at the intended block application site.\n* Body Mass Index (BMI) ≥ 35 kg\u002Fm².\n* History of chronic opioid use.\n* Presence of neurological disease.\n* Refusal to participate in the study.",{"count":116,"type":22},[25],"This randomized controlled trial aims to compare the effects of ultrasound-guided lateral Quadratus Lumborum Block (QLB) and Transversalis Fascia Plane (TFP) block on postoperative analgesia in patients undergoing laparoscopic inguinal hernia repair. Ninety patients will be randomly assigned to one of three groups: Group QLB, Group TFP, or Group Control. The primary objective is to compare postoperative pain scores (NRS) at various time points within the first 24 hours. Secondary objectives include evaluating the need for rescue analgesia, total tramadol consumption, and the incidence of opioid-related side effects.",[639,640],"İnguinal Hernia","Post Operative Pain",[642],"Laparoscopic inguinal hernia, Quadratus Lumborum Block, Transversalis Fascia Plane Block, Postoperative analgesia, Regional anesthesia.","2026-05-18",{"date":645,"type":39},"2026-05-22",{"date":583,"type":22},{"date":648,"type":22},"2027-05-10",{"name":45,"class":46},""]