[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":331},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,46,78,111,142,179,207,237,261,283,303],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100650757","probiotic-research-for-mental-health-in-adult-volunteers-100650757",false,"NCT07751614","Probiotic Research for Mental Health in Adult Volunteers","A Randomized, Placebo-Controlled Pilot Study Evaluating a Probiotic Intervention for Mental Health","Inclusion Criteria:\n\n* 18-30 years of age\n* Native-level Danish language skills\n* No current psychiatric illness, confirmed with the Presence State Examination (PSE) and the Standardized Assessment of Personality (SAPAS)\n* No previous history of severe psychiatric illness, including bipolar disorder, recurrent unipolar depression, psychosis spectrum disorders, personality disorders, autism spectrum disorders, or attention deficit (hyperactivity) disorder (ADHD\u002FADD), confirmed with PSE and SAPAS. Participants may still be included if they have a history of a single depressive episode, or have experienced symptoms of anxiety, stress, or burnout more than 6 months ago.\n\nExclusion Criteria:\n\n* Recent use of probiotics (within the past 4 weeks)\n* Use of antibiotics within the past 3 months\n* Smoking, chewable tobacco, vaping, or use of other nicotine products\n* Neurological disorders (including dementia)\n* Use of psychotropic medication within the previous 6 months, including:\n* Anxiolytics\n* Antidepressants\n* Antipsychotics\n* Anticonvulsants\n* Centrally acting corticosteroids\n* Opioid pain relievers\n* Hypnotics\n* Prescribed sleep medications or herbal sleep aids (e.g., valerian)\n* Dyslexia\n* Severe physical illness, including:\n* Cardiovascular disease\n* Diabetes\n* Gastrointestinal pathology (e.g., colon cancer, colitis, Crohn's disease)\n* Gynecological pathology (e.g., endometriosis)\n* Urologic pathology (e.g., prostate cancer)\n* Severely immunocompromised status, including:\n* HIV positive\n* Being a transplant recipient\n* Use of anti-rejection medication\n* Use of steroids for more than 30 days\n* Chemotherapy or radiotherapy within the last year\n* Current alcohol or substance abuse disorder\n* Previous severe head trauma\n* History of epilepsy\n* Pregnancy or breastfeeding\n* Known allergy to any component of the test product\n* Participation in a clinical study with another investigational product within 60 days before screening, or plans to participate in another study during the study period\n* Significant change in dietary habits within the previous 4 weeks (e.g., starting a fibre-enriched diet)\n* Planned major changes in diet or exercise habits during the study period\n* Current pregnancy",true,"ALL","18 Years","30 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized, double-blind, placebo-controlled pilot study will evaluate the effects of four weeks of supplementation with a probiotic on mental health in healthy adults aged 18-30 years. Participants will be randomized to receive either probiotic or placebo and will complete study assessments at baseline and end of intervention, and will complete a range of behavioral, physiological, and questionnaire-based assessments before and after the intervention. The primary objective is to assess the effect on emotional reactivity measured in a virtual reality scenario at the end of the intervention. This exploratory study is intended to generate data to inform future clinical research.",[28],"Healthy Adult Participants",[30,31,32,33],"Gut microbiome","Mental well-being","Probiotic","Healthy adults","NOT_YET_RECRUITING","2026-08-05",{"date":37,"type":38},"2026-08-07","ACTUAL",{"date":40,"type":22},"2026-09-01",{"date":42,"type":22},"2027-03-31",{"name":44,"class":45},"Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":57,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},"100648154","topus---testing-an-implemented-intervention-to-reduce-duration-of-untreated-psychosis-100648154","NCT07716969","TOPUS - Testing an Implemented Intervention to Reduce Duration of Untreated Psychosis","Duration of Untreated Psychosis Revisited - Testing the Effect of Early Detection Services on the Duration of Untreated Psychosis. the TOPUS Study","TOPUS","Inclusion Criteria:\n\n18 or older In treatement in an OPUS treatment center in The Capital Region or Region Zealand.\n\nStarted OPUS treatment within the last 9 months Suspected to have a psychotic disorder within the ICD 10 Schizophrenia spectrum (DF2X, excluding schizotypal disorder and schizophrenia simplex) Able to communicate adequately regarding symptoms and functioning in Danish or English.\n\n\\-\n\nExclusion Criteria:\n\n* IQ bellow 70 I primary diagnoses of drug or alcohol dependency","35 Years",{"count":56,"type":22},250,"18 Months","OBSERVATIONAL","This study examines whether an early-detection program for psychosis can shorten the time patients remain untreated after the first appearance of psychotic symptoms, and whether such a reduction improves later functioning for people with first-episode schizophrenia.\n\nPsychosis involves symptoms such as hallucinations and delusions. When these symptoms are recognized and treatment begins, most patients improve. However, many individuals live with psychotic symptoms for months-or even longer-before receiving care. This period is known as the duration of untreated psychosis (DUP). A long DUP has repeatedly been linked to poorer long-term outcomes, but it is still unclear whether DUP itself causes worse outcomes or simply reflects different illness courses.\n\nIn Denmark, Region Zealand has implemented a large-scale early-detection effort. This includes public awareness campaigns and a specialized team that identifies people with emerging psychosis and helps them start treatment quickly. The Capital Region of Denmark provides usual care without these additional initiatives. This situation makes it possible to compare two regional systems that differ in their approach to early detection but provide the same specialized treatment once patients enter care.\n\nThe study follows a quasi-experimental design, recruiting adults (18+) who receive a first diagnosis of a schizophrenia-spectrum disorder within the OPUS early-intervention programs in the two regions. No interventions are assigned by the research team; participants receive standard clinical care. Researchers conduct interviews to establish how long psychotic symptoms were present before treatment began and to assess functioning and symptoms over a two-year follow-up period. Functioning, symptoms, cognition, and treatment factors will be examined at baseline and at follow-ups.\n\nThe study addresses three questions:\n\nWhether early-detection efforts in Region Zealand reduce the duration of untreated psychosis compared with usual detection.\n\nWhether a shorter duration of untreated psychosis leads to better functional and clinical outcomes fifteen months after treatment begins.\n\nHow DUP can best be defined and measured so that it reliably predicts later outcomes.\n\nResults may provide evidence for whether early-detection services improve timely access to care and whether reducing the duration of untreated psychosis contributes to better long-term functioning. The study may also help establish clearer international standards for how DUP should be measured in both research and clinical practice.",[61,62,63],"Psychosis","Schizo Affective Disorder","SCHIZOPHRENIA 1 (Disorder)",[65,66,61,67],"Duration of Untreated Psychosis","Early Detection","Schizophrenia","RECRUITING","2026-07-16",{"date":71,"type":38},"2026-07-21",{"date":73,"type":38},"2024-03-01",{"date":75,"type":22},"2028-07-31",{"name":44,"class":45},2,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},"100624011","epigenetic-enhancement-of-cognitive-training-in-aging-mood-disorder-populations-100624011","NCT07404085","Epigenetic Enhancement of Cognitive Training in Aging Mood Disorder Populations","Epigenetic Priming to Enhance Cognitive Training Gains and Neuroplasticity in Middle-age and Older Adults With Past Depression or Bipolar Disorder (EPIC)","EPIC","Inclusion Criteria:\n\n* Confirmed ICD-10 diagnosis of BD or recurrent UD in partial, or full remission (Hamilton Depression Rating Scale-17 items and Young Mania Rating Scale scores ≤14)\n* Subjective cognitive complaints (self-reported: COBRA ≥12) or objectively-verified cognitive impairment (measured using Screening for Cognitive Impairment in Psychiatry SCIP: total score or at least two subscores ≥ 0.5 SD below expected norms)\n* Fluency in Danish language\n\nExclusion Criteria:\n\n* Diagnosis of schizophrenia\n* Neurological disorders (including dementia)\n* Dyslexia\n* Severe Physical illness\n* Kidney disease\n* Cardiovascular disease\n* Diabetes\n* Alcohol or substance abuse\n* Previous severe head trauma\n* History of epilepsy\n* Pregnancy or breastfeeding\n* BMI \\>30\n* Bodyweight \\\u003C 45kg\n* Daily use of benzodiazepines \\> 22.5 mg. oxazepam or \\> 7.5 mg. diazepam per day\n* Serum lithium levels \\> 0.8 mmol\u002FL\n* Received electroconvulsive therapy \\\u003C 2 months prior to participation\n* Hypertension (\\>140 systolic or \\> 90 diastolic mm Hg)","40 Years","75 Years",{"count":89,"type":22},160,[25],"The aim of this clinical trial is to investigate the effects of a three-week virtual reality-based cognitive remediation training (VR-CRT) programme in combination with daily intake of a histone deacetylase inhibitor (HDACi) sodium butyrate on cognition in symptomatically stable patients with mood disorders (depression or bipolar disorder).\n\nThe investigators hypothesize that the VR-based cognitive remediation training (VR-CRT) combined with HDACi butyrate vs. a VR-based control treatment combined with placebo will improve global cognition (primary outcome measure) over three weeks.\n\nSecondly, the investigators hypothesize that VR-CRT with placebo will improve cognition relative to the VR control treatment with placebo, although to a lesser extent than VR-CRT with HDACi butyrate.\n\nThirdly, the investigators hypothesize that the HDACi butyrate with VR control treatment will not produce cognitive improvements relative to placebo with VR control treatment.\n\nFinally, the investigators hypothesize that the combined treatment (VR-CRT + HDACi butyrate) will enhance neuroplasticity (exploratory outcome) vs. VR control with placebo, as indicated by increase in hippocampal volume and\u002For memory-related activity shown with structural and functional MRI.",[93,94,95],"Bipolar Disorder (BD)","Depression - Major Depressive Disorder","Cognitive Impairment",[97,98,99,100,101],"Cognition","Cognitive impairment","Mood disorders","Cognitive decline","Neuroplasticity","2026-02-04",{"date":104,"type":38},"2026-02-11",{"date":106,"type":38},"2025-11-14",{"date":108,"type":22},"2028-07-01",{"name":44,"class":45},1,{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":122,"conditions":123,"keywords":128,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":110},"100516483","a-randomized-clinical-trial-comparing-active-versus-sham-t-pemf-headband-treatment-for-depression-100516483","NCT06005103","A Randomized Clinical Trial Comparing Active Versus Sham T-PEMF Headband Treatment for Depression","Active Versus Sham Transcranial Pulsed Electromagnetic Field Headband Treatment for Major Depression: a Study Protocol for a Double-blinded Randomized Trial","Inclusion Criteria:\n\n* Meeting the diagnostic criteria for moderate to severe depressive episode without psychotic symptoms according to the International Classification of Diseases and Related Health Problems 10th Revision (ICD-10)(The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research 1993).\n* Female participants: Females in the fertile age must deliver a negative pregnancy test, or previously have been sterilized.\n* Female fertile participants: They must use safe contraceptive methods to be included in the study, and during the whole study.\n* Has given written, informed consent to the trial.\n\nExclusion Criteria:\n\n* Inability to speak or understand the Danish language.\n* A current high risk of suicide (a score of 2 or more on the HAM-D-17 item 3).\n* A co-morbid substance dependence.\n* Bipolar affective disorder.\n* Psychotic illness.\n* Dementia.\n* Other diagnoses of organic brain disease.\n* The participant has any kind of implant, e.g. pacemakers or cochlear implants.\n* Female participants: Pregnancy","65 Years",{"count":120,"type":22},117,[25],"An 8-week, two-armed, randomized-controlled trial that examines the antidepressant effect of treatment with transcranial pulsed electromagnetic fields (T-PEMF) in patients diagnosed with moderate to severe depression using using a new device, the MoodHeadBand (MHB).\n\nThe participants will use an active or placebo MHB for 30 minutes daily for 8 weeks.\n\nAdditionally, the following research questions will be answered:\n\n1\\. If there is a positive effect on the patients' emotional and non-emotional cognition after 8 weeks of active treatment compared to the sham group and if possible early changes in the emotional cognition can predict the treatment response after 8 weeks of treatment.\n\n1\\. If the T-PEMF treatment provides improvement in restorative sleep after 8 weeks of treatment",[124,125,126,127],"Moderate Depression","Severe Depressive Episode Without Psychotic Symptoms","Recurrent Depressive Disorder, Current Episode Moderate","Recurrent Depressive Disorder, Current Episode Severe Without Psychotic Symptoms",[129,130,131,132,97,133],"Randomized Controlled Trial","Depression","Transcranial Pulsed Electro-Magnetic Fields (T-PEMF)","Psychiatry","Sleep","2025-08-19",{"date":136,"type":38},"2025-08-26",{"date":138,"type":38},"2024-06-17",{"date":140,"type":22},"2026-08-30",{"name":44,"class":45},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":152,"briefSummary":153,"conditions":154,"keywords":164,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":77},"100540305","a-transdiagnostic-mentalization-based-intervention-for-parents-with-mental-disorders-100540305","NCT06315114","A Transdiagnostic Mentalization-based Intervention for Parents With Mental Disorders","A Transdiagnostic Mentalization-based Intervention (LIGHTHOUSE Parenting Program) Versus Care as Usual for Parents With Mental Disorders in Adult Mental Health Service: a Randomised Clinical Trial","LIGHTHOUSE","Inclusion Criteria exclusive to the Outpatient Clinic\n\n* Age \\>18 years\n* Seeking treatment for one of the following non-psychotic disorders according to ICD-10: obsessive-compulsive disorder and anxiety disorders (F40-42), posttraumatic stress disorder (DF43), personality disorders (F60-61), or one of the previous disorders and a drug-or alcohol related disorder (F10-19) (i.e. 'dual diagnosis disorder')\n\nInclusion Criteria exclusive to the trial:\n\n* Parent of at least one child aged 0-17 years of age at baseline\n* Fluent i.e., sufficient Danish language skills\n* Parent is living with child or is in regular contact (min. 5 days monthly)\n* Written informed consent\n\nExclusion Criteria exclusive to the Outpatient Clinic:\n\n* Possibility of a learning disability (IQ\\\u003C75)\n* A diagnosis of schizotypal personality disorder or antisocial personality disorder\n* Presence of a comorbid psychiatric disorder that requires specialist treatment elsewhere\n* Concurrent psychotherapeutic treatment outside the clinic\n\nExclusion Criteria exclusive to the trial:\n\n* Acute suicidal risk or state of crises\n* Lack of informed consent\n* Acute child endangerment\n* Participation in another parenting focused intervention simultaniously",{"count":151,"type":22},170,[25],"The aim of this randomised clinical trial is to evaluate the short and longterm effects of a transdiagnostic mentalization-based intervention (Lighthouse MBT Parenting Program) compared to care as usal (CAU) for parents with a mental disorder in adult mental health service.",[155,156,157,158,159,160,161,162,163],"Mental Disorder","Behavior Disorders","Diagnosis, Psychiatric","Diagnosis Dual","Severe Mental Disorder","Mental Illness","Psychiatric Disorder","Psychiatric Disease","Psychiatric Illness",[165,166,167,168,169,170],"Mental disorder","Parent","Child","Preventive intervention","Prevention","Intergenerational transmission","2025-05-09",{"date":173,"type":38},"2025-05-14",{"date":175,"type":38},"2024-03-11",{"date":177,"type":22},"2028-04-01",{"name":44,"class":45},{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":17,"minAge":185,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":23,"phases":189,"briefSummary":190,"conditions":191,"keywords":193,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":206},"100453064","teens-multi-site-trial-100453064","NCT05179655","TEENS Multi-site Trial","Inclusion Criteria:\n\n* ≥ 5 non-suicidal self-injury episodes in the past year and ≥ 1 non-suicidal self-injury episodes in the past month assessed by the Deliberate Self-Harm Inventory, Youth version (DSHI-Y).\n* Age-appropriate literacy assessed by referring clinicians and the self-injury team, i.e. age between 13 and 17.\n* Having at least one parent committing to participate in the parent program.\n* Informed consent from parents\u002Flegal caretakers and assent from participants above 15 years of age.\n\nExclusion Criteria:\n\n* Imminent suicidal risk assessed by clinicians during routine screening procedure (that can be rated as no risk, elevated risk, or imminent risk) in need of admission or other life saving strategies.\n* Lack of informed consent from parents\u002Flegal caretakers.\n* Lack of informed assent from the participant above 15 years of age.","13 Years","17 Years",{"count":188,"type":22},356,[25],"Emotion Regulation Individual Therapy for Adolescents, also called ERITA, is a youth friendly online therapy aiming to provide skills and train emotion regulation.\n\nThe aim of the TEENS Multi-site Trial is to investigate the effect of ERITA, including an app, as add-on to treatment as usual in young patients referred to Mental Health Services. We expect 356 families to participate from three designated Regions in Denmark.",[192],"Self-Injurious Behavior",[194,195,196,197],"Internet-based intervention","Online therapy","Emotion regulation","ERITA","2025-03-07",{"date":200,"type":38},"2025-03-10",{"date":202,"type":38},"2022-02-01",{"date":204,"type":22},"2026-12-31",{"name":44,"class":45},4,{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":11,"sex":17,"minAge":214,"maxAge":186,"enrollmentInfo":215,"targetDuration":4,"studyType":23,"phases":217,"briefSummary":218,"conditions":219,"keywords":223,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":110},"100540097","the-via-family-20---a-family-based-intervention-for-families-with-parental-mental-illness-100540097","NCT06312410","The VIA Family 2.0 - a Family Based Intervention for Families with Parental Mental Illness","The VIA Family 2.0 Study: a Randomized Clinical Trial Evaluating Family-based Interventions for Children Born to Parents with Mental Disorders","Inclusion Criteria:\n\n* At least one of the parents must be living in Capital Region or in Region North, Denmark, and at least one biological child under age 18 must be living with one of the parents. Only biological children of the parent with at mental health problem can be included.\n* The parent with the mental health problems has at some point been diagnosed in the secondary sector and has within the last three years been treated in the primary sector (GP or private psychiatric clinic) or in the secondary sector (hospital psychiatry).\n* Patients with substance abuse can only be included if substance abuse is a secondary diagnosis to another mental illness disorder being treated within the secondary sector during the last three years.\n* All adult participants must give informed consent. Both parents will need to consent in case of shared custody, but do not have to participate if they are reluctant to do so.\n\nExclusion Criteria:\n\n* Not fulfilling inclusion criteria\n* Not giving informed consent\n* Living at Læsø or at Bornholm, Denmark\n* Children placed in care outside of the home fulltime in institution of professional family care (the family is not excluded if the children placed in part time in care outside home or fulltime family care within the family)\n* No risk factors found after baseline assessment (as described in the stepped care model) at baseline - these families can be re-referred if their situation changes.\n* Ongoing intensive family treatment in the municipality (for example staying at an institution for parental evaluation by the authorities)?","0 Years",{"count":216,"type":22},1452,[25],"VIA Family 2.0 - a Family Based Intervention for families with parental mental illness\n\nBackground: Children born to parents with mental illness have consistently been shown to have increased risks for a range of negative life outcomes including increased frequencies of mental disorders, somatic disorders, poorer cognitive functioning, social, emotional and behavioral problems and lower quality of life. Further these children are often overlooked by both society and mental health services, although they represent a potential for prevention and early intervention.\n\nA collaboration between researchers and clinicians from two regions, the Capital Region and the North Region Denmark has been established as the Research Center for Family Based Interventions. The research center is an umbrella for a series of research activities, all focusing on children and adolescents in families with parental mental illness.\n\nMethod: A large randomized, controlled trial (RCT) for families with parental mental illness will be conducted in order to evaluate the effect of a two-year multidisciplinary, holistic team intervention (the VIA Family 2.0 team intervention) against treatment as usual (TAU). Inclusion criteria will be biological children 0-17 of parents with any mental disorder treated in the secondary sector at any time of their life and receiving treatment in primary or secondary sector within the previous three years. A total of 870 children or approx. 600 families will be included from two sites. Primary outcomes will be changes in child well being, parental stress, family functioning and quality of the home environment, .\n\nTime plan: The RCT will start including families from March 1st, 2024 to Dec 2025 (or later if needed). All families will be assessed at baseline and at end of treatment, i.e. after 24 months and after 36 months. Baseline data will inform the intervention team about each family's needs, problems, and motivation. TAU will be similar in the two regions, which means three family meetings and option for children to participate in peer groups.\n\nChallenges: final funding is being applied for. Recruitment of families can be challenging but we have decades of experience in conducting research in the field. Since both the target group, their potential problems and the intervention is complex, primary outcome is difficult to determine.",[167,220,155,221,222],"Parents","Child of Impaired Parents","Preventive Health Services",[224,225,226,227,228],"family based intervention","early intervention","familial high risk","COPMI - children of parents with mental illness","parental mental illness","2024-10-23",{"date":231,"type":38},"2024-10-26",{"date":233,"type":38},"2024-03-18",{"date":235,"type":22},"2028-12-31",{"name":44,"class":45},{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":17,"minAge":245,"maxAge":186,"enrollmentInfo":246,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":248,"conditions":249,"keywords":251,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":110},"100512739","effectiveness-of-family-based-intervention-for-youn-persons-with-eating-disorders-100512739","NCT05956366","Effectiveness of Family-based Intervention for Youn Persons With Eating Disorders","Effectiveness of Family-based Intervention in a Child and Adolescent Mental Health Service for Children and Adolescents With Eating Disorders","VIBUS-wp1","Inclusion Criteria:\n\n* begin treatment for eating disorder\n\nExclusion Criteria:\n\n* lack of informed consent","7 Years",{"count":247,"type":22},1000,"This research project aims to characterize a naturalistic cohort of children and adolescents with eating disorders in terms of biological, psychological and psychopathological features. Further, the project will examine the effectiveness of treatment, the determinants of treatment outcome and the course of treatment response for children and adolescents with eating disorders (ED), treated in a generic specialist child and adolescent mental health service. The first choice of treatment is outpatient family-based treatment (FBT), which has documented effect for anorexia nervosa and bulimia nervosa. However, a subgroup of young persons with eating disorders does not respond sufficiently to this treatment, and evidence concerning effective treatment for children and adolescents with atypical eating disorders is still lacking. Further, treatment effectiveness for children and adolescents in a Danish naturalistic setting has never been examined.",[250],"Eating Disorders",[252],"eating disorders, adolescents","2024-04-02",{"date":255,"type":38},"2024-04-03",{"date":257,"type":38},"2018-04-01",{"date":259,"type":22},"2037-12-31",{"name":44,"class":45},{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":267,"eligibilityCriteria":268,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":269,"enrollmentInfo":270,"targetDuration":4,"studyType":23,"phases":271,"briefSummary":272,"conditions":273,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":110},"100504716","rufus---group-rumination-focused-cbt-for-negative-symptoms-100504716","NCT05851950","RUFUS - Group Rumination-focused CBT for Negative Symptoms","RUFUS - a Randomized Mixed Methods Pilot Clinical Trial Investigating the Relevance and Feasibility of Rumination-focused Cognitive Behavioral Therapy in the Treatment of Patients With Emergent Psychosis Spectrum Disorder","RUFUS","Inclusion Criteria:\n\n1. Diagnosed with a psychosis spectrum disorder (ICD-10 F2x)\n2. At least 8 months left of their OPUS treatment\n3. The presence of rumination behavior as assessed by a score of minimum 30 on the Perseverative Thinking Questionnaire (PTQ)\n4. Danish-speaking\n\nExclusion Criteria:\n\n1. Substance abuse or positive symptoms that make participation in therapy difficult\n2. Severe suicidal thoughts\u002Fbehavior\n3. Lacks capacity to consent\n4. Mild, moderate, or severe intellectual disability (IQ ˂ 70)\n5. Planned adjustment of antidepressant and\u002For antipsychotic treatment (noted in the patient's medical record)","37 Years",{"count":21,"type":22},[25],"Abstract - --\n\nIntroduction:\n\nPsychosis spectrum disorders are characterized by both positive and negative symptoms, but whereas there is good effect of treatment on positive symptoms, there is still a scarcity of effective interventions aimed at reducing negative symptoms. Rumination has been proposed as an important and fundamental factor in the development and maintenance of symptoms across psychiatric diagnoses, and there is a need to develop effective interventions targeting rumination behaviors and negative symptoms in patients with psychotic disorders. The aim of the current study is to investigate the feasibility and acceptability of group rumination-focused cognitive behavioral therapy (RFCBT) in the treatment of young people with psychosis spectrum disorders as well as investigating potential indications of treatment efficacy.\n\nMethods and analysis: The study is a mixed-method clinical randomized controlled pilot trial with a target sample of 60 patients, who are randomized to either receive 13 weeks of group CFCBT or 13 weeks of treatment as usual (TAU). All patients are examined at the start of the project and at the 13-week follow-up. The researcher will compare changes in outcomes from baseline to posttreatment between group CFCBT and TAU. In addition, qualitative analyzes are carried out to explore feasibility and acceptability and to uncover the patients' experience of receiving the intervention.",[274],"Psychotic Disorders","2023-10-20",{"date":277,"type":38},"2023-10-23",{"date":279,"type":38},"2023-08-01",{"date":281,"type":22},"2026-07-01",{"name":44,"class":45},{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":23,"phases":292,"briefSummary":293,"conditions":294,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":302,"locationsCount":110},"100380194","effects-of-smartphone-based-treatment-for-bipolar-disorder---the-smart-bipolar-100380194","NCT04230421","Effects of Smartphone-based Treatment for Bipolar Disorder - the Smart Bipolar","Effects of Smartphone-based Treatment for Bipolar Disorder - the Smart Bipolar RCT","Inclusion Criteria:\n\n* All patients in CAG Bipolar, i.e., with a main diagnosis of bipolar disorder in the five large centers, in the Mental Health Services, Capital Region of Denmark (Psychiatric Center Copenhagen, Psychiatric Center Hilleroed, Psychiatric Center Amager, Psychiatric Center Glostrup and Psychiatric Center Ballerup)\n\nExclusion Criteria:\n\n* None",{"count":291,"type":22},200,[25],"The Smart Bipolar RCT is a pragmatic RCT aiming to investigate effects of smartphone-based add on treatment in large scale clinical practice (N= 200 patients).",[295],"Bipolar Disorder","2023-06-06",{"date":298,"type":38},"2023-06-07",{"date":300,"type":38},"2021-03-01",{"date":281,"type":22},{"name":44,"class":45},{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":307,"acronym":308,"eligibilityCriteria":309,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":310,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":311,"conditions":312,"keywords":317,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":110},"100302971","prospective-longitudinal-all-comer-inclusion-study-in-eating-disorders-100302971","NCT03224091","PROspective Longitudinal All-comer Inclusion Study in Eating Disorders","PROLED","Inclusion Criteria:\n\n* Eating Disorder (ICD-10)\n\nExclusion Criteria:\n\n* Forced care\u002Fnon-voluntary",{"count":247,"type":22},"The PROLED study is a prospective and longitudinal study of patients with Eating Disorders. Annual interviews and collection of biological samples are done, as well as during changes in disease course e.g. during hospitalization. Included are qualitative interviews, psychometric tests, questionnaires which are used to collect data on psychopathology. There is also collection of blood, urine and faeces.",[313,314,315,316],"Anorexia Nervosa","Bulimia Nervosa","Binge-Eating Disorder","Eating Disorder NOS",[318,319,320,321,322],"Eating disorders","psychopathology","pathophysiology","prospective","longitudinal","2022-04-06",{"date":325,"type":38},"2022-04-07",{"date":327,"type":38},"2016-01-25",{"date":329,"type":22},"2030-04-01",{"name":44,"class":45},""]