[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Min Hou\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100650527","cognitive-effects-of-hesperidin-in-overweightobese-older-adults-100650527",false,"NCT07750223","Cognitive Effects of Hesperidin in Overweight\u002FObese Older Adults","A Randomized Controlled Trial of Hesperidin for Improving Cognitive Function in Overweight and Obese Middle-Aged and Older Adults","Inclusion Criteria:\n\n* Age 55-75 years\n* BMI ≥ 24 kg\u002Fm² or waist circumference ≥ 90 cm (men) \u002F ≥ 85 cm (women)\n* Willing to participate and sign informed consent\n\nExclusion Criteria:\n\n* MMSE score \\\u003C 20\n* History of neurological diseases (Parkinson's, Alzheimer's, stroke, etc.)\n* Malignant tumors, severe liver\u002Fkidney\u002Fgastrointestinal diseases\n* Use of weight-loss drugs or antidepressants (except statins) within recent months\n* Strict vegetarians, binge eating disorder, heavy alcohol consumption\n* Participation in other intervention studies\n* Other conditions judged by investigators as unsuitable","ALL","55 Years","75 Years",{"count":20,"type":21},105,"ESTIMATED","INTERVENTIONAL",[24],"NA","A randomized, double-blind, placebo-controlled trial was designed to test whether two doses of hesperidin (a natural flavonoid from citrus fruits) improve cognitive function in overweight and obese older adults.\n\nA total of 105 participants, aged 55-75 years with a BMI ≥24 kg\u002Fm² or elevated waist circumference, will be randomly assigned to one of three 10-week treatments: placebo, low-dose hesperidin (300 mg\u002Fday), or high-dose hesperidin (600 mg\u002Fday).\n\nThe primary aim is to see if hesperidin supplementation enhances cognitive performance - specifically executive function, memory, and attention - and to explore any dose-response relationship.\n\nSecondary aims include examining changes in gut microbiota composition and related metabolites, as well as exploring potential mechanisms behind any observed effects.\n\nThe findings are expected to provide scientific evidence on whether hesperidin could serve as a nutritional strategy to support cognitive health in this population.",[27,28],"Cognitive Dysfunction","Overweight and Obesity",[30,31,32,33,34,35,36],"Hesperidin","Cognitive Function","Citrus Flavonoids","Gut Microbiota","Nutritional Intervention","Middle-aged and Elderly","Randomized Controlled Trial","RECRUITING","2026-08-01",{"date":40,"type":41},"2026-08-06","ACTUAL",{"date":43,"type":41},"2026-02-01",{"date":45,"type":21},"2027-03-30",{"name":47,"class":48},"Min Hou","OTHER",""]