[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Muhammad Zubair Shoukat\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":91},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,59],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100647829","oral-antibiotics-vs-no-antibiotics-in-pediatric-colorectal-surgery-100647829",false,"NCT07713433","Oral Antibiotics vs. No Antibiotics in Pediatric Colorectal Surgery","Comparison of Outcomes of Pre-operative Oral Antibiotics vs no Antibiotics in Elective Colorectal Surgeries in Children","PEACO","Inclusion Criteria:\n\nChildren with colostomy planned for colostomy closure or pull through procedure for conditions including\n\n1. Anorectal malformation\n2. Hirschsprung's Disease\n3. Perianal Infections\n4. Perineal Trauma\n5. Any other condition requiring diversion colostomy\n\nExclusion Criteria:\n\n1. Children with small bowel stomas\n2. poor general condition (Malnutrition, immunodeficiency)\n3. Previous attempt at repair of colostomy (Reversal\u002FPull through)","ALL","1 Year","15 Years",{"count":21,"type":22},74,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to evaluate whether giving oral antibiotics before elective colorectal surgery can improve recovery and reduce complications in children.\n\nColorectal surgery is commonly performed in children for conditions such as Hirschsprung disease, anorectal malformations, and other bowel disorders. Because the large intestine normally contains many bacteria, these operations carry a higher risk of infection and other postoperative complications. Some surgeons prescribe oral antibiotics before surgery to reduce the number of bacteria in the bowel, while others do not use this approach routinely.\n\nIn this study, children scheduled for elective colorectal surgery will be randomly assigned to one of two groups. One group will receive oral antibiotics before surgery, while the other group will receive standard preparation without oral antibiotics. All children will otherwise receive the same surgical and postoperative care according to hospital guidelines.\n\nResearchers will compare the two groups for important outcomes including surgical site infection, leakage from the bowel connection (anastomotic leak), and length of hospital stay. Additional information regarding recovery and postoperative complications will also be collected.\n\nParticipation in the study will not affect the quality of treatment provided. Parents or guardians may withdraw their child from the study at any time without affecting routine medical care. The results of this research may help determine whether preoperative oral antibiotics should be routinely used in children undergoing elective colorectal surgery and may contribute to improving surgical outcomes and reducing healthcare costs.",[28,29],"Bowel Cleansing Prior to Clinical Procedures","Colorectal Anastomosis",[31,32,33,34,35,36,37,38,39,40,41,42,43,44,45],"pediatric","colorectal","colostomy","duhamel","closure","hirschprung's disease","anorectal malformation","soave pull through","swenson","abdomino-perineal pull through","perineal injury","perineal wounds","ARM","Bowel preparation","oral antibiotics","RECRUITING","2026-07-16",{"date":49,"type":50},"2026-07-20","ACTUAL",{"date":52,"type":50},"2025-01-06",{"date":54,"type":22},"2026-08",{"name":56,"class":57},"Muhammad Zubair Shoukat","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":4,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":17,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":23,"phases":70,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":90,"locationsCount":58},"100647369","eras-in-choledochal-cyst--biliary-atresia-100647369","NCT07709702","ERAS in Choledochal Cyst & Biliary Atresia","Early Oral Feeding Versus Conventional Feeding After Surgery for Biliary Atresia and Choledochal Cyst: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. All children diagnosed with choledochal cyst type I and IV on MRCP or CT scan, undergoing elective Roux-En-Y hepaticojejunostomy\n2. All children with provisional diagnosis of biliary atresia undergoing Roux-En-Y portoenterostomy\n\nExclusion Criteria:\n\n1. Patients with suspected biliary atresia not undergoing portoenterostomy after Per-op cholangiogram either due to ruling out of disease or advanced disease deemed candidates for liver transplant\n2. patients with history of Emergency surgery or external drainage of choledochal cyst\n3. Hemodynamically unstable patients after surgery\n4. Previous history of GI surgery","1 Month","14 Years",{"count":69,"type":22},100,[25],"This study aims to compare two feeding approaches after surgery for biliary atresia and choledochal cyst in children.\n\nTraditionally, children are kept without oral feeding for more than 48 hours after these operations until bowel activity returns. However, newer Enhanced Recovery After Surgery (ERAS) programs suggest that starting feeding earlier may help children recover faster.\n\nIn this study, children undergoing surgery for biliary atresia or choledochal cyst will be randomly assigned to one of two groups. One group will start oral liquids within 24 hours after surgery and gradually progress to normal feeding as tolerated (early feeding group). The other group will receive conventional care, where feeding is started after more than 48 hours once bowel activity has returned.\n\nResearchers will compare both groups for postoperative complications such as wound infection and anastomotic leakage, as well as the duration of hospital stay. Additional observations will include vomiting, abdominal distension, need for reinsertion of a nasogastric tube, requirement for repeat surgery, and time taken to resume normal feeding.\n\nParticipation in the study will not affect the standard surgical treatment provided. All children will receive routine perioperative care and will be monitored closely throughout their hospital stay and follow-up visits. The findings of this study may help determine whether early oral feeding is a safe and effective strategy to improve recovery and reduce hospitalization after pediatric hepatobiliary surgery.",[73,74],"Choledochal Cyst Resection","Biliary Atresia, Kasai Portoenterostomy Status",[76,77,78,79,80,81,82,83,84],"ERAS","Choledochal Cyst","Pediatric","Children","Post-Operative Management","Biliary Atresia","Feeding Protocol","Fast-Tract Discharge","Hospital Stay","2026-07-13",{"date":47,"type":50},{"date":88,"type":50},"2024-07-27",{"date":54,"type":22},{"name":56,"class":57},""]