[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Nardin Aymn Boshra\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100657248","driving-pressure-optimization-rv-pa-coupling-and-aki-in-mechanically-ventilated-critically-ill-patients-100657248",false,"NCT07836387","Driving Pressure Optimization, RV-PA Coupling, and AKI in Mechanically Ventilated Critically Ill Patients","Effect of Driving Pressure Optimization on RV-PA Coupling (TAPSE\u002FPASP Ratio) and Acute Kidney Injury Progression in Mechanically Ventilated Critically Ill Patients","Inclusion Criteria:\n\n* Age ≥18 years.\n* ICU admission.\n* Invasive mechanical ventilation expected to continue for ≥48 hours.\n* Adequate transthoracic echocardiographic acoustic window for assessment of TAPSE\u002FPASP.\n\nExclusion Criteria:\n\n* Pre-existing end-stage renal disease on chronic dialysis.\n* Severe pulmonic or tricuspid valve disease precluding reliable TAPSE\u002FPASP assessment.\n* Pre-existing RV dysfunction of a non-pulmonary cause.\n* Pregnancy.\n* Patients expected to die within 24 hours.\n* Technically inadequate echocardiographic window.\n* Clinical contraindication to the proposed ventilation strategy.","ALL","18 Years",{"count":19,"type":20},90,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study evaluates the effect of driving pressure optimization on right ventricular-pulmonary artery (RV-PA) coupling, assessed by TAPSE\u002FPASP ratio, and its association with acute kidney injury (AKI) progression in mechanically ventilated critically ill patients.",[26,27,28,29],"Acute Kidney Failure","Mechanical Ventilation Strategies","Right Ventricular (RV) Dysfunction","Critical Illness",[31,32,33,34,35,36],"Driving Pressure","RV-PA Coupling","TAPSE\u002FPASP Ratio","Mechanical ventilation","Acute Kidney Injury","KDIGO","NOT_YET_RECRUITING","2026-09-22",{"date":40,"type":41},"2026-09-23","ACTUAL",{"date":43,"type":20},"2026-10-01",{"date":45,"type":20},"2028-04-01",{"name":47,"class":48},"Nardin Aymn Boshra","OTHER",""]