[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"National Institute for Communicable Diseases, South Africa\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100659065","mucosal-and-systemic-immunity-correlates-of-protection-against-influenza-in-young-children-aged-2-5-years-music-flu-100659065",false,"NCT07861854","Mucosal and Systemic Immunity Correlates of Protection Against Influenza in Young Children, Aged 2-5 Years (MUSIC-Flu)","Mucosal and Systemic Immunity Correlates of Protection Against Influenza in Young Children (MUSIC-Flu)","MUSIC-Flu","Inclusion Criteria:\n\n* Children aged 2-5 years of age (i.e. from the second birthday until 5 years and 11 months of age) at the time of enrolment.\n\n  * Healthy children as established by medical history and clinical examination before entering the study.\n  * Parent availability and willingness to provide written informed consent to all study procedures\n  * Child planning to reside in the selected community for the duration of the study.\n\nExclusion Criteria:\n\n* Presence of malnutrition (defined as z score for age \\\u003C-2 based on WHO child grown standard at time of screening for eligibility).\n\n  * Presence of any serious systemic disorder determined by medical history and\u002For physical examination that would compromise the participant's health or is likely to result in non-conformance to the protocol or a child who is on treatment for any chronic medical condition.\n  * Prior history of receiving influenza vaccination.\n  * Not providing consent for storage and shipment of samples for immunological testing.\n  * Parent of participating child not able, available or willing to accept active weekly follow-up by the study staff, performing a twice-weekly caregiver swab and completing symptom diary on an electronic device or any medical condition in the parents that, in the judgment of the investigator, would interfere with or serves as a contraindication to protocol adherence or a parent's ability to give informed consent. History of chronic administration (defined as more than 14 days) of immunosuppressant medications, including corticosteroids, in the last 6 months (those on inhaled or topical steroids may be permitted to participate in the study.\n  * Child is HIV-infected as identified by self-report or if screening of study eligibility identifies that the child is HIV-infected.",true,"ALL","2 Years","5 Years",{"count":22,"type":23},150,"ESTIMATED","OBSERVATIONAL","Title: Mucosal and systemic immunity correlates of protection against influenza in young children (MUSIC-Flu). The goal of this observational study is to better understand how immune responses in the blood and mucosa are linked to protection against influenza infection and illness in young children. We will compare immune responses in children who get influenza infection to those who do not.\n\nChildren aged 2-5 years of age will be followed from April through October 2026 during the influenza season in South Africa. During this time, nasal swabs will be collected three times per week to test for influenza and other respiratory viruses. Information on symptoms and temperature will be collected by nurses at weekly visits and daily by caregivers using an electronic symptom diary.\n\nBlood samples will be collected before and after the influenza season, and at two additional time points during the study. Special immune cells will also be collected from blood samples before and after the season. In addition, samples from the nose and mouth will be collected every month. These samples will be tested to measure immune responses, including antibodies, signaling proteins (cytokines), and specific immune cells (T cells and B cells).",[27,28],"Influenza -Like Illness","Influenza (Healthy Volunteers)",[30,31],"influenza, correlates of protection, infection","correlates of protection","RECRUITING","2026-10-02",{"date":35,"type":36},"2026-10-06","ACTUAL",{"date":38,"type":36},"2026-03-12",{"date":40,"type":23},"2026-10-31",{"name":42,"class":43},"National Institute for Communicable Diseases, South Africa","OTHER",""]