[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"New Hope Fertility Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":59},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":5},"100658945","intra-ovarian-capa-ivm-vs-standard-ivm-100658945",false,"NCT07858435","Intra-ovarian CAPA-IVM vs Standard IVM","A Within-Patient Comparison of CAPA-IVM (Biphasic Capacitation IVM) With the Contralateral Ovary Undergoing Minimal Controlled Ovarian Stimulation (OS-IVF)","IO-CAPA","Inclusion Criteria:\n\n* Female, age 18 to 38 years.\n* Undergoing assisted reproductive treatment for infertility.\n* Both ovaries present and anatomically suitable for oocyte retrieval, with no prior oophorectomy.\n* Adequate ovarian reserve for study participation, including AMH greater than 0.5 ng\u002FmL and antral follicle count greater than 6 per ovary.\n* Both ovaries considered suitable for their assigned study procedures: right ovary for CAPA-IVM and left ovary for minimal-stimulation OS-IVF.\n* Access to partner or donor sperm for fertilization\u002FICSI according to clinic protocol.\n* Willing and able to provide written informed consent and comply with study procedures and follow-up.\n\nExclusion Criteria:\n\n* Severe endometriosis, Stage III or IV.\n* Known diminished ovarian reserve with AMH less than 0.2 ng\u002FmL, unless specifically permitted under an approved study amendment.\n* Active pelvic infection.\n* Untreated hydrosalpinx.\n* Known chromosomal abnormality in either reproductive partner, unless appropriate genetic testing is planned.\n* Contraindication to oocyte retrieval or sedation\u002Fanesthesia.\n* Any medical or gynecologic condition that, in the investigator's judgment, would interfere with study participation, oocyte retrieval, study procedures, or participant safety.","FEMALE","18 Years","38 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","This prospective study compares two approaches to obtaining mature oocytes for fertility treatment within the same participant. Immature oocytes are first retrieved from the right ovary and matured in the laboratory using a two-step biphasic capacitation in vitro maturation method (CAPA-IVM). Beginning on Day 5 of the same menstrual cycle, the left ovary undergoes minimal controlled ovarian stimulation followed by routine oocyte retrieval and IVF\u002FICSI.\n\nThe primary objective is to evaluate the maturation of CAPA-IVM oocytes to the metaphase II (MII) stage and compare reproductive laboratory outcomes between the CAPA-IVM and minimal-stimulation OS-IVF approaches. Secondary outcomes include fertilization, embryo development, blastocyst formation, embryo quality, pregnancy and live birth outcomes, and safety.",[28,29,30],"Infertility (IVF Patients)","Infertility","Infertility Female",[32,33,34,35,36,37,38,39,40,41,42,43,44,45,46],"In Vitro Maturation","IVM","CAPA-IVM","Biphasic In Vitro Maturation","Oocyte Maturation","Oocyte","Assisted Reproductive Technology","IVF","ICSI","Minimal Ovarian Stimulation","Controlled Ovarian Stimulation","Embryo Development","Blastocyst Formation","Female Infertility","Within-Patient Comparison","NOT_YET_RECRUITING","2026-09-29",{"date":50,"type":51},"2026-10-05","ACTUAL",{"date":53,"type":22},"2026-10",{"date":55,"type":22},"2027-10",{"name":57,"class":58},"New Hope Fertility Center","OTHER",""]