[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ocular Aesthetics, LLC dba Ocular Clinical Trials\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100647146","treating-contact-lens-discomfort-with-varenicline-solution-nasal-spray-003mg-100647146",false,"NCT07705893","Treating Contact Lens Discomfort With Varenicline Solution Nasal Spray 0.03mg","A Clinical Evaluation of Treating Contact Lens Discomfort With Varenicline Solution Nasal Spray 0.03mg","Inclusion Criteria:\n\n* Adult male and female subjects of any race or ethnicity who are ≥18 years of age.\n* Best corrected CL visual acuity of 0.3 Logarithm of the Minimum Angle of Resolution (logMAR) or better in both eyes (Snellen equivalent 20\u002F40).\n* Soft 1-day silicone hydrogel CL wearer (daily disposable only)\n* Contact Lens Dry Eye Questionnaire (CLDEQ)-8 scores (CLDEQ-8 scores ≥ 12).16\n* A VAS score of ≥40 for Eye Dryness and End of Day Contact Lens Discomfort;18, 19\n* A corneal fluorescein staining on the original NEI scale of ≥3.\n* Habitually wears soft CLs for a minimum of 5 days per week for 6 hours per day during the month prior to enrollment.20\n* Willing to maintain habitual CL wear routine for the 3 months duration of the study.20\n* Willing to only use Tyrvaya nasal spray prescription dry eye treatment for the 3 months duration of the study.\n* Willing to not use any lipid containing artificial tear (AT) for the 3 months duration of the study.\n* Willing to only use non-lipid containing preservative free artificial tear for the 3 months duration of the study if needed, but no more than 4 times per day; also must agree to record frequency of daily AT use if applicable.\n* Willing to record daily time for CL application, removal, and Tyrvaya applications.\n* Habitual CLs have an acceptable fit (good centration, movement, and coverage\n\nExclusion Criteria:\n\n* Any history of Tyrvaya use within six months of enrollment\n* Are currently an overnight CL wearer.\n* Are currently wearing rigid gas permeable CLs, scleral CL, hybrid CLs, or reusable soft CLs.\n* Have known systemic health conditions that are known to alter tear film physiology (e.g., primary and secondary Sjögren's syndrome).\n* Have a history of ocular surgery within the past 12 months.\n* Have a history of viral eye disease.\n* Have a history of severe ocular trauma, active ocular infection or inflammation.\n* Have ever used using isotretinoin-derivates (e.g., Accutane).\n* Are currently taking ocular medications or plan to during the study (e.g., DED, glaucoma, etc).\n* Subjects with meibomian gland blockage or significant atrophy (e.g., severe MGD). Currently having \\>50% blockage of Meibomian glands in more than two eyelids\n* Having blepharitis and\u002For demodex blepharitis \\> grade 1\n* Have had a physical meibomian gland dysfunction treatment withing three months of enrollment (iLux, Lipiflow, Radio Frequency and IPL with manual expressions, microblepharoexfoliation etc.).\n* Have used a prescription DED or ocular surface disease medication in the last 1 month.\n* Have a condition or in a situation, which in the examiner's opinion, may put the subject at significant risk, may confound the study results, or may significantly interfere with their participation.\n* Are pregnant or breast feeding or plan to get pregnant.\n* Are a student, employee, or relative of the study team.",true,"ALL","18 Years","99 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","The objective of this study is to evaluate whether twice-daily use of Tyrvaya improves contact lens comfort in contact lens wearers.",[28],"Dry Eye",[30,28,31,32],"Tyrvaya","Contact Lens","Symptoms","RECRUITING","2026-07-28",{"date":36,"type":37},"2026-07-30","ACTUAL",{"date":34,"type":37},{"date":40,"type":22},"2027-03",{"name":42,"class":43},"Ocular Aesthetics, LLC dba Ocular Clinical Trials","OTHER",""]