[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Oriol Roca\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100647892","comparison-of-lung-recruitability-assessment-by-hysteresis-ratio-and-recruitment-to-inflation-ratio-and-peep-titration-in-ards-100647892",false,"NCT07713420","COMPARISON OF LUNG RECRUITABILITY ASSESSMENT BY HYSTERESIS RATIO AND RECRUITMENT-TO-INFLATION RATIO, AND PEEP TITRATION IN ARDS.","COMPARISON OF LUNG RECRUITABILITY ASSESSMENT BY HYSTERESIS RATIO AND RECRUITMENT-TO-INFLATION RATIO AND THE USE OF DIFFERENT PEEP TITRATION METHODS IN PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)","PV-TOOL","Inclusion Criteria:\n\n* Intubated patients with acute respiratory distress syndrome (ARDS): PaO2\u002FFiO2 ratio \\\u003C200, with bilateral infiltrates of non-cardiogenic origin, with a PEEP of at least 5 cmH2O.\n* The patient is receiving mechanical ventilation and continuous sedation.\n* The patient has an esophageal balloon.\n* Written informed consent signed and dated by the patient or one relative in case the patient is unable to consent, after a full explanation of the study by the investigator and prior to study participation\n\nExclusion Criteria:\n\n* Patients with\\\u003C 18 years old\n* Pregnant woman\n* Lung recruitment maneuvers are deemed unsafe by the medical team\n* Unable to fit EIT belt due to patient size\n* Contraindications to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode placement)\n* Hemodynamic instability (Systolic BP \\\u003C 75 mmHg or MAP \\\u003C 60 mmHg despite vasopressors and\u002For heart rate \\\u003C 55 bpm)\n* Hypernatremia (Na+ \\>145mEq\u002FL)\n* The formalized ethical decision to withhold or withdraw life support\n* Patient under guardianship\n* Patients deprived of liberties\n* Impossibility to give informed consent by both patient and family (i.e. language barrier)\n* Patient was already enrolled in the present study in a previous episode of acute respiratory failure.","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This multicenter, single-blind physiological study aims to compare two bedside methods for assessing lung recruitability in mechanically ventilated patients with acute respiratory distress syndrome (ARDS): the recruitment-to-inflation (R\u002FI) ratio and the pressure-volume (PV) loop hysteresis ratio. Lung recruitability will be defined according to the reduction in lung collapse measured by electrical impedance tomography (EIT) during a standardized lung recruitment maneuver.\n\nFollowing baseline measurements, participants will undergo sequential physiological assessments, including lung recruitability evaluation using both the R\u002FI ratio and a low-flow PV loop, a standardized lung recruitment maneuver with a decremental PEEP trial, and a second PV loop performed at a lower maximum inflation pressure. The order of the R\u002FI ratio assessment and the PV loop maneuver will be randomized.\n\nIn a final crossover phase, four different PEEP titration strategies will be evaluated in randomized order. Each strategy will be applied for 15 minutes and separated by a washout period at the patient's baseline clinical PEEP. Respiratory mechanics, gas exchange, ventilation\u002Fperfusion distribution, and hemodynamic variables will be assessed throughout the protocol.\n\nThe primary objective is to determine the agreement between the hysteresis ratio and the R\u002FI ratio for identifying lung recruitability. Secondary objectives include evaluating whether a PV loop performed with a lower maximum pressure provides similar information on recruitability and comparing the physiological effects of different PEEP titration strategies. Approximately 30 patients with moderate-to-severe ARDS receiving invasive mechanical ventilation will be enrolled.",[27],"Acute Respiratory Distress Syndrome (ARDS)",[29,30,31,32,33,34,35,36,37],"Mechanical ventilation","Lung recruitability","PEEP titration","Hysteresis Ratio","Recruitment-to-Inflation Ratio","Pressure-Volume Loop","Electrical Impedance Tomography (EIT)","Esophageal Pressure","Acute Respiratory Distress Syndrome","NOT_YET_RECRUITING","2026-07-14",{"date":41,"type":42},"2026-07-20","ACTUAL",{"date":44,"type":21},"2026-07",{"date":46,"type":21},"2029-01",{"name":48,"class":49},"Oriol Roca","OTHER",""]