[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Plovdiv Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":73},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100647709","innovative-mouthwash-in-school-aged-children-with-fixed-orthodontic-appliances-100647709",false,"NCT07710144","Innovative Mouthwash in School-Aged Children With Fixed Orthodontic Appliances","Laboratory and Clinical Evaluation of an Innovative Mouthwash in School-Aged Children With Fixed Orthodontic Appliances","Inclusion Criteria:\n\n1. Participants aged 12 to 17 years.\n2. Presence of fixed metal orthodontic appliances placed at least 6 months before enrollment.\n3. Generalized plaque-induced gingivitis.\n4. Full Mouth Bleeding Score greater than 30%.\n5. Gingival Index greater than 0.95 according to Loe and Silness.\n6. Written informed consent obtained from a parent or legal guardian.\n7. Participant willingness to comply with the study protocol.\n\nExclusion Criteria:\n\n1. Refusal to participate or withdrawal of informed consent.\n2. Non-compliance with the intervention regimen or inability to attend follow-up visits.\n3. Development of an adverse reaction or condition requiring discontinuation.\n4. Antibiotic or antimicrobial therapy during follow-up if it may affect the study outcomes.\n5. Presence of concomitant systemic diseases.\n6. Current systemic medication intake that could influence oral health or inflammatory status.\n7. Use of systemic or local antimicrobial agents during the previous 3 months, including mouthwashes, gels, chewing gums or other local oral agents.\n8. Known allergy or hypersensitivity to any component of the tested mouthwash formulations.\n9. Use of removable orthodontic appliances only. Inability or unwillingness to follow the study instructions.","ALL","12 Years","17 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","Fixed metal orthodontic appliances create additional plaque-retentive areas around brackets, archwires and ligatures, making mechanical plaque control more difficult in children and adolescents. Increased plaque accumulation may contribute to gingival inflammation, bleeding, halitosis and early enamel changes. Therefore, adjunctive preventive agents, including mouthwashes, may be clinically useful as part of a comprehensive oral hygiene program during fixed orthodontic treatment.\n\nThe aim of the study is to evaluate the clinical effectiveness and tolerability of a test mouthwash in children and adolescents with fixed orthodontic appliances by monitoring plaque accumulation, gingival inflammation, gingival bleeding and halitosis.",[27,28,29],"Plaque-Induced Gingivitis","Dental Plaque Accumulation","Halitosis","NOT_YET_RECRUITING","2026-07-13",{"date":33,"type":34},"2026-07-17","ACTUAL",{"date":36,"type":21},"2026-09-01",{"date":38,"type":21},"2028-05-31",{"name":40,"class":41},"Plovdiv Medical University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":42},"100553669","early-phase-1-remineralizing-effect-of-different-silver-containing-agents-on-initial-caries-lesions-in-primary-teeth-in-children-100553669","NCT06489093","Remineralizing Effect of Different Silver-containing Agents on Initial Caries Lesions in Primary Teeth in Children","Evaluation of the Effect of Green Synthesized Nano-silver Fluoride and Silver Diamine Fluoride on Carious Lesions in Children","Inclusion Criteria:\n\n* Age: 3 - 8 years\n* Signed informed consent from parents to participate in the study. Verbal consent from the child for the upcoming manipulations.\n* Enrolled patients do not have any common diseases or conditions associated with decreased salivation and are not taking medications that suppress salivary flow. Study participants have no cognitive or behavioral impairment. The absence of disease will be confirmed by a history-taking interview with the parent.\n* Presence of incipient carious lesions (white spots) reaching the enamel interior, assessed with ICDAS system values 01 (first visible enamel change) and 02 (localized visible enamel change) and laser fluorescence values up to 20. The diagnostic threshold of the included lesions is defined as D1 A (active enamel lesion visible after drying) or D2 A (active enamel lesion visible without drying). Criteria for active lesions: under plaque, loss of gloss, loss of smoothness, diffuse borders of the lesion, opaque appearance, white colour, at pre-selection sites (in the cervical third of the enamel). The lesions are located on tooth surfaces with no preceding obturations.\n* Study participants had not performed remineralization or topical fluoride therapy on the included lesions within six months prior to study inclusion.\n* Children with no history of allergy to the medications administered.\n\nExclusion Criteria:\n\n* Children who are considered medically compromised or medically complex patients. The presence of a medical condition is confirmed by a history interview with the child's parent or guardian and involves common diseases or conditions associated with decreased salivation and intake of medications that suppress salivary flow, cognitive and behavioral disorders.\n* Patients who underwent remineralizing or topical fluoride therapy to the included lesions in the last six months prior to study inclusion.\n* Patients with a history of allergy to the administered medication.",true,"3 Years","8 Years",{"count":54,"type":21},30,[56],"EARLY_PHASE1","The aim of the present work is to study the effect of the application of Silver diamine fluoride (SDF) and a novel green synthesized Nano-silver fluoride (NSF) on early enamel lesions in primary teeth. Proving their positive effect would be the basis for the development of innovative dental materials and hygienic agents to combat the carious process, which is a critical prerequisite for improving the quality of dental services and reducing dental anxiety and fear.",[59],"White Spot Lesion of Tooth",[61,62,63],"sdf","nano silver fluoride","white spot lesions","RECRUITING","2024-07-03",{"date":67,"type":34},"2024-07-05",{"date":69,"type":21},"2024-07-29",{"date":71,"type":21},"2025-06",{"name":40,"class":41},""]