[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Poznan University of Physical Education\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":521},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,54,85,115,136,156,173,205,241,270,300,329,360,388,418,446,471,496],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100650851","effects-of-basketball-specific-interval-exercise-on-metabolic-inflammatory-and-fatigue-responses-in-female-basketball-players-100650851",false,"NCT07752459","Physiological Responses to Basketball-Specific Interval Exercise in Female Basketball Players","The Effect of Basketball-Specific Interval Exercise on Metabolic and Inflammatory Responses, Energy Substrate Utilization, and Perceived Fatigue in Female Basketball Players","INTER-BASKET","Inclusion Criteria:\n\n* Female, aged 16-22 years.\n* Regular participation in organized basketball training.\n* Current medical clearance for sports participation.\n* No contraindications to high-intensity physical exercise.\n* Willingness and ability to provide written informed consent (and parental\u002Flegal guardian consent where required for minors).\n* Willingness to comply with all study procedures.\n* Menstrual cycle phase will be recorded for all participants and considered as a potential covariate in the statistical analyses.\n\nExclusion Criteria:\n\n* Current musculoskeletal injury or any condition preventing maximal exercise.\n* Metabolic, cardiovascular, inflammatory, or other chronic diseases affecting exercise capacity or study outcomes.\n* Current use of anti-inflammatory medications.\n* Use of supplements or substances that may influence the measured metabolic or inflammatory parameters.\n* Refusal to undergo blood sampling.\n* Failure to comply with pre-test instructions (e.g., dietary or exercise restrictions).",true,"FEMALE","16 Years","22 Years",{"count":22,"type":23},25,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study aims to evaluate the effects of interval exercise on metabolic and inflammatory responses, energy substrate utilization, and fatigue in trained female basketball players. High-intensity intermittent exercise is a key component of basketball performance and induces substantial metabolic and physiological stress. However, the acute relationships between exercise-induced metabolic changes, inflammatory responses, substrate utilization, and fatigue in female basketball players remain insufficiently understood.\n\nIn this prospective interventional study, eligible female basketball players will complete a standardized interval exercise protocol designed to replicate the physiological demands of competitive basketball. Physiological, biochemical, and perceptual measurements will be collected before exercise, immediately after exercise, and during recovery. Primary outcomes include changes in metabolic and inflammatory biomarkers, energy substrate utilization, and fatigue-related responses. Secondary outcomes include selected physiological and performance-related variables associated with recovery from high-intensity interval exercise.\n\nThe findings of this study will improve the understanding of the physiological responses to interval exercise in female basketball players and may contribute to the development of evidence-based training and recovery strategies aimed at optimizing performance and athlete health.",[29,30,31],"Exercise","Fatigue","Sport Physiology",[33,34,35,36,37,38,39,40],"basketball","Yo-Yo test","High-Intensity Interval Exercise","Reaction Time","Energy Metabolism","Free Fatty Acids","Exercise-Induced Fatigue","Female Athletes","NOT_YET_RECRUITING","2026-08-11",{"date":44,"type":45},"2026-08-12","ACTUAL",{"date":47,"type":23},"2026-09-20",{"date":49,"type":23},"2026-12-30",{"name":51,"class":52},"Poznan University of Physical Education","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":17,"sex":61,"minAge":19,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":24,"phases":65,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":53},"100650362","the-effects-of-acute-nitrate-and-caffeine-co-ingestion-on-discipline-specific-exercise-performance-100650362","NCT07748416","The Effects of Acute Nitrate and Caffeine Co-ingestion on Discipline-Specific Exercise Performance.","The Acute Effects of Dietary Nitrate (Beetroot Juice), Caffeine, and Their Combination on Discipline-Specific Exercise Performance, Lactate Kinetics, and Physiological Responses in Trained Functional Fitness Athletes and Elite Junior Swimmers.","Inclusion Criteria:\n\nA) Cohort A (HIFT \u002F CrossFit \u002F Hyrox):\n\n* Aged 18-45 years.\n* Minimum of 2 years of systematic HIFT\u002FCrossFit\u002FHyrox training experience.\n* Performing \\>4 training sessions per week.\n* Ability to perform the HYROX Physical Fitness Test (P'F'T) and has participated in at least one official HYROX event.\n* Possession of a valid medical certificate proving eligibility for competitive sports.\n\nB) Cohort B (Competitive Junior Swimmers):\n\n* Aged 16-19 years.\n* Active member of the Polish Junior National Swimming Team.\n* Minimum of 5 years of competitive swimming experience.\n* Current training volume of at least 8-10 pool training sessions per week.\n* Written informed consent obtained from both the participant and their legal guardian (for minors under 18).\n\nC)Common Criteria for Both Cohorts:\n\n* No history of cardiovascular, respiratory, metabolic, or musculoskeletal disease contradicting high-intensity exercise or stimulant intake.\n* No known food allergies or adverse reactions to beetroot products or caffeine.\n* No current use of medications that alter nitrate\u002Fcaffeine metabolism (e.g., proton pump inhibitors, antibiotics, phosphodiesterase inhibitors).\n* History of uneventful habituation to caffeine use during training\u002Fcompetition.\n* Willingness to abstain from dietary supplements, antibacterial mouthwashes, alcohol, and high-nitrate foods for 48 hours prior to each testing session.\n* Good general health and physical well-being.\n\nExclusion Criteria (Applicable to both cohorts):\n\n* Occurrence of acute musculoskeletal injury or trauma during the study period.\n* Any medical or health contraindications (including severe menstrual disorders, planned pregnancy, or breastfeeding).\n* Failure or refusal to strictly adhere to the dietary, supplementation, and exercise testing protocols.","ALL","45 Years",{"count":64,"type":23},112,[26],"The purpose of this study is to investigate the acute, separate, and combined ergogenic effects of dietary nitrate (beetroot juice, BJ) and caffeine (CAF) supplementation on discipline-specific athletic performance. The project employs a double-blind, randomized, placebo-controlled, four-arm crossover design. It evaluates two highly distinct, heterogeneous populations of athletes: (A) adult high-intensity functional training (HIFT\u002FCrossFit\u002FHyrox) competitors performing the standardized Hyrox Physical Fitness Test (P'F'T), and (B) elite junior competitive swimmers (National Team members) performing a progressive 8 × 100 m swimming test. The study will assess physical performance, lactate kinetics, subjective exertion, biochemical indices, psychological metrics, and gastrointestinal tolerance.",[68,69,70],"Athletic Performance","Dietary Supplement","Iron Status",[72,73,74,75,76],"Caffeine","Sports nutrition","Swimming","High-Intensity Functional Training","Nitric oxide","2026-08-06",{"date":79,"type":45},"2026-08-07",{"date":81,"type":23},"2026-10-01",{"date":83,"type":23},"2029-06-30",{"name":51,"class":52},{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":17,"sex":61,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":24,"phases":96,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":112,"leadSponsor":114,"locationsCount":53},"100650347","placebo-effect-on-cycling-performance-laboratory-crossover-study-100650347","NCT07748429","Placebo Effect on Cycling Performance: Laboratory Crossover Study","The Impact of Expectations on Physical Performance and Psychophysiological Potential: a Randomized, Double-blind, Placebo-controlled Crossover Study on the Placebo Effect in the Context of Caffeine Supplementation","Inclusion Criteria:\n\n* Age between 20 and 30 years,\n* Healthy adults,\n* Regular physical activity, but not professional athletes,\n* Normal or corrected-to-normal vision,\n* Habitual caffeine consumption.\n\nExclusion Criteria:\n\n* History of neurological, psychiatric, cardiovascular, or metabolic disorders,\n* Current use of medication or supplements affecting the central nervous system,\n* Musculoskeletal injuries that would impair physical performance,\n* No habitual caffeine consumption or severe negative side effects of caffeine,\n* Diagnosed sleep disorders or chronic fatigue,\n* Diagnosed major depressive disorder or other severe psychiatric conditions,\n* Presence of any menstrual disorders,\n* Inability to attend all experimental study visits.","20 Years","30 Years",{"count":95,"type":23},80,[26],"This study aims to determine the impact of the placebo (PLA) effect on physical and cognitive performance in a controlled laboratory setting. The study investigates how expectations and beliefs about substance intake (caffeine vs. placebo) interact with actual consumption to influence performance and physiological stress markers. Healthy adults (n = 80) will participate in four testing sessions using a randomized, double-blind, placebo-controlled crossover design. Physiological stress markers (cortisol and alpha-amylase), heart rate, and performance metrics will be monitored during a standardized cycling exercise protocol. This phase provides the dense mechanistic data required to refine a mathematical model of the placebo effect, offering insights into how individual personality traits and cognitive anchoring influence psychophysiological potential.",[99,100,101],"Physical Performance","Placebo Effect","Cognitive Performance",[72,103,104,105,106,107],"Expectancy","Psychophysiology","Exercise PHysiology","Postural Control","Human Performance","2026-07-31",{"date":110,"type":45},"2026-08-05",{"date":81,"type":23},{"date":113,"type":23},"2029-03-31",{"name":51,"class":52},{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":17,"sex":61,"minAge":92,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":24,"phases":125,"briefSummary":126,"conditions":127,"keywords":128,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":135,"locationsCount":53},"100649915","placebo-effect-in-field-based-physical-performance-100649915","NCT07742150","Placebo Effect in Field-Based Physical Performance","Psychophysiological Mechanisms of the Placebo Effect on Physical Performance in Field Settings","Inclusion Criteria:\n\n* Age between 20 and 35 years,\n* Healthy adults,\n* Regular physical activity,\n* Normal or corrected-to-normal vision,\n* Habitual caffeine consumption.\n\nExclusion Criteria:\n\n* History of neurological, psychiatric, cardiovascular, or metabolic disorders,\n* Current use of medication or supplements affecting the central nervous system,\n* Musculoskeletal injuries that would impair physical performance,\n* No habitual caffeine consumption or severe negative side effects of caffeine,\n* Diagnosed sleep disorders or chronic fatigue,\n* Diagnosed major depressive disorder or other severe psychiatric conditions,\n* Presence of any menstrual disorders,\n* Inability to attend all experimental study visits.","35 Years",{"count":124,"type":23},120,[26],"This study aims to investigate the placebo (PLA) effect on physical performance across different sports disciplines in real-world, field-based settings. The study investigates how participant expectations and beliefs regarding caffeine (CAF) intake influence physical performance and psychomotor function outside the controlled laboratory environment. Healthy, physically active adults (n = 120) from diverse sports backgrounds will be randomly assigned to receive caffeine, placebo, or no intervention. Participants will perform discipline-specific field exercise tests (e.g., running-based protocols or repeated sprint protocols) while physiological responses are monitored using wearable technology. Physical performance outcomes and psychomotor responses will be analyzed to evaluate the real-world impact of the placebo effect and to distinguish the pharmacological effects of caffeine from those driven by psychological expectations across different athletic settings.",[99,100,101],[72,103,104,129,106,107],"Exercise Physiology",{"date":131,"type":45},"2026-08-03",{"date":133,"type":23},"2026-09-01",{"date":113,"type":23},{"name":51,"class":52},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":18,"minAge":143,"maxAge":122,"enrollmentInfo":144,"targetDuration":4,"studyType":24,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":150,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":151,"startDateStruct":152,"completionDateStruct":153,"leadSponsor":155,"locationsCount":53},"100626607","psychophysiological-responses-to-six-single-session-self-regulation-interventions-in-a-female-adult-with-adhd-and-stabilized-bipolar-disorder-100626607","NCT07437833","Psychophysiological Responses to Six Single-Session Self-Regulation Interventions in a Female Adult With ADHD and Stabilized Bipolar Disorder","Psychophysiological Responses to Six 15-Minute Single-Session Self-Regulation Interventions in a Female Adult With ADHD and Stabilized Bipolar Disorder: A Single-Case Study","Inclusion Criteria:\n\n* Diagnosis of ADHD and bipolar disorder (type I or II) in stable remission.\n* No active depressive, manic, or psychotic episodes for at least 2 years.\n* No use of psychotropic medications, including mood stabilizers, antidepressants, antipsychotics, or ADHD medications, for at least 2 years.\n* No chronic somatic diseases (including neurological, cardiovascular, or metabolic disorders).\n* Regular sleep-wake rhythm during the week preceding the study.\n* Non-smoker.\n* No night-shift work in the week preceding the study.\n\nExclusion Criteria:\n\n* Acute medical conditions that could affect study procedures.\n* Use of medications in the past 3 months that influence cardiovascular or neurological parameters.\n* Consumption of alcohol or psychoactive substances on the day before or day of the study.\n* Intense physical activity on the day before or day of the study.\n* Contraindications to moderate-intensity exercise on a cycle ergometer (e.g., recent injuries, chronic musculoskeletal conditions).\n* Contraindications to EEG measurement (e.g., scalp skin conditions preventing proper electrode placement, hypersensitivity to conductive gels or pastes).","18 Years",{"count":53,"type":23},[26],"This study aims to explore how six short, 15-minute self-regulation techniques affect the body and brain in a female adult with ADHD and stabilized bipolar disorder. The techniques being tested include:\n\n* Aerobic exercise\n* Controlled breathing (cyclic sighing)\n* Aromatherapy with lavender essential oil\n* Listening to specific music (Solfeggio 528 Hz)\n* Virtual reality relaxation with forest imagery\n* Emotional Freedom Technique (EFT) tapping One session of quiet sitting with eyes open serves as a comparison.\n\nThe participant will attend one 15-minute session per week for each technique. Before and after each session, the researchers will measure:\n\n* Heart rate and heart rate variability\n* Stress levels using Subjective Units of Distress Scale\n* Mood using a questionnaire\n* Blood pressure\n* Brain activity using EEG\n* Memory performance with a simple test (N-back)\n* Pain sensitivity The goal is to understand how these short, non-invasive techniques influence both physiological and psychological responses. Sessions are safe, short, and designed to involve minimal risk. The findings may help guide future research on relaxation and exercise strategies for people with ADHD and bipolar disorder.",[148,149],"ADHD - Attention Deficit Disorder With Hyperactivity","Bipolar Affective Disorder; Remission in","RECRUITING",{"date":131,"type":45},{"date":108,"type":45},{"date":154,"type":23},"2026-10-30",{"name":51,"class":52},{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":17,"sex":61,"minAge":143,"maxAge":122,"enrollmentInfo":163,"targetDuration":4,"studyType":24,"phases":165,"briefSummary":166,"conditions":167,"keywords":4,"overallStatus":150,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":169,"startDateStruct":170,"completionDateStruct":171,"leadSponsor":172,"locationsCount":53},"100622129","effects-of-moderate-exercise-and-cyclic-sighing-on-stress-cognition-and-physiological-markers-in-young-adults-100622129","NCT07379606","Effects of Moderate Exercise and Cyclic Sighing on Stress, Cognition and Physiological Markers in Young Adults","A Comparison of Psychophysiological Effects Between Relaxation Techniques and Physical Exercise in Young Adults","Inclusion Criteria:\n\n* male or female participants,\n* age 18-35,\n* without chronic somatic diseases,\n* no current episode of psychiatric disorder (no active depression, mania, or psychosis),\n* regular sleep schedule in the week prior to the study,\n* not taking psychotropic drugs or medications,\n* non-smoker,\n* not working nightshifts.\n\nExclusion Criteria:\n\n* consumption of alcohol or psychoactive substances the day before or on the day of the study,\n* intense physical activity less than 2 hours before the study,\n* consuming coffee, black tee, energy drinks less than 2 hours before the study,\n* contraindications to moderate-intensity physical activity on cycle ergometer (e.g., recent injuries),\n* contraindications to EEG (e.g., scalp skin conditions preventing proper electrode placement, hypersensitivity to conductive gels or pastes).",{"count":164,"type":23},30,[26],"This study investigates the effects of moderate physical exercise and cyclic sighing (breathing training) on stress, cognition, and physiological markers in young adults. It is a randomized cross-over trial with two interventions. Each participant will take part in two intervention sessions:\n\n1. Moderate-intensity physical activity (PA): 15 minutes of stationary cycling at 65-75% of maximum heart rate (HRmax).\n2. Breathing training (CS): 15 minutes of cyclic sighing, a technique involving inhaling, pausing briefly, taking a deeper breath, and exhaling slowly.\n\nA one-week washout period between sessions is planned to minimise carry-over effects and to ensure participants' physiological state is similar before the next session. During this week, participants will wear Polar Ignite wrist-worn devices to monitor physical activity and sleep.\n\nA total of 30 participants (you adults) will be enrolled.\n\nMeasurements performed before and after each intervention include:\n\n* EEG using Emotiv EPOC Flex Gel (32-channel device): 2 minutes with eyes open, 2 minutes with eyes closed, during the interventions, and while performing cognitive test (N-back).\n* Heart rate variability (HRV) using the Polar H10 sensor.\n* SUDS - Subjective Units of Disress Scale for perceived stress.\n* N-back test for cognitive performance using Emotiv App.\n* Blood pressure (systolic and diastolic) and heart rate.\n* Pain threshold measured with a dolorimeter.\n* PANAS-SF - Positive and Negative Affect Schedule.\n\nBaseline questionnaires completed by participants the day before the study:\n\n* PSS-10 - Perceived Stress Scale (Cohen, Kamarck, Mermelstein).\n* MAAS - Mindful Attention Awareness Scale\n* Psychological well-being - short version\n* Mini-COPE - Coping with Stress Inventory\n* Sleep quality and average sleep duration\n* Chronotype questionnaire (morningness-eveningness)\n* GPAQ - Global Physical Activity Questionnaire\n* Pittsburgh Sleep Quality Index\n\nThe study aims to understand how brief interventions like moderate exercise and breathing techniques affect stress, cognitive performance, and physiological responses in young adults.",[168],"Stress",{"date":131,"type":45},{"date":108,"type":45},{"date":154,"type":23},{"name":51,"class":52},{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":17,"sex":18,"minAge":122,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":24,"phases":184,"briefSummary":185,"conditions":186,"keywords":189,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":4},"100647190","a-two-way-path-to-health-environmental-influences-on-skeletal-muscle-endocrine-function-100647190","NCT07706465","A Two-Way Path to Health: Environmental Influences on Skeletal Muscle Endocrine Function","A Two-Way Path to Health: Exploring Whether Environmental Factors Influence Skeletal Muscle Endocrine Function and Modulate Physical Activity-Induced Adaptations in Middle-Aged Women","COMPASS","Inclusion Criteria (HICT, IWT and Control groups):\n\n* Women,\n* aged 35-75 years\n* qualified by a physician for participation in the study and with no contraindications to the training intervention (e.g., heart failure, asthma, chronic obstructive pulmonary disease \\[COPD\\], or arthritis)\n\nInclusion Criteria (Onco Group):\n\n* Women ,\n* aged 35-75 years,\n* Diagnosed with invasive breast cancer, Stage I-III disease according to the TNM classification,\n* Estrogen receptor-positive (ER+) breast cancer, defined as expression in at least 10% of tumor cell nuclei,\n* Adjuvant hormone therapy with an aromatase inhibitor for at least 6 months,\n* BMI between 18.5 and 32 kg\u002Fm².\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.\n* No chronic diseases limiting the possibility of oncological treatment.\n* No contraindications to daily physical activity.\n* Willingness to maintain a daily step count of 8,000 steps.\n\nExclusion Criteria (HICT, IWT and Control groups):\n\n* history of cardiovascular disease,\n* previous hospitalization for cardiovascular conditions,\n* ongoing cardiovascular treatment, or recent cardiovascular symptoms,\n* advanced osteoporosis\n\nExclusion Criteria (Onco Group):\n\n* Stage IV invasive breast cancer according to the TNM classification.\n* ECOG performance status ≥2.\n* Unstable ischemic heart disease.\n* Cardiac arrhythmias.\n* Advanced degenerative joint disease.\n* Rheumatic disorders (including rheumatoid arthritis, osteoarthritis, or fibromyalgia).\n* Progression of chronic diseases.\n* Pregnancy.\n* BMI \\\u003C18.5 or \\>32 kg\u002Fm².\n* Uncontrolled hypothyroidism or hyperthyroidism.","75 Years",{"count":183,"type":23},300,[26],"Given the well-established anti-inflammatory and health-promoting effects of physical activity as a non-pharmacological intervention, an important question remains whether different types of exercise differ in their ability to reduce the body burden of per- and polyfluoroalkyl substances (PFAS) and whether PFAS exposure modifies exercise-induced adaptive responses. The investigators hypothesize that the coexistence of physical inactivity, overweight\u002Fobesity, reduced muscle mass, and consequently lower concentrations of myokines\u002Fexerkines contributes to impaired cardiovascular function, reduced exercise capacity, and a greater PFAS body burden. Collectively, these factors may adversely affect work ability, reduce occupational participation, and discourage continued employment among middle-aged women. In the context of unfavorable demographic trends, such consequences may represent a significant economic burden for society.\n\nThe primary objective of this project is to determine whether baseline PFAS concentrations are associated with the health status of women entering the study and to characterize circulating profiles of myokines\u002Fexerkines and arginine metabolites. A secondary objective is to compare the effects of different exercise programs on PFAS concentrations and their potential elimination from the body. In addition, we will investigate whether a history of cancer treatment, despite increasingly favorable clinical outcomes, is associated with long-term alterations in skeletal muscle endocrine function, myokine and exerkine release, and PFAS body burden.\n\nThe study will include perimenopausal women. Participants will be allocated to one of two supervised exercise programs: high-intensity circuit training (HICT) or interval walking training (IWT). Both interventions will last six months and will be performed two times per week (with possible additional unit performed at home). This period will be followed by six months of unsupervised maintenance training. Two additional groups will be included: a control group maintaining their usual lifestyle and a group of women who have completed cancer treatment. Participants in the oncology group will be instructed to maintain a daily physical activity level of approximately 7,000-10,000 steps.\n\nAssessments will be performed at baseline, immediately after the intervention, and six months after its completion. Circulating concentrations of selected myokines, exerkines, arginine metabolites, and 18 PFAS compounds will be measured in blood, while PFAS concentrations will also be determined in urine samples. Cardiorespiratory fitness, body composition assessed by dual-energy X-ray absorptiometry (DXA), dietary habits, quality of life, and health literacy will also be evaluated.",[187,188],"Healthly Volunteers","Oncologic Disease",[190,191,192,193,194,195,196],"PFAS","skeletal muscle endocrine function","myokines and exerkines","physical activity","perimenopausal women","exercise adaptation","women's health","2026-07-13",{"date":199,"type":45},"2026-07-15",{"date":201,"type":23},"2026-08-20",{"date":203,"type":23},"2029-01-30",{"name":51,"class":52},{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":212,"minAge":143,"maxAge":213,"enrollmentInfo":214,"targetDuration":4,"studyType":24,"phases":215,"briefSummary":216,"conditions":217,"keywords":224,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":53},"100646720","assessment-of-effectiveness-of-pelvic-floor-muscle-training-with-biofeedback-in-male-with-hypogonadism-and-erectile-dysfunction-100646720","NCT07687173","Assessment of Effectiveness of Pelvic Floor Muscle Training With Biofeedback in Male With Hypogonadism and Erectile Dysfunction","Assessment of Effectiveness of Pelvic Floor Muscle Training (PFMT) With Biofeedback in Male With Hypogonadism and Erectile Dysfunction (ED) a Randomised Control Trial.","Inclusion Criteria:\n\n* diagnosed functional hypogonadism\n* diagnosed erectile disorders\n* no diagnosed neurological disorders in pelvic floor area\n* no surgical interventions in pelvic floor area\n* no cancer in its active phase\n* ability to give individual consent\n* consent of participation and following the protocol\n\nExclusion Criteria:\n\n* severe cardiovascular diseases\n* cancer treatment in progress\n* scars and surgical interventions in the pelvic floor area\n* neurological disorders affecting to pelvic floor\n* scars that makes measurements impossible\n* other treatment that affects sexual field similar to this protocol\n* participation in other rehabilitation programme less than 6 months before this programme\n* severe neurological disorders that makes cooperation impossible\n* no technical possibilities to do the measures to the patient\n* disagreement to participate in the programme","MALE","60 Years",{"count":124,"type":23},[26],"The goal of this clinical trial is to learn if Pelvic Floor Muscle Training (PFMT) with biofeedback works to treat Erectile Disorders (ED) in males with Functional Hipogonadism. The main hypothesis is:\n\n1\\. Biofeedback-assisted Pelvic Floor Muscle Training will cause greater improvement in pelvic floor muscle strength and endurance and sexual life than in group without biofeedback and control group in males with Erectile Disorders caused by functional hypogonadism.\n\nThe main questions it aims to answer are:\n\n1. Does biofeedback-assisted pelvic floor muscle training cause greater improvement in pelvic floor muscle strength and endurance and sexual life than in group without biofeedback and control group.\n2. Does using handheld biofeedback trainer device improves technique of Pelvic Floor Muscle Training performance compare to NO biofeedback.\n3. Does 12-week intervention cause greater improvement in analyzed parameters than 6-week intervention.\n4. Does participants using biofeedback will have greater adherence to training protocol than no biofeedback group.\n\nResearch will compare biofeedback-assisted Pelvic Floor Muscle Training to non-biofeedback Pelvic Floor Muscle Training and control group to see if Pelvic Floor Muscle Training works to treat Erectile Disorders in males with functional hypogonadism.\n\nParticipants will:\n\n1. Be measured using questionnaires and pelvic floor muscle electromyography\n2. Do Pelvic Floor Muscle Training for 12 weeks\n3. Provide a diary of their training routine\n4. Have repeated measurements in 6 and 12 weeks",[218,219,220,221,222,223],"Erectile Disfunction","Hypogonadal Males","Functional Hypogonadism","Pelvic Floor Muscle Exercise","Biofeedback Training","EMG",[225,226,220,227,228,229,230,231,232,223],"ED","Erectile Disoreders","Hyopogonadal males","Physiotherapy","PFMT","Pelvic Floor Muscles","Biofeedback","pelvic floor exercise","2026-07-03",{"date":235,"type":45},"2026-07-07",{"date":237,"type":23},"2026-07-01",{"date":239,"type":23},"2029-06-01",{"name":51,"class":52},{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":11,"sex":61,"minAge":143,"maxAge":213,"enrollmentInfo":248,"targetDuration":4,"studyType":24,"phases":250,"briefSummary":251,"conditions":252,"keywords":254,"overallStatus":150,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":269,"locationsCount":53},"100641610","longitudinal-stripping-massage-vs-percussion-device-for-neck-pain-ultrasound-study-100641610","NCT07630142","Longitudinal Stripping Massage vs. Percussion Device for Neck Pain: Ultrasound Study.","The Effect of Percussion Therapy on Neck Functional Disability, Pain and Upper Trapezius Muscle Properties Assessed by Elastography and Doppler Ultrasound in Patients With Neck Pain.","Inclusion Criteria:\n\n* Age: 18-60 years\n* Neck pain persisting for at least 3 months\n* Visual Analog Scale (VAS) score between 3 and 7\n* Neck Disability Index (NDI) between 30% and 48%\n\nExclusion Criteria:\n\n* Pregnancy and postpartum period\n* History of cervical spine or shoulder surgery\n* Diagnosed fibromyalgia, radiculopathy, or myelopathy\n* Myofascial therapy within the last 3 months\n* Use of analgesic medication within 48 hours before assessment\n* Venous diseases",{"count":249,"type":23},35,[26],"This study evaluates whether a single session of percussion therapy can reduce muscle tension and increase blood flow in the transverse cervical artery in individuals with neck pain. The investigators will evaluate muscle stiffness using ultrasound elastography, and assess blood flow in the transverse cervical artery via Doppler imaging before and after treatment. The primary objective is to determine how this therapy affects neck muscle relaxation and vascular responses, specifically within the upper trapezius region.",[253],"Chronic Neck Pain",[255,256,257,258,259,260,261,262],"neck pain","longitudinal stripping massage","percussion massage","trapezius","elastography","shear wave","Doppler ultrasound","cervical pain","2026-06-14",{"date":265,"type":45},"2026-06-17",{"date":267,"type":23},"2026-06-01",{"date":239,"type":23},{"name":51,"class":52},{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":4,"eligibilityCriteria":276,"healthyVolunteers":17,"sex":61,"minAge":277,"maxAge":278,"enrollmentInfo":279,"targetDuration":280,"studyType":281,"phases":4,"briefSummary":282,"conditions":283,"keywords":285,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":4},"100637772","multilevel-exercise-response-in-rowers-100637772","NCT07613619","Multilevel Exercise Response in Rowers","Multilevel Assessment of Physiological, Molecular, Metabolic, Intestinal, and Psychophysiological Responses to Rowing Ergometer Exercise in Competitive Rowers","Inclusion Criteria:\n\n* Male and female members of the Polish Youth National Rowing Team.\n* Age between 19 and 24 years.\n* Regular participation in structured rowing training.\n* Medical clearance for participation in maximal exercise testing.\n* Ability and willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Lack of consent for blood sampling or study participation.\n* Current injury or health condition contraindicating maximal exercise.\n* Acute infection, fever, or inflammatory condition at the time of testing.\n* Use of anti-inflammatory medications.\n* Use of performance-enhancing substances.\n* Use of dietary supplements within 3 months before study participation.\n* Any medical contraindications identified by the study physician.","19 Years","24 Years",{"count":164,"type":23},"6 Months","OBSERVATIONAL","This observational study aims to evaluate multilevel physiological, molecular, metabolic, intestinal, immunological, and psychophysiological responses to rowing-specific exercise in elite rowers. The study is designed to investigate how maximal and prolonged rowing ergometer exercise influences integrated adaptive mechanisms related to mitochondrial function, metabolic regulation, intestinal permeability, immune activation, DNA damage response, and psychological status.\n\nThirty members of the Polish Youth National Rowing Team, aged 19-24 years, will participate in the study during two different training periods. During the competitive phase, participants will perform a 2000-m maximal rowing ergometer test, whereas during the preparatory phase they will complete a 6000-m rowing ergometer test. Blood samples and physiological measurements will be collected before exercise, immediately after exercise, and after 1 hour of recovery.\n\nThe study will assess gene expression, circulating biomarkers, flow cytometry parameters, blood morphology, lactate concentration, continuous glucose monitoring data, wearable metabolic sensor measurements, nutritional status, and psychological responses. The primary objective is to identify integrated biomarkers reflecting exercise load, recovery dynamics, and adaptive capacity in highly trained athletes. The study also aims to improve understanding of the interaction between metabolic, mitochondrial, intestinal, immunological, and psychophysiological responses to intensive exercise in rowing.",[284],"Healthy Adult Participants",[286,287,288,289,290,104,291],"Rowing","Exercise physiology","Mitochondrial function","Intestinal permeability","DNA damage response","Elite athletes","2026-05-21",{"date":294,"type":45},"2026-05-29",{"date":296,"type":23},"2026-05-17",{"date":298,"type":23},"2027-01-30",{"name":51,"class":52},{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":11,"sex":61,"minAge":143,"maxAge":307,"enrollmentInfo":308,"targetDuration":4,"studyType":24,"phases":310,"briefSummary":311,"conditions":312,"keywords":315,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":4},"100610842","cytokines-neuroplasticity-modulators-and-biomarkers-in-spinal-canal-stenosis-and-endoscopic-decompression-100610842","NCT07232836","Cytokines, Neuroplasticity Modulators, and Biomarkers in Spinal Canal Stenosis and Endoscopic Decompression","The Role of Cytokines and Neuroplasticity Modulators in the Development of Spinal Canal Stenosis and the Identification of Biomarkers for the Biochemical Evaluation of Treatment in Patients Undergoing Endoscopic Spinal Canal Decompression","Inclusion Criteria for the experimental group:\n\n1. Spinal stenosis in the lumbar spine with a referral for surgical treatment using endoscopic spinal decompression.\n2. Age: 40-90 years.\n3. Current MRI results.\n4. Consent to participate in the study.\n\nInclusion Criteria for the control no spinal stenosis group:\n\n1. Intervertebral disc herniation in the lumbar spine with a referral for surgical treatment using endoscopic discectomy.\n2. Age: 18-40 years.\n3. Current MRI results.\n4. Consent to participate in the study.\n\nExclusion Criteria:\n\nHistory of:\n\n* rheumatoid arthritis of the intervertebral joints,\n* joint pain located elsewhere if it is more severe than the pain caused by stenosis,\n* pathologies and\u002For medications that may disturb the balance between pro- and anti-inflammatory factors (e.g. inflammatory diseases, rheumatoid arthritis, ankylosing spondylitis, acute infection),\n* uncontrolled diabetes, poorly controlled hypertension, clinically significant liver function impairment, acute coronary event, unstable angina pectoris, symptoms of heart failure, pacemaker implantation,\n* neurological diseases within the last 6 months,\n* previous spine surgery at the lumbar level,\n* mechanical injuries to the spine after an accident,\n* advanced osteoporosis,\n* pregnancy, lactation.","90 Years",{"count":309,"type":23},100,[26],"Research Rationale and Study Design Lumbar spinal stenosis (LSS) is a common degenerative musculoskeletal disorder characterized by narrowing of the spinal canal, often leading to pain and disability. One of the primary contributors to this condition is hypertrophy (thickening) of the ligamentum flavum (LF), along with facet joint degeneration, intervertebral disc herniation, and ligament ossification. However, the pathophysiological mechanisms behind these changes remain incompletely understood.\n\nHistological changes in hypertrophied LF include fibrocartilaginous metaplasia, type II collagen proliferation, ossification, calcium crystal deposition, and degeneration of elastic and collagen fibers. Both mechanical stress and inflammatory processes, particularly macrophage infiltration, are considered key contributors to degeneration, especially in the aging population. Yet, inflammation linked to systemic metabolic disorders-such as obesity and sarcopenia-may also significantly influence the degeneration of spinal structures.\n\nMetabolic Inflammation and the Role of Adipokines Recent research has highlighted the role of adipokines in the pathogenesis of degenerative spinal and joint diseases. Disrupted lipid metabolism and chronic low-grade inflammation contribute to tissue remodeling, extracellular matrix (ECM) degradation, and ectopic fat deposition in spinal structures.\n\nEpidural fat, normally present in the spinal canal, can become inflamed and secrete pro-inflammatory cytokines, potentially affecting adjacent tissues such as muscles and ligaments. Conditions like spinal epidural lipomatosis, which is associated with obesity, exemplify this pathological mechanism.\n\nWhile adipokines like leptin and visfatin have been previously associated with LF ossification and degeneration, the presence and role of others-such as adipsin, vaspin, resistin, lipocalin-2, progranulin, chemerin, omentin-1, and GDF-15-have not yet been studied in LF or epidural fat. Given their known effects on inflammation and ECM remodeling, these molecules are strong candidates for involvement in spinal canal narrowing.\n\nResearch Hypotheses and Objectives\n\nThis study hypothesizes that adipose tissue-derived cytokines, particularly from epidural fat, contribute to LF degeneration and LSS through inflammatory and metabolic signaling. The main research objectives are to:\n\n1. Identify differences in biomarker concentrations in LF, paraspinal muscle, and epidural fat from patients with and without LSS.\n2. Determine correlations between tissue and blood biomarker levels and clinical parameters such as pain, disability, and body mass.\n3. Select potential biomarkers for monitoring surgical outcomes of spinal decompression.\n4. Identify cytokines that modulate LF inflammation and metabolism.\n5. Evaluate the direct effects of adipokines on LF cell behavior in vitro. Study Design and Methods\n\n   Study population:\n\n   • 100 patients undergoing lumbar spine surgery at the Orthopaedic-Rehabilitation Clinical Hospital in Poznań:\n\n   o 50 with LSS (ages 40-90)\n   * 50 with disc herniation only (ages 18-40; control group)\n\n   Tissue collection (intraoperative):\n\n   • Ligamentum flavum\n\n   • Paraspinal muscles\n\n   • Epidural adipose tissue\n\n   Blood samples:\n\n   • Collected from all participants:\n\n   o Within 48 hours before surgery\n\n   o Two months post-surgery\n\n   Clinical assessments:\n\n   • Disability and pain scales\n   * Preoperative MRI scans\n\n   Laboratory analysis:\n\n   • Molecular testing:\n   * mRNA expression of selected cytokines and adipokines using PCR\n   * Protein levels determined via ELISA in both serum and tissue homogenates • Cell culture studies:\n   * One-third of collected tissue is used to establish primary cell cultures from LF, paraspinal muscles, and epidural fat\n   * Cells will be stimulated with conditioned media from epidural fat and with selected recombinant cytokines (e.g., vaspin, lipocalin-2, GDF-15)\n   * Experiments will assess the gene and protein expression of key molecules involved in inflammation, ECM remodeling, bone metabolism, fibrosis, and matrix degradation.\n\n   The goal is to clarify the local and systemic roles of adipokines and inflammation in the pathogenesis of LF hypertrophy and LSS. This knowledge may aid in identifying biomarkers for disease progression and therapeutic targets for non-surgical interventions in the future.",[313,314],"Spinal Stenosis","Ligamentum Flavum Hypertrophy",[316,317,318,319,320],"adipokines","biomarkers","endoscopic spinal canal decompression","inflammation","epidural adipose tissue","2025-11-15",{"date":323,"type":45},"2025-11-18",{"date":325,"type":23},"2025-11-17",{"date":327,"type":23},"2030-12-31",{"name":51,"class":52},{"id":330,"slug":331,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":4,"eligibilityCriteria":335,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":336,"enrollmentInfo":337,"targetDuration":4,"studyType":24,"phases":338,"briefSummary":340,"conditions":341,"keywords":344,"overallStatus":150,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":53},"100600087","phase-3-effects-of--alanine-and-sodium-bicarbonate-supplementation-on-physical-capacity-and-biochemical-markers-concentrations-100600087","NCT07092930","Effects of β-alanine and Sodium Bicarbonate Supplementation on Physical Capacity and Biochemical Markers Concentrations","Evaluation of the Synergistic Effect of β-alanine and Sodium Bicarbonate Supplementation on Physical Capacity and Blood Biochemical Markers Concentrations in Trained Female Basketball Players","Inclusion Criteria:\n\n* written consent to participate,\n* general good health condition,\n* a current medical clearance to practice sports,\n* training experience: at least 4 years,\n* minimum of 4 workout sessions (in the discipline covered by the study) a week.\n\nExclusion Criteria:\n\n* current injury,\n* any health-related contraindication,\n* declared general feeling of being unwell,\n* taking supplements, especially ergogenic supplements that modulate extra- and intracellular capacity 3 months prior to research (except taking protein and\u002For carbohydrate powders, isotonic drinks),\n* unwilling to follow the study protocol.","40 Years",{"count":309,"type":23},[339],"PHASE3","This randomized, double-blind, placebo-controlled, parallel-group study aims to evaluate the potential synergistic effect of beta-alanine (BA) and sodium bicarbonate (SB) supplementation, compared to their separate administration or placebo (PL), on physical performance and selected blood biochemical markers in highly trained female basketball players.",[342,343,40],"Supplementation","Sports",[345,346,347,73,348,349,350,351],"Beta-alanine","Sodium bicarbonate","Ergogenic aids","Team sports","Physical capacity","Body composition","Blood and urine biochemical markers","2025-07-28",{"date":354,"type":45},"2025-07-30",{"date":356,"type":45},"2023-10-01",{"date":358,"type":23},"2025-12",{"name":51,"class":52},{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":364,"acronym":4,"eligibilityCriteria":365,"healthyVolunteers":17,"sex":61,"minAge":366,"maxAge":62,"enrollmentInfo":367,"targetDuration":4,"studyType":24,"phases":369,"briefSummary":370,"conditions":371,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":381,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":387,"locationsCount":53},"100587274","effects-of-vr-based-respiratory-training-on-motor-reaction-time-and-correctness-stress-levels-attention-motor-skills-postural-stability-and-sleep-quality-in-shift-healthcare-workers-100587274","NCT06926257","Effects of VR-based Respiratory Training on Motor Reaction Time and Correctness, Stress Levels, Attention, Motor Skills, Postural Stability and Sleep Quality in Shift Healthcare Workers","The study will be conducted in a group of paramedics and nurses of both sexes, aged 23-45. It is expected that 60 people will be examined. The study will include hospital emergency department employees, working shifts, with a minimum of two years of work experience. Those who receive a doctor's consent to participate in the study and give informed consent will be admitted to the study.","23 Years",{"count":368,"type":23},60,[26],"This study investigates the effects of virtual reality (VR)-based respiratory training on various physiological and cognitive functions in shift-working healthcare professionals, including paramedics and nurses. The research will evaluate how VR-guided breathing exercises influence: stress levels, motor reaction time and accuracy, attention and cognitive performance, motor skills and postural stability, sleep quality\n\nParticipants will be divided into three groups:\n\nVR-based respiratory training group - performing guided breathing exercises in a VR environment.\n\nMusic-based relaxation group - listening to relaxing music without structured breathing instructions.\n\nControl group - no intervention.\n\nThe findings will help determine whether VR-based respiratory training is an effective method for improving stress resilience, cognitive function, and physical performance in shift-working healthcare professionals.",[372,373,374,375,376,377,378,379],"Healthcare Workers","Stress Level","Emergency Department","Shift Work Sleep Disorder","Postural Stability","VR Breathing Exercises","Attention","Time Reaction","2025-04-11",{"date":382,"type":45},"2025-04-13",{"date":384,"type":23},"2025-04-07",{"date":386,"type":23},"2025-12-30",{"name":51,"class":52},{"id":389,"slug":390,"hasResults":11,"nctId":391,"briefTitle":392,"officialTitle":392,"acronym":393,"eligibilityCriteria":394,"healthyVolunteers":17,"sex":61,"minAge":143,"maxAge":307,"enrollmentInfo":395,"targetDuration":4,"studyType":24,"phases":396,"briefSummary":397,"conditions":398,"keywords":406,"overallStatus":150,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":417,"locationsCount":53},"100584618","use-of-tdcs-stimulation-in-neurological-and-gynaecological-conditions-100584618","NCT06891690","Use of TDCS Stimulation in Neurological and Gynaecological Conditions","tDCS","Neurological patients\n\nInclusion Criteria:\n\n* impairment of upper and lower limb function.\n\nExclusion Criteria:\n\n* no written consent to participate in the study.\n\nGynaecological patients\n\nInclusion Criteria:\n\n* women with selected gynaecological conditions (endometriosis, painful menstruation, dyspareunia, polycystic ovary syndrome) with no treatment other than tDCS stimulation.\n\nExclusion Criteria:\n\n* no written consent to participate in the study.",{"count":183,"type":23},[26],"The aim of the study is to test the effect of tDCS stimulation on upper and lower limb function in neurological patients and to reduce pain in gynaecological patients. And the impact of tDCS stimulation on patients' quality of life. Standardised questionnaires will be used for pre- and post-stimulation evaluation.",[399,400,401,402,403,404,405],"Stroke","Spinal Cord Diseases","Nerve Root Disorder","Endometriosis","Dyspareunia","Painful Menstruation","Polycystic Ovary",[407,408,409],"tDCS stimulation","quality of life","pain","2025-03-17",{"date":412,"type":45},"2025-03-24",{"date":414,"type":45},"2025-02-05",{"date":416,"type":23},"2025-12-31",{"name":51,"class":52},{"id":419,"slug":420,"hasResults":11,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":424,"eligibilityCriteria":425,"healthyVolunteers":11,"sex":18,"minAge":143,"maxAge":213,"enrollmentInfo":426,"targetDuration":4,"studyType":24,"phases":428,"briefSummary":429,"conditions":430,"keywords":433,"overallStatus":150,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":445,"locationsCount":53},"100514432","functional-links-between-the-temporomandibular-joint-and-the-pelvis-in-gynecology-100514432","NCT05978414","Functional Links Between the Temporomandibular Joint and the Pelvis in Gynecology","Functional Relationships Between the Temporomandibular Joint and the Pelvis in Women With Gynecological Diseases of Genital Prolapse and Endometriosis","TMJ and Pelvis","Inclusion Criteria:\n\n1. Written consent to participate in the study.\n2. Female patients after surgical treatment with prolapse of reproductive organs and diagnosed endometriosis.\n\nExclusion Criteria:\n\n1. No written consent to participate in the study.\n2. Cancer.\n3. Injury to the temporomandibular joint and pelvis.\n4. Fibromyalgia.\n5. Rheumatic diseases.\n6. At each stage of the experiment if the patient decides that she does not want to participate she is excluded.",{"count":427,"type":23},200,[26],"1 Recruitment. 2. Collection of written consents for the study. 3. Random assignment to groups with and without intervention. 4. Completion of questionnaires by study participants, postural pattern assessment, temporomandibular joint assessment, and platform assessment.\n\n5\\. Performance of visceral therapy in the group with intervention, in the group without intervention placebo. Duration 5 weeks, treatment 1x per week at the same time of day and given day e.g. Mondays only.\n\n6\\. Reassessment as in step 4. 7. Data collection, statistical analyses. 8. Interpretation of results for female participants. 9. Preparation of results for scientific publications.",[431,432],"Prolapse; Female","Endometriosis-related Pain",[434,435,436,437,438,439],"quaity of life","women","prolapse; female","endometriosis-related pain","visceral therapy","temporomandibular joint",{"date":441,"type":45},"2025-02-07",{"date":443,"type":45},"2023-11-14",{"date":133,"type":23},{"name":51,"class":52},{"id":447,"slug":448,"hasResults":11,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":17,"sex":18,"minAge":92,"maxAge":453,"enrollmentInfo":454,"targetDuration":4,"studyType":24,"phases":455,"briefSummary":456,"conditions":457,"keywords":459,"overallStatus":150,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":464,"startDateStruct":466,"completionDateStruct":468,"leadSponsor":470,"locationsCount":53},"100560780","physiotherapy-management-in-women-with-urinary-incontinence-100560780","NCT06581601","Physiotherapy Management in Women With Urinary Incontinence","Physiotherapy Management in Women With Urinary Incontinence Considering Postural Stability, Postural Pattern, Pelvic Type, Quality of Life, and Sexual Aspect","Inclusion Criteria:\n\n* Urinary incontinence\n* Regular menstrual cycles\n* Pre and post-menopausal period\n* Natural childbirth or cesarean section\n* Deliveries using forceps and vacuum extractors\n\nExclusion Criteria:\n\n* No urinary incontinence\n* Irregular menstrual cycles\n* No childbirth\n* Abdominal surgeries\u002Fprocedures Active cancer No gynecological check-up in the last 12 months Recurrent urogenital infections Joint hypermobility\n\nContorl group will be healthy women","80 Years",{"count":183,"type":23},[26],"Main objective:\n\nThe primary aim of the study is to assess whether the author's exercise programme has an effect on reducing urinary incontinence and pelvic floor dysfunction after childbirth, considering vacuum extractor, forceps and caesarean section deliveries.\n\nSecondary objective:\n\nThe secondary objective is to determine whether the duration of the author's exercise programme is sufficient to achieve positive changes in women.",[458],"Urinary Incontinence",[460,461,462],"the author's exercise program","urinary incontinence","physiotherapy","2024-11-05",{"date":465,"type":45},"2024-11-07",{"date":467,"type":45},"2024-08-21",{"date":469,"type":23},"2027-11-20",{"name":51,"class":52},{"id":472,"slug":473,"hasResults":11,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":477,"eligibilityCriteria":478,"healthyVolunteers":17,"sex":18,"minAge":479,"maxAge":4,"enrollmentInfo":480,"targetDuration":4,"studyType":24,"phases":481,"briefSummary":482,"conditions":483,"keywords":486,"overallStatus":150,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":53},"100562715","physical-activity-guarantees-bone-density-100562715","NCT06606769","Physical Activity Guarantees Bone Density.","Fizyczne Aktywnosci Gwarantem Zdrowych Kosci","BONES","Inclusion Criteria:\n\nwomen\n\nExclusion Criteria:\n\ndiagnosed osteoporosis","50 Years",{"count":183,"type":23},[26],"Bone tissue is crucial for overall health and quality of life, but it undergoes constant internal remodeling, leading to osteoporosis, a widespread bone disease. Regular physical activity can improve bone mineral density (BMD) and prevent osteoporosis. Studies have shown that premenopausal women with regular physical activity have greater BMD. Diagnosing bone resorption is essential, and dual-energy X-ray absorptiometry tests (DXA) and circulating microRNAs (miRNAs) may offer more prognostic potential than conventional markers. The gut microbiome may also regulate bone metabolism, with metabolites like trimethylamine N-oxide (TMAO) playing a role. A project aims to promote systematic physical activity to improve BMD and well-being, support societal mobilization, and conduct preventive examinations for osteoporosis risk. Implementing systematic prevention is important not only for health but also for reducing social and financial costs associated with osteoporosis and associated fractures.",[484,485],"Osteoporosis","Osteopenia",[193,487],"bone mineral density","2024-10-08",{"date":490,"type":45},"2024-10-10",{"date":492,"type":45},"2024-09-13",{"date":494,"type":23},"2027-06-30",{"name":51,"class":52},{"id":497,"slug":498,"hasResults":11,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":4,"eligibilityCriteria":502,"healthyVolunteers":11,"sex":61,"minAge":143,"maxAge":366,"enrollmentInfo":503,"targetDuration":4,"studyType":281,"phases":4,"briefSummary":504,"conditions":505,"keywords":509,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":514,"startDateStruct":516,"completionDateStruct":518,"leadSponsor":520,"locationsCount":53},"100550875","relative-energy-deficiency-in-rowers-100550875","NCT06452758","Relative Energy Deficiency in Rowers","Relative Energy Deficiency in Females and Males Rowers - Observational Study","Inclusion Criteria:\n\n* Membership in Polish Rowing Team,\n* minimum five years of training,\n* total training time minimum of 240 minutes,\n* filling out a food diary,\n* finishing 2000-meter ergometer test.\n\nExclusion Criteria:\n\n* Probiotics within the last three months,\n* prebiotics within the last three months\n* antibiotic therapy within the last three months,\n* dietary regime,\n* gastrointestinal diseases.",{"count":164,"type":23},"This study aims to learn about relative energy deficiency in male and female rowers at the end of the direct sport preparation phase of the annual training cycle. The main questions:\n\n\\- How will energy intake influence leptin, cortisol levels, mood, gut discomfort, and permeability? The observational study involves male and female rowers from the Polish rowing team.\n\nParticipants will perform 2000 meter ergometer test and 6000 ergometer test in annual training cycle. Researchers will compare outcomes from both tests.",[506,507,508],"Endothelial Dysfunction","Mood Disorders","Malnutrition, Calorie",[510,511,512],"relative energy deficiency","gut permeability","rowers","2024-06-11",{"date":515,"type":45},"2024-06-13",{"date":517,"type":23},"2024-06-20",{"date":519,"type":23},"2024-06-30",{"name":51,"class":52},""]