[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Prof Ibrahim Janahi\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100640565","phase-3-metformin-treatment-for-children-with-obesity-associated-asthma-100640565",false,"NCT07622290","Metformin Treatment for Children With Obesity-associated Asthma","The Role of Metformin in Asthma Control in Obese\u002FOverweight Children, a Randomized Placebo Controlled Clinical Trial","MOACT","Inclusion Criteria:\n\n* Participant who are capable of giving assent and parentral consent\n* Male\u002FFemale participant aged between10-17 years old,\n* overweight\u002Fobese children (Overweight and obesity are defined as BMI equal and above the 85th percentile, and BMI above the 95th percentile for age and sex, respectively).\n* Diagnosed with mild persistent, moderate persistent \u002Fsevere asthma based on GINA guidelines within the 6 months prior to the recruitment date and having ACT score \\\u003C 20, residing in Qatar\n* Partcipants on standard asthma therapy for at least the last 6 months prior to the recruitment\n* Participant who are currently not taking part in any other interventional study\n\nExclusion Criteria:\n\n* Non-asthma chronic lung disease\n* Broncho-pulmonary dysplasia\n* Inflammatory bowel disease\n* Syndromic disorders (e.g. Down's syndrome, Turner's syndrome)\n* Inborn errors of metabolism\n* Symptomatic or previously symptomatic congenital heart disease\n* Craniofacial abnormalities\n* Primary thoracic cage abnormalities\n* Neuromuscular disorders\n* Swallowing disorders\n* Secondary endocrinopathies causing obesity\n* Renal complications\n* Ongoing treatment for cancer\n* Taking metformin or GLP1 medication less than 3 months of the recruitment date\n* Children diagnosed with type-1 diabetes","ALL","10 Years","17 Years",{"count":21,"type":22},182,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","The goal of this clinical trial is to learn if metformin can improve asthma control in overweight and obese children with mild, moderate, or severe asthma. It will also evaluate the safety and metabolic effects of metformin in this population. The main questions the study aims to answer are:\n\n1\\) Does metformin improve asthma control, as measured by the Asthma Control Test (ACT) score? 2) Does metformin improve lung function, reduce asthma exacerbations, and improve metabolic and inflammatory markers in overweight\u002Fobese children with asthma? Researchers will compare metformin with a placebo (a look-alike substance that contains no active drug) to see if metformin improves asthma outcomes in overweight\u002Fobese children with asthma. Participants will take either metformin or a placebo in addition to their standard asthma treatment during the study period. They will attend scheduled clinic visits for asthma assessments, lung function testing, and safety monitoring. Blood, stool, and saliva samples, along with clinical information, will be collected from participants to assess asthma control, and markers related to metabolism and inflammation. Participants will also complete asthma control questionnaires and report medication use and asthma symptoms throughout the study period.",[28],"Obesity-associated Asthma",[30,31,32],"obesity-associated asthma","pediatric asthma","metformin","NOT_YET_RECRUITING","2026-05-30",{"date":36,"type":37},"2026-06-03","ACTUAL",{"date":39,"type":22},"2026-06",{"date":41,"type":22},"2028-03",{"name":43,"class":44},"Prof Ibrahim Janahi","OTHER",""]