[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Radiomedix, Inc.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":60},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":5},"100649317","phase-1-study-of-203pb-rmx-vh-pib-dosimetry-and-biodistribution-in-patients-with-glioblastoma-multiform-gbm-and-pancreatic-ductal-adenocarcinoma-pdac-100649317",false,"NCT07733674","Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Glioblastoma Multiform (GBM) and Pancreatic Ductal Adenocarcinoma (PDAC)","Dosimetry and Bio-distribution of 203Pb-RMX-VH-PIB in Newly Diagnosed or Recurrent Patients With Solid Tumors: A Phase I Exploratory Study","RMX-VH","Inclusion Criteria:\n\n1. Signed informed consent.\n2. Subjects aged ≥18 years.\n3. Karnofsky status ≥60.\n4. Negative urine pregnancy test in women of childbearing potential.\n5. Histologically confirmed and \u002For highly suspicious GBM (Adult type Astrocytoma grade IV both IDH-Mutant and IDH-Wild Type) including primary, recurrent or stable enhancing residual or primary, recurrent or stable enhancing residual PDAC.\n\n   a. GBM group i. Contrast enhanced Brain MRI image with results compatible with GBM within the 2 weeks of dosing day.\n\n   ii. Tumor size of ≥ 1.0 cm in any dimension by MRI. iii. No antiangiogenic therapy within 4 weeks of the day of dosing. iv. No chemotherapy within 2 weeks of the day of dosing. v. Subjects receiving corticosteroids must be on a stable or decreasing dose regimen prior to enrollment b. PDAC group i. No chemotherapy within 2 weeks of the day of dosing ii. Tumor size of ≥ 1.0 cm in any dimension by MRI or CT\n6. Recent blood test results (within 4 weeks pre-dose) as follows:\n\n   1. WBC: ≥ 2 x 109\u002FL\n   2. Haemoglobin: ≥ 8 g\u002FdL\n   3. Platelets: ≥75 x 109\u002FL\n   4. ALT, AST, AP ≤ 5 times ULN\n   5. Bilirubin: ≤ 2 times ULN\n   6. Creatinine clearance ≥ 60 mL\u002Fmin, calculated by the Cockcroft-Gault equation\n\nExclusion Criteria:\n\n1. Known hypersensitivity to RMX-VH peptide analogue, 203Pb-RMX-VH-PIB, 203Pb (Lead) , or any of the excipients of 203Pb-RMX-VH-PIB.\n2. Inability to undergo MRI or CT\u002FSPECT\u002FCT scans\n3. Current somatic or psychiatric disease\u002Fcondition that may interfere with consent or the objectives and assessments of the study.\n4. Pregnancy or plans to conceive during the course of study participation.\n5. In GBM groups participants requiring MRI: History of hypersensitivity or contraindication to gadolinium-based contrast agents, including prior allergic or anaphylactoid reactions to gadolinium contrast media, or any condition (e.g., severe renal impairment, acute kidney injury) that, in the investigator's judgment, increases the risk associated with gadolinium administration.\n6. In PDAC groups participants requiring CT scans: Any contraindications to iodinated contrast agents include a history of severe hypersensitivity or allergic reaction to iodinated contrast media, significant renal impairment (e.g., eGFR \\\u003C 30 mL\u002Fmin\u002F1.73 m² or acute kidney injury), uncontrolled hyperthyroidism or other thyroid disorders that may worsen with iodine exposure, prior contrast-induced nephropathy, pregnancy, and any unstable medical condition such as severe heart failure or hemodynamic instability that, in the investigator's judgment, increases the risk of contrast administration.\n7. Male and female participants of childbearing potential who are unwilling or unable to use an acceptable method of contraception for the duration of the study.\n8. Women who are breastfeeding\n9. Participants who are currently receiving treatment with statins (HMG-CoA reductase inhibitors), including but not limited to atorvastatin, rosuvastatin, pitavastatin, simvastatin, lovastatin, pravastatin, or fluvastatin, are excluded unless the medication has been discontinued for at least four (4) drug half-lives prior to administration of the investigational product","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","The goal of this Phase I clinical trial is to evaluate how the imaging drug 203Pb- RMX-VH-PIB distributes in the body and how much radiation different organs receive in patients with glioblastoma multiforme (GBM) or pancreatic ductal adenocarcinoma (PDAC).\n\nThe main questions it aims to answer are:\n\nHow does 203Pb-RMX-VH-PIB spread in the body (biodistribution)? What is the radiation dose delivered to organs (dosimetry)?\n\nParticipants will:\n\nReceive a single intravenous (IV) injection of 203Pb-RMX-VH-PIB. Undergo multiple single-photon emission computed tomography\u002Fcomputed tomography (SPECT\u002FCT) imaging scans.\n\nHave blood, urine, vital signs, and electrocardiogram (ECG) monitored for safety.\n\nBe followed for any side effects for up to 30 days.",[27,28],"Glioblastoma Multiforme (GBM)","Pancreatic Ductal Adenocarcinoma (PDAC)",[27,28,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47],"203Pb-RMX-VH-PIB","SPECT\u002FCT Imaging","Radiopharmaceutical","Brain Tumor","Pancreatic Cancer","RMX-VH-02","lead-203","radiolabeled peptide","investigational radiopharmaceutical","diagnostic radiopharmaceutical","tumor-targeted radiopharmaceutical","malignant glioma","high-grade glioma","malignant brain tumor","astrocytoma","IDH-wildtype glioblastoma","brain tumor targeting","Astrocytoma grad IV","RECRUITING","2026-08-04",{"date":51,"type":52},"2026-08-07","ACTUAL",{"date":54,"type":21},"2026-08-15",{"date":56,"type":21},"2027-06-30",{"name":58,"class":59},"Radiomedix, Inc.","INDUSTRY",""]