[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Recep Tayyip Erdogan University Training and Research Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":445},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,43,65,88,109,129,145,164,184,209,239,262,287,311,335,354,374,400,424],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100647897","different-local-anesthesia-techniques-for-mandibular-primary-molar-pulpectomy-100647897",false,"NCT07714915","Different Local Anesthesia Techniques for Mandibular Primary Molar Pulpectomy","Comparison of Computer-Controlled and Conventional Local Anesthesia Techniques on Dental Anxiety and Pain During Mandibular Primary Molar Pulpectomy: A Split-Mouth Randomized Clinical Trial","Inclusion Criteria:\n\n* Children aged 6 to 8 years.\n* Requiring bilateral pulpectomy treatment of mandibular primary molars.\n* Frankl Behavior Rating Scale score of 3 or 4.\n* American Society of Anesthesiologists (ASA) Physical Status I.\n* No known allergy to local anesthetic agents.\n* No previous experience with dental local anesthesia.\n* No signs of acute abscess or swelling in the treatment area.\n* Parent or legal guardian able to provide written informed consent and child willing to participate.\n\nExclusion Criteria:\n\n* ASA Physical Status II or higher.\n* Known allergy or contraindication to local anesthetic agents.\n* Frankl Behavior Rating Scale score of 1 or 2.\n* Children receiving psychological or psychiatric treatment.\n* Physical or intellectual disabilities that could interfere with study procedures.\n* Previous experience with dental local anesthesia.\n* Presence of acute abscess, cellulitis, or diffuse swelling in the treatment area.",true,"ALL","6 Years","8 Years",{"count":21,"type":22},38,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to compare the effects of computer-controlled local anesthesia and conventional inferior alveolar nerve block on dental anxiety and pain in children undergoing pulpectomy of mandibular primary molars. Both anesthesia techniques are routinely used in pediatric dental practice and are considered standard methods of care.\n\nChildren aged 6 to 8 years who require bilateral pulpectomy of mandibular primary molars will be included in this split-mouth randomized clinical trial. Each participant will receive both anesthesia techniques during separate treatment sessions. Dental anxiety, pain, and physiological parameters, including heart rate, blood pressure, oxygen saturation, and body temperature, will be assessed before, during, and after treatment using validated pediatric assessment scales and routine clinical measurements.\n\nThe findings of this study may help identify the anesthesia technique that provides greater comfort and reduces anxiety and pain during pediatric dental treatment, thereby improving the overall treatment experience for children.",[28,29,30],"Dental Anxiety","Pain","Pulpal Diseases","NOT_YET_RECRUITING","2026-08-11",{"date":34,"type":35},"2026-08-12","ACTUAL",{"date":34,"type":22},{"date":38,"type":22},"2026-10-15",{"name":40,"class":41},"Recep Tayyip Erdogan University Training and Research Hospital","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":16,"sex":17,"minAge":19,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":62,"leadSponsor":64,"locationsCount":4},"100650871","effects-of-long-term-antihistamine-use-on-mandibular-bone-in-children-100650871","NCT07752485","Effects of Long-Term Antihistamine Use on Mandibular Bone in Children","Effects of Long-Term H1 Antihistamine Use on Mandibular Trabecular Bone Structure and Panoramic Mandibular Index in Children: A Retrospective Radiographic Study","Inclusion Criteria\n\n* Children aged 8 to 10 years.\n* Availability of a diagnostic-quality digital panoramic radiograph obtained as part of routine dental care.\n* Presence of complete mandibular permanent first molars and permanent incisors.\n* Belonging to one of the following study groups:\n* Children receiving regular H1 antihistamine therapy for at least 12 months.\n* Children diagnosed with an allergic disease who have not received H1 antihistamine therapy during the previous 12 months.\n* Healthy children without allergic disease or long-term antihistamine use.\n* Availability of complete medical and dental records. Exclusion Criteria\n* History of systemic diseases or conditions known to affect bone metabolism.\n* Use of medications affecting bone metabolism (other than H1 antihistamines in the antihistamine group).\n* Craniofacial anomalies or syndromes.\n* History of orthodontic treatment.\n* Previous mandibular trauma or surgery.\n* Presence of radiographic pathology affecting the mandibular regions of interest (e.g., cysts, tumors, fractures, or extensive bone lesions).\n* Poor-quality panoramic radiographs with positioning errors or artifacts that interfere with image analysis.\n* Missing permanent first molars or incomplete eruption of teeth required for the analysis.","10 Years",{"count":52,"type":22},84,"OBSERVATIONAL","The purpose of this retrospective radiographic study is to evaluate the effects of long-term H1 antihistamine use on mandibular trabecular bone structure in children aged 8-10 years. Mandibular trabecular bone will be assessed using fractal dimension analysis and the panoramic mandibular index on digital panoramic radiographs. Three groups will be compared: children receiving long-term H1 antihistamine therapy, allergic children without antihistamine use, and age- and sex-matched healthy controls. The findings will provide information on whether long-term antihistamine therapy is associated with alterations in mandibular bone microarchitecture.",[56,57],"Fractals","Panoramic Radiography","2026-08-03",{"date":60,"type":35},"2026-08-07",{"date":58,"type":22},{"date":63,"type":22},"2026-09-03",{"name":40,"class":41},{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":16,"sex":17,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":4},"100650812","radiographic-predictors-of-the-mandibular-lateral-lingual-canal-100650812","NCT07752914","Radiographic Predictors of the Mandibular Lateral Lingual Canal","Mandibular Canal Dimensions and Sublingual Fossa Morphology as Predictors of the Mandibular Lateral Lingual Canal","Inclusion Criteria\n\n* Individuals aged 18 to 75 years.\n* Availability of previously acquired cone-beam computed tomography (CBCT) images obtained for diagnostic purposes.\n* Presence of a unilateral mandibular lateral lingual canal (MLLC) on CBCT images.\n* CBCT images of sufficient diagnostic quality to evaluate the location, diameter, and course of the MLLC.\n* Both mandibular sides included in the same CBCT examination, allowing comparison between the side with the MLLC and the contralateral side.\n* Absence of significant motion artifacts, metal artifacts, or reconstruction errors in the regions to be measured.\n\nExclusion Criteria\n\n* CBCT images of insufficient quality for morphometric measurement or anatomical assessment.\n* Inability to clearly identify the mandibular canal, mental foramen, MLLC, or sublingual fossa boundaries.\n* Presence of bilateral mandibular lateral lingual canals.\n* History of surgery, trauma, fracture, resection, bone grafting, or implant placement in the mandibular region under evaluation.\n* Motion or metal artifacts that prevent reliable visualization or measurement of the anatomical structures.\n* History of systemic disease or syndrome affecting craniofacial or mandibular development.\n* Presence of cystic or tumoral lesions, exostoses, or other pathological changes affecting the region of interest.\n* History of orthodontic treatment affecting the region evaluated.","18 Years","75 Years",{"count":75,"type":22},210,"The purpose of this retrospective observational study is to investigate whether mandibular canal dimensions and sublingual fossa morphology can serve as radiographic predictors of the mandibular lateral lingual canal (MLLC) using cone-beam computed tomography (CBCT). CBCT images of adults with unilateral MLLC will be retrospectively evaluated. Mandibular canal diameter, mental foramen diameter, and sublingual fossa depth will be compared between the side with the MLLC and the contralateral side. In addition, the location, diameter, and course of the MLLC will be analyzed to identify radiographic features associated with its presence and to improve preoperative assessment for mandibular surgical procedures.",[78,79,80],"Mandibular Canal Visibility","MANDIBLE","CBCT Segmentation","2026-08-02",{"date":60,"type":35},{"date":84,"type":22},"2026-08-04",{"date":86,"type":22},"2026-09-30",{"name":40,"class":41},{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":16,"sex":17,"minAge":19,"maxAge":50,"enrollmentInfo":95,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":4},"100650433","pain-and-anxiety-during-vital-pulp-therapy-using-different-local-anesthesia-techniques-in-children-100650433","NCT07748390","Pain and Anxiety During Vital Pulp Therapy Using Different Local Anesthesia Techniques in Children","Evaluation of the Effects of Different Local Anesthesia Techniques on Dental Anxiety and Pain During Vital Pulp Therapy","Inclusion Criteria:\n\n* Children aged 8-10 years.\n* Children and parents\u002Flegal guardians who agree to participate in the study and provide informed consent.\n* Patients requiring vital pulp therapy of a permanent mandibular first molar.\n* Patients classified as Frankl Behavior Rating Scale score 3 or 4. Systemically healthy children (ASA I).\n* Children with adequate cognitive and communication abilities to understand the study procedures and pain\u002Fanxiety assessment scales.\n* Permanent mandibular first molars without clinical or radiographic signs of abscess, fistula, or periapical pathology.\n\nExclusion Criteria:\n\n* Children with systemic diseases or medical conditions affecting dental treatment.\n* Children classified as Frankl Behavior Rating Scale score 1 or 2.\n* Patients with known allergy or hypersensitivity to local anesthetic agents (e.g., lidocaine, articaine).\n* Teeth with acute dental infection signs, including abscess, cellulitis, or extensive infection.\n* Teeth showing clinical or radiographic evidence of periapical pathology.\n* Children unable to understand or complete pain and anxiety assessment scales due to cognitive, visual, hearing, or communication limitations.\n* Patients who do not comply with the study procedures or withdraw consent.",{"count":96,"type":22},120,"This prospective observational study aims to evaluate the effects of different local anesthesia techniques on dental anxiety and pain in children undergoing vital pulp therapy of permanent mandibular first molars. Conventional inferior alveolar nerve block and two computer-controlled local anesthetic delivery (CCLAD) systems used in routine clinical practice will be compared. The choice of anesthesia technique will be based on the clinician's routine decision-making, and no additional intervention or modification of standard treatment will be performed for research purposes. Dental anxiety, pain, physiological parameters, and postoperative complications will be assessed using validated clinical scales and routine clinical measurements. The findings may help improve pain and anxiety management during pediatric dental treatment while supporting evidence-based selection of local anesthesia techniques.",[99,100],"Pediatric","Anesthesia","2026-07-31",{"date":103,"type":35},"2026-08-05",{"date":105,"type":22},"2026-08-01",{"date":107,"type":22},"2026-12-30",{"name":40,"class":41},{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":16,"sex":17,"minAge":72,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":123,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":42},"100649975","effect-of-dental-education-duration-on-halitosis-and-associated-factors-100649975","NCT07740876","Effect of Dental Education Duration on Halitosis and Associated Factors","Assessment of the Relationship Between Duration of Dental Education and Halitosis, Oral Hygiene Behaviors, and Associated Factors Among Dental Students","Inclusion Criteria:\n\n* Undergraduate students enrolled in the Faculty of Dentistry at Recep Tayyip Erdoğan University.\n* First-year and fifth-year dental students who agree to participate in the study and provide written informed consent.\n* Healthy students with no systemic diseases affecting oral health or halitosis assessment.\n* Students with normal nasal breathing ability.\n* Participants who comply with the pre-assessment instructions required for accurate halitosis measurements.\n* Participants who are able to complete the questionnaires and clinical evaluation procedures.\n\nExclusion Criteria:\n\n* Students with systemic diseases that may affect halitosis, including diabetes mellitus, respiratory disorders, liver cirrhosis, chronic renal failure, or gastrointestinal disorders.\n* Participants with active upper respiratory tract infection, sinusitis, tonsilloliths, or other conditions affecting oral odor.\n* Participants with a history of antibiotic use within the previous 3 weeks.\n* Pregnant or breastfeeding students.\n* Students unwilling to provide written informed consent.\n* Students receiving active orthodontic treatment or requiring orthognathic treatment.\n* Participants unable to comply with the pre-assessment restrictions (dietary restrictions, oral hygiene restrictions, smoking and product-use restrictions) before halitosis evaluation.","25 Years",{"count":118,"type":22},100,"The study population will consist of undergraduate dental students enrolled at Recep Tayyip Erdoğan University Faculty of Dentistry. A total of 100 students, including 50 first-year and 50 fifth-year dental students, will be included. Eligible participants will be healthy students who meet the study criteria and provide written informed consent. Participants will undergo subjective and objective halitosis assessments, including questionnaires, organoleptic evaluation, volatile sulfur compound measurements, tongue coating assessment, and DMFT index recording.",[121,122],"Halitosis","Dentistry",{"date":58,"type":35},{"date":125,"type":22},"2026-09-15",{"date":127,"type":22},"2026-11-15",{"name":40,"class":41},{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":16,"sex":17,"minAge":19,"maxAge":50,"enrollmentInfo":136,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":140,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":144,"locationsCount":4},"100649946","effect-of-nail-biting-habit-on-mandibular-bone-structure-a-retrospective-radiological-study-100649946","NCT07740889","Effect of Nail Biting Habit on Mandibular Bone Structure: A Retrospective Radiological Study","Evaluation of the Effects of Nail Biting Habit on Mandibular Bone Structure Using Fractal Analysis and Panoramic Morphometric Indices: A Retrospective Radiological Study","Inclusion Criteria:\n\n* Children aged 8-10 years who were examined at the Department of Pediatric Dentistry, Faculty of Dentistry, Recep Tayyip Erdoğan University.\n* Systemically healthy participants.\n* Participants with available diagnostic-quality panoramic radiographs obtained during routine dental examinations.\n* Participants with and without a history of nail biting habit.\n* Panoramic radiographs with sufficient image quality for fractal dimension analysis and mandibular morphometric measurements.\n* Radiographs without periapical pathology in teeth adjacent to the regions of interest (ROI) used for fractal analysis.\n* Participants with at least 20 existing teeth.\n* Radiographic records with available parental radiographic information and consent documentation.\n\nExclusion Criteria:\n\n* Participants with systemic diseases or conditions that may affect bone metabolism, including diabetes mellitus, osteoporosis, osteomalacia, renal diseases, hypothyroidism, or hyperparathyroidism.\n* Participants using medications that may influence bone density or bone metabolism.\n* Participants with temporomandibular joint disorders affecting the subcondylar region.\n* Participants with mandibular pathological conditions, including cysts, tumors, or other lesions affecting mandibular bone structure.\n* Participants with periapical pathology adjacent to the regions selected for fractal analysis.\n* Participants with fewer than 20 teeth.\n* Panoramic radiographs with insufficient diagnostic quality or image artifacts that prevent reliable measurements.\n* Radiographs that do not allow accurate evaluation of mandibular cortical and trabecular bone parameters.",{"count":118,"type":22},"Nail biting (onychophagia) is a common parafunctional habit characterized by repetitive and non-functional biting behavior. Although the effects of nail biting on dental structures and occlusion have been reported, its potential effects on mandibular bone structure remain unclear. This retrospective radiological study aims to evaluate the association between nail biting habit and mandibular bone characteristics using fractal analysis and panoramic morphometric indices. Existing panoramic radiographs of individuals with and without nail biting habits will be retrospectively analyzed. Trabecular bone complexity, mandibular cortical width, panoramic mandibular index, and Klemetti index values will be compared between groups to investigate whether nail biting habit is associated with alterations in mandibular bone morphology.",[139],"Onychophagia",{"date":58,"type":35},{"date":142,"type":22},"2026-07-27",{"date":60,"type":22},{"name":40,"class":41},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":16,"sex":17,"minAge":72,"maxAge":73,"enrollmentInfo":152,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":4},"100649800","serrated-inferior-turbinate-variation-and-sinonasal-findings-on-cbct-100649800","NCT07739927","Serrated Inferior Turbinate Variation and Sinonasal Findings on CBCT","Evaluation of the Relationship Between Serrated Inferior Turbinate Variation, Maxillary Sinus Mucosal Thickness, and Sinonasal Anatomical Structures Using Cone-Beam Computed Tomography","Inclusion Criteria:\n\n* Individuals aged 18-75 years.\n* Patients who underwent cone-beam computed tomography (CBCT) imaging for routine diagnostic purposes between January 2025 and June 2026.\n* CBCT images including both maxillary sinuses, nasal cavity, ostiomeatal complex, and inferior turbinates.\n* CBCT images with sufficient diagnostic quality and clearly visible anatomical boundaries for evaluation and measurements.\n* CBCT images in which the anatomical landmarks required for nasal septal deviation angle measurement (crista galli, maxillary spine, and the most deviated point of the nasal septum) can be clearly identified.\n\nExclusion Criteria:\n\n* Patients with maxillofacial trauma, fractures, or conditions affecting the midface anatomy.\n* Patients with congenital craniofacial anomalies (e.g., cleft lip and palate) or syndromes affecting facial anatomy.\n* Patients with a history of sinonasal, inferior turbinate, or maxillary sinus surgery.\n* CBCT images with insufficient diagnostic quality, motion artifacts, or metal artifacts preventing accurate evaluation.\n* Patients with pathological lesions affecting the maxillary sinus or nasal cavity anatomy, including cysts, tumors, or aggressive inflammatory lesions.\n* CBCT findings suggestive of fungal sinusitis, including heterogeneous hyperdense contents, calcifications, bone expansion, or invasive changes.",{"count":153,"type":22},105,"regulate nasal airflow, humidify and filter inspired air. Serrated inferior turbinate is a rare anatomical variation characterized by an irregular, serrated appearance of the inferior turbinate bone. Although this variation has been described in radiological studies, its possible relationship with maxillary sinus mucosal changes and other sinonasal anatomical features remains unclear.\n\nThis retrospective observational study aims to evaluate the relationship between serrated inferior turbinate variation and maxillary sinus mucosal thickness, mucosal abnormalities, and other sinonasal anatomical structures using cone-beam computed tomography (CBCT) images.\n\nCBCT images obtained from patients who underwent imaging for routine diagnostic purposes will be retrospectively reviewed. The presence of serrated inferior turbinate variation, maxillary sinus findings, inferior turbinate measurements, and nasal septum characteristics will be evaluated.\n\nThe study aims to improve understanding of the radiological significance of serrated inferior turbinate variation and to provide information that may contribute to more accurate evaluation and reporting of sinonasal anatomical variations.",[156,80],"Nasal Cavity","2026-07-28",{"date":101,"type":35},{"date":160,"type":22},"2026-07-15",{"date":162,"type":22},"2026-08-30",{"name":40,"class":41},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":171,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":4},"100649289","effects-of-topical-anesthetics-on-pain-and-anxiety-in-children-100649289","NCT07733622","Effects of Topical Anesthetics on Pain and Anxiety in Children","Evaluation of the Effects of Different Topical Anesthetic Agents on Pain and Anxiety in Pediatric Patients","Inclusion Criteria:\n\n* Children aged 6 to 8 years.\n* Frankl Behavior Rating Scale score of 3 or 4.\n* No previous history of local anesthetic injection for dental treatment.\n* Requiring maxillary infiltration anesthesia for treatment of a maxillary second primary molar.\n* Requiring non-emergency, painless dental treatment.\n* Medically healthy children with no chronic systemic disease, mental disability, or physical disability.\n* Written informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\n* Frankl Behavior Rating Scale score of 1 or 2.\n* Physical or intellectual disability.\n* History of cardiovascular disease, diabetes mellitus, Graves' disease, epilepsy, hyperthyroidism, active infection, phenylketonuria, cardiovascular shock, otorrhea, or otitis.\n* Known hypersensitivity or allergy to benzocaine, lidocaine, or any component of the topical anesthetic formulations.\n* Emergency dental treatment or presence of dental pain requiring urgent intervention.\n* Chronic liver or kidney disease.\n* History of methemoglobinemia.",{"count":172,"type":22},160,"Dental anxiety and pain associated with local anesthetic injections are among the most common barriers to successful dental treatment in children. Topical anesthetic agents are widely used to reduce discomfort during needle insertion; however, evidence regarding the comparative effectiveness of different formulations remains limited.\n\nThis prospective observational study aims to evaluate the effects of four routinely used topical anesthetic applications (benzocaine spray, benzocaine gel, lidocaine spray, and lidocaine gel) on pain and anxiety during local infiltration anesthesia in pediatric dental patients. The study will include 160 healthy children aged 6-8 years who require maxillary infiltration anesthesia for routine dental treatment. The choice of topical anesthetic will be determined by the treating clinician as part of routine clinical practice, and no additional intervention or treatment modification will be performed for research purposes.\n\nDental anxiety will be assessed using the Modified Child Dental Anxiety Scale-faces version (MCDASf), behavioral responses during local anesthetic administration will be evaluated using the Sound, Eye, and Motor (SEM) scale, and self-reported pain will be measured using the Wong-Baker FACES Pain Rating Scale. Physiological parameters, including heart rate, blood pressure, peripheral oxygen saturation (SpO₂), and body temperature, will be recorded before, during, and after local anesthetic administration. The findings are expected to provide evidence regarding the effectiveness of commonly used topical anesthetic formulations in reducing pain and anxiety during pediatric dental treatment and may contribute to optimizing behavior management strategies in clinical practice.",[28,175],"Children","2026-07-24",{"date":178,"type":35},"2026-07-29",{"date":180,"type":22},"2026-07-30",{"date":182,"type":22},"2026-09-10",{"name":40,"class":41},{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":17,"minAge":72,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":23,"phases":193,"briefSummary":194,"conditions":195,"keywords":197,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":206,"leadSponsor":208,"locationsCount":42},"100648257","diagnostic-accuracy-of-onsd-ode-and-the-crescent-sign-100648257","NCT07719842","Diagnostic Accuracy of ONSD, ODE, and the Crescent Sign","Diagnostic Accuracy of ONSD, ODE, and the Crescent Sign on Ultrasound for Identifying Increased Intracranial Pressure: A Multicenter Study","Inclusion Criteria:\n\n* All patients presenting at the ED with any symptoms, who have undergone a cranial CT or cranial MRI for the diagnosis of cranial pathologies, and who do not meet the exclusion criteria\n\nExclusion Criteria:\n\n* Patients under the age of 18\n* Patients who have not undergone a cranial CT or cranial MRI\n* Patients with orbital injuries\n* Patients in whom ultrasonographic measurements cannot be performed\n* Patients brought to ED following a cardiac arrest\n* Patients who do not consent to diagnosis and treatment of their own volition",{"count":192,"type":22},10,[25],"Our aim was to determine the diagnostic accuracy of the ONSD, ODE, and crescent sign, as detected by POCUS, in identifying the clinical and radiological features of increased intracranial pressure.",[196],"Assessment of ONSD, ODE and the Crescent Sign Using POCUS",[198,199,200,201],"POCUS","ONSD","ODE","crescent sign","2026-07-19",{"date":204,"type":35},"2026-07-22",{"date":105,"type":22},{"date":207,"type":22},"2027-01-31",{"name":40,"class":41},{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":16,"sex":17,"minAge":72,"maxAge":216,"enrollmentInfo":217,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":219,"conditions":220,"keywords":224,"overallStatus":230,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":42},"100644292","evaluation-of-the-effect-of-hyperuricemia-on-alveolar-bone-loss-100644292","NCT07666126","Evaluation of the Effect of Hyperuricemia on Alveolar Bone Loss","Evaluation of the Effect of Hyperuricemia on Alveolar Bone Loss and Oxidative Stress","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Being systemically healthy or diagnosed with hyperuricemia\n* Having at least 20 natural teeth\n* Being periodontally healthy or diagnosed with periodontitis\n\nExclusion Criteria:\n\n* Diabetes, cardiovascular disease, osteoporosis, chronic kidney disease, metabolic syndrome, and obesity are systemic diseases that may affect purine metabolism.\n* Smoking\n* Pregnancy or lactation\n* Having received periodontal treatment within the last 3-6 months\n* Use of antibiotics, anti-inflammatory drugs, or uric acid-lowering drugs\n* Presence of systemic diseases that may affect purine metabolism","65 Years",{"count":218,"type":22},80,"Periodontitis is a multifactorial disease characterized by chronic inflammation of the gum tissue and alveolar bone destruction, and is known to be associated with various systemic diseases. Hyperuricemia, on the other hand, is a metabolic condition characterized by increased serum uric acid levels and can affect inflammation, oxidative stress, and bone metabolism. In recent years, the relationship between hyperuricemia and periodontal diseases has been increasingly investigated, but the biological mechanisms of this relationship have not yet been fully elucidated. Therefore, this study aimed to determine whether there is a relationship between hyperuricemia and periodontitis and to reveal the possible pathophysiological mechanisms of this relationship, which are shaped by inflammation, oxidative stress, and bone metabolism.\n\nA total of 80 individuals aged 18-65 years will be included in this clinical observational study. The periodontal status of the participants will be assessed using clinical periodontal parameters such as probing pocket depth, clinical attachment loss, plaque index, gingival index, and bleeding on probing. Participants will be divided into four groups according to their periodontal status and the presence of hyperuricemia: individuals with periodontitis and hyperuricemia, individuals with periodontally healthy and hyperuricemia, individuals with periodontitis but without hyperuricemia, and individuals with periodontally healthy and without hyperuricemia. Gingival crevicular fluid and serum samples will be taken from the participants. In these samples, receptor-mediated nuclear factor kappa B ligand, osteoprotegerin, total antioxidant status, total oxidant status, oxidative stress index, interleukin-1 beta, interleukin-10, interleukin-18, and nucleotide-binding oligomerization domain-like receptor protein 3 levels will be analyzed. This study is considered unique because it examines the relationship between hyperuricemia and periodontitis by evaluating inflammation, oxidative stress, and bone metabolism parameters together.",[221,222,223],"Periodontal Diseases","Hyperuricemia","Oxidative Stress",[225,226,227,228,229],"periodontal disease","hyperuricemia","oxidative stress","alveolar bone loss","inflammation","RECRUITING","2026-06-23",{"date":233,"type":35},"2026-06-26",{"date":235,"type":22},"2026-06-10",{"date":237,"type":22},"2026-10-01",{"name":40,"class":41},{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":11,"sex":17,"minAge":246,"maxAge":216,"enrollmentInfo":247,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":248,"conditions":249,"keywords":251,"overallStatus":230,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":42},"100615049","anti-inflammatory-nutrition-on-the-outcomes-of-non-surgical-periodontal-therapy-100615049","NCT07287540","Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy","Evaluation of the Effects of Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy in Individuals With Periodontitis","Inclusion Criteria:\n\n* Being systemically healthy\n* Not smoking\n* Not using anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months\n* Not being pregnant or lactating\n* Not having received periodontal treatment in the last 6 months\n* Having at least 20 teeth in the mouth\n* Being diagnosed with periodontitis by the investigator\n* Having a dietary inflammatory index \\>0\n\nExclusion Criteria:\n\n* Having a systemic disease\n* Smoking\n* Using anti-inflammatory drugs within the last 3 months, antibiotics within the last 6 months, or systemic corticosteroids\n* Being pregnant or lactating\n* Having received periodontal treatment within the last 6 months\n* Having fewer than 20 teeth in the mouth\n* No periodontitis","20 Years",{"count":118,"type":22},"This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical periodontal parameters.\n\nA total of 100 volunteers identified as having a pro-inflammatory diet (Q3 and Q4) will be included in the study. Individuals will be assigned to two groups. These groups will then be further divided into two groups based on whether or not they will receive anti-inflammatory nutrition education. Group Q3-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q3-2 (n=25) will receive only non-surgical periodontal treatment. Group Q4-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q4-2 (n=25) will receive only non-surgical periodontal treatment. After the periodontal index measurements are completed, the patients will receive non-surgical periodontal treatment. GCF and serum samples, periodontal clinical parameters and Dietary Inflammatory Index will be collected 3 times: at baseline, 1.5 and 3 months after non-surgical periodontal treatment. Levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, total oxidant status (TOS), total antioxidant status (TAS), and C-reactive protein (CRP) will be assessed from these samples. This will investigate the role of anti-inflammatory nutrition in reducing periodontal inflammation and increasing treatment success.",[250],"Periodontitis",[252,253,254],"periodontitis","diet inflammatory index","anti-inflammatory nutrition","2026-06-18",{"date":231,"type":35},{"date":258,"type":35},"2025-11-22",{"date":260,"type":22},"2026-07-04",{"name":40,"class":41},{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":4,"eligibilityCriteria":268,"healthyVolunteers":16,"sex":17,"minAge":72,"maxAge":269,"enrollmentInfo":270,"targetDuration":4,"studyType":23,"phases":271,"briefSummary":272,"conditions":273,"keywords":276,"overallStatus":230,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":42},"100643649","the-effect-of-vitamin-d-supplementation-on-the-anti-inflammatory-response-in-periodontal-diseases-100643649","NCT07636733","The Effect of Vitamin D Supplementation on the Anti-inflammatory Response in Periodontal Diseases","The Effect of Vitamin D Levels and Supplementation on Anti-inflammatory Response in Periodontal Disease: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Study groups will be formed according to the 2017 Periodontal Disease Classification. Accordingly:\n* Periodontally healthy; absence of bleeding on probing, erythema, edema, patient symptoms, attachment, and bone loss\n* Gingivitis; patients with an average gingival index ≥0.5 according to Löe and Silness\n* Stage I-II periodontitis; patients with CAL 1-2 or 3-4 mm and a maximum PPD ≤5 mm, showing radiographic horizontal bone loss up to the coronal third of the root (15%-33%), but without tooth loss due to periodontitis\n* Stage III-IV periodontitis; Stage 3 and 4 patients with ≥15 teeth in their mouth, with CAL ≥5 and PPD ≥6 in at least 6 areas, and radiographic bone loss extending to the middle or apical third of the root.\n\nExclusion Criteria:\n\n* Individuals who have undergone periodontal treatment in the last 6 months, have systemic diseases (such as diabetes, parathyroid and thyroid-related endocrine diseases) that may affect periodontal status, patients with chronic liver disease, hypoparathyroidism and renal failure, those who have been using medications that may affect periodontal response (aspirin, non-steroidal anti-inflammatory drugs or steroids) for a long time, those who are using additional vitamin D or calcium supplements in the pre-study phase, those who are pregnant or breastfeeding, and those with hypercalcemia and malabsorption syndrome will not be included in the study.","70 Years",{"count":96,"type":22},[25],"A review of the literature revealed that while there are studies investigating the relationship between vitamin D and periodontal disease, there are no studies investigating the anti-inflammatory effect of vitamin D on periodontal disease. Investigators hypothesized that the increased incidence of periodontal disease in individuals with vitamin D deficiency might be due not only to pro-inflammatory effects but also to impaired bone metabolism and a decrease in the anti- inflammatory mechanism. Investigators aimed to determine this by comparing serum and DOS levels of 1,25-dihydroxyvitamin D (1,25(OH)2D), 25-hydroxyvitamin D (25(OH)D3), Receptor activator nuclear kappa B ligand (RANKL), osteoprotegerin (OPG), Tumor Necrosis Factor Related Apoptosis induced Ligand (TRAIL), Developmental endothelial locus (Del)-1, Lipoxin, Resolvin, interleukin (IL)-10, and transforming growth factor-β (TGF-β).\n\nThe study will include 120 individuals who are systemically healthy based on clinical and radiographic examinations and diagnosed with Stage I-II periodontitis, Stage III-IV periodontitis, chronic gingivitis, and periodontally healthy. Periodontal clinical parameters (Probing pocket depth (PPD), Clinical attachment level (CAL), Bleeding on probing (BOP), Plaque index (PI), Gingival index (GI)) will be recorded three times: before treatment, and 6 and 12 weeks after treatment. Gingival crevicular fluid (GCF) and serum samples will be collected from participants at baseline and 12 weeks later for biochemical analysis.",[221,274,275],"Gingivitis","Vitamin D Deficiency",[252,277,278,279],"gingivitis","Vitamin D","anti-inflammatory","2026-06-08",{"date":235,"type":35},{"date":283,"type":35},"2026-06-03",{"date":285,"type":22},"2026-10-16",{"name":40,"class":41},{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":4,"eligibilityCriteria":293,"healthyVolunteers":11,"sex":17,"minAge":72,"maxAge":216,"enrollmentInfo":294,"targetDuration":295,"studyType":53,"phases":4,"briefSummary":296,"conditions":297,"keywords":300,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":42},"100628474","metabolic-syndrome-associated-diet-100628474","NCT07462104","Metabolic Syndrome Associated Diet","Pro-İnflammatory Diet as a Modifying Factor in Periodontal Tissue Destruction Associated With Metabolic Syndrome","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Presence of at least three of the following parameters: (For MetS diagnosis) Waist circumference: ≥ 94 cm for men, ≥ 88 cm for women Blood pressure ≥ 130\u002F85 mmHg or taking antihypertensive medication Fasting blood glucose ≥ 100 mg\u002Fdl or diagnosed with Type 2 Diabetes Triglycerides ≥ 1.7 mmol\u002FL HDL \\\u003C 1.29 mmol\u002FL\n* Having at least 20 teeth\n* Not having received periodontal therapy in the last 6 months\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks\n* Not having any autoimmune disease, osteoporosis, or cancer\n* Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates\n* Not being pregnant\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)\n* Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)\n* Not taking antioxidant supplements in the last 6 months\n\nExclusion Criteria:\n\n* Patients with an active infectious disease,\n* Those taking medications that could affect periodontal tissues,\n* History of endocarditis,\n* Recent antibiotic use (within 4 months),\n* Alcohol\u002Fdrug use,\n* Psychological disorders,\n* Eating disorders,\n* Dementia,\n* Pregnancy and breastfeeding,\n* Patients who did not sign the informed consent form",{"count":118,"type":22},"1 Day","The goal of this observational study is to examine the relationship between metabolic syndrome (MetS) and periodontitis, and to evaluate the role of the Dietary Inflammatory Index (DII) in this association.\n\nThe main question it aims to answer is:\n\nDoes a pro-inflammatory diet, as measured by the DII, increase the risk or severity of periodontitis in individuals with metabolic syndrome?\n\nParticipants will include adults who meet the diagnostic criteria for metabolic syndrome. Their periodontal health will be assessed through standard clinical parameters, and dietary data will be collected using a validated food frequency questionnaire to calculate individual DII scores. The study will observe and analyze these factors to explore potential links between diet-induced inflammation, systemic metabolic health, and periodontal outcomes.",[298,250,299],"Metabolic Syndrome (MetS)","Diet, Food and Nutrition",[301,252,302,229],"metabolic syndrome","diet","2026-03-04",{"date":305,"type":35},"2026-03-10",{"date":307,"type":22},"2026-03-23",{"date":309,"type":22},"2026-11-23",{"name":40,"class":41},{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":16,"sex":17,"minAge":72,"maxAge":216,"enrollmentInfo":318,"targetDuration":295,"studyType":53,"phases":4,"briefSummary":320,"conditions":321,"keywords":323,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":42},"100625781","the-relationship-between-ultra-processed-food-consumption-and-oral-health-100625781","NCT07427095","The Relationship Between Ultra-Processed Food Consumption and Oral Health","Investigating the Relationship Between Ultra-Processed Food Consumption and Caries and Periodontal Disease","Inclusion Criteria:\n\n* Individuals between the ages of 18 and 65,\n* Individuals with at least 20 teeth,\n* Not having received periodontal treatment in the last 6 months,\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks,\n* Not having any autoimmune disease, osteoporosis, or cancer,\n* Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates,\n* Not being pregnant,\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS),\n* Not using chronic medications that affect periodontal tissues (cyclosporine A, Phenytoin),\n* Not having taken antioxidant supplements in the last 6 months.\n\nExclusion Criteria:\n\n* Patients with endocrine or genetic disorders such as hypothyroidism, type 1 diabetes mellitus, or Cushing's syndrome\n* Patients with active infectious disease\n* Patients taking medications that may affect periodontal tissues\n* Patients who have recently taken antibiotics (within 4 months)\n* Patients with alcohol\u002Fdrug use\n* Patients with psychological disorders\n* Patients with eating disorders, dementia\n* Patients who are pregnant or breastfeeding\n* Patients with any food allergies\n* Patients who do not sign the informed consent form",{"count":319,"type":22},200,"The goal of this observational study is to examine the potential relationship between ultra-processed food consumption and the presence of dental caries and periodontal disease, and to evaluate the role of the Ultra-Processed Food Index (UPFI) in this association.\n\nThe main question it aims to answer is:\n\nDoes increased consumption of ultra-processed foods raise the risk or severity of dental caries and periodontal disease in individuals?\n\nParticipants will include individuals within a specified age range who voluntarily agree to participate in the study. Oral health status will be assessed through standard clinical parameters, including the presence of caries, plaque index, probing pocket depth, clinical attachment loss, and bleeding on probing. Dietary habits will be evaluated using a validated food frequency questionnaire, and individual UPFI scores will be calculated. The study will aim to observe and analyze the effects of ultra-processed food consumption on oral health outcomes.",[322],"Ultra-processed Food",[324,325,225,326],"Ultra-Processed Food","tooth decay","oral health","2026-02-21",{"date":329,"type":35},"2026-02-24",{"date":331,"type":22},"2026-04-27",{"date":333,"type":22},"2026-10-26",{"name":40,"class":41},{"id":336,"slug":337,"hasResults":11,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":4,"eligibilityCriteria":341,"healthyVolunteers":11,"sex":17,"minAge":72,"maxAge":216,"enrollmentInfo":342,"targetDuration":295,"studyType":53,"phases":4,"briefSummary":343,"conditions":344,"keywords":346,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":348,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":42},"100625779","chronic-kidney-disease-associated-diet-100625779","NCT07427069","Chronic Kidney Disease Associated Diet","The Role of Pro-Inflammatory Diet in Periodontal Tissue Destruction in Chronic Kidney Disease","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Being diagnosed with Chronic Kidney Disease (having an eGFR below 60 ml\u002Fmin\u002F1.73 m² for at least 3 months or a urine albumin-to-creatinine ratio above 30 mg\u002Fg (proteinuria))\n* Having at least 20 teeth\n* Not having received periodontal therapy in the last 6 months\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks\n* Not having any autoimmune disease, osteoporosis, or cancer\n* Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates\n* Not being pregnant\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)\n* Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)\n* Not taking antioxidant supplements in the last 6 months\n\nExclusion Criteria:\n\n* Patients with an active infectious disease,\n* Those taking medications that could affect periodontal tissues,\n* History of endocarditis,\n* Recent antibiotic use (within 4 months),\n* Alcohol\u002Fdrug use,\n* Psychological disorders,\n* Eating disorders,\n* Dementia,\n* Pregnancy and breastfeeding,\n* Patients who did not sign the informed consent form",{"count":118,"type":22},"The goal of this observational study is to investigate the relationship between chronic kidney disease (CKD) and periodontitis, and to evaluate the potential mediating role of dietary inflammatory potential, measured by the Dietary Inflammatory Index (DII), in this association.\n\nThe main question it aims to answer is:\n\nDoes a pro-inflammatory diet, as reflected by a higher DII score, exacerbate periodontal inflammation in individuals with chronic kidney disease?\n\nParticipants will include adults diagnosed with CKD at various stages. Periodontal status will be assessed through clinical parameters such as probing depth, clinical attachment loss, and bleeding on probing. Dietary intake will be evaluated using a validated food frequency questionnaire, and DII scores will be calculated accordingly. The study will aim to observe and analyze whether dietary inflammation contributes to increased periodontal disease severity in CKD patients, potentially offering insight into modifiable risk factors relevant to both systemic and oral health.",[345,250,299],"Chronic Kidney Disease",[347,252,302,229],"Chronic kidney disease",{"date":329,"type":35},{"date":350,"type":22},"2026-04-20",{"date":352,"type":22},"2026-11-16",{"name":40,"class":41},{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":11,"sex":17,"minAge":72,"maxAge":216,"enrollmentInfo":361,"targetDuration":295,"studyType":53,"phases":4,"briefSummary":362,"conditions":363,"keywords":364,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":42},"100620222","metabolic-syndrome-associated-periodontal-inflammatory-surface-area-100620222","NCT07354815","Metabolic Syndrome-Associated Periodontal Inflammatory Surface Area","Determination of the Level of Correlation Between Periodontal Inflammatory Surface Area and Metabolic Syndrome-Associated Periodontal Tissue Destruction","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Presence of at least three of the following parameters: (For MetS diagnosis) Waist circumference: ≥ 94 cm for men, ≥ 88 cm for women Blood pressure ≥ 130\u002F85 mmHg or taking antihypertensive medication Fasting blood glucose ≥ 100 mg\u002Fdl or diagnosed with Type 2 Diabetes Triglycerides ≥ 1.7 mmol\u002FL HDL \\\u003C 1.29 mmol\u002FL\n* Having at least 20 teeth\n* Not having received periodontal therapy in the last 6 months\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks\n* Not having any autoimmune disease, osteoporosis, or cancer\n* Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates\n* Not being pregnant\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)\n* Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)\n* Not taking antioxidant supplements in the last 6 months\n\nExclusion Criteria:\n\n* Patients with active infectious disease,\n* Those taking medications that may affect periodontal tissues,\n* Those who did not sign the informed consent form.",{"count":118,"type":22},"This study aims to examine the potential of metabolic syndrome (MetS), a systemic, inflammatory disease, to influence the relationship between periodontal inflammatory surface area (PISA) and diabetes and obesity parameters. The primary question addressed by the study is:\n\nCan PISA be used as a significant parameter in the relationship between periodontal disease and MetS? In this context, the relationship between PISA and periodontal clinical parameters and serum parameters directly related to the diagnosis of MetS will be examined.",[298,250],[301,252,365],"periodontal inflammatory surface area","2026-01-12",{"date":368,"type":35},"2026-01-21",{"date":370,"type":22},"2026-02-23",{"date":372,"type":22},"2026-06-30",{"name":40,"class":41},{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":17,"minAge":72,"maxAge":216,"enrollmentInfo":381,"targetDuration":295,"studyType":53,"phases":4,"briefSummary":383,"conditions":384,"keywords":386,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":399,"locationsCount":42},"100605100","pathogenesis-of-periodontal-disease-in-individuals-with-psoriasis-100605100","NCT07158125","Pathogenesis of Periodontal Disease in Individuals With Psoriasis","Role of Th17 and Stress-related Neuroendocrine Markers in the Pathogenesis of Periodontal Disease in Individuals With Psoriasis","Inclusion Criteria:\n\n* Being between the ages of 18 and 65\n* Being diagnosed with psoriasis by a dermatologist\n* Having at least 20 teeth\n* Not having received periodontal treatment in the last 6 months\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks\n* Not having any autoimmune disease, osteoporosis, or cancer\n* Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates\n* Not being pregnant\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)\n* Not using chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)\n* Not having taken antioxidant supplements in the last 6 months\n\nExclusion Criteria:\n\n* \\\u003C20 teeth\n* Any significant oral infection (i.e., herpes or candidiasis)\n* Oral injuries or bleeding unrelated to periodontitis\n* Periodontal therapy and antibiotic therapy within the past 3 months\n* Salivary gland dysfunction\n* Acute illness (fever, sore throat)\n* Systemic illness, mental illness, immunosuppressive drugs or immunodeficiency\n* Pregnancy or breastfeeding\n* Use of antidepressants",{"count":382,"type":22},60,"The aim of this study is to evaluate the levels of Th17 cell-associated cytokines (IL-17, IL-21, IL-23) and the salivary stress biomarkers cortisol, dehydroepiandrosterone, and Chromogranin A in the pathogenesis of periodontal disease in individuals with psoriasis, thereby revealing immunological and neuroendocrine interactions.\n\nThe fundamental question it aims to answer is:\n\nWhat are the biological mechanisms that may increase the risk of periodontal disease in individuals with psoriasis?\n\nIn this context, the periodontal status of individuals with psoriasis will be clinically assessed, followed by analysis of the levels of Th17-associated cytokines and stress biomarkers in gingival crevicular fluid and saliva samples. Additionally, patients will be asked questions from the Social Appearance Anxiety Scale. The periodontal status of individuals with psoriasis will be determined cross-sectionally, and the resulting biomarker levels will be examined. In addition, the data obtained will be evaluated with statistical analysis in relation to disease severity and clinical parameters.",[385],"Psoriasis",[387,252,388,389,390,391],"psoriasis","Th17","cortisol","dehydroepiandrosterone","chromogranin A","2025-08-28",{"date":394,"type":35},"2025-09-05",{"date":396,"type":22},"2025-09-15",{"date":398,"type":22},"2026-04-06",{"name":40,"class":41},{"id":401,"slug":402,"hasResults":11,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":4,"eligibilityCriteria":406,"healthyVolunteers":11,"sex":17,"minAge":407,"maxAge":72,"enrollmentInfo":408,"targetDuration":295,"studyType":53,"phases":4,"briefSummary":410,"conditions":411,"keywords":413,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":421,"leadSponsor":423,"locationsCount":42},"100602763","relationship-between-malocclusion-severity-and-periodontitis-risk-100602763","NCT07127744","Relationship Between Malocclusion Severity and Periodontitis Risk","Determination of the Relationship Between Orthodontic Malocclusion Severity and Periodontitis Risk Using RANKL, OPG and Oxidative Stress Markers","Inclusion Criteria:\n\n* Patients between the ages of 12 and 18,\n* Patients with all permanent teeth,\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks,\n* Not having an active infectious disease,\n* Not having chronic medication use that affects periodontal tissues (cyclosporine A, Phenytoin),\n* Not having taken antioxidant supplements in the last 6 months.\n\nExclusion Criteria:\n\n* Presence of any congenital craniofacial deformity (cleft lip and palate or any other craniofacial syndrome or deformity),\n* Patients who have previously started or completed orthodontic treatment,\n* Patients who have received periodontal treatment in the last 6 months,\n* Acute illness,\n* Systemic illness, mental illness, immunosuppressive medications, or immunodeficiency.","12 Years",{"count":409,"type":22},70,"The goal of this observational study is to examine the potential relationship between the severity of orthodontic malocclusion and the risk of developing periodontitis in individuals by evaluating salivary and gingival crevicular levels of RANKL, osteoprotegerin (OPG), and oxidative stress biomarkers.\n\nThe main question it aims to answer is:\n\nDoes increasing severity of orthodontic malocclusion contribute to a higher risk of periodontitis through changes in RANKL\u002FOPG balance and oxidative stress levels?\n\nParticipants with different levels of tooth misalignment (malocclusion) will be examined to assess the condition of their teeth and gums. During this examination, information such as dental plaque, gum bleeding, and the depth of gum pockets will be recorded. In addition, fluid samples collected from the gums will be tested in the laboratory to measure certain biological substances and chemical markers related to the body's balance between harmful and protective effects. These measurements will be done using special laboratory tests.",[412],"Malocclusion",[414,252,415,416,227],"malocclusion","RANKL","Osteoprotegerin","2025-08-16",{"date":419,"type":35},"2025-08-22",{"date":396,"type":22},{"date":422,"type":22},"2026-01-19",{"name":40,"class":41},{"id":425,"slug":426,"hasResults":11,"nctId":427,"briefTitle":428,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":11,"sex":17,"minAge":407,"maxAge":72,"enrollmentInfo":431,"targetDuration":295,"studyType":53,"phases":4,"briefSummary":432,"conditions":433,"keywords":434,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":441,"completionDateStruct":442,"leadSponsor":444,"locationsCount":42},"100601885","salivary-stress-markers-associated-with-malocclusion-severity-100601885","NCT07116317","Salivary Stress Markers Associated With Malocclusion Severity","Determination of the Relationship Between Orthodontic Malocclusion Severity and Salivary Cortisol, Dehydroepiandrosterone and Chromogranin A Levels","Inclusion Criteria:\n\n* Patients between the ages of 12 and 18,\n* Patients with all permanent teeth,\n* Patients with the ability to read and understand,\n* Patients with a cephalometric evaluation file and maxillary and mandibular impression dental models before diagnostic orthodontic treatment.\n\nExclusion Criteria:\n\n* Presence of any congenital craniofacial deformity (cleft lip and palate or any other craniofacial syndrome or deformity),\n* Patients who have previously initiated or completed orthodontic treatment,\n* Patients with a history of psychiatric illness, the presence of caries, facial asymmetry, and any skin deformity affecting facial aesthetics.",{"count":96,"type":22},"The aim of this observational study is to evaluate the relationship between the severity of orthodontic malocclusion and psychophysiological stress levels in individuals aged 12 to 18 years. The study will investigate the association between malocclusion severity and both stress-related salivary biomarkers and psychosocial factors.\n\nThe primary research question is as follows:\n\nAs the severity of orthodontic malocclusion increases, do levels of salivary stress biomarkers (cortisol, DHEA, and chromogranin A), self-esteem, and social appearance anxiety significantly change in adolescent individuals?\n\nMethod:\n\nThe study will include participants between the ages of 12 and 18. The severity of malocclusion will be assessed through clinical examination. Psychological assessments will be conducted using structured questionnaires to measure self-esteem and social appearance anxiety. In addition, saliva samples collected in the morning will be analyzed using the ELISA method to determine levels of cortisol, DHEA, and chromogranin A (CgA). The data will be statistically analyzed to identify the potential relationship between orthodontic malocclusion and biological and psychosocial indicators of stress.",[412],[414,435,389,436,437],"stress","Dehydroepiandrosterone","Chromogranin A","2025-08-08",{"date":440,"type":35},"2025-08-11",{"date":440,"type":22},{"date":443,"type":22},"2026-02-09",{"name":40,"class":41},""]