[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Riga Stradins University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":236},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,40,66,96,123,151,186,213],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100652766","predictable-method-for-restoring-endodontically-treated-teeth-comparing-indirect-and-direct-methods-and-materials-in-aesthetic-dentistry-100652766",false,"NCT07778563","Predictable Method for Restoring Endodontically Treated Teeth, Comparing Indirect and Direct Methods and Materials in Aesthetic Dentistry.","SARC","Inclusion Criteria:\n\n* Have two endodontically treated molars suitable for restoration, allowing a split-mouth design for the indirect restorations (zirconia and glass-ceramic onlays).\n\nHave sufficient tooth structure circumferentially above the gingival margin to allow adequate isolation during restoration cementation.\n\nHave controlled periodontal disease and adequate periodontal health for participation.\n\nHave maxillary or mandibular molars that are in functional occlusion. Both smokers and non-smokers are eligible to participate. For the direct composite injection moulding group, one suitable endodontically treated molar per participant will be restored.\n\nExclusion Criteria:\n\n\\-","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical study is to evaluate the long-term clinical performance and cost-effectiveness of different restorative approaches for endodontically treated teeth, with a particular focus on zirconia and glass-ceramic onlays cemented using different resin cementation protocols, as well as direct composite restorations produced using the injection moulding technique.\n\nThe main questions it aims to answer are:\n\nDo zirconia onlays cemented with self-adhesive resin cement show comparable long-term clinical performance to those cemented with conventional adhesive resin cement? Does the choice of cement influence restoration survival, marginal integrity, discoloration, retention, and the occurrence of biological or technical complications? How do zirconia and glass-ceramic onlays compare with direct composite restorations produced using the injection moulding technique? Which treatment approach provides the best balance between clinical performance, cost-effectiveness, and patient satisfaction?\n\nThe clinical study will include 30 patients requiring restoration of two endodontically treated teeth. A split-mouth design will be used for the indirect restorations, allowing direct comparison of two cementation protocols within the same patient and minimizing the influence of individual patient-related factors. Zirconia and glass-ceramic onlays will be cemented using either a conventional adhesive resin cement or a self-adhesive resin cement. A third group will receive direct composite restorations using the injection moulding technique.\n\nPatients will be followed clinically at baseline, 1 year, and 3 years. The evaluations will assess restoration survival and condition, including fractures, cracks, loss of retention, marginal integrity, and discoloration. The condition of the abutment teeth and periodontal tissues will also be assessed, including secondary caries, endodontic complications, probing depth, bleeding on probing, and gingival recession. Patient-reported outcomes, including satisfaction and well-being, will be evaluated using questionnaires.\n\nAn initial in vitro phase will assess the influence of tooth surface pretreatment on the bond strength of self-adhesive resin cement after artificial aging. The results of this phase will be used to establish the most effective surface pretreatment protocol for the clinical study.\n\nThis study is expected to provide clinically relevant data on the long-term performance of zirconia, glass-ceramic, and direct composite restorations, as well as the influence of different cementation protocols. By combining clinical outcomes with complication rates, treatment costs, cost-effectiveness, and patient-reported outcomes, the study may help identify predictable, simplified, and economically sustainable restorative approaches for endodontically treated teeth.",[26],"Endodontically Treated Teeth Requiring Indirect Restorative Treatment",[28],"Zirconia Onlays, Self-Adhesive Resin Cement, Endodontically Treated Teeth, Bond Strength, Surface Pretreatment, Clinical Performance","NOT_YET_RECRUITING","2026-08-18",{"date":32,"type":33},"2026-08-21","ACTUAL",{"date":30,"type":20},{"date":36,"type":20},"2031-07-01",{"name":38,"class":39},"Riga Stradins University","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":47,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100613856","office-massage-effects-on-hrv-and-stress-100613856","NCT07272031","Office Massage Effects on HRV and Stress","Randomized Controlled Trial to Evaluate the Effectiveness of Three Different 15-Minute Office Massage Types (Head, Cervical Area, Hand) on Autonomic Nervous System Balance and Chronic Stress Reduction Using Heart Rate Variability (HRV)","Inclusion Criteria:\n\nBiological females aged 18 years or older. Currently working in an office job with at least 75% of the working day spent sitting (sedentary work).\n\nSelf-reported regular menstrual cycle (cycle length 21-35 days). Able to attend all scheduled intervention sessions (8 sessions over 4 weeks). Able to provide informed consent to participate in the study.\n\nExclusion Criteria:\n\nCurrent pregnancy or breastfeeding. Diagnosis of cardiovascular diseases (e.g., heart failure, cardiac arrhythmias, deep vein thrombosis) or presence of a pacemaker Endocrine or metabolic disorders (e.g., insulin-dependent diabetes, hyperthyroidism, or other thyroid dysfunctions) Active cancer or receiving active cancer treatment (e.g., chemotherapy, radiation therapy) History of major surgery or trauma in the head, neck, or upper extremities within the last 3 months Current diagnosis of a major psychiatric disorder (e.g., major depressive disorder, bipolar disorder) Regular use of medications affecting heart rate or the nervous system (e.g., beta-blockers, ACE inhibitors, antidepressants, anxiolytics, or asthma inhalers) Current participation in another interventional clinical trial","FEMALE",{"count":49,"type":20},140,[23],"This study is a randomized controlled trial designed to investigate which of three short office massage types (head, neck\u002Fshoulder area, or hand) is most effective for reducing chronic stress in women who perform sedentary office work.\n\nMany sedentary female office employees experience long-term tension and work-related strain, which can affect the body's ability to recover. The investigators are testing whether a 15-minute massage, performed twice a week for four weeks, can help restore balance within the body.\n\nThe investigators will evaluate the impact of these massages using Heart Rate Variability (HRV)-an objective measure that shows how well the body manages stress (autonomic nervous system balance)-as well as analyzing participants' self-reported levels of perceived stress, sleep quality, and overall well-being. Participants receiving massage will be compared to a control group engaging in quiet rest.",[53,54,55],"Occupational Health","Autonomic Nervous System (ANS) Functioning and Mood State","Stress","RECRUITING","2026-08-12",{"date":59,"type":33},"2026-08-13",{"date":61,"type":33},"2026-01-05",{"date":63,"type":20},"2026-09-30",{"name":38,"class":39},1,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":47,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":21,"phases":77,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":65},"100648031","remotely-supervised-exercise-during-chemotherapy-in-women-with-breast-cancer-100648031","NCT07716306","Remotely Supervised Exercise During Chemotherapy in Women With Breast Cancer","Effect of Remotely Supervised Combined Aerobic and Resistance Exercise Training on Physical Health and Quality of Life in Women With Breast Cancer During Chemotherapy","Inclusion Criteria:\n\n* previously untreated primary breast cancer;\n* stage IIA-B, IIIA-C at diagnosis;\n* diagnosis established by core needle biopsy;\n* age 30-65 years;\n* prescribed doxorubicin\u002Fcyclophosphamide-based NACT.\n\nExclusion Criteria:\n\n* cardiac pathologies (assessed by echocardiogram);\n* blood transfusion in the last six months;\n* another oncological disease;\n* previous chemotherapy, hormonal or X-ray treatment;\n* participation in another clinical trial.","30 Years","65 Years",{"count":76,"type":20},60,[23],"The RE-CARE project is designed to evaluate the effects of a 24-week, remotely supervised, combined high-intensity interval aerobic and resistance exercise training on physical health and quality of life in patients with breast cancer (BC) undergoing neoadjuvant chemotherapy (NACT). The study will enroll women aged 30-65 years with previously untreated, primary breast cancer, clinical stage IIA-IIB or IIIA-IIIC, who are scheduled to receive doxorubicin\u002Fcyclophosphamide-based NACT. Participants will be randomly allocated to either an experimental intervention group or a control group. At baseline, comprehensive assessments will be conducted to evaluate cardiorespiratory fitness, physical endurance, muscle strength, cognitive function, and health-related quality of life. The primary objective is to determine the impact of the remotely supervised combined aerobic and resistance exercise on incidence and severity of NACT-related adverse effects in patients with BC.",[80],"Breast Cancer",[82,83,84,85,86,87],"Breast cancer","Quality of life","Physical health","Combined exercise","Aerobic exercise","Resistance training","2026-07-16",{"date":90,"type":33},"2026-07-21",{"date":92,"type":20},"2027-01",{"date":94,"type":20},"2028-10",{"name":38,"class":39},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":47,"minAge":105,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":21,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":122,"locationsCount":65},"100626732","tumour-cell-response-to-acute-aerobic-exercise-in-breast-cancer-survivors-modulatory-effects-of-exercise-type-and-intensity-100626732","NCT07439458","Tumour Cell Response to Acute Aerobic Exercise in Breast Cancer Survivors: Modulatory Effects of Exercise Type and Intensity","Tumour Cell Response to Acute Aerobic Exercise in Breast Cancer Survivors: Modulatory Effects of Exercise Type and Intensity (TCReX) No: RSU\u002FLSPA-PA-2024\u002F1-0004 is Financed by the Investment of the European Union Recovery and Resilience Facility and the State Budget Within the Project \"RSU Internal and RSU With LASE External Consolidation\" No. 5.2.1.1.i.0\u002F2\u002F24\u002FI\u002FCFLA\u002F005.","TCReX","Inclusion Criteria (intervention group):\n\n* Reproductive age (premenopausal);\n* Diagnosis of Stage II-III Triple-Negative Breast Cancer (TNBC) (negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2));\n* Timeframe of 3 to 9 months after completion of surgery, adjuvant chemotherapy, radiation therapy, and\u002For immunotherapy;\n* Physician-certified (cardiologist) physical fitness for exercise testing, supported by echocardiography (ECHO).\n\nInclusion Criteria (control group):\n\n* Reproductive age (premenopausal);\n* No current or prior diagnosis of any type of cancer;\n* Matched by age, body constitution, and physical fitness to the breast cancer participant group.\n\nExclusion Criteria:\n\n* Pregnancy;\n* Autoimmune diseases (e.g., thyroiditis, inflammatory bowel disease, atopic dermatitis, etc.);\n* Endocrine disorders (e.g., metabolic syndrome, diabetes);\n* Cardiovascular diseases;\n* Diagnosis of any other type of oncological disease;\n* Any condition for which physical activity is contraindicated (e.g., asthma, COPD, spinal disc herniation, severe iron deficiency anemia).",true,"35 Years",{"count":107,"type":20},40,[23],"Cancer has emerged as a prominent cause of mortality in the 21st century, with breast cancer (BC) being the most diagnosed malignancy. Multidisciplinary cancer management has improved survival chances, but side effects and long-term consequences of treatments have significant implications for cancer survivors' health-related quality of life. Exercise is increasingly considered and used in cancer treatment and follow-up. However, studies demonstrating the biological mechanisms underlying the anticarcinogenic effects (ACE) of exercise are insufficient to justify the most appropriate physical activity for different clinical scenarios. Achieving scientific excellence in understanding the ACE of exercise in cancer management is critical to optimize treatment and enhance patients' quality of life.",[111,112,113,114,115],"Acute Exercise","Breast Cancer Cell Lines","Breast Cancer Survivors","Healthy Women","Myokine Response","2026-05-11",{"date":118,"type":33},"2026-05-14",{"date":120,"type":33},"2024-04-01",{"date":63,"type":20},{"name":38,"class":39},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":21,"phases":131,"briefSummary":132,"conditions":133,"keywords":138,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":65},"100630756","adhesive-cementation-materials-and-techniques-in-aesthetic-dentistry-100630756","NCT07491809","Adhesive Cementation Materials and Techniques in Aesthetic Dentistry","Adhesive Cementation Materials and Techniques in Aesthetic Dentistry and Their Effect on the Longevity of Porcelain Veneers","Inclusion Criteria:\n\n* healthy periodontium, needs at least 4 veneers, enamel around all veneer borders\n\nExclusion Criteria:\n\n* heavy bruxism, poor oral hygiene, active periodontal disease",{"count":76,"type":20},[23],"AIM: To determine the most effective cementation method and resin cement material for long term success of esthetical restorations TASKS: 1. Compare Panavia Veneer LC (Kuraray Noritake) cement with universal Panavia V5 (Kuraray Noritake) cement for porcelain veneer cementation in terms of marginal defects and discolouration; 2. Evaluating direct vs indirect restorations after 1-year and 3-year follow up periods in terms of patient satisfaction (evaluated by OES scale).\n\nMATERIAL AND METHODS: Participants: Patients attending the Department of Prosthodontics at the RSU Institute of Stomatology, and willing to improve the aesthetics of front teeth with porcelain veneers. Approx. 30 patients. Inclusion criteria: healthy periodontium, needs 4 veneers, stable occlusion. Exclusion criteria: heavy bruxism, poor oral hygiene, active periodontal inflammation.\n\nVeneer preparations will be done for maxillary anterior teeth approximately 0.5mm deep, involving the whole facial surface and keeping enamel around all borders. For digital impressions of preparations intra-oral scans with intraoral scanner (3Shape TRIOS 5 WIRELESS, Denmark) will be taken. Veneers will be fabricated according to the CAD\u002FCAM technique. This will be a prospective paired design study, i.e., two different composite cements (Panavia V5 and Panavia Veneer LC) will be used for each patient, cementing two veneers with each of the cements.\n\nData on following variables will be collected:\n\n1. Restoration condition (defects related to restoration - ceramic fractures, cracks, loss of retention, discolouration);\n2. Condition of the abutment teeth (secondary caries, endodontic complications);\n3. Periodontal condition (probing depth, bleeding on probing, gum recessions);\n4. Patient satisfaction questionnaire (OES).",[134,135,136,137],"Dental Veneers","Resin Cements","Composite Restoration","Orofacial Esthetic Scale",[137,139,140,141,142],"Dental veneers","Direct composite restorations","Patient satisfaction","Resin cements","2026-03-31",{"date":145,"type":33},"2026-04-06",{"date":147,"type":33},"2025-09-30",{"date":149,"type":20},"2029-08",{"name":38,"class":39},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":160,"phases":4,"briefSummary":161,"conditions":162,"keywords":171,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":65},"100612479","the-role-of-granulation-tissue-in-periodontal-regeneration-100612479","NCT07254117","The Role of Granulation Tissue in Periodontal Regeneration","The Role of Biochemical and Microbiological Properties of Granulation Tissue in Periodontal Regeneration","Inclusion Criteria:\n\n1. Both genders.\n2. Systemically healthy.\n3. Both smokers (smoking at least 10 cigarettes a day or electronic cigarettes daily or quit less than 5 years ago) and non-smokers (never smoked, smoke no more than once a month or quit at least 5 years ago).\n4. Patients aged 18 years and over.\n5. Patients with a history of severe periodontitis (stage III or IV, grade B-C) and, after completion of the non-surgical stage of periodontal treatment with at least one residual vertical bone defects (with ≥3 mm infrabony component) in premolar-molar region.\n6. Patients with a plaque index and bleeding on probing of 20% or lower before surgery.\n\nExclusion Criteria:\n\n1. Systemic diseases that may affect study results (uncontrolled type 2 diabetes mellitus (HBA1c level of \\>7%); recent (less than 6 months ago) myocardial infarction or stroke; blood coagulation disorders; recent use of antibiotics (less than 6 months).\n2. Use of medications that may affect study results (anti-osteoporotic drugs, statins, corticosteroids, calcium channel blockers, cyclosporine A, antiepileptic drugs, antipsychotic medication or antidepressants, chemotherapy and\u002For radiotherapy (active or history)).\n3. Current pregnancy and\u002For breastfeeding.\n4. Patients who have received any form of systemic antibiotics in the last six months prior to the start of the study.\n5. Patients who require antibiotic premedication prior to periodontal treatment.\n6. Prosthetic factors in teeth associated with suitable bone defects that prevent clinical measurements.\n7. Lack of patient motivation to undertake adequate dental care at home or to complete periodontal treatment.\n8. Strong vomiting reflex preventing adequate periodontal treatment.",{"count":159,"type":20},46,"OBSERVATIONAL","The goal of this observational study is to distinguish the infectious, healing, and regeneration-related characteristics of two types of gingival granulation tissues, namely infra-osseous and supra-osseous granulation tissues, in people with severe periodontitis (gum disease). Researchers aim to denote if these tissues may play role in healing after periodontal treatment. Researchers will also compare smokers and non-smokers to see if smoking disrupts the healing potential or infectious properties of granulation tissue. Participants will provide gingival fluid (before) and granulation tissue samples (at the time of) periodontal surgery. The main questions this study aims to answer are: 1. Do infra- and supra-osseous granulation tissues have different healing potential and infectious properties? 2. How do these tissues differ in people who smoke compared to people who do not smoke?",[163,164,165,166,167,168,169,170],"Periodontal Bone Loss","Periodontitis","Periodontal Disease","Periodontal Diseases","Periodontal Regeneration","Periodontal Granulation Tissue","Vertical Periodontal Bone Defects","Periodontal Healing",[172,164,173,174,175,176,177],"Periodontal granulation tissue","Vertical periodontal bone defects","Vertical defects","Granulation tissue","Periodontal regeneration","Periodontal healing","2025-11-19",{"date":180,"type":33},"2025-11-28",{"date":182,"type":33},"2025-05-29",{"date":184,"type":20},"2026-09",{"name":38,"class":39},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":16,"minAge":192,"maxAge":17,"enrollmentInfo":193,"targetDuration":4,"studyType":21,"phases":195,"briefSummary":196,"conditions":197,"keywords":199,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":210,"leadSponsor":212,"locationsCount":65},"100558464","smart-textile-solutions-as-biofeedback-method-for-injury-prevention-for-latvian-football-youth-league-players-100558464","NCT06551454","Smart Textile Solutions as Biofeedback Method for Injury Prevention for Latvian Football Youth League Players","Inclusion Criteria:\n\n1. youth football league players;\n2. agree to participate in the study;\n3. age from 14 to 18 years;\n4. understands and speaks Latvian.\n\nExclusion Criteria:\n\n1. operative treatment in the lower limb within the last 9 months;\n2. injuries or pain in the lower limb during the last 6 months;\n3. disorders of the vestibular apparatus\n4. presence of metallic implants in the sensor application areas.","14 Years",{"count":194,"type":20},80,[23],"Lower limb injuries are the most common in youth football leagues, accounting for 72% to 93% of all injuries. The leading prevention program in football today is the FIFA 11+ warm-up program, which reduces the risk of injury by 30%. Evidence from several studies confirms the addition of feedback during training reduces the incidence of injury by 40% . Recent studies have shown that the smart textile sock system is an objective, easy-to-use tool for real-time foot monitoring and is an interactive feedback tool for athletes. However, there is a lack of information on the impact of the objective feedback provided by the Smart Textile Sensor Socks System on the outcome measures of football players prevention programs. In the first phase of the project, a cross-sectional study involving youth league footballers will be conducted to identify the most effective feedback elements of the smart sock system. In the second phase, a pilot study will be conducted to evaluate the effectiveness of prevention exercises using the feedback provided by smart textile sensor socks. The results of the functional tests and the study outcomes will be selected as performance indicators to evaluate the smart textile sensor sock system. Conclusions on the use of the smart textile sensor sock system as a feedback method for injury prevention in Latvian Youth Football League players will be drawn based on the results obtained from the project.",[198],"Sport Injury",[200,201,202,203,204,205],"smart textile sock system","youth athletes","football","soccer","biofeedback","injurie prevention","2025-09-25",{"date":208,"type":33},"2025-10-01",{"date":206,"type":33},{"date":211,"type":20},"2026-10-01",{"name":38,"class":39},{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":220,"targetDuration":4,"studyType":21,"phases":221,"briefSummary":222,"conditions":223,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":65},"100568710","a-chitosan-brush-and-enamel-matrix-derivative-for-non-surgical-treatment-of-furcations-100568710","NCT06684769","A Chitosan Brush and Enamel Matrix Derivative for Non-surgical Treatment of Furcations","Non-surgical Treatment of Mandibular and Maxillary Molar Furcations With a Chitosan Brush With Adjunct Enamel Matrix Derivative- a Split-mouth Randomized Clinical Trial","Inclusion criteria:\n\n1. The patient is 18 years of age or older\n2. The patient does not have any systemic diseases that may affect the results of the study\n3. The patient has a plaque index of 20% or less at the study entry\n4. The patient has a history of severe localized or generalized periodontitis (stage III or IV)\n5. Completed the first and second steps of periodontal treatment (According to Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline) (Sanz M. et al.)\n6. Buccal and\u002For lingual Class 2A and\u002For 2B furcation involvement (FI) defects on both sides of the Mandibular first and\u002For second molars after completing the first and second steps of periodontal treatment.\n7. Buccal Class 2A and\u002For 2B furcation involvement (FI) defects on both sides of the maxillary first and\u002For second molars after completion of the first and second step of periodontal treatment if furcation involvement on the palatal side (mesiopalatal and distopalatal) does not exceed Class 1.\n8. Psychological appropriateness\n9. Consents to all follow-up visits\n\nExclusion Criteria:\n\n1. Patients who have systemic diseases that may affect the results of the study\n2. Use of medications that may affect study results (anti-osteoporotic drugs, statins, corticosteroids, anticoagulants)\n3. Patients who use calcium channel blockers, cyclosporine A or antiepileptic drugs if there are clinically visible hyperplastic changes in the gingival margin.\n4. Patients who have received any type of systemic antibiotics in the last six months prior to the start of the study and patients starting antibiotics during the study\n5. Patients requiring antibiotic premedication prior to periodontal treatment\n6. Oncological disease\n7. Chemotherapy and\u002For radiotherapy (active or history)\n8. Pregnancy and breastfeeding\n9. Any condition or current treatment which, in the opinion of the investigator and\u002For consulting physician, may present an unreasonable risk\n10. Psychoemotional disorders and depression\n11. Use of antipsychotic medication or antidepressants\n12. Lack of patient motivation to undertake adequate dental care at home or complete periodontal treatment, patients residing outside Latvia\n13. Molars with combined endodontic-periodontal lesions, active endodontic infection\n14. Prosthetic factors for molars not allowing clinical measurements\n15. Huge restoration or amalgam fillings that could potentially cause fractures or furcation involvement\n16. Enamel pearls or filling or crown margins\n17. Decay or root resorption\n18. Tooth mobility degree 3\n19. Molars in which the gingival margin is positioned apically from the entrance into the furcation area\n20. Clinical attachment level and or pockets mesial and distal to the furcation involvement defect of 6 or more mm\n21. Strong vomiting reflex that would prevent adequate periodontal treatment\n22. People close to the study subjects, work colleagues, relatives, etc.",{"count":107,"type":20},[23],"Patients diagnosed with stage III or IV periodontitis who exhibit mandibular first or second molars with Class II, Subclass A, or B buccal and\u002For lingual mandibular furcation defects (horizontal probing depth of ≥ 3 mm ) will be recruited.\n\nPatients diagnosed with stage III or IV periodontitis who exhibit maxillary first or second molars with Class II, Subclass A, or B buccal furcation defects (horizontal probing depth of ≥ 3 mm ) if furcation involvement on the palatal side (mesiopalatal and distopalatal) does not exceed Class 1 will be recruited.\n\nThis study will be a prospective, randomized, single-blinded, controlled clinical trial with a split-mouth design.\n\nPatients will be recruited from the clinics of the Riga Stradiņš University Institute of Stomatology of Riga, Latvia.\n\nBefore the baseline treatment, all patients who meet the inclusion criteria will be given detailed oral hygiene instructions and motivation.\n\nPatients' furcation defects in each quadrant will be randomly allocated at a 1:1 ratio to either the application of Oscillating Chitosan Brush with Enamel Matrix Derivatives (test group) or Oscillating Chitosan Brush alone (control group).\n\nNon-surgical periodontal treatment of furcation defects on the test side will be performed through the application of Oscillating Chitosan Brush with Enamel Matrix Derivatives and on the control side with Oscillating Chitosan Brush alone.\n\nThe re-evaluation of periodontal status will be performed 12 weeks following the baseline treatment.\n\nBiofilm samples and gingival crevicular fluid (GCF) samples will be taken at the baseline and at 4 weeks.",[224,225,226,227],"Periodontitis, Adult","Furcation Defects","Furcation of Root of Tooth","Periodontitis Complex","2025-08-31",{"date":230,"type":33},"2025-09-08",{"date":232,"type":33},"2024-11-15",{"date":234,"type":20},"2026-11",{"name":38,"class":39},""]