[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Riphah International University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":622},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,509,0,25,[9,48,72,97,124,149,172,195,219,245,267,293,317,337,356,380,409,433,457,485,504,525,561,579,601],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100652176","effect-of-bg-versus-ri-on-the-depth-of-wsl-100652176",false,"NCT07770724","Effect of BG Versus RI on the Depth of WSL","Effect of Bioactive Glass Versus Resin Infiltration (ICON) on the Depth of White Spot Lesions: An in Vitro Study","Inclusion Criteria:\n\n* Upper and lower premolars will be collected from patients undergoing extractions.\n\n  * The teeth should be healthy with no carious lesions.\n  * The crown and root morphology of teeth should be normal.\n  * The extracted premolar teeth of patients should have no history of previous dental treatment.\n\nExclusion Criteria:\n\n* • Fractured premolars due to any cause.\n\n  * Loss of enamel due to parafunctional habits.\n  * Presence of enamel anomalies (amelogenesis imperfecta, hypoplasia etc.).\n  * Presence of stains, demineralization, decay, fluorosis and restorations",true,"ALL","15 Years","35 Years",{"count":22,"type":23},90,"ESTIMATED","INTERVENTIONAL",[26],"NA","The aim of this in vitro study is to assess the mean lesion depth improvement and hardness of artificial white spot lesions by comparing the effects of bioactive glass toothpaste and resin infiltration (ICON).",[29],"White Spot Lesions",[31,32,33,34],"white spot lesions","orthodontic brackets","resin infiltration","Fluoride toothpaste","NOT_YET_RECRUITING","2026-08-13",{"date":38,"type":39},"2026-08-18","ACTUAL",{"date":41,"type":23},"2026-09-01",{"date":43,"type":23},"2027-03-30",{"name":45,"class":46},"Riphah International University","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":47},"100651670","effects-of-a-wearable-device-phone-app-and-exercise-on-cervico-thoracic-posture-in-university-students-100651670","NCT07763327","Effects of a Wearable Device ,Phone App and Exercise on Cervico-thoracic Posture in University Students.","Comparison of Wearable Device -Based , App- Based ,and Conventional Exercise Therapy for Cervico-Thoracic Postural Training in University Students.","Inclusion Criteria:\n\n1. University students aged 18-30 years enrolled in a degree program at Riphah International University.\n2. Daily sitting duration ≥ 5 hours (academic and\u002For device-related activities).\n3. Presence of at least one observable postural deviation confirmed at baseline assessment: forward head posture (CVA \\\u003C 50°), rounded shoulders (protracted shoulder distance in supine line), or thoracic kyphosis (\\> 40° via digital inclinometer).\n4. Smartphone ownership and basic digital literacy\n\nExclusion Criteria:\n\n1. History of spinal surgery, vertebral fracture, or major cervical\u002Fthoracic trauma within the past 12 months.\n2. Diagnosed neurological disorders affecting posture or motor control (e.g., Parkinson's disease, stroke, cervical dystonia).\n3. Structural spinal deformities requiring active medical or surgical management (e.g., scoliosis Cobb angle \\> 20°, Scheuermann's kyphosis).\n4. Current participation in physiotherapy, chiropractic treatment, or another structured posture correction program.\n5. Cardiovascular or pulmonary conditions contraindicating moderate-intensity exercise (e.g., uncontrolled hypertension, severe asthma).\n6. Skin conditions, open wounds, or allergies precluding safe use of the posture correction belt.","18 Years","30 Years",{"count":58,"type":23},87,[26],"Forward head posture and thoracic kyphosis are among the most common postural problems in university students, driven largely by long hours of screen use and poor sitting habits. Research suggests that nearly two-thirds of university students show measurable forward head posture, and if uncorrected, it is linked to chronic neck pain and long-term musculoskeletal strain. This study compares three approaches to correcting posture over a six-week supervised exercise program: a wearable sensor belt that vibrates in real time when posture slips, a smartphone app that sends scheduled reminders throughout the day, and exercise alone with no reminders. The two technology-assisted groups are prompted to correct their posture throughout daily activities, not just during exercise sessions. The study will show whether real-time or scheduled reminders produce greater improvements in posture, neck pain, and neck function than exercise alone . Helping physical therapists and university health services to identify the most practical strategy for correcting posture in screen-heavy academic environments.",[62],"Forward Head Posture",[64],"forward head posture , thoracic kyphosis , Craniovertebral angle , Posture Correction , Neck Disability , University Students","2026-08-10",{"date":36,"type":39},{"date":68,"type":23},"2026-08-17",{"date":70,"type":23},"2027-07-31",{"name":45,"class":46},{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":12,"sex":18,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":24,"phases":83,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":91,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":95,"locationsCount":96},"100651590","pain-neuroscience-education-and-graded-motor-imagery-combined-with-conventional-physiotherapy-on-diabetic-adhesive-capsulitis-100651590","NCT07763366","Pain Neuroscience Education and Graded Motor Imagery Combined With Conventional Physiotherapy on Diabetic Adhesive Capsulitis","Effects of Pain Neuroscience Education and Graded Motor Imagery Combined With Conventional Physiotherapy on Pain, Kinesiophobia, and Functional Disability in Diabetic Adhesive Capsulitis","Inclusion Criteria:\n\n* Diagnosed cases of adhesive capsulitis (Stage I or II)\n* Diagnosed with Type II Diabetes Mellitus\n* Age between 40-65 years\n* Shoulder pain lasting more than 3 months\n* Limited shoulder range of motion.\n\nExclusion Criteria:\n\n* Previous shoulder surgery\n* History of fracture or dislocation of shoulder\n* Cervical radiculopathy\n* Neurological disorders\n* Severe diabetic complications\n* Cognitive impairments.","40 Years","65 Years",{"count":82,"type":23},50,[26],"The purpose of this study is to determine the effects of Pain Neuroscience Education (PNE) and Graded Motor Imagery (GMI) combined with conventional physiotherapy on pain, kinesiophobia, central sensitization, functional disability, range of motion, and quality of life in patients with Type II diabetic adhesive capsulitis. Adhesive capsulitis is a common musculoskeletal condition characterized by pain and progressive restriction of shoulder movement, particularly among individuals with diabetes mellitus. Conventional physiotherapy is widely used to restore shoulder mobility and function; however, it may not adequately address central sensitization and fear of movement. Pain Neuroscience Education aims to improve patients' understanding of pain mechanisms and reduce maladaptive beliefs, while Graded Motor Imagery targets cortical reorganization and movement-related fear. The combination of these interventions with conventional physiotherapy may improve clinical outcomes and enhance quality of life.",[86,87,88],"Diabetic Adhesive Capsulitis","Frozen Shoulder","Type II Diabetes Mellitus",[90],"Diabetic Adhesive Capsulitis Frozen Shoulder Pain Neuroscience Education Graded Motor Imagery Conventional Physiotherapy Kinesiophobia Central Sensitization",{"date":36,"type":39},{"date":93,"type":23},"2026-08-15",{"date":70,"type":23},{"name":45,"class":46},2,{"id":98,"slug":99,"hasResults":12,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":24,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":47},"100651279","effect-of-somatosensory-motor-control-with-and-without-kinesio-tape-in-patients-with-sciatica-100651279","NCT07756905","Effect of Somatosensory Motor Control With and Without Kinesio Tape in Patients With Sciatica","Effects of Somatosensory Motor Control With and Without Kinesio Tape on Pain, Range of Motion of Lumbar, Dynamic Balance and Function Disability in Patients With Sciatica","Inclusion Criteria:\n\n* • Both male and females.\n\n  * Age between 35-50 years.\n  * Discogenic pain due to Diagnosed herniation lumbar disc L4\u002FL5 and L5\u002FS1 (confirmed by MRI).\n  * unilateral leg pain radiating below the knee accompanied by numbness, tingling, or weakness in the affected leg.\n  * Pain persists between 3-6 months.\n  * Positive Straight Leg Raise (SLR) test between 40° to 70°, suggestive of neural irritation.\n\nExclusion Criteria:\n\n* • Patients with inflammatory diseases like ankylosing spondylitis, vertebral collapse, rheumatoid arthritis, stenosis, spondylolisthesis, or osteoporosis.\n\n  * Recent spinal surgery\n  * Abdominal or lower limb surgery\n  * Pregnancy\n  * Skin allergies","50 Years",{"count":106,"type":23},58,[26],"Sciatica can be defined as a radicular pain that runs through the sciatic nerve from the lower back to the lower limbs and also may be associated with weakness or numbness in the muscles. These symptoms may affect proprioception, dynamic balance and functional mobility, which result in limitations of activity and disability. Training to improve somatosensory motor control has been shown to be effective in improving coordination and postural stability and Kinesio taping has the potential to increase proprioceptive input, decrease pain and aid functional recovery.",[110],"Sciatica",[112,113,114,115],"Pain","Lumbar Range of Motion","Dynamic Balance","Functional Disability","RECRUITING",{"date":118,"type":39},"2026-08-11",{"date":120,"type":39},"2025-06-01",{"date":122,"type":23},"2026-09-30",{"name":45,"class":46},{"id":125,"slug":126,"hasResults":12,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":20,"enrollmentInfo":131,"targetDuration":4,"studyType":24,"phases":133,"briefSummary":134,"conditions":135,"keywords":138,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":143,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":47},"100651141","effects-of-extracorporeal-shockwave-therapy-versus-dry-needling-on-jumpers-knee-100651141","NCT07756918","Effects of Extracorporeal Shockwave Therapy Versus Dry Needling on Jumpers Knee","Effects of Extracorporeal Shockwave Therapy Versus Dry Needling on Pain, Knee Function and Quality of Life in Jumpers Knee","Inclusion Criteria:\n\n* Participants of either gender between the age of 18-35 years with a confirmed diagnosis of jumper's knee for more than 1 month.\n* Confirmed diagnosis of jumper's knee for more than 1 month.\n* Pain NPRS (Numeric Pain Rating Scale) score greater than 4 at the first evaluation.\n\nExclusion Criteria:\n\n* Surgery around the knee joint within the last 6 months.\n* Chronic knee joint disease.\n* Knee pain management with corticosteroid injections in the last 3 months.\n* Trauma history\n* Systemic illness",{"count":132,"type":23},48,[26],"The study is randomized and single-blinded. Ethical approval is taken from ethical committee of Riphah International University, Lahore. Participants who meet the inclusion criteria will be enrolled and allocated in group A \\& B through sealed envelope method by Non-probability Convenient random sampling technique. Subjects in Group A will receive Shock wave therapy. Group B will receive Dry needing.",[112,136,137],"Quality of Life","Jumper's Knee",[139,140,141,142],"dry needling","extra-corporeal shock wave therapy","pain","jumper knee",{"date":118,"type":39},{"date":145,"type":39},"2025-10-15",{"date":147,"type":23},"2026-08-30",{"name":45,"class":46},{"id":150,"slug":151,"hasResults":12,"nctId":152,"briefTitle":153,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":12,"sex":155,"minAge":156,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":24,"phases":160,"briefSummary":161,"conditions":162,"keywords":164,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":169,"leadSponsor":171,"locationsCount":96},"100651096","dose-response-effects-of-a-6-week-progressive-resistance-training-program-on-premenstrual-syndrome-in-adolescent-girls-100651096","NCT07754149","Dose-Response Effects of a 6-Week Progressive Resistance Training Program on Premenstrual Syndrome in Adolescent Girls","Inclusion Criteria:\n\n1. Diagnosed with Premenstrual Syndrome (PMS) based on PSST screening tool.\n2. Not currently engaged in any structured resistance or exercise training program.\n3. Medically cleared to participate in moderate-intensity resistance training.\n4. Provided written informed consent for participation.\n\nExclusion Criteria:\n\n1. Current use of hormonal therapy or oral contraceptives.\n2. History of endocrine disorders (e.g., PCOS, thyroid dysfunction).\n3. Any musculoskeletal or cardiovascular condition limiting exercise participation.\n4. Ongoing psychiatric medication or diagnosed depression\u002Fanxiety disorder.\n5. Participation in a structured exercise or resistance training program within the last 3 months.\n6. Use of analgesics, anti-inflammatory, or hormonal medications during the study period.","FEMALE","11 Years","19 Years",{"count":159,"type":23},32,[26],"This study examines the dose-response effects of a 6-week progressive resistance training program on premenstrual syndrome (PMS) in adolescent girls. PMS is a common condition that affects physical, psychological, and social well-being. While exercise is known to reduce symptoms, the optimal intensity of resistance training remains unclear. Using a randomized controlled trial design, participants are assigned to progressive or low-intensity training groups. PMS symptoms and quality of life are assessed over time. The study aims to determine whether higher exercise intensity leads to greater symptom reduction and improved overall well-being.",[163],"Premenstrual Syndrome",[165],"Premenstrual Syndrome, Resistance Training, Dose-Response, Adolescent Girls, Exercise Therapy, Quality of Life, Randomized Controlled Trial",{"date":167,"type":39},"2026-08-12",{"date":65,"type":39},{"date":170,"type":23},"2027-01",{"name":45,"class":46},{"id":173,"slug":174,"hasResults":12,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":12,"sex":155,"minAge":55,"maxAge":79,"enrollmentInfo":179,"targetDuration":4,"studyType":24,"phases":181,"briefSummary":182,"conditions":183,"keywords":186,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":190,"startDateStruct":191,"completionDateStruct":192,"leadSponsor":194,"locationsCount":47},"100650783","comparative-effects-of-telerehabilitation-versus-in-person-core-stability-training-in-postpartum-women-100650783","NCT07751952","Comparative Effects of Telerehabilitation Versus In-Person Core Stability Training in Postpartum Women","Comparative Effects Of Telerehabilitation And In-Person Core Stability Training On Inter Recti Distance And Body Image In Postpartum Women.","Inclusion Criteria: Participants falling in this category would be recruited into the study.\n\n* 6 weeks to 6 months postpartum\n* Multiparous or primiparous\n* Diagnosis of diastasis recti (IRD ≥ 2cm)\u002F\n* Able to use or operate digital\u002Felectronic devices\n* With internet access and the ability to participate in remote group sessions.\n\nExclusion Criteria: Participants fall in this category would be excluded of the study.\n\n* Significant musculoskeletal or systemic comorbidities i.e. diabetes mellitus, cardiovascular disease, Severe psychiatric disorders, Active malignancy.\n* Prior major abdominal or pelvic surgery (except cesarean)\n* Any Contraindications to exercise.\n* Recent\u002FCurrent pregnancy.",{"count":180,"type":23},54,[26],"Diastasis recti abdominis (DRA) is common among postpartum women and can negatively affect abdominal muscle function and body image. Core stability exercises are widely recommended for postpartum rehabilitation; however, access to supervised physiotherapy may be limited. Tele rehabilitation may improve accessibility while maintaining treatment effectiveness. This randomized controlled trial compares tele rehabilitation-based and in-person supervised core stability exercise programs in postpartum women with diastasis recti. The primary objective is to compare changes in inter-recti distance, while the secondary objective is to compare changes in body image after an 8-week intervention",[184,185],"Postpartum","Diastasis Recti Abdominis (DRA)",[187,188,189],"Inter-Recti Distance","Telerehabilitation","Body Image",{"date":167,"type":39},{"date":65,"type":39},{"date":193,"type":23},"2026-12",{"name":45,"class":46},{"id":196,"slug":197,"hasResults":12,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":12,"sex":202,"minAge":203,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":24,"phases":207,"briefSummary":208,"conditions":209,"keywords":211,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":215,"startDateStruct":216,"completionDateStruct":217,"leadSponsor":218,"locationsCount":47},"100648753","comparative-effects-of-closed-kinetic-chain-exercises-and-throwers-ten-exercises-in-glenohumeral-instability-100648753","NCT07724977","Comparative Effects of Closed Kinetic Chain Exercises and Thrower's Ten Exercises in Glenohumeral Instability","Comparative Effects of Closed Kinetic Chain Exercises and Thrower's Ten Exercises on Pain, Mobility and Performacne in Glenohumeral Instability Among Bowlers","Inclusion Criteria:\n\n* Male bowlers are included in this study\n* Healthy athletes with age group 16-25y\n* Athletes having 2 years of bowling experience\n\nExclusion Criteria:\n\n* Bowlers with prior history of trauma and shoulder injuries from past 6 months bowlers with any medical issues such as hypertension, any , neurological , cardiovascular and psychological problems\n* if athlete suffered from any upper extremity orthopedic or musculoskeletal injury from last 6 months","MALE","16 Years","25 Years",{"count":206,"type":23},40,[26],"The study is randomized and single-blinded. Ethical approval is taken from ethical committee of Riphah International University, Lahore. Participants who meet the inclusion criteria will be enrolled and allocated in group A \\& B through sealed envelope method by Non-probability Convenient random sampling technique. Subjects in Group A will receive closed kinetic chain exercises. Group B will receive thrower's ten exercises.",[210],"Instability, Joint",[212,213,214],"closed chain kinetic exercises","thrower's ten exercises","instability",{"date":167,"type":39},{"date":145,"type":39},{"date":147,"type":23},{"name":45,"class":46},{"id":220,"slug":221,"hasResults":12,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":227,"targetDuration":4,"studyType":24,"phases":229,"briefSummary":230,"conditions":231,"keywords":238,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":240,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":244,"locationsCount":47},"100648655","dynamic-neuromuscular-stability-exercises-with-and-without-rhythmic-auditory-stimulation-in-lateral-ankle-sprain-100648655","NCT07726810","Dynamic Neuromuscular Stability Exercises With and Without Rhythmic Auditory Stimulation in Lateral Ankle Sprain","Effect of Dynamic Neuromuscular Stability Exercises With and Without Rhythmic Auditory Stimulation on Balance, Proprioception, and Performance Among Badminton Players With Lateral Ankle Sprain","DNS","Inclusion Criteria:\n\n* Age 18-30 years\n* Both male and female genders\n* Diagnosed with Grade I or II lateral ankle sprain (subacute to chronic phase)\n* Within 2-8 weeks post-injury\n\nExclusion Criteria:\n\n* History of ankle surgery\n* Vestibular, neurological, or hearing disorders\n* Acute pain prevents participation\n* Current involvement in other rehab programs\n* Any fracture or other injury\n* Any systemic illness\n* Any inflammatory disease (Rheumatoid arthritis, gout)",{"count":228,"type":23},44,[26],"To examine the effects of Dynamic Neuromuscular Stability exercises with and without Rhythmic Auditory Stimulation on balance, proprioception, and functional performance in badminton players with lateral ankle sprain.",[232,233,234,235,236,237],"Ankle Sprain","Lateral Ankle Sprain","Lateral Ankle Instability","Dynamic Neuromuscular Stabilization (DNS)","Balance","Proprioception",[239],"Rhythmic Auditory Stimulation",{"date":167,"type":39},{"date":242,"type":39},"2026-07-14",{"date":41,"type":23},{"name":45,"class":46},{"id":246,"slug":247,"hasResults":12,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":12,"sex":18,"minAge":252,"maxAge":253,"enrollmentInfo":254,"targetDuration":4,"studyType":24,"phases":256,"briefSummary":257,"conditions":258,"keywords":260,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":262,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":266,"locationsCount":96},"100642348","obstacle-course-versus-neuromotor-task-training-in-children-with-dcd-100642348","NCT07575178","Obstacle Course Versus Neuromotor Task Training in Children With DCD","Comparison of Obstacle Course Training and Neuromotor Task Training on Motor Planning and Functional Mobility in Children With Developmental Coordination Disorder","Inclusion Criteria:\n\n* • Diagnosis of DCD based on DSM4\u002F5 criteria.\n\n  * Children aged 7-10.\n  * Gender male and female.\n  * Mini-Mental State Examination (MMSE) score \\>24 .\n  * Cognitive development appropriate for chronological age.\n  * Raven Intelligence Test Scale (IQ \\> 75) .\n  * Developmental Coordination Questionnaire ≤48 points: likely DCD (≤ 10th percentile).\n  * BOT-2 score ≤ 40.\n\nExclusion Criteria:\n\n* History of surgery and lower limb injuries over the past 12 months.\n* Use of assistive devices to balance and walk.\n* Severe ADHD, Autism Spectrum Disorder (if it significantly interferes with participation), or major psychiatric disorders.\n* Taking neuroleptics or any other medications that significantly alter muscle tone, coordination, or attention.","7 Years","10 Years",{"count":255,"type":23},28,[26],"Developmental Coordination Disorder (DCD) affects motor planning and functional mobility in children, leading to long-term functional and psychosocial difficulties. This randomized clinical trial will compare the effectiveness of Obstacle Course Training (OCT) and Neuromotor Task Training (NTT) in improving motor planning and functional mobility in children aged 7-10 years diagnosed with DCD. Participants will be randomly allocated to either OCT or NTT for 9 weeks (two sessions per week). Outcomes will be assessed using standardized motor performance measures to determine the more effective intervention.",[259],"Developmental Coordination Disorder (DCD)",[261],"DCD, Motor coordination, Neuromotor training,",{"date":167,"type":39},{"date":264,"type":39},"2026-01-01",{"date":65,"type":23},{"name":45,"class":46},{"id":268,"slug":269,"hasResults":12,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":12,"sex":18,"minAge":274,"maxAge":275,"enrollmentInfo":276,"targetDuration":4,"studyType":24,"phases":278,"briefSummary":279,"conditions":280,"keywords":282,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":288,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":292,"locationsCount":47},"100630193","effects-of-the-active-cycle-of-breathing-technique-with-and-without-balloon-blowing-therapy-in-tuberculosis-100630193","NCT07484490","Effects of the Active Cycle of Breathing Technique With and Without Balloon Blowing Therapy in Tuberculosis","Effects of the Active Cycle of Breathing Technique With and Without Balloon Blowing Therapy on Sputum Secretion, Dyspnea, and Functional Capacity in Children With Tuberculosis","Inclusion Criteria\n\n1. Children aged 8 to14 years\n2. Diagnosed with tuberculosis\n3. Patients with excessive pulmonary secretions and\u002For difficulty clearing airway secretions.\n4. Adequate cognitive ability to understand and follow verbal commands and perform ACBT.\n5. Informed consent from parent\u002Fguardian\n\nExclusion Criteria:\n\n1. Diagnosed with multi-drug-resistant (MDR) TB\n2. Presence of hemoptysis\n3. The patient who is unconscious and unresponsive.\n4. Received physical therapy intervention in the past 2 weeks","8 Years","14 Years",{"count":277,"type":23},34,[26],"The study design will be a randomized controlled trial. The data will be collected from Gulab Devi Teaching Hospital, Lahore. 34 kids aged 8 to 14 years will be randomly assigned either to an experimental group or a control group. The intervention group includes the active Cycle of Breathing technique with balloon-blowing therapy for 3 days. The control group includes the active cycle of breathing technique. Sputum secretion will be measured by 'sputum measurement cups.\" Dyspnea will be measured by the \"Modified Borg dyspne Scale,\" and functional capacity will be measured by the \"6-Minute Walk Test.\" Data will be analyzed through SPSS version 25.0.",[281],"Tuberculosis",[283,284,285,286,287],"Sputum secretion","Dyspnea","Functional Capacity","Balloon blowing therapy","Active cycle of breathing",{"date":167,"type":39},{"date":290,"type":39},"2026-01-29",{"date":122,"type":23},{"name":45,"class":46},{"id":294,"slug":295,"hasResults":12,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":4,"eligibilityCriteria":299,"healthyVolunteers":12,"sex":155,"minAge":55,"maxAge":300,"enrollmentInfo":301,"targetDuration":4,"studyType":24,"phases":303,"briefSummary":304,"conditions":305,"keywords":307,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":316,"locationsCount":47},"100650994","diaphragm-pelvic-floor-synergy-training-in-young-females-with-primary-dysmenorrhea-100650994","NCT07754305","Diaphragm-Pelvic Floor Synergy Training in Young Females With Primary Dysmenorrhea.","Effects of Diaphragm-Pelvic Floor Synergy Training on Pain and Quality of Life in Young Females With Primary Dysmenorrhea.","Inclusion Criteria:\n\n1. University going girls aged 18-24 years.\n2. Normal weight (BMI 18.5-24.9 kg\u002Fm²) based on measured height and weight.\n3. Primary dysmenorrhea: recurrent menstrual pain without pelvic pathology, present for ≥6 months, with pain intensity ≥4\u002F10 on VAS.\n4. Regular menstrual cycles (21-35 days).\n5. From socioeconomically disadvantaged backgrounds (e.g., low parental education, low household income, government\u002Fpublic school enrolment - specify in protocol).\n6. Currently enrolled in school\u002Fcollege.\n7. Informed consent\u002Fassent obtained (with parental consent if \\\u003C18 years).\n8. Willing to participate in intervention and data collection.\n\nExclusion Criteria:\n\n1. diagnosed pelvic pathologies (e.g., endometriosis, fibroids, pelvic inflammatory disease).\n2. Irregular menstrual cycles (\\\u003C21 days or \\>35 days).\n3. Current or recent use of hormonal contraceptives or hormonal therapy (within last 3 months).\n4. History of pelvic\u002Fabdominal surgery.\n5. Pregnancy or recent childbirth (within 6 months).\n6. Any diagnosed musculoskeletal, neurological, or medical condition contraindicating exercise or acupressure.\n7. Current participation in another clinical trial or structured exercise\u002Fphysiotherapy program for dysmenorrhea.\n8. Unwillingness to provide consent\u002Fassent or comply with study procedures","24 Years",{"count":302,"type":23},64,[26],"The research investigating the effects of Diaphragm-Pelvic Floor Synergy (DPFS) training targets primary dysmenorrhea in university-aged females. This randomized controlled trial evaluates how restoring the functional \"piston\" relationship between the diaphragm and pelvic floor can alleviate menstrual pain and enhance quality of life. By implementing an eight-week progressive exercise protocol, the study compares DPFS training against standard symptomatic care like TENS and heat therapy. Using the WALIDD scale and WHOQOL-BREF, the research aims to establish a non-pharmacological, evidence-based physiotherapy intervention that reduces medication reliance and academic absenteeism in South Asian clinical settings.",[306],"Dysmenorrhea",[308,136,309,310],"Diaphragm-Pelvic Floor Synergy","Young Females","Primary Dysmenorrhea","2026-08-07",{"date":65,"type":39},{"date":314,"type":23},"2026-07-28",{"date":193,"type":23},{"name":45,"class":46},{"id":318,"slug":319,"hasResults":12,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":4,"eligibilityCriteria":323,"healthyVolunteers":12,"sex":202,"minAge":55,"maxAge":79,"enrollmentInfo":324,"targetDuration":4,"studyType":325,"phases":4,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":47},"100651092","inter-rater-reliability-of-ultra-sound-based-rectus-abdominis-thickness-following-blood-flow-restriction-training-100651092","NCT07754162","Inter-Rater Reliability of Ultra Sound Based Rectus Abdominis Thickness Following Blood Flow Restriction Training","Inter-Rater Reliability of Ultra Sound Based Rectus Abdominis Thickness Following Blood Flow Restriction Training : A Retrospective Analysis.","Inclusion Criteria:\n\n* Recreationally Active\n\nExclusion Criteria:\n\n* Known Musculoskeletal injury",{"count":82,"type":23},"OBSERVATIONAL","Accurate assessment of skeletal muscle morphology is important in sports physiotherapy, exercise rehabilitation, and research. B-mode ultrasonography is a non-invasive and accessible method for assessing muscle thickness; however, ultrasound-based measurements may be influenced by image acquisition, anatomical landmark identification, and operator-dependent measurement procedures. Establishing inter-rater reliability is therefore essential to determine whether different assessors can obtain consistent measurements of muscle thickness from the same ultrasound images. The rectus abdominis is an important component of the abdominal musculature and contributes to trunk stabilization and functional performance during exercise. Blood flow restriction (BFR) training has gained increasing attention as a low-load exercise strategy for promoting muscular adaptations, although research has predominantly focused on peripheral limb muscles. Therefore, this study aims to evaluate the inter-rater reliability of ultrasound-based rectus abdominis muscle thickness measurements following a standardized BFR training protocol using ImageJ software. Establishing reliable measurement of rectus abdominis thickness will provide a methodological basis for future research investigating abdominal muscle morphology and adaptations in sports physiotherapy, exercise rehabilitation, and BFR-based training.",[328,329],"Reliability","Ultrasound","2026-08-05",{"date":65,"type":39},{"date":333,"type":39},"2026-08-04",{"date":335,"type":23},"2026-09-20",{"name":45,"class":46},{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":18,"minAge":79,"maxAge":344,"enrollmentInfo":345,"targetDuration":4,"studyType":24,"phases":346,"briefSummary":347,"conditions":348,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":350,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":47},"100651082","effect-of-habit-ile-on-balance-and-coordination-among-stroke-patients-100651082","NCT07754110","Effect of HABIT-ILE on Balance and Coordination Among Stroke Patients","Effect of HABIT-ILE ( Hand Arm Bimanual Intensive Training Including Lower Limb Extremity ) on Balance and Coordination Among Stroke Patients","Inclusion Criteria:\n\n* Participants falling in the following category would be recruited into the study:\n\n  1. A hemiplegic patient due to unilateral stroke\n  2. Patients having sub-acute and chronic stroke\n  3. Stroke survivors between 40 and 60years old\n  4. Both genders\n  5. A hemiparetic patient with a chronic stroke (over 6 months of evolution)\n\nExclusion Criteria:\n\n* Participants falling in the following category would be excluded from the study:\n\n  1. Pregnancy\n  2. Major cognitive impairment interfering with the study (severe aphasia, psychiatric conditions)\n  3. Uncontrolled health issues (cardiac\u002Frenal failure)\n  4. Patients with depression who will be unable to cooperate during treatment\n  5. Patients who cannot perform the active movement of limb due to pre-stroke musculoskeletal problems\n  6. Cardiopulmonary diseases which could hinder their ability to participate in rehabilitation\n  7. Patients with any neuron disease and with lower-limb impairment caused by other neurological diseases\n  8. Visual and auditory abnormalities","60 Years",{"count":228,"type":23},[26],"Strokes frequently affect motor function, balance, and coordination, reducing independence. HABIT-ILE combines upper and lower limb exercises to improve coordination and balance.\n\nObjective To determine the effectiveness of HABIT-ILE on balance and coordination among stroke patients.\n\nwe used randomized controlled trails (two-arm parallel design) on 44 people who were allocated evenly into two groups using purposive sampling. The Berg Balance Scale, Finger-to-Nose Test, and 6-Minute Walk Test were administered during a six-month period at HHRD Center, Mansehra. Data was analyzed using SPSS 25 with repeated measures ANOVA and the Shapiro-Wilk test to ensure normality",[349],"Stroke (CVA) or Transient Ischemic Attack",{"date":65,"type":39},{"date":352,"type":39},"2026-07-30",{"date":354,"type":23},"2027-02-01",{"name":45,"class":46},{"id":357,"slug":358,"hasResults":12,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":362,"eligibilityCriteria":363,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":364,"targetDuration":4,"studyType":24,"phases":366,"briefSummary":367,"conditions":368,"keywords":370,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":374,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":47},"100651009","suboccipital-release-vs-smartphone-app-guided-exercises-in-smartphone-neck-syndrome-100651009","NCT07756125","Suboccipital Release vs Smartphone App Guided Exercises in Smartphone Neck Syndrome","Comparison of Suboccipital Release and Smartphone App Guided Exercises in Smartphone Neck Syndrome","the","Inclusion Criteria:\n\n* Adults aged 18 -30 years\n* Both genders\n* Neck pain (\\>3 months duration)\n* Smartphone use ≥3 h\u002Fday\n* Presence of ≥ 3 symptoms (neck pain, upper back pain, shoulder pain, headache, insomnia,intermittent tingling\u002Fnumbness in upper limbs)\n* Smartphone use with neck flexion ≥ 15°.\n* Pain intensity ≥ 3\u002F10 on NPRS\n* Disability score ≥ 10\u002F50 on Neck Disability Index (NDI)\n* Forward head posture with a craniovertebral angle (CVA) \\\u003C 50\n* Able to understand and independently follow smartphone application-guided\n\nExclusion Criteria:\n\n* History of cervical spine trauma, surgery, or fracture.\n* Presence of clinically confirmed cervical radiculopathy or objective neurological deficits (e.g., dermatomal sensory loss, myotomal weakness, diminished deep tendon reflexes, or positive clinical tests for cervical radiculopathy).\n* Structural spinal deformities (e.g., scoliosis, torticollis)\n* Presence of acute infection, inflammatory, or systemic musculoskeletal conditions (e.g., rheumatoid arthritis)\n* Vestibular deficits\n* Current participation in other neck pain treatments",{"count":365,"type":23},52,[26],"Randomized controlled trial comparing suboccipital release and smartphone app-guided exercises on pain, disability, craniovertebral angle and cervical ROM in 52 participants with smartphone neck syndrome over 4 weeks.",[369],"Neck Syndrome",[371,372,373],"Suboccipital Release","Smartphone App Guided Exercises","Smartphone Neck Syndrome",{"date":65,"type":39},{"date":376,"type":23},"2026-08-01",{"date":378,"type":23},"2027-08-05",{"name":45,"class":46},{"id":381,"slug":382,"hasResults":12,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":386,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":18,"minAge":79,"maxAge":80,"enrollmentInfo":388,"targetDuration":4,"studyType":24,"phases":390,"briefSummary":391,"conditions":392,"keywords":394,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":403,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":47},"100649891","effects-of-imt-on-cardiopulmonary-endurance-and-functional-mobility-in-koa-100649891","NCT07738627","Effects of IMT on Cardiopulmonary Endurance and Functional Mobility in KOA","Inspiratory Muscle Training as an Adjunct to Standard Care: Effects on Cardiopulmonary Endurance and Functional Mobility in Knee Osteoarthritis","IMT","Inclusion Criteria:\n\n* Age 40-65 years\n* Male and Female participants\n* Bilateral Knee Osteoarthritis\n* Diagnosed according to American College of Rheumatology criteria\n* Kellgren and Lawrence Grade II-III\n* Able to walk independently\n* Willing to provide informed consent\n\nExclusion Criteria:\n\n* Participation in structured physical activity programs\n* Intra-articular corticosteroid injection within last 3 months\n* Hyaluronic acid injection within last 6 months\n* Lower limb trauma or surgery history\n* Planned surgery during study period\n* Severe cardiovascular disease\n* Severe pulmonary disease\n* Neurological disorders\n* Psychological disorders",{"count":389,"type":23},65,[26],"The purpose of the study is to investigate whether adding Inspiratory Muscle Training (IMT) to the usual treatment of patients with knee osteoarthritis improves their cardiopulmonary endurance and functional mobility more than standard care alone.",[393],"Knee Osteoarthritis",[393,395,396,397,398,399,400,401,402],"Inspiratory Muscle Training","Cardiopulmonary Endurance","Aerobic capacity","Respiratory Muscle Strength","Functional Mobility","6-Minute Walk Test","WOMAC","TUG Test",{"date":311,"type":39},{"date":405,"type":23},"2026-08",{"date":407,"type":23},"2027-12-11",{"name":45,"class":46},{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":362,"eligibilityCriteria":415,"healthyVolunteers":12,"sex":18,"minAge":79,"maxAge":416,"enrollmentInfo":417,"targetDuration":4,"studyType":24,"phases":418,"briefSummary":419,"conditions":420,"keywords":422,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":427,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":47},"100649466","eccentric-vs-low-load-blood-flow-restriction-training-in-knee-osteoarthritis-in-knee-osteoarthritis-100649466","NCT07733518","Eccentric vs Low-Load Blood Flow Restriction Training in Knee Osteoarthritis in Knee Osteoarthritis","Comparison of Eccentric and Low-Load Blood Flow Restriction Training on Neuromuscular Adaptations in Knee Osteoarthritis","Inclusion Criteria:\n\n* Age group 40-70\n* Both genders male and female\n* Clinical diagnosis of knee OA (Kellgren-Lawrence grade 1-3) of the most symptomatic knee.\n* Pain stable enough to permit exercise on Numeric Pain Rating Scale 3\u002F10.\n* Participants must demonstrate a gastrocnemius muscle strength of grade ≥3 on the Manual Muscle Testing (MMT) scale (0-5), assessed using the standard standing heel-rise position.\n* Participants must be able to ambulate independently and participate in supervised exercise.\n\nExclusion Criteria:\n\n* • Presence of a prosthetic knee in the affected limb.\n\n  * Inflammatory arthritis (e.g., rheumatoid arthritis) or active flare-up of OA.\n  * Cardiovascular disease contraindicating exercise (e.g., unstable angina, recent MI, uncontrolled hypertension ≥160\u002F100 mmHg).\n  * Pulmonary disease that limits safe participation (e.g., severe COPD, recent exacerbation).\n  * History of deep vein thrombosis (DVT), peripheral vascular disease, or bleeding\u002Fclotting disorders.\n  * Current anticoagulant therapy that increases bleeding risk (unless cleared by physician).\n  * Any pathology causing significant muscle weakness (e.g., neuromuscular disorders, severe neuropathy).","70 Years",{"count":132,"type":23},[26],"The aim of this randomized controlled trial is to find the effects of eccentric and low-load blood flow restriction training on neuromuscular adaptations, muscle strength, functional performance, and disability in patients with knee osteoarthritis",[421],"Knee Arthritis, Osteoarthritis",[423,424,425,426],"Eccentric training,","Low-load blood flow restriction training","Muscle weakness","knee Osteoarthritis",{"date":311,"type":39},{"date":429,"type":39},"2026-07-21",{"date":431,"type":23},"2026-12-28",{"name":45,"class":46},{"id":434,"slug":435,"hasResults":12,"nctId":436,"briefTitle":437,"officialTitle":438,"acronym":4,"eligibilityCriteria":439,"healthyVolunteers":12,"sex":18,"minAge":440,"maxAge":55,"enrollmentInfo":441,"targetDuration":4,"studyType":325,"phases":4,"briefSummary":443,"conditions":444,"keywords":446,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":451,"startDateStruct":452,"completionDateStruct":453,"leadSponsor":455,"locationsCount":456},"100638064","rehabilitation-assessment-of-motor-function-in-cerebral-palsy-using-explainable-ai-100638064","NCT07629024","Rehabilitation Assessment of Motor Function In Cerebral Palsy Using Explainable AI","Rehabilitation Assessment of Motor Function in Ambulatory Children With Cerebral Palsy Using Explainable Machine Learning","Inclusion Criteria:\n\n* Age 4 to18 years\n* Diagnosed any motor type of cerebral palsy (spastic, dyskinetic, ataxic, mixed),)\n* GMFCS levels I -III (able to walk with or without an assistive device).\n* All participants must be able to ambulate at least 10 meters with or without an assistive device.\n* Capable of following simple verbal instructions.\n* Parental informed consent and child assent\n\nExclusion Criteria:\n\n* Recent orthopedic or neurosurgical interventions (\\\u003C6 months).\n* Uncontrolled seizures affecting gait.\n* Non-ambulatory (GMFCS IV-V) or cognitive impairments preventing cooperation.","4 Years",{"count":442,"type":23},200,"The goal of this observational study is to develop and validate an AI-based prediction model for functional mobility and gait outcomes in children with cerebral palsy using low-cost clinical and gait data collected in rehabilitation settings in Pakistan.",[445],"Cerebral Palsy Children",[447,448,449,450],"CP Assesment","Explainable machine learning","Gait symmetry","Functional independence",{"date":65,"type":39},{"date":147,"type":23},{"date":454,"type":23},"2027-12-30",{"name":45,"class":46},4,{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":461,"acronym":4,"eligibilityCriteria":462,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":20,"enrollmentInfo":463,"targetDuration":4,"studyType":24,"phases":465,"briefSummary":466,"conditions":467,"keywords":469,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":482,"leadSponsor":484,"locationsCount":47},"100637041","effectiveness-of-tele-rehabilitation-in-managing-rhomboid-trigger-points-in-patients-with-myofascial-pain-syndrome-100637041","NCT07573527","Effectiveness of Tele-Rehabilitation in Managing Rhomboid Trigger Points in Patients With Myofascial Pain Syndrome","Inclusion Criteria:\n\n* Participants falling in this category would be recruited into the study.\n\n  * Age 18-35 years\n  * Both Genders: Male and Female\n  * Paitents experiencing Neck and upper back pain due to active trigger points.(16) According to Travell and Simons (1999)criteria, active myofascial trigger points (MTrPs) are identified.\n  * NPRS ≥4\n  * Presence of maximum one or more than one MTrPs in the Romboids muscle.\n  * Prolong sitting at least 6 hours per day.\n  * Access to a device with internet connection ( for tele rehabilitation group).\n\nExclusion Criteria:\n\n* Participants falling in this category would be excluded from the study.\n\n  * Participants fall in this category would be excluded of the study.\n  * Patients currently taking analgesics (painkillers) or muscle relaxants.\n  * Any inflammatory pathology, neurological impairment, and cervical tumor.\n  * Other deformities such as scoliosis or torticollis.\n  * Spinal Injuries and any other co morbidity.\n  * Any surgery, trauma, fracture and fall.\n  * Pregnancy.\n  * Patient unwilling to comply follow up schedule.\n  * Patient involvement in another interventional study.",{"count":464,"type":23},36,[26],"This randomized controlled trial aims to assess the effectiveness of tele-rehabilitation, including self-myofascial release and exercise therapy, in reducing pain, improving functional range of motion, and decreasing neck disability in patients with rhomboid trigger points associated with myofascial pain syndrome.",[468],"Myofascial Pain Syndrome",[470,471,472,473,474,475,476,477,478],"Tele-rehabilitation","Myofascial Release","Self-Myofascial Release,","Rhomboid Trigger Points","Neck Pain","Postural Correction","cervical retraction","scapular retraction","Upper Trapezius & Levator Scapulae Stretch",{"date":480,"type":39},"2026-08-06",{"date":330,"type":39},{"date":483,"type":23},"2027-02",{"name":45,"class":46},{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":492,"targetDuration":4,"studyType":24,"phases":494,"briefSummary":495,"conditions":496,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":498,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":47},"100644722","safety-and-efficacy-of-hemoglobin-f-inducers-in-patients-with-beta-thalassemia-100644722","NCT07673302","Safety and Efficacy of Hemoglobin F Inducers in Patients With Beta Thalassemia","Safety and Efficacy of Hemoglobin F Inducers in Patients With Beta Thalassemia: a Prospective 12 Months Study","Inclusion criteria:\n\n* Confirmed diagnosis of Beta thalassemia Major (BTM) ascertained by Hemoglobin Electrophoresis or HPLC report performed pre-transfusion or genetic testing profile (comprising PCR or HBB gene sequencing) suggestive of β-thalassemia syndrome.\n* All ages and both genders will be included\n* Written informed consent\n\nExclusion criteria:\n\n* Pregnancy or unwilling to follow contraception or planning conception (Enrolled female patients will be strictly advised to avoid pregnancy during the study period and until 6 months after thalidomide withdrawal.\n* Hemoglobinopathies other than beta thalassemia\n* History of neurological problems\n* Inability to regularly follow up",{"count":493,"type":23},240,[26],"The aim of this study is to determine the safety and therapeutic effect of HbF inducers (combination therapy: thalidomide and hydroxyurea) on beta thalassemia patients. The main objectives of this study are:\n\n* To determine the therapeutic efficacy of HbF inducers (combination therapy: thalidomide and hydroxyurea) on hemoglobin level and blood transfusion in beta thalassemia patients.\n* To determine the safety of HbF inducers (combination therapy: thalidomide and hydroxyurea) in beta thalassemia patients\n* To determine effect of HbF inducers (combination therapy: thalidomide and hydroxyurea) on quality of life of beta thalassemia patients",[497],"Thalassemia",{"date":480,"type":39},{"date":500,"type":39},"2026-06-20",{"date":502,"type":23},"2027-06-19",{"name":45,"class":46},{"id":505,"slug":506,"hasResults":12,"nctId":507,"briefTitle":508,"officialTitle":509,"acronym":4,"eligibilityCriteria":510,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":511,"targetDuration":4,"studyType":24,"phases":512,"briefSummary":513,"conditions":514,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":519,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":96},"100641502","metformin-as-adjunct-therapy-in-depression-obesity-comorbidity-clinical-and-genetic-evaluation-100641502","NCT07654179","Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation","Efficacy of Metformin With Antidepressant Medication as Adjunct Therapy in Depression-obesity Ccomorbidity and Ssociation With NEGR1\u002FRPL31P12 Variants Based on Genotyping","INCLUSION CRITERIA Group I: Normal Controls Group II: Depression Group III: Obesity\n\nGroup IV and V:\n\n* Age ≥ 18 years\n* Both males and females\n* Recurrent depressive disorder (6A71) according to ICD-11,\n* Asian cut off: Obese and overweight (BMI \\\u003C 23)\n* BDI score ≥ 13 or PHQ score ≥ 4\n* Either medication-naïve or medication-free for at least 2 weeks before enrollment, or the patient did not take antidepressants during the last 7 days before study entry (discontinuation of effective medication to enable study participation is prohibited)\n* In case of non-psychotropic medication: The patient received stable pharmacological medication for at least 14 days before study entry (any changes in medication dose or frequency of therapy must be answered with no)\n\nEXCLUSION CRITERIA Groups I-III: Negative Controls (Normal: no depression and Obesity for SNP comparison only)\n\n* Age less than 18\n* Dementia\u002F Mentally impaired who can not fill self report performas for inclusion criteria\n\nGroup IV: Positive Control (RCT patients)\n\n* Patients with comorbid conditions (HTN, CKD) if taking any drug for that condition.\n* The patient is not an employee of the investigator study site, or a family member of the employees or the investigator, or otherwise dependent on the sponsor, the investigator, or the investigator study site.\n* The patient did not participate in other interventional trials during the 6 months before and at the time of this trial. The patient does not have a history of non-response to antidepressants included in the study.\n* The patient has not given birth within the 6 months before study entry and is not breastfeeding\n* The patient did not receive treatment with ketamine, irreversible MAO inhibitor (e.g. tranylcypromine), electroconvulsive therapy (ECT) or other stimulatory treatments in the index episode.\n* The patient is not diagnosed with dementia and does not have moderate or severe impairment of general cognitive function according to clinical impression.\n* The patient does not meet the criteria for alcohol use disorder (DSM-5: 303.90; ICD-10: F10.20) or substance use disorder (DSM-5: 304; ICD-10: F11.20 - F19.20) in DSM-5, and a urine\u002Fserum drug screening is negative (except for benzodiazepines and opiates).\n* The patient does not have:\n\n  * A known allergy or contraindication against antidepressants included in the study\n  * History of suicidal tendencies\n  * Uncontrolled hepatic disorder, renal or cardiovascular disease\n  * DM\n  * Untreated hypothyroidism\n  * History of myocardial infarction or stroke\n  * Symptomatic peripheral arterial disease\n  * Monogenic familial hypercholesterolemia",{"count":442,"type":23},[26],"The patients with depression and obesity will receive add-on metformin with antidepressant therapy, which may result in greater improvement in depressive symptoms and BMI reduction compared to antidepressant monotherapy. NEGR1\u002FRPL31P12 gene polymorphisms may influence the comparative efficacy of antidepressant monotherapy versus combination therapy (antidepressant + metformin) in Pakistani patients. Patients with certain variants may respond better or worse to antidepressants and may have different weight outcomes.",[515,516,517,518],"Depression","Depressive Disorder","Overweight or Obesity","Depressive Symptoms",{"date":311,"type":39},{"date":521,"type":39},"2026-06-17",{"date":523,"type":23},"2027-06-11",{"name":45,"class":46},{"id":526,"slug":527,"hasResults":12,"nctId":528,"briefTitle":529,"officialTitle":529,"acronym":4,"eligibilityCriteria":530,"healthyVolunteers":12,"sex":18,"minAge":531,"maxAge":4,"enrollmentInfo":532,"targetDuration":4,"studyType":24,"phases":533,"briefSummary":535,"conditions":536,"keywords":545,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":556,"startDateStruct":557,"completionDateStruct":559,"leadSponsor":560,"locationsCount":96},"100627454","phase-4-intralesional-therapies-for-cutaneous-viral-warts-a-comparative-analysis-of-vitamin-d3-and-acyclovir-100627454","NCT07448844","Intralesional Therapies For Cutaneous Viral Warts: A Comparative Analysis Of Vitamin D3 And Acyclovir","Inclusion Criteria:\n\n* Patients aged 12 years and above with clinically diagnosed cutaneous warts\n* Common, plantar, flat, or periungual warts\n* Both treatment-naïve patients and those with recalcitrant warts\n\nExclusion Criteria:\n\n* Pregnant or lactating women\n* Immunocompromised patients\n* Individuals with history of hypersensitivity to vitamin D3 or acyclovir\n* Individuals receiving systemic immunosuppressive or antiviral therapy\n* Patients with secondary infection at injection site\n* Patients who had received any topical or destructive treatment for wart in previous three months","12 Years",{"count":206,"type":23},[534],"PHASE4","The goal of this clinical trial is to learn if injecting acyclovir (an antiviral drug) or vitamin D3 directly into skin warts works to clear them in people aged 12 and older with common, plantar, flat, or periungual (around the nail) warts. The main questions it aims to answer are:\n\n1. Does intralesional acyclovir or vitamin D3 lead to complete clearance of warts by week 8?\n2. Which treatment clears warts more effectively?\n3. What side effects do participants have with each treatment?\n\nResearchers will compare acyclovir injections (Group A) to vitamin D3 injections (Group B), with 20 participants in each group, to see which treatment works better at clearing warts.\n\nParticipants will:\n\n1. Receive an injection directly into the wart every 2 weeks for up to 4 sessions\n2. Have photographs taken of their warts before treatment and at each visit\n3. Visit the clinic for checkups where the size and number of warts will be measured\n4. Be followed for up to 3 months to check for wart recurrence and side effects",[537,538,539,540,541,542,543,544],"Viral Wart","Plantar Wart","Common Warts (Verruca Vulgaris)","Common Wart","Flat Wart","Warts of Foot","Warts Hand","Wart",[546,547,548,549,550,551,552,553,554,555],"Cutaneous warts","intralesional therapy","treatment efficacy","plantar warts","common warts","human papillomavirus","randomized controlled trial","vitamin D3","acyclovir","flat warts",{"date":311,"type":39},{"date":558,"type":39},"2026-02-20",{"date":335,"type":23},{"name":45,"class":46},{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":565,"acronym":4,"eligibilityCriteria":566,"healthyVolunteers":12,"sex":155,"minAge":55,"maxAge":567,"enrollmentInfo":568,"targetDuration":4,"studyType":24,"phases":569,"briefSummary":570,"conditions":571,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":575,"completionDateStruct":576,"leadSponsor":578,"locationsCount":47},"100642983","therapeutic-synergy-of-probiotic-augmented-conventional-antidiabetic-pharmacotherapy-in-gestational-diabetes-mellitus-100642983","NCT07645001","Therapeutic Synergy of Probiotic Augmented Conventional Antidiabetic Pharmacotherapy in Gestational Diabetes Mellitus","Inclusion Criteria:\n\n* Pregnant women (18-45 years of age).\n* Diagnosed with GDM between 18-26 weeks of gestation.\n* Singleton pregnancy. (Multiple gestations carry inherently higher risks like preterm birth, growth restriction and neonatal morbidity, Inclusion may introduce confounding thus restricting singleton pregnancies ensures population homogeneity).\n\nExclusion Criteria:\n\n* Pre-existing diabetes mellitus.\n* Pregnancy induced hypertension.\n* Chronic gastrointestinal, hepatic, or renal disease.\n* Use of antibiotics or probiotics within the previous 4 weeks.\n* Multiple pregnancy.\n* Pregnancy with known fetal anomalies.","45 Years",{"count":442,"type":23},[26],"1. To compare the effects of metformin, insulin, and their combination with multistrain probiotics on glycemic control and insulin resistance in women with gestational diabetes mellitus (GDM), assessed by FPG, HbA1c, fasting insulin, and HOMA-IR.\n2. To compare the effects of metformin, insulin, and their combination with multistrain probiotics on inflammatory biomarkers in women with GDM.\n3. To determine the effect of multistrain probiotic supplementation alongside standard therapy on maternal and neonatal outcomes, including gestational age at delivery, mode of delivery, birth weight, Apgar score, and NICU admission.",[572],"Gestational Diabetes","2026-07-29",{"date":352,"type":39},{"date":573,"type":39},{"date":577,"type":23},"2027-06",{"name":45,"class":46},{"id":580,"slug":581,"hasResults":12,"nctId":582,"briefTitle":583,"officialTitle":584,"acronym":4,"eligibilityCriteria":585,"healthyVolunteers":12,"sex":18,"minAge":104,"maxAge":586,"enrollmentInfo":587,"targetDuration":4,"studyType":24,"phases":589,"briefSummary":590,"conditions":591,"keywords":593,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":596,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":600,"locationsCount":47},"100630192","sedentary-behavior-modification-cardiopulmonary-function--qol-post-cardiac-surgery-patients-100630192","NCT07484477","Sedentary Behavior Modification, Cardiopulmonary Function & QOL Post Cardiac Surgery Patients.","Effects of Sedentary Behaviour Modification on Cardiopulmonary Function and Quality of Life in Post-Cardiac Surgery Patients","Inclusion Criteria:\n\n* Patient Aged 50-80 years (represents the majority cases)\n* Natural decline in physical capacity, making them an ideal population for studying these outcomes)\n* Underwent elective or emergency cardiac surgery (once patient is in ward)\u002F1\n\nExclusion Criteria:\n\n* Those requiring invasive mechanical ventilation\n* Individuals with significant cognitive impairment affecting consent or compliance\n* Pregnant women or Lactating Mother","80 Years",{"count":588,"type":23},24,[26],"This study aims to investigate randomized controlled trial to evaluate whether reducing sedentary behavior improves recovery in post-cardiac surgery patients. Participants are assigned to either a behavioral intervention that substitutes sitting with light activity or to usual care. Changes in exercise capacity and quality of life are the primary measured outcomes. It is hypothesized that the intervention group will demonstrate superior gains in both physical function and well-being. The results could inform a valuable adjunct to existing cardiac rehabilitation programs.",[592],"Post-cardiac Surgery Patients",[594,136,595],"Sedentary Behaviour","Cardiopulmonary Function",{"date":573,"type":39},{"date":598,"type":39},"2026-04-15",{"date":122,"type":23},{"name":45,"class":46},{"id":602,"slug":603,"hasResults":12,"nctId":604,"briefTitle":605,"officialTitle":606,"acronym":4,"eligibilityCriteria":607,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":608,"enrollmentInfo":609,"targetDuration":4,"studyType":24,"phases":610,"briefSummary":611,"conditions":612,"keywords":614,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":616,"lastUpdatePostDateStruct":617,"startDateStruct":618,"completionDateStruct":619,"leadSponsor":621,"locationsCount":47},"100649664","acapella-vs-flutter-devices-for-improving-breathing-and-lung-function-after-lobectomy-100649664","NCT07737093","Acapella vs Flutter Devices for Improving Breathing and Lung Function After Lobectomy","Comparative Effects of Acapella and Flutter Devices on Secretion Clearance, Dyspnea, Arterial Blood Gases, and Lung Function Test in Post-Lobectomy Patients","Inclusion Criteria:\n\n* Patients aged 35 to 54 years\n* Both male and female patients\n* Patients who have undergone lobectomy surgery\n* Hemodynamically stable patients\n* Patients with adequate respiratory function (able to maintain oxygenation)\n* Patients 48 hours post-surgery\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Hemodynamically unstable patients\n* Patients within less than 48 hours post-surgery\n* Presence of pneumothorax or air leak complications\n* Patients with recent major trauma or additional surgery\n* Patients with unstable cardiac conditions\n* Patients with massive hemoptysis\n* Patients unable to cooperate or perform breathing exercises with devices\n* Any contraindication to airway clearance techniques as judged by the clinician","54 Years",{"count":255,"type":23},[26],"Lobectomy patients frequently experience postoperative respiratory complications such as secretion retention, dyspnea, impaired gas exchange, and reduced lung function, which can delay recovery. Oscillatory Positive Expiratory Pressure (OPEP) devices such as Acapella and Flutter are commonly used to improve airway clearance and pulmonary function. This study aims to compare the effects of Acapella and Flutter devices on secretion clearance, dyspnea, arterial blood gases, and lung function in post-lobectomy patients.",[613],"Lobotomy Syndrome",[615],"Acapella device Flutter device Post-lobectomy patients Secretion clearance Dyspnea Arterial blood gases Lung function Chest physiotherapy","2026-07-27",{"date":352,"type":39},{"date":500,"type":39},{"date":620,"type":23},"2026-12-15",{"name":45,"class":46},""]