[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Robert Chen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":62},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100646542","theta-burst-transcranial-focused-ultrasound-as-a-novel-treatment-for-cervical-dystonia-100646542",false,"NCT07690514","Theta Burst Transcranial Focused Ultrasound as a Novel Treatment for Cervical Dystonia","Inclusion Criteria:\n\n* 18 - 90 years of age\n* Confirmed diagnosis cervical dystonia\n* 3 months since last botulinum toxin injection\n* Stable medications in the past month\n\nExclusion Criteria:\n\n* Has neurological disorder other than dystonia (such as compressive neuropathy, limb trauma, epilepsy)\n* Cognitive deficits leading to inability to understand study purposes and risks as well as the consent information without legal trustee\n* Presence of metal implanted in body that is contraindicated in MRI\n* Pregnancy\n* Has a previous surgical intervention to treat CD such as lesioning or a DBS system in place\n* Major systemic illness or infection","ALL","18 Years","90 Years",{"count":19,"type":20},48,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study is a single-blinded, randomized control study that aims to recruit 48 participants. Participants will be \"randomized\" into one of the study arms of the study: active stimulation to GPi, active stimulation to DN, or sham stimulation. The purpose of the study is to look into the effects of LIFUS in patients with cervical dystonia. The participation will include seven study visits, at least 24 hours apart. All study visits will take place at TWH. The first visit is a screening visit. Visits 2-6 will be on consecutive days. Visit 7 will be a week from Visit 6 or from your last day of LIFUS, whichever comes first.",[26],"Cervical Dystonia",[26],"RECRUITING","2026-07-05",{"date":31,"type":32},"2026-07-08","ACTUAL",{"date":34,"type":32},"2024-11-18",{"date":36,"type":20},"2029-12",{"name":38,"class":39},"Robert Chen","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":40},"100646203","pedunculopontine-nucleus-transcranial-ultrasound-stimulation-as-a-treatment-of-freezing-of-gait-in-parkinsons-disease-100646203","NCT07695233","Pedunculopontine Nucleus Transcranial Ultrasound Stimulation as a Treatment of Freezing of Gait in Parkinson's Disease","Inclusion Criteria:\n\n* 18-90 years of age\n* Confirmed diagnosis of a movement disorder with Freezing of Gait\n* Stable dopaminergic medication dose for a minimum of 4 weeks\n\nExclusion Criteria:\n\n* History of stroke or seizure\n* Comorbid dementia\n* Scored below 22 on the Montreal Cognitive Assessment (MoCA)\n* Has intracranial implant(s) or device(s)\n* Has an implanted cardiac pacemaker or implantable cardioverter-defibrillator (ICD)\n* Has a previous surgical intervention to treat the movement disorder such as lesioning or a DBS system in place.\n* Presence of metal implanted in body that is contraindicated in TMS\u002FMRI\n* Pregnancy\n* Major depression\u002Fpsychiatric disorder that in the opinion of the Investigator will affect patient's understanding of study procedures and willingness to abide by all procedures during the course of the study\n* Is on antipsychotics, marijuana, or other recreational drugs that affect the nervous system\n* Major musculoskeletal or neuromuscular disease or disorder of the hands, wrists and limbs\n* Major systemic illness or infection",true,{"count":49,"type":20},50,[23],"This study is investigating the use of transcranial ultrasound stimulation (TUS) on the Pedunculopontine nucleus (PPN) in changing freezing of gait in people with Parkinson's disease. The PPN is noted to be involved in voluntary movements, locomotion, and muscle tone. This will be assessed by patient-reported outcomes and analyzing the gait. The study will also investigate the effects of the stimulation on the PPN and surrounding connectivity by using magnetic resonance imaging (MRI).",[53,54],"Parkinson Disease","Freezing of Gait Symptoms in Parkinson Disease",{"date":56,"type":32},"2026-07-10",{"date":58,"type":32},"2024-05-17",{"date":60,"type":20},"2028-12",{"name":38,"class":39},""]