[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Royan Institute\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":77},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100647514","early-phase-1-safety-and-feasibility-of-cik-cell-therapy-in-hcc-after-tumor-resection-100647514",false,"NCT07709299","Safety and Feasibility of CIK Cell Therapy in HCC After Tumor Resection","Safety and Feasibility of Autologous Cytokine Induced Killer (CIK) Cells Infusion as an Adjuvant Therapy in Post Resection Hepatocellular Carcinoma (HCC) Patients","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Documented HCC at BCLC stage 0-A, having undergone surgical tumor resection\n* Single tumor or ≤3 nodules, each ≤3 cm\n* Child-Pugh score A-B\n* ECOG performance status 0-1\n* Confirmed cancer-free status one month after surgery\n* Written informed consent\n* Leukocyte count \\> 3 × 10⁹\u002FL\n* Absolute neutrophil count (ANC) ≥ 1,000\u002FµL\n* Hemoglobin ≥ 8.5 g\u002FdL\n* Platelet count \\> 50 × 10⁹\u002FL\n* BUN and serum creatinine ≤ 1.5 × upper limit of normal No extrahepatic abdominal disease spread, confirmed by abdominal CT\u002FMRI\n\nExclusion Criteria:\n\n* Active infection or uncontrolled viremia (particularly HBV, HCV, or HIV)\n* Any cell therapy or immunotherapy in the past 6 months, or current participation in another clinical study\n* Another malignancy (prior or concurrent) differing from HCC in primary site or histology\n* Clinically significant cardiovascular disease (e.g., heart failure, serious arrhythmia, symptomatic coronary artery disease)\n* History of organ transplantation\n* Primary or secondary immunodeficiency, or active autoimmune disease\n* Severe allergic disorder or history of anaphylaxis\n* Pregnancy or breastfeeding at study entry\n* Women of childbearing potential intending to become pregnant","ALL","18 Years","80 Years",{"count":20,"type":21},6,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","This study tests whether it is safe and feasible to give patients with hepatocellular carcinoma (liver cancer) an infusion of their own (autologous) immune cells, called cytokine-induced killer (CIK) cells, after they have had surgery to remove their liver tumor. The patient's own blood cells are collected and grown in a laboratory to create the CIK cells, which are then given back to the patient through six intravenous infusions over about two months. Patients are followed for six months to check for side effects and early signs of whether the cancer returns.",[27],"Hepatocellular Carcinoma (HCC)",[29,30,31,32,33,34],"Cytokine-induced killer cell","CIK Cells","Hepatocellular carcinoma","HCC recurrence","HCC resection","Adjuvant therapy","NOT_YET_RECRUITING","2026-07-14",{"date":38,"type":39},"2026-07-16","ACTUAL",{"date":41,"type":21},"2026-07",{"date":43,"type":21},"2028-07",{"name":45,"class":46},"Royan Institute","OTHER_GOV",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100636929","phase-1-safety-and-feasibility-of-bilateral-striatal-transplantation-of-dopacell-in-parkinsons-disease-100636929","NCT07572071","Safety and Feasibility of Bilateral Striatal Transplantation of DopaCell in Parkinson's Disease","Evaluation of the Safety and Feasibility of a Single Transplantation of 10 Million Human Embryonic Stem Cell-Derived Dopaminergic Progenitor Cells Into the Bilateral Striatum of Patients With Moderately Severe Parkinson's Disease: a Multicenter, Open-label, Single-arm Phase I Clinical Trial","Inclusion Criteria:\n\n* Age: 30-70 years\n* Diagnosis of PD: MDS clinical Diagnostic Criteria for Parkinson's disease\n* The disease duration more than 5 years\n* Moderate Parkinson's disease, defined as a Hoehn and Yahr stage of 2 or 3 during the OFF period.\n* The patient is receiving oral pharmacological therapy, and in the opinion of the Principal Investigator, the patient's symptoms remain inadequately controlled despite optimal medical management, or the patient is experiencing adverse effects related to their current treatment\n* No history or only mild levodopa-induced dyskinesia, defined as a score of 2 or less on the UDysRS scale in any body region during the ON state.\n* The patient demonstrates a clinically meaningful response to a therapeutic dose of levodopa, as determined by the Principal Clinical Investigator or a trained specialist under the supervision of the Principal Investigator.\n* The performance of different organs based on laboratory evaluations:\n\n  * Number of neutrophils ≥2000 \u002F microliter\n  * Platelet count ≥100,000 \u002F microliter\n  * AST \u002F ALT: less than or equal to three times the maximum normal value at the intervention site\n  * Total bilirubin less than or equal to 1.5 times the maximum normal amount at the intervention site\n  * eGFR \\* rate: greater than or equal to 60 ml \u002F min \u002F 1.73 m2 \\* eGFR (mL \u002F min \u002F 1.73 m2) = 194 X Cr \\^ -1.094 X age \\^ -0.287 (X 0.739 for females)\n* Informed consent\n\nExclusion Criteria:\n\n* The abnormal function of immune system\n* The symptomatic brain injuries (brain atrophy, cerebral Infarct, trauma, vascular malformation) confirmed by brain MRI\n* Markedly reduced or normal signal in the ventral striatum on TRO-DaT SPECT imaging.\n* Any abnormal findings on brain MRI.\n* Positive GBA mutation test.\n* Diagnosis of dementia based on a MoCA score \\\u003C 24.\n* The abnormality of thrombotic system or high risk of bleeding\n* Positive for any of the following viral markers or active infections: HBsAg, HBsAb, HBcAb, anti-HIV antibodies, anti-HTLV-1\\&2 antibodies, active hepatitis C infection, syphilis, or active CMV, VZV, EBV, or COVID-19 infection.\n* Impossibility of MRI imaging for patients with metal in the body, pacemaker in the body, claustrophobia, with artificial heart valves that are incompatible with MRI or body weight is not within the tolerable range for MRI.\n* Patients with contraindications to the study drug: Tacrolimus, Prednisolone, Basiliximab, Cotrimoxazole, MRI contrast agent.\n* Patients undergoing other cell transplants, including embryonic stem cell-derived dopaminergic progenitor cells.\n* Patients with a history of PD at the same time and concurrent: Malignant neoplasm, epilepsy, cerebral hemorrhage or a positive history\n* Psychiatric disorders confirmed by a psychiatrist, including major depression, bipolar disorder, or schizophrenia, that are uncontrolled or treatment resistant.\n* Patients with intellectual disability who, in the judgment of a psychiatrist, are unable to fully comprehend the study requirements.\n* History of pallidotomy, thalamotomy, or deep brain stimulation (DBS).\n* Patients considered high-risk candidates for surgery, particularly neurosurgery or DBS implantation, due to significant cardiovascular, pulmonary, or other systemic comorbidities identified during preoperative evaluation.\n* Patients who have a history of taking the following in the three months prior to enrollment: Immunosuppressant, antipsychotic drug, anticonvulsant drugs or anticoagulant therapy (if discontinuation or perioperative adjustment is not feasible), botulinum toxin (within 6 months), phenol injections, or other treatments for dystonia or muscle spasm\n* History of Apomorphine use\n* History of chronic alcohol use or illicit drug abuse.\n* Patients who are pregnant, lactating, or people who did not avoid pregnancy during the study.\n* Patients who, according to the researchers' opinions, are not suitable for safe study.","30 Years","70 Years",{"count":20,"type":21},[59],"PHASE1","Dopason is a phase I, open-label, multicenter, single-arm clinical trial designed to evaluate the safety and feasibility of intraputaminal transplantation of human embryonic stem cell-derived dopaminergic progenitor cells (DopaCells) in patients with moderately severe Parkinson's disease.",[62],"Parkinson Disease (PD)",[64,65,66],"Parkinson's disease","Dopaminergic progenitor cell transplantation","Intrastriatal","RECRUITING","2026-06-16",{"date":70,"type":39},"2026-06-18",{"date":72,"type":39},"2025-08-01",{"date":74,"type":21},"2030-08-01",{"name":45,"class":46},3,""]