[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"São Paulo State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":136},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,83,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100652516","twenty-four-hour-movement-behaviors-and-atherosclerotic-risk-100652516",false,"NCT07774507","Twenty-four Hour Movement Behaviors and Atherosclerotic Risk","Physical Activity, Sleep and Sedentary Behavior on Atherosclerotic Risk Outcomes Among People With Rheumatoid Arthritis","PASSARO","Inclusion Criteria:\n\n* Medical diagnosis of rheumatoid arthritis.\n* Age between 18 and 65 years.\n* Provide written informed consent.\n* Independence in daily living activities defined as a Katz Index score of 5 or 6 points.\n\nExclusion Criteria:\n\n* Acute infectious disease at the time of assessment.\n* Pregnancy or breastfeeding.\n* Cognitive impairment identified by the Mini-Mental State Examination according to established cutoff values.\n* History of cardiovascular disease, including coronary artery disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, congenital heart disease, deep vein thrombosis, or pulmonary embolism.\n* Use of uncontrolled vasoactive medication.\n* Inability to comply with accelerometer wear requirements.\n* Inability to complete study questionnaires or physical assessments.\n* Invalid accelerometer data according to the study wear-time criteria.","ALL","18 Years","65 Years",{"count":21,"type":22},150,"ESTIMATED","1 Year","OBSERVATIONAL","This observational study aims to investigate how 24-hour movement behaviors are associated with atherosclerotic risk in adults with rheumatoid arthritis.\n\nThese behaviors include physical activity, sedentary behavior, and sleep.\n\nThe main questions it aims to answer are:\n\n* Are 24-hour movement behaviors, both individually and in combination, associated with indicators of atherosclerotic risk in adults with RA?\n* Do changes in 24-hour movement behaviors over 12 months relate to changes in indicators of atherosclerotic risk?\n\nParticipants will:\n\n* Wear activity monitors (accelerometers) continuously for 7 days to measure physical activity, sedentary behavior, and sleep.\n* Answer questionnaires about their health and lifestyle.\n* Undergo cardiovascular assessments, body composition measurements, physical fitness tests, and blood tests to measure lipid and inflammatory profile.\n* Return 12 months later for follow-up assessments.\n\nThe researchers hope this study will improve understanding of how daily movement behaviors influence cardiovascular health in people with rheumatoid arthritis. The findings may help inform future recommendations to promote healthier movement behaviors and improve cardiovascular risk management in this population.",[27,28,29],"Cardiovascular Risk Assessment","Rheumatoid Arthritis (RA)","24-Hour Movement Guidelines",[31,32,33,34,35],"Rheumatoid Arthritis","Cardiovascular Health","Physical activity","Sleep","Sedentary behavior","RECRUITING","2026-08-19",{"date":39,"type":40},"2026-08-20","ACTUAL",{"date":42,"type":22},"2026-09-01",{"date":44,"type":22},"2028-06-30",{"name":46,"class":47},"São Paulo State University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":48},"100627092","effects-of-beetroot-extract-on-blood-pressure-and-exercise-in-hypertensive-older-women-100627092","NCT07444138","Effects of Beetroot Extract on Blood Pressure and Exercise in Hypertensive Older Women","Acute Effects of Beetroot Extract Supplementation on Blood Pressure, Oxidative Stress, and Muscle Oxygen Saturation in Hypertensive Older Women Submitted to an Aerobic Exercise Session","Inclusion Criteria:\n\n* Female sex: Older women aged between 60 and 70 years.\n* Physical capability: Absence of health conditions that could compromise performance in the required physical exercise tests.\n\nExclusion Criteria:\n\n* Smoking: Current smokers.\n* Alcohol use: History of alcohol abuse or excessive alcohol consumption.\n* Cardiovascular Disease: Diagnosis of cardiovascular diseases (other than the primary condition of hypertension).",true,"FEMALE","60 Years",{"count":60,"type":22},20,"INTERVENTIONAL",[63],"NA","The goal of this clinical trial is to learn about the acute effects of beetroot extract in older women with high blood pressure. The main questions it aims to answer are:\n\nDoes beetroot extract affect blood pressure during exercise? Does it change oxygen levels in the muscles? Participants will take a beetroot supplement and perform an aerobic exercise session to check how their bodies respond.",[66,67],"Hypertension","Hypertension (HTN)",[69,70,71,72,73,74],"Dietary Nitrate","Beetroot Extract","Aerobic Exercise","Nitric Oxide","Older Adults","Blood Pressure","2026-02-27",{"date":77,"type":40},"2026-03-02",{"date":79,"type":40},"2025-10-08",{"date":81,"type":22},"2026-07",{"name":46,"class":47},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":57,"minAge":4,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":61,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100624289","exercise-insulin-resistance-and-chronic-pain-in-postmenopausal-women-100624289","NCT07407699","Exercise, Insulin Resistance, and Chronic Pain in Postmenopausal Women.","Isulin Resistance as a Mediator of Chronic Pain in Postmenopausal Women: Effects of a Combined Exercise Program on Metabolic and Inflammatory Mechanisms","EX-PAIN-MENO","Inclusion Criteria:\n\n* Postmenopausal women, defined as between 12 months and 5 years since the last menstrual period.\n* Not using hormone replacement therapy.\n* Not engaged in regular physical exercise (defined as more than once per week in the last months).\n* With or without insulin resistance.\n\nExclusion Criteria:\n\n* Diagnosis of neurological diseases (e.g., Parkinson's disease, multiple sclerosis, or stroke sequelae).\n* Severe psychiatric disorders.\n* Inflammatory autoimmune diseases (e.g., rheumatoid arthritis or systemic lupus erythematosus).\n* Active neoplasms.\n* Use of systemic corticosteroids or immunosuppressive drugs within the last three months.\n* Severe decompensated cardiovascular disease.\n* Any medical condition that contraindicates participation in physical exercise.",{"count":92,"type":22},50,[63],"This study aims to investigate the effects of a combined exercise program on chronic pain in postmenopausal women, considering insulin resistance as a potential physiological mediator. The intervention will assess changes in pain intensity, metabolic and inflammatory biomarkers, psychosocial factors, and body composition. The findings may contribute to understanding the metabolic mechanisms underlying chronic pain in postmenopausal women and support exercise as a non-pharmacological therapeutic strategy.",[96,97,98],"Chronic Pain","Postmenopausal","Insulin Resistance","NOT_YET_RECRUITING","2026-02-05",{"date":102,"type":40},"2026-02-12",{"date":104,"type":22},"2026-08",{"date":106,"type":22},"2027-07",{"name":46,"class":47},{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":61,"phases":117,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":48},"100619405","phase-1-dual-site-transcranial-magnetic-stimulation-of-the-supplementary-motor-area-and-cerebellum-for-the-treatment-of-essential-tremor-100619405","NCT07344194","Dual-Site Transcranial Magnetic Stimulation of the Supplementary Motor Area and Cerebellum for the Treatment of Essential Tremor.","Dual-Site Transcranial Magnetic Stimulation of the Supplementary Motor Area and Cerebellum for the Treatment of Essential Tremor","Inclusion Criteria:\n\n* Male or female participants, aged 18 to 80 years; women of childbearing potential must not be pregnant.\n* Diagnosis of Essential Tremor with a score greater than 2 on items 5 or 6 of the Fahn-Tolosa-Marin Tremor Rating Scale despite optimized medical therapy.\n* Medication-refractory tremor, defined as prior use of both first-line medications (propranolol and primidone) at maximally tolerated doses without adequate tremor control.\n* Ability to provide written informed consent in accordance with institutional policies.\n* Ability to comply with all study procedures and follow-up assessments as defined by the study protocol.\n\nExclusion Criteria:\n\n* Unstable or untreated psychiatric disorders.\n* Inability to provide informed consent.\n* Uncontrolled medical conditions, including but not limited to uncontrolled diabetes mellitus, hypertension, symptomatic pulmonary disease, or symptomatic cardiac disease.\n* Concomitant participation in another investigational drug or device study.\n* Pregnancy or breastfeeding.\n* Presence of an implanted deep brain stimulation (DBS) system.\n* History of epilepsy not adequately controlled, defined as seizure-free for less than 5 years.\n* Presence of a cardiac pacemaker.\n* Presence of metallic implants in any part of the body that are contraindicated for rTMS.",{"count":116,"type":22},36,[118,119],"PHASE1","PHASE2","Essential tremor is a common movement disorder that causes involuntary shaking, mainly during voluntary actions such as writing or holding objects. Recent research suggests that essential tremor is not caused by a single brain area, but by abnormal activity within a network that includes the cerebellum and motor areas of the brain. However, most non-invasive brain stimulation studies to date have targeted only one brain region and have shown inconsistent clinical benefits.\n\nThis randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effects of a dual-site transcranial magnetic stimulation (rTMS) protocol targeting the supplementary motor area (SMA) and the cerebellum in patients with essential tremor that does not respond adequately to standard medications. The study is based on previous pilot data showing meaningful tremor reduction using combined stimulation of these two brain regions.\n\nParticipants will receive five sessions of rTMS, consisting of low-frequency stimulation over the SMA followed by high-frequency stimulation over the cerebellum. The main hypothesis is that this combined approach will lead to an immediate and sustained improvement in action tremor of the dominant upper limb, measured up to four weeks after treatment. Secondary outcomes include quality of life, safety, side effects, and changes in brain excitability associated with tremor improvement.",[122],"Essential Tremor",[124,125,126,127],"essential tremor","rTMS","movement disorders","non-invasive neuromodulation","2026-01-19",{"date":130,"type":40},"2026-01-21",{"date":132,"type":40},"2026-01-15",{"date":134,"type":22},"2027-01",{"name":46,"class":47},""]