[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Samar Ali Abdu Salamah\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100653970","effect-of-advanced-prf-and-hyaluronic-acid-on-dental-implant-healing-100653970",false,"NCT07792720","Effect of Advanced PRF and Hyaluronic Acid on Dental Implant Healing","Clinical Efficacy of A-PRF With Hyaluronic Acid\" in Enhancing Bone Formation in Dental Implantation","Inclusion Criteria:\n\n\\- Adults aged 18-65 years.\n\nPatients requiring delayed dental implant placement in a posterior mandibular edentulous site\n\nSufficient residual alveolar bone height and width to permit conventional implant placement without the need for simultaneous guided bone regeneration (GBR), ridge augmentation, or other bone-grafting procedures.\n\nGood general health or a medically controlled and stable systemic condition compatible with elective implant surgery and not expected to materially compromise wound or bone healing.\n\nNon-smokers with no current use of tobacco products.\n\nAcceptable oral hygiene and a periodontal condition compatible with implant surgery following any required professional treatment and reassessment.\n\nAbility and willingness to undergo the required clinical and radiographic assessments, including CBCT examinations at baseline and at the 6-month follow-up.\n\nAbility and willingness to attend the scheduled follow-up visits and comply with the study procedures.\n\nProvision of written informed consent before study participation.\n\nExclusion Criteria:\n\n\\-\n\nAny uncontrolled systemic disease or medical condition that conensions for conventional implant placement without augmentation.\n\nRequirement for immediate implant placement, simultaneous guided bone regeneration, ridge augmentation, or any other adjunctive bone-grafting procedure.\n\nInability or unwillingness to complete the required 6-month clinical and radiographic follow-up.traindicates elective implant surgery or may substantially impair wound or bone healing, including uncontrolled diabetes mellitus.\n\nImmunocompromised status or current systemic immunosuppressive therapy.\n\nCurrent or previous use of oral or parenteral bisphosphonates or other antiresorptive medications associated with a risk of medication-related osteonecrosis of the jaw.\n\nPregnancy at the time of screening or enrollment.\n\nUnresolved active periodontal disease or active local infection involving the intended implant site, including suppuration.\n\nInadequate oral hygiene that persists after professional oral-hygiene instruction, necessary periodontal treatment, and reassessment.\n\nInsufficient residual alveolar bone dim","ALL","18 Years","65 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized parallel-group clinical trial aimed to evaluate the clinical efficacy of advanced platelet-rich fibrin (A-PRF) combined with hyaluronic acid (HA) in enhancing peri-implant bone formation in patients undergoing delayed dental implant placement. Participants will be allocated to either a test group, in which A-PRF combined with HA is applied at the implant site, or a control group receiving conventional implant placement without adjunctive biomaterials. Peri-implant bone changes will be assessed using cone-beam computed tomography (CBCT), including radiographic bone density and bone volume measurements. Implant stability will also be evaluated using resonance frequency analysis at the time of implant placement and during follow-up. Additional clinical outcomes include postoperative pain and implant survival. The participants will be followed up for six months after implant placement.",[27,28],"Partial Edentulism","Dental Implant Placement",[28,30,31,32,33,34,35,36,37],"Advanced Platelet-Rich Fibrin","A-PRF","Hyaluronic Acid","Osseointegration","Implant Stability","Cone-Beam Computed Tomography","Peri-Implant Bone","Bone Formation","RECRUITING","2026-08-29",{"date":41,"type":42},"2026-09-02","ACTUAL",{"date":44,"type":42},"2025-06-05",{"date":46,"type":21},"2027-06",{"name":48,"class":49},"Samar Ali Abdu Salamah","OTHER",""]