[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Shaheed Suhrawardy Medical College and Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100653282","phase-2-efficacy-and-safety-of-mycophenolate-mofetil-in-refractory-iga-nephropathy-100653282",false,"NCT07785128","Efficacy and Safety of Mycophenolate Mofetil in Refractory IgA Nephropathy","Efficacy and Safety of Mycophenolate Mofetil in Patients With Refractory IgA Nephropathy in Bangladesh: A Phase II Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥18 years Biopsy-proven refractory IgA nephropathy, defined as persistent proteinuria \\>1.0 g\u002Fday despite completion of optimized supportive therapy according to KDIGO recommendations, including corticosteroid and\u002For immunosuppressive therapy and ACE inhibitor and\u002For angiotensin receptor blocker therapy (unless contraindicated) for a minimum of six months eGFR ≥30 mL\u002Fmin\u002F1.73 m² at enrollment\n\nExclusion Criteria:\n\n* Complete or partial remission of IgA nephropathy at enrollment Secondary IgA nephropathy associated with systemic diseases Diabetes mellitus with diabetic kidney disease or any other known non-IgA cause of proteinuria End-stage renal disease requiring dialysis or previous kidney transplantation eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m² at enrollment Active infection requiring systemic antimicrobial therapy Significant hepatic impairment (ALT or AST \\>3 times the upper limit of normal) Pregnancy, planned pregnancy, or breastfeeding Known hypersensitivity or contraindication to MMF","ALL","18 Years",{"count":19,"type":20},104,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","This study is testing whether a medicine called mycophenolate mofetil (MMF) works better than the usual treatment for people whose kidney disease, called IgA nephropathy, has not improved with standard care.\n\nIgA nephropathy is a kidney disease that can cause protein to leak into the urine and, over time, can damage the kidneys. Some people with this disease do not get better even after standard treatment. Doctors call this \"refractory\" disease. Right now, there is no proven best treatment for these patients in Bangladesh.\n\nThis study will include 116 adults with kidney disease that has been confirmed by a kidney tissue sample and has not improved with standard treatment. Participants will be split into two equal groups by chance, like a coin flip. One group will take MMF by mouth for 6 months, along with the usual supportive care. The other group will take a steroid medicine called prednisolone, along with the usual supportive care. Both groups will also continue treatments like blood pressure medicines that are already part of standard care for this condition.\n\nResearchers want to find out how many people in each group get better, meaning their urine protein drops to a low level and their kidney function stays stable. They will also look at changes in kidney function and any side effects from the medicines.\n\nThe study will take place at the National Institute of Kidney Diseases and Urology Hospital in Dhaka, Bangladesh, over about one year. Each participant will be followed for 6 months, with check-up visits and blood and urine tests at the start, at 3 months, and at 6 months.",[26],"IgA Nephropathy",[28,29,30,31,32],"Mycophenolate mofetil","IgA nephropathy","Refractory proteinuria","Immunosuppressive therapy","Bangladesh","NOT_YET_RECRUITING","2026-08-20",{"date":36,"type":37},"2026-08-25","ACTUAL",{"date":39,"type":20},"2026-09-01",{"date":41,"type":20},"2027-08-31",{"name":43,"class":44},"Shaheed Suhrawardy Medical College and Hospital","OTHER",3,""]