[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Sherief Ayman Hussein Shaamash\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100659387","phase-2-efficacy-of-botulinum-toxin-a-versus-nanofat-in-the-treatment-of-androgenetic-alopecia-a-comparative-clinical-trial-100659387",false,"NCT07863856","Efficacy of Botulinum Toxin A Versus Nanofat in the Treatment of Androgenetic Alopecia: A Comparative Clinical Trial","AGA","Inclusion Criteria:\n\n* Male patients aged 18 to 40 years.\n* Clinical diagnosis of androgenetic alopecia confirmed by history, scalp examination, and dermoscopy.\n* Norwood-Hamilton grade II or III androgenetic alopecia.\n* Presence of visible hair follicles in the target scalp area on dermoscopy.\n\nExclusion Criteria:\n\n* Significant systemic illness affecting safety, wound healing, or hair growth (e.g., neuromuscular disorders, uncontrolled diabetes, autoimmune disease, hematological disease, active malignancy, or recent chemotherapy).\n* Active scalp infection, inflammation, dermatitis, wounds, scarring, or other skin lesions at the treatment area.\n* Other causes of alopecia (alopecia areata, telogen effluvium, traction alopecia, cicatricial alopecia, thyroid-related hair loss, iron deficiency-related hair loss, or drug-induced alopecia).\n* Any previous topical treatment for AGA within the past 1-2 months.\n* Use of systemic corticosteroids, JAK inhibitors, immunosuppressive drugs, or other hair-growth-altering medications within the last 3 months.\n* Known hypersensitivity to botulinum toxin, albumin, local anesthetics, or any component used in the procedure.\n* Bleeding disorder, thrombocytopenia, or current anticoagulant\u002Fantiplatelet therapy.\n* Inadequate fat, site infection, site scarring, or any condition making fat harvesting unsuitable.","MALE","18 Years","40 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","The goal of this clinical trial is to learn whether botulinum toxin A (BTA) or autologous nanofat injection is more effective for treating male androgenetic alopecia. It will also assess the safety of both treatments. The main questions it aims to answer are:\n\n* Does botulinum toxin A or nanofat produce a greater increase in total hair count after 6 months?\n* How do the treatments affect terminal hairs, vellus hairs, hair shaft characteristics, and other dermoscopic features?\n* What side effects occur with each treatment?\n* How satisfied are participants with the improvement in their hair condition? Researchers will compare intramuscular botulinum toxin A injections with intradermal autologous nanofat injections in men aged 18 to 40 years with Norwood Hamilton grade II or III androgenetic alopecia.\n\nParticipants will:\n\n* Be randomly assigned to receive either botulinum toxin A or nanofat\n* Receive one treatment session at the beginning of the study\n* Have clinical, dermoscopic, and photographic assessments at baseline, 3 months, and 6 months\n* Have changes in total hair count and other hair characteristics measured during follow-up\n* Report any treatment-related side effects and their satisfaction with the result",[28],"Androgenetic Alopecia",[28,14],"NOT_YET_RECRUITING","2026-10-04",{"date":33,"type":34},"2026-10-07","ACTUAL",{"date":36,"type":21},"2026-12",{"date":38,"type":21},"2028-10",{"name":40,"class":41},"Sherief Ayman Hussein Shaamash","OTHER",""]