[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Slb Pharma\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":38},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100654857","polymodal-fall-prediction-in-healthy-older-adults-clinical-laboratory-and-blood-based-biomarkers-100654857",false,"NCT07804771","Polymodal Fall Prediction in Healthy Older Adults: Clinical, Laboratory, and Blood-Based Biomarkers","PrediFall","Inclusion Criteria:\n\n* being aged ≥65 years,\n* having independent ambulation,\n* having an Mini Mental State Examination (MMSE) score ≥24,\n* being fluent in French,\n* being affiliated with the national social security system,\n* providing written informed consent.\n\nExclusion Criteria:\n\n* neurological or psychiatric disorders affecting motor or cognitive function (e.g., Parkinson's disease, stroke sequelae, major depression) or other severe comorbidities that could affect participant safety and study outcomes,\n* recent lower-limb surgery (\\\u003C12 months),\n* polypharmacy (use of more than four medications) or fall-risk increasing drugs,\n* significant sensory impairments limiting assessment,\n* immune-related conditions or recent infections,\n* contraindications to MRI,\n* hospitalization within the past 30 days,\n* participation in another clinical study,\n* unable or unwilling to provide informed consent.",true,"ALL","65 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to identify clinical, laboratory, and biological markers associated with past (and future falls) in healthy older adults aged 65 years and over.\n\nThe main question it aims to answer is: Which clinical, functional, laboratory, and blood-based markers distinguish older adults who have fallen at least once during the previous 12 months from those who have not?\n\nResearchers will compare older adults with a history of falls with similar older adults without a history of falls. One hundred healthy older adults aged 65 and over, including both fallers and non-fallers, will be recruited for the study.\n\nParticipants will complete questionnaires and undergo cognitive and physical tests, physical activity and sleep monitoring, gait, balance, muscle, sensory and vestibular assessments, brain and muscle imaging, and blood sampling. Blood samples will be used to study proteins and genetic variants that may be associated with falls. Participants will then be followed for one year using a smartphone-based application to report falls.\n\nThe study is based on the hypothesis that a history of falling in an otherwise healthy older adult may be associated with subtle clinical, functional, and biological differences compared with a similar older adult without a history of falls. The findings may support the future development of more accurate and scalable tools for early fall-risk detection and targeted fall-prevention strategies. No direct therapeutic benefit is expected from participation.",[25],"Accidental Falls","NOT_YET_RECRUITING","2026-09-03",{"date":29,"type":30},"2026-09-04","ACTUAL",{"date":32,"type":21},"2026-09-01",{"date":34,"type":21},"2027-12-31",{"name":36,"class":37},"Slb Pharma","OTHER",""]