[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"State University of New York at Buffalo\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":623},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,57,0,25,[9,45,70,94,122,147,170,199,226,249,273,297,326,351,368,398,426,447,465,488,516,544,562,583,603],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100652955","infant-safe-sleep-in-pediatric-emergency-depratment-100652955",false,"NCT07779512","Infant Safe Sleep in Pediatric Emergency Depratment","A Pediatric Emergency Department-based Intervention to Increase Infant Adherence to Safe Sleep Practices","Inclusion Criteria:\n\n* Legal guardian of infants ages 0 to \\\u003C 4 months , evaluated in GCHB PED ages 0 to \\\u003C 4 months\n* English speaking primary caregiver of infant\n* Infant ED triaged ESI 2-5\n* Able to complete follow-up surveys via phone or email\n* Family not completely adherent to all 4 pre-determined safe sleep guideline recommended behaviors. If they are adherent to 3 out of 4 guidelines, they are eligible for the study.\n\nExclusion Criteria:\n\n* Infants requiring intensive interventions where PED education is not feasible\n* Non-English-speaking primary caregiver\n* Legal guardian unable to complete baseline survey or provide follow-up contact\n* Legal guardian completely adherent to safe sleep guidelines","ALL","3 Months",{"count":20,"type":21},214,"ESTIMATED","INTERVENTIONAL",[24],"NA","Safe sleep recommendations from the American Academy of Pediatrics (AAP) are designed to reduce the risk of sudden infant death syndrome (SIDS) and other sleep-related infant deaths. These recommendations include placing infants on their backs to sleep, using a crib or bassinet, avoiding soft bedding, and not sharing a sleep space with other people.\n\nMany families do not consistently follow all recommended safe sleep practices, particularly when infants are sick. Research has shown that educational programs provided in pediatric emergency departments can improve some safe sleep behaviors, but improvements have been limited and may not continue over time. Additional strategies are needed to help families adopt and maintain safe sleep practices.\n\nThe purpose of this study is to determine whether a daily safe sleep tracking tool, used together with brief safe sleep education, can improve caregivers' adherence to recommended safe sleep practices compared with education alone. The information learned from this study may help healthcare providers develop more effective ways to promote safe sleep and reduce the risk of sleep-related infant deaths.",[27,28],"Infant Safe Sleep Practices","SIDS",[30,31],"Safe Sleep","Pediatric Emergency Department","NOT_YET_RECRUITING","2026-08-19",{"date":35,"type":36},"2026-08-21","ACTUAL",{"date":38,"type":21},"2026-08-17",{"date":40,"type":21},"2027-09-01",{"name":42,"class":43},"State University of New York at Buffalo","OTHER",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":44},"100616470","evaluation-of-toothbrush-bristles-100616470","NCT07306026","Evaluation of Toothbrush Bristles","Evaluation of Toothbrush Bristles in Reduction of Plaque, Inflammation, Bleeding, and Abrasion: A Comparative Study of Tapered vs. End-Rounded Bristles","Inclusion Criteria:\n\n* Must have read, understood and signed an informed consent prior to being entered into the study.\n* Must be 18 to 70 years of age, male or female.\n* Have at least 20 natural or restored teeth, not including implants.\n* Must have average Plaque Index of greater than 2 at screening.\n* Must have more than 20% of pockets with bleeding on probing at screening.\n* Agree not to have a dental prophylaxis or any other elective, non-emergency dental procedures any time during the study.\n* Agree to refrain from regular oral hygiene regimen for 24 hours and eating for 4 hours before the appointment in the study.\n* Agree to abstain from the use of any dental products other than those provided in the study.\n* Agree to comply with the conditions and schedule of the study.\n\nExclusion Criteria:\n\n* Physical limitations or restrictions that might preclude normal tooth brushing.\n* Evidence of gross oral pathology\n* Periodontal probing pocket depths (PPD) ≥ 5mm.\n* Evidence of major soft tissue lesions or trauma at the baseline visit as determined by the examiner.\n* Chronic disease with concomitant oral manifestations\n* Subjects who are currently undergoing, or require, extensive dental work, orthodontic treatment or periodontal surgery, or orthodontic treatment in the preceding 3 months\n* Currently using bleaching trays\n* Eating disorders\n* Recent history of substance abuse\n* Smoking \\>10 cigarettes\u002Fday\n* Participation in other clinical studies within 14 days of screening\n* Pregnancy",true,"18 Years","70 Years",{"count":56,"type":21},70,[24],"The goal of this randomized clinical trial is to investigate two different types of toothbrush bristles.\n\nThe main questions it aims to answer are the effects of two different bristle types on:\n\n* how much plaque is on the teeth\n* how deep the space is between gums and teeth\n* how much gum and bone are attached to the teeth\n* whether the gums bleed when checked\n* if the gums get scratched or irritated\n\nResearchers will compare toothbrushes with tapered bristles to those with regular round bristles.\n\nParticipants will be randomly assigned toothbrush A or B to use at home during the study.",[60],"Gingivitis and Periodontal Diseases","RECRUITING","2026-08-18",{"date":64,"type":36},"2026-08-20",{"date":66,"type":36},"2025-10-21",{"date":68,"type":21},"2026-11-30",{"name":42,"class":43},{"id":71,"slug":72,"hasResults":12,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":88,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":44},"100652158","pediatric-food-is-medicine-study-100652158","NCT07770490","Pediatric Food is Medicine Study","Comparative Effectiveness of Food Prescription Programs for Food Insecure Families With Young Children","Inclusion Criteria:\n\n* parent or primary caregiver of a child aged 2-6\n* child must receive Medicaid benefits\n* child must receive pediatric care at one of the study's 3 pediatric practice partners\n* participant must screen positive for food insecurity using the two-item food security measures on NYS Medicaid Accountable Health Communities (AHC) Health-Related Social Needs Screening Tool): 1.) Within the past 12 months, you worried that your food would run out before you got money to buy more (Often true, Sometimes true, Never true), and 2.) Within the past 12 months, the food you bought just didn't last and you didn't have money to get more (Often true, Sometimes true, Never true).\n* participant must be responsible for at least 50% of the household food shopping\n* participant must be able to store and prepare food in their home\n\nExclusion Criteria:\n\n* families with severe food allergies\n* parents who report their child aged 2-6 is diagnosed with Avoidant\u002FRestrictive Food Intake Disorder (ARFID), Pediatric Feeding Disorder (PFD), or dysphagia\n* parents who report their child aged 2-6 is diagnosed with any conditions they feel would limit their child's eating\u002Ffeeding to the point they are unable to participate in this study\n* individuals who do not speak English or Spanish fluently\n* households receiving nutrition services through NYS Medicaid 1115 waiver or similar free programs providing produce prescriptions or meal kits will be excluded until these free nutrition services end as these services would be duplicative of the interventions offered through this study",{"count":78,"type":21},225,[24],"The goal of this clinical trial is to learn how to increase the usage and acceptability of Food Is Medicine programs among families with young children experiencing food insecurity who receive Medicaid benefits. Food Is Medicine programs connect food and nutrition programs to the healthcare system to address health issues. Food Is Medicine programs include food prescription programs that are recommended to patients by healthcare providers. These programs are designed to increase the amount of fruit and vegetables people eat to improve their health. The program described here works with pediatric practices serving a high Medicaid population in Buffalo, NY to recruit families with children aged 2-6 who are experiencing food insecurity-not having reliable access to the food they need. The main questions it aims to answer are:\n\n* What food prescription program is used most completely and consistently by food insecure families with children aged 2-6?\n* How do the programs being tested impact the amount of fruits and vegetables children eat and the household's food and nutrition security status?\n\nResearchers will compare 2 experimental delivery Food Is Medicine programs, a meal kit program and a produce prescription program, to each other and a standard of care mobile market voucher program to understand which program works the best for families with young children.\n\nParticipants will:\n\n* Receive 1 of 3 food prescription programs for 24 weeks (6 months)\n* Complete a short survey at different times throughout the program reporting how much of the food in the food prescription their family ate and why they didn't eat it all (if applicable).\n* Complete a phone survey about their family, their eating and shopping habits, and other health questions before they start the program, at the end of the program, and 6 months after the program ended.\n* Complete an online diet recall survey recording what their child aged 2-6 ate for a 24-hour period before they start the program, at the end of the program, and 6 months after the program ended.",[82,83,84],"Food Insecurity","Fruit and Vegetable Consumption in Children","Produce Prescription Program Utilization",[86,87],"Food Is Medicine","Produce Prescription",{"date":62,"type":36},{"date":90,"type":36},"2026-07-23",{"date":92,"type":21},"2029-12-31",{"name":42,"class":43},{"id":95,"slug":96,"hasResults":12,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":12,"sex":17,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":44},"100590275","ai-enhanced-app-based-intervention-for-adolescent-e-cigarette-cessation-100590275","NCT06965296","AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation","Inclusion Criteria\n\n* Adolescents who are 14 to 20 years old\n* Currently use nicotine-containing e-cigarettes (those responding \"Yes\" to: Have you used an electronic vaping product such as PuffBar, ElfBar, Lost Mary, JUUL, Vuse, e-cigarettes, vapes, vape pens, e-cigars, e-hookahs, hookah pens, or mods at least 1 day in the last 30 days? \\[CDC, 2020\\])\n* Interested in participating in an e-cigarette use cessation program\n* Owners of an iPhone or Android smartphone who use their phone daily\n* Able to read English\n\nExclusion Criteria\n\n* Individuals who fall outside the age range of 14 to 20 years\n* Those who have not used a nicotine-containing e-cigarette in the past 30 days\n* Individuals not interested in participating in an e-cigarette cessation program\n* Adolescents who do not own or regularly use an iPhone or Android smartphone\n* Non-English speakers","14 Years","20 Years",{"count":103,"type":21},100,[24],"The goal of this quasi-experimental study is to test if a smartphone app can help adolescents aged 14-20 quit e-cigarettes. The main questions it aims to answer are:\n\n* Can the app help adolescents manage cravings and increase their readiness to quit?\n* Does the personalized and real-time support provided by the app improve their success in quitting e-cigarettes?\n\nResearchers will compare two groups: an immediate-intervention group that starts using the app right away and a delayed-intervention group that begins after three months, to see if the timing of app access influences outcomes in e-cigarette cessation.\n\nParticipants will:\n\n* Set personal goals and track their daily progress within the app.\n* Use a real-time \"urge\" feature that provides immediate support during cravings.\n* Engage with a chatbot for quick answers and motivational support around quitting.\n\nThis study aims to create an accessible, personalized tool to help adolescents reduce or quit e-cigarette use, exploring its feasibility as a broader intervention model.",[107],"Nicotine Dependence, Cigarettes",[109,110,111,112,113],"Adolescent e-cigarette use","E-cigarette cessation","Smartphone app","Digital health intervention","Personalized health support","2026-08-04",{"date":116,"type":36},"2026-08-06",{"date":118,"type":21},"2026-08-24",{"date":120,"type":21},"2027-06-30",{"name":42,"class":43},{"id":123,"slug":124,"hasResults":12,"nctId":125,"briefTitle":126,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":131,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":4},"100650247","rapid-cool-heat-stroke-treatment-100650247","NCT07743619","Rapid Cool: Heat Stroke Treatment","Inclusion Criteria:\n\n1. Adult participant (18 - 39 years old)\n2. Body mass index (BMI) 18 - 30 kg\u002Fm2\n3. At least moderate intensity aerobic exercise ≥60 min per week\n4. Participant is able and willing to follow study procedures\n\nExclusion Criteria:\n\n1. History of cardiovascular, neurological, metabolic, pulmonary, renal, gastrointestinal, or autoimmune disease\n2. Taking prescription medication (with exception of psychiatric medication)\n3. If taking a psychiatric medication, the dosage has changed within the month prior to first study visit\n4. Cannot abstain from taking over-the-counter medications or supplements for 24 hours before study visits (with exception of vitamins)\n5. Resting systolic blood pressure ≥130 mmHg and\u002For diastolic blood pressure ≥90 mmHg\n6. Resting heart rate of ≥100 beats per minute\n7. Regular smoker of cigarettes or has regularly smoked in the past year\n8. Musculoskeletal injury\u002Fcondition that negatively impacts the protocol\n9. History of heat illness that resulted in a visit to a medical center in the past 2 years\n10. Has donated blood or plasma in the past 3 months\n11. Has taken antibiotics or corticosteroids within 4 weeks of enrollment\n12. Has a medical implant device such as a pacemaker, patient monitoring system, or metallic implant\n13. Has a full or partially amputated limb\n14. Pregnant or breastfeeding\n15. Study physician or PI discretion based on any other medical condition or medication","39 Years",{"count":130,"type":21},20,[24],"Hot climates such as in Phoenix, AZ commonly have individuals experiencing heat stroke, a life-threatening medical emergency. The dangerously high body temperature can result in death if not treated immediately with rapid body cooling. Rapid core temperature reduction within 30 min of diagnosis results in 100% survival and positive outcomes. While this is easily achieved with whole-body cold water immersion, this modality is not feasible in an ambulance.\n\nThe Phoenix emergency medical services protocol consists of lying the patient on a large volume of ice. While this is somewhat effective, this cooling strategy results in a sub-optimal cooling rate, difficulty obtaining this large volume of ice, and a very wet ambulance as the ice melts. Recently, a company created a cooling strategy that utilizes a small amount of ice and a small amount of recirculated water to keep the patient cool. The purpose of this study is to determine the core temperature cooling rate of this cooling strategy and compare it to the cooling rate of the currently used Phoenix protocol.",[134],"Hyperthermia",[136,137,138,139],"heat stroke","cooling","water","exercise","2026-07-30",{"date":114,"type":36},{"date":143,"type":21},"2026-09-21",{"date":145,"type":21},"2027-08-31",{"name":42,"class":43},{"id":148,"slug":149,"hasResults":12,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":52,"sex":154,"minAge":53,"maxAge":128,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":158,"conditions":159,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":44},"100325253","maternal-smoking-cessation-and-pediatric-obesity-prevention-100325253","NCT03514602","Maternal Smoking Cessation and Pediatric Obesity Prevention","Pilot Study on Pediatric Obesity Prevention by Maternal Smoking Cessation in Pregnancy and Lactation","Inclusion Criteria:\n\n1. Able to read, understand, and speak English.\n2. Are 18-39 years old\n3. Are less than 20 weeks of gestation\n4. Have a singleton pregnancy\n5. Currently smoking one or more cigarettes per day, based on self-report.\n6. Currently smoking biochemically verified by a level of 1 or higher in urine cotinine test (i.e., \\>100ng\u002FmL cotinine concentration).\n7. Willing to try to quit or reduce smoking by behavioral intervention\n8. Willing to monitor smoking status by breath carbon monoxide and saliva cotinine.\n9. Willing to provide breath, saliva, and urine samples to test smoking status\n10. With low household income (meeting federal income eligibility guidelines for the Special Supplemental Nutrition Program for Women, Infants, and Children) and\u002For low education level (≤12 years). These disadvantaged pregnant women are very likely not to quit spontaneously, and thus need extra intervention most.\n11. Currently living in Erie County or Niagara County; don't plan to move out of these two counties during the current pregnancy.\n\nExclusion Criteria:\n\n1. Previous history of major chronic disease or blood clotting disorders such as cancer, thyroid disorders, heart disease, kidney disease\n2. Depression or have been diagnosed with depression or post-partum depression at any time\n3. In treatment for Axis 1 disorders that prevent them following smoking cessation interventions","FEMALE",{"count":156,"type":21},48,[24],"The objective of this study is to test the effect of smoking cessation in pregnancy or in lactation on preventing rapid infant adiposity gain. Investigators propose a randomized, controlled experiment among smoking pregnant women from 1st prenatal care visit through 6 months of postpartum period. Two-phase randomization will be applied to separate the effects of smoking cessation in two different critical periods (i.e., pregnancy and lactation) on infant adiposity gain. Investigators will first randomly assign 40 smoking pregnant women into either the multicomponent intervention (N=30) or the education-only control group (N=10). The multicomponent intervention group will receive education and counseling, monitoring and feedback, contingent financial incentives, and family support, while the control group will receive education only. At the end of pregnancy, investigators will further randomize successful quitters (estimated N=20) from the multi-component intervention group into either the continuous multi-component intervention group in lactation (N=10) or the education-only control group (N=10). All women and their newborns will be followed from enrollment to 6 months postpartum. The key outcomes include maternal smoking abstinence confirmed by urine-cotinine and infant gain in weight-for-length z-score. Specific Aim 1 is to examine the effects of maternal smoking cessation intervention in pregnancy on infant gain in weight-for-length z-score from birth to 6 months. Specific Aim 2 is to examine the effect of maternal smoking abstinence intervention in lactation and infant post-weaning gain in weight-for-length z-score among the women who have successfully quit smoking in pregnancy.",[160,161,162],"Childhood Obesity","Smoking, Cigarette","Pregnancy","2026-07-28",{"date":140,"type":36},{"date":166,"type":36},"2015-07-01",{"date":168,"type":21},"2027-12-31",{"name":42,"class":43},{"id":171,"slug":172,"hasResults":12,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":186,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":44},"100632361","titrated-ambulatory-oxygen-in-fibrotic-ild-and-copd-with-isolated-exertional-hypoxemia-100632361","NCT07512687","Titrated Ambulatory Oxygen in Fibrotic ILD and COPD With Isolated Exertional Hypoxemia","Impact of Ambulatory Oxygen Delivery on Real-world Activity and Quality-of-life in Patients With Interstitial Lung Disease (ILD) and Chronic Obstructive Pulmonary Disease (COPD)","Inclusion Criteria:\n\n* Adults \\>= 18 years old and \\\u003C= 85 years old with fibrotic ILD or COPD able to provide informed consent\n* Fibrotic ILD includes idiopathic pulmonary fibrosis, sarcoidosis, or other ILD with fibrotic changes on lung imaging (reticulations, honeycombing, traction bronchiectasis)\n* COPD participants will have fixed airway obstruction on spirometry less than 70%-predicted as per Global Initiative for Obstructive Lung Disease (GOLD) diagnostic criteria\n* Participants will self-report as being ambulatory outside of home without use of assistance device such as a cane or walker\n* Stable lung disease on stable medical therapy for preceding 3 months\n* Isolated exertional hypoxemia (SpO2 less than 89% for \\>=10 seconds) on a 6MWT conducted while breathing room air\n* Able to maintain SpO2 \\>=89% for the full duration of a 6MWT while using the the POC and portable oxygen D-tank at POC setting of no higher than 6 and D-tank flow rate no higher than 6 liters per minute\n\nExclusion Criteria:\n\n* People \\\u003C18 years old or \\>85 years old\n* Participants with mixed ILD and COPD diagnoses\n* Resting hypoxemia less than 89% while breathing room air\n* Emergency room visit or hospital admission in 3 months prior to recruitment\n* Change in medical therapy in 3 months prior to recruitment\n* Need for ambulatory assistive device such as cane or walker\n* Pregnant\n* Currently smoking or residing with a current smoker\n* Currently engaged in a pulmonary rehabilitation program\n* Participants without a smartphone compatible with the Oxiwear app (necessary to collect Oxiwear oxygen saturation data) or those with a compatible smartphone but without home wifi or cellular service plan allowing for Oxiwear data uploading","85 Years",{"count":179,"type":21},24,[24],"Fibrotic forms of interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD) are chronic lung disease which often affect how well oxygen can get from the lungs into the blood. Low blood oxygen levels often leads to shortness of breath which can affect patients' activity levels and quality-of-life. Many people with fibrotic ILD and COPD only have low oxygen levels when they are walking or exercising. Oxygen that is only used for walking or exercise is called ambulatory oxygen therapy (AOT). Laboratory studies suggest that AOT improves shortness of breath and exercise ability. However, real-world studies of AOT have not shown similar results. AOT can be given to patients through different types of equipment, most commonly oxygen tanks or portable oxygen concentrators (POCs). While previous studies have suggested that AOT does not significantly improve patients' breathing or activity in the real-world, these studies most often gave all participants the same amount of oxygen with the same device. However, patients with ILD and COPD often have very different oxygen needs during exercise, and POCs and oxygen tanks are very different in how oxygen is administered.\n\nThis trial will test the feasibility of a study to determine whether real-world activity, symptoms, and quality-of-life are different with the use of different oxygen equipment when oxygen therapy has been adjusted to meet each participants' oxygen needs. A total of 24 participants (12 with fibrotic ILD and 12 with COPD) who only have low oxygen levels with activity will be randomly assigned to 2-week periods using either no oxygen therapy or oxygen delivered by oxygen tanks or POC. This trial will provide preliminary data to support a larger clinical trial to further test how different AOT equipment titrated to meet individual patients' needs may affect real-world outcomes in people with ILD and COPD.",[183,184,185],"Interstitial Lung Disease","Chronic Obstructive Pulmonary Disease","Hypoxemia",[187,188,189,190,191],"Ambulatory Oxygen Therapy","Portable Oxygen Concentrator","Exertional Hypoxemia","6-Minute Walk Test","Real-World Activity","2026-07-22",{"date":90,"type":36},{"date":195,"type":21},"2026-09-01",{"date":197,"type":21},"2027-10",{"name":42,"class":43},{"id":200,"slug":201,"hasResults":12,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":206,"targetDuration":208,"studyType":209,"phases":4,"briefSummary":210,"conditions":211,"keywords":213,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":44},"100285296","krabbe-disease-global-patient-registry-100285296","NCT02993796","Krabbe Disease Global Patient Registry","The Institute for Myelin and Glia Exploration's Clinical Database of Patients With Krabbe Disease, A World-Wide Registry","Inclusion Criteria:\n\n* Anyone diagnosed with Krabbe disease\n* Anyone at-risk for Krabbe disease\n* Family members of someone diagnosed with, or at-risk for, Krabbe disease.\n\nExclusion Criteria:\n\n* Anyone who is not diagnosed with, or at-risk for, Krabbe disease\n* Anyone who is not a family member of someone diagnosed with, or at-risk for, Krabbe disease",{"count":207,"type":21},60,"5 Years","OBSERVATIONAL","The purpose of this study is to develop a clinical database of individuals diagnosed with Krabbe disease in order to determine which symptoms herald the onset of clinical disease in the various phenotypes of Krabbe disease; to determine whether level of GALC enzyme activity, or a specific genetic mutation predict the clinical course; and to determine which neurodiagnostic tests predict onset and\u002For severity of the disease.",[212],"Krabbe Disease",[214,215,216,217],"Krabbe disease","globoid cell leukodystrophy","galactosylceramide lipidosis","sphingolipidosis","2026-07-15",{"date":220,"type":36},"2026-07-17",{"date":222,"type":36},"2014-09",{"date":224,"type":21},"2026-09",{"name":42,"class":43},{"id":227,"slug":228,"hasResults":12,"nctId":229,"briefTitle":230,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":232,"enrollmentInfo":233,"targetDuration":4,"studyType":22,"phases":235,"briefSummary":236,"conditions":237,"keywords":239,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":245,"completionDateStruct":246,"leadSponsor":248,"locationsCount":4},"100647580","effects-of-cognitive-fatigue-on-gait-100647580","NCT07710755","Effects of Cognitive Fatigue on Gait","Inclusion Criteria:\n\n* Adults aged 18-60 years.\n* Neurotypical individuals with no self-reported history of neurological or cognitive disorders.\n* Able to walk independently, without an assistive device.\n* Fluent in English.\n* Recruitment will aim for gender balance across the sample.\n* For Day 2, participants must arrive with clean, dry hair, free of styling products (e.g., gels, oils), to ensure adequate EEG electrode contact.\n\nExclusion Criteria:\n\n* Outside the age range of 18-60 years.\n* Self-reported history of neurological or cognitive disorders (e.g., epilepsy, multiple sclerosis, stroke\u002Ftraumatic brain injury).\n* Any musculoskeletal condition or injury affecting normal gait.\n* Use of an assistive device for walking (e.g., cane, walker, brace).\n* Self-reported photosensitive epilepsy or seizure disorder triggered by screen\u002Fvisual stimuli.\n* Non-English speaking.\n* Day 2 restrictions: less than 6 hours of sleep the night before; caffeine within 2 hours of the session; alcohol within 24 hours of the session.","60 Years",{"count":234,"type":21},30,[24],"The goal of this study is to comprehend how mental fatigue could affect human gait. The main questions to answer are:\n\n* Does mental fatigue change how people walk?\n* How long does it take for walking patterns to return to normal after mental fatigue sets in?\n* What role do constructs like boredom, sleepiness, and motivation play in this relationship?\n\nTo achieve this, participants will take part in the experiment, split into two sessions:\n\nDay 1 (online, about 25 minutes): Practice session. Participants will practice a computer task that will be used to induce mental fatigue in the next session.\n\nDay 2 (in-person, about 1.5 to 2 hours): Participants will wear several wearable sensors: motion sensors on their legs, feet, and back, sensor insoles in their shoes, a cap that measures brain activity, and glasses that track eye movement. After sensor placement, participants will walk in a straight line for 10 meters to measure their normal walking pattern. They will then complete a 32-minute computer task designed to induce mental fatigue. Afterward, participants will walk in a straight line for 10 meters again, rest for 3 minutes, and repeat this walk-and-rest cycle 3 more times. Participants will also answer short questions about how tired, bored, and alert they feel throughout the session.",[238],"Mental Fatigue",[240,241,242],"Mental fatigue","Fatigue","Cognitive Fatigue","2026-07-13",{"date":220,"type":36},{"date":224,"type":21},{"date":247,"type":21},"2026-11",{"name":42,"class":43},{"id":250,"slug":251,"hasResults":12,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":255,"eligibilityCriteria":256,"healthyVolunteers":52,"sex":154,"minAge":53,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":22,"phases":260,"briefSummary":261,"conditions":262,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":44},"100626256","pairs-friend-based-aisa-intervention-100626256","NCT07433270","PAIRS: Friend-Based AISA Intervention","Friend-based Intervention to Reduce Alcohol-Involved Sexual Assault Risk","PAIRS","Inclusion Criteria:\n\n* Women\n* 4 or more drinks in a single sitting 2 or more times monthly in the past 3 months\n* does not live at home with parents\n* reports going out (not necessarily drinking) with the other member of their dyad \\> 1\u002Fweek\n\nExclusion Criteria:\n\n* Can not speak and understand English sufficiently","24 Years",{"count":259,"type":21},560,[24],"This Phase 2 trial will to examine the efficacy of a brief dyad-based motivational interview (PAIRS MI) delivered to friend dyads with an active treatment-as-usual condition, and a 1-year follow-up.",[263,264,265],"Sexual Violence","College Drinking","Behavioral Changes","2026-07-09",{"date":243,"type":36},{"date":269,"type":36},"2026-05-06",{"date":271,"type":21},"2030-08-01",{"name":42,"class":43},{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":279,"eligibilityCriteria":280,"healthyVolunteers":52,"sex":17,"minAge":281,"maxAge":282,"enrollmentInfo":283,"targetDuration":4,"studyType":22,"phases":285,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":44},"100509056","the-early-childhood-friendship-project---phase-3-100509056","NCT05908461","The Early Childhood Friendship Project - Phase 3","The Early Childhood Friendship Project: Testing Key Mechanisms and the Moderating Role of Physiological Reactivity","ECFP-3","Inclusion Criteria:\n\n* A child is eligible if attending one of the participating child care centers in the greater Buffalo region of Western New York and planning to enter kindergarten in the fall.\n\nExclusion Criteria:\n\n* None","4 Years","6 Years",{"count":284,"type":21},600,[24],"The purpose of this study is to assess the impact of the Early Childhood Friendship Project (ECFP) on changes in aggression\u002Fpeer victimization subtypes, prosocial behavior, and social and academic competence with a teacher-implemented (with coaching) version of the program. Further, investigators will examine whether changes in executive functioning, emotion regulation, and hostile attribution biases indirectly account for the program effects. Investigators will test if physiological reactivity (skin conductance and respiratory sinus arrhythmia) serves as moderators of intervention effects. Data will be collected from 600 children (30 randomly assigned preschool classrooms) diverse in socioeconomic status and race\u002Fethnicity. Investigators will use multiple methods (school-based observations, direct academic assessments, child interviews, physiological reactivity using two tasks, observer, caregiver, and teacher reports) to assess the efficacy of the program, hypothesized mechanisms, and role of physiology as a moderator of intervention effects. The duration of the effects will be tested at both 4 month and 12-month follow-up and will thus demonstrate the impact the program has on children's school readiness and transition to kindergarten. It is expected that preschool children randomly assigned to the ECFP intervention relative to the control condition will show significant and moderate reductions in physical and relational aggression\u002Fvictimization at post-test and follow-up; the ECFP intervention group will also show increases in prosocial behavior, social competence, and academic competence, relative to the control group at post-test and follow-up (4-months at the end of preschool and 12 months after transitioning to kindergarten). Additionally, it is hypothesized that changes in executive functioning, emotion regulation, and hostile attribution biases will mediate treatment effects from baseline to respective follow-ups. It is anticipated that these hypothesis will be moderated by gender such that effects will be stronger for girls relative to boys. Finally, it is hypothesized that physiological reactivity will act as a moderator of intervention effects and of the executive functioning, emotion regulation, and hostile attribution biases mechanisms.",[288],"Healthy","2026-07-06",{"date":291,"type":36},"2026-07-08",{"date":293,"type":36},"2023-08-16",{"date":295,"type":21},"2027-04-16",{"name":42,"class":43},{"id":298,"slug":299,"hasResults":12,"nctId":300,"briefTitle":301,"officialTitle":301,"acronym":302,"eligibilityCriteria":303,"healthyVolunteers":12,"sex":17,"minAge":304,"maxAge":305,"enrollmentInfo":306,"targetDuration":4,"studyType":209,"phases":4,"briefSummary":307,"conditions":308,"keywords":310,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":325},"100596677","tides-20-prevalence-and-longitudinal-course-of-depression-anxiety-and-behavior-problems-in-children-with-cystic-fibrosis-under-12-years-of-age-100596677","NCT07048574","TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age","TIDES 2","Inclusion Criteria:\n\n1. Child with a diagnosis of Cystic fibrosis (CF) actively followed by the CF care team at a participating site\n2. Child is age 18 months thru 11 years\n3. English and\u002For Spanish speaking\n4. Parent\u002Flegal guardian willing and able to give informed consent, and for minor participants ages 7 thru 11 years able to give assent.\n\nExclusion Criteria:\n\n* Unable or unwilling to participate in study procedures, or at Site PI discretion.","18 Months","11 Years",{"count":284,"type":21},"This is a longitudinal, observational epidemiological study designed to estimate the prevalence of depression, anxiety, and behavior problems in children ages 18 months through 11 years with cystic fibrosis (CF).",[309],"Cystic Fibrosis (CF)",[311,312,313,314,315,316,317],"Cystic Fibrosis","Children","Mental health screening","Depression","Anxiety","CFTR modulators","Neuropsychiatric adverse events","2026-07-01",{"date":289,"type":36},{"date":321,"type":36},"2025-06-02",{"date":323,"type":21},"2028-06-30",{"name":42,"class":43},13,{"id":327,"slug":328,"hasResults":12,"nctId":329,"briefTitle":330,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":332,"enrollmentInfo":333,"targetDuration":4,"studyType":22,"phases":335,"briefSummary":336,"conditions":337,"keywords":340,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":4},"100596481","work-design-interventions-for-older-workers-during-consecutive-days-in-the-heat-100596481","NCT07046026","Work Design Interventions for Older Workers During Consecutive Days in the Heat","Inclusion Criteria:\n\n* Healthy individuals\n* 18-29 years old and 40-65 years old\n* Completes at least 120 minutes of moderate to vigorous physical activity each week for at least the past 4 weeks\n* Resistance trained or have recently held a job involving box carrying or a similar task\n\nExclusion Criteria:\n\n* History of cardiovascular, metabolic, respiratory, neural, or renal disease\n* Hypertensive (systolic blood pressure \\> 139 mmHg or diastolic blood pressure \\> 89 mmHg) or tachycardic (resting heart rate \\> 100 bpm) during the screening visit\n* Current nicotine use or previous use within the past 6 months\n* Current of previous musculoskeletal injury limiting physical activity\n* A positive pregnancy test at any point during the study\n* Currently breastfeeding\n* Study physician discretion based on any other medical condition or medication","65 Years",{"count":334,"type":21},32,[24],"The goal of this project is to compare different ways to schedule a workday to see if older workers should follow a specific work protocol to reduce strain on the heart and muscles across two consecutive days of work.\n\nParticipants will come to the lab a total of six times. During four of the visits participants will complete a box carrying task, simulating unloading a delivery truck. This will take place in a hot and humid room to simulate being outdoors during the summer.",[134,338,339],"Fatigue; Heat","Work-Related Condition",[341,342],"hyperthermia","worker","2026-06-26",{"date":345,"type":36},"2026-06-30",{"date":347,"type":21},"2028-09",{"date":349,"type":21},"2030-09",{"name":42,"class":43},{"id":352,"slug":353,"hasResults":12,"nctId":354,"briefTitle":355,"officialTitle":355,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":332,"enrollmentInfo":356,"targetDuration":4,"studyType":22,"phases":357,"briefSummary":358,"conditions":359,"keywords":360,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":362,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":4},"100562178","work-design-interventions-for-heat-resilience-100562178","NCT06599788","Work Design Interventions for Heat Resilience",{"count":334,"type":21},[24],"The goal of this project is to compare different ways to schedule a workday to see if older workers should follow a specific work protocol to reduce strain on the heart and muscles.\n\nParticipants will come to the lab a total of six times. During four of the visits participants will complete a box carrying task, simulating unloading a delivery truck. This will take place in a hot and humid room to simulate being outdoors during the summer.",[134,338,339],[341,342,361],"fatigue",{"date":345,"type":36},{"date":364,"type":21},"2027-09",{"date":366,"type":21},"2029-09",{"name":42,"class":43},{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":374,"eligibilityCriteria":375,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":376,"enrollmentInfo":377,"targetDuration":4,"studyType":22,"phases":379,"briefSummary":380,"conditions":381,"keywords":385,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":395,"completionDateStruct":396,"leadSponsor":397,"locationsCount":44},"100636430","examining-migration-social-bonds-transnationalism-and-hiv-prevention-pathways-among-african-immigrants-100636430","NCT07565584","Examining Migration, Social Bonds, Transnationalism, and HIV Prevention Pathways Among African Immigrants.","Migration, Social Bonds, Transnationalism, and HIV Prevention Pathways Among African Immigrants (MiST-Pathways)","MiST-Pathways","Inclusion Criteria: Individuals must meet ALL of the following criteria:\n\n* Age 18 to 50 years at the time of enrollment\n* Self-identify as a first-generation African immigrant (born in an African country and currently residing in the United States)\n* Currently reside in New York or Massachusetts\n* Able to communicate in English at approximately a 3rd-grade reading level\n* Have access to a smartphone or computer with internet capability sufficient to participate in Zoom and\u002For WhatsApp-based study activities\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Are under 18 years of age\n* Do not self-identify as a first-generation African immigrant\n* Do not reside in New York or Massachusetts\n* Are unable to provide informed consent\n* Do not have access to the technology required for virtual participation (Zoom and\u002For WhatsApp)","50 Years",{"count":378,"type":21},144,[24],"The goal of this mixed-methods pilot study is to learn whether migration experiences, social bonds, and transnational ties shape HIV prevention decision-making, including HIV testing, HIV self-testing (HIVST), and pre-exposure prophylaxis (PrEP) uptake, among first-generation African immigrants aged 18 to 50 residing in New York and Massachusetts. The main questions it aims to answer are:\n\n* What relationship typologies and migration-related relational mechanisms influence HIV testing, HIVST, and PrEP decision-making among African immigrants?\n* Can a relationship-tailored HIV prevention intervention component, co-developed with the community, demonstrate feasibility and acceptability among African immigrants?\n* Does exposure to the prioritized intervention component show directional increases in HIV testing intention, willingness to use HIVST, interest in PrEP, and readiness for relationship-based prevention communication? There is no comparison group. All Aim 3 participants receive the same co-developed intervention component.\n\nParticipants will:\n\n* Complete a qualitative interview (60-90 minutes) and\u002For a structured electronic survey (15-20 minutes) about their relationship experiences, migration history, and HIV prevention behaviors.\n* Take part in a 3-4 hour structured group deliberation session called a Palava Hut Conversation to co-develop and prioritize HIV prevention intervention ideas.\n* Complete a baseline survey, receive the prioritized intervention component in a structured Zoom session, and complete a follow-up survey with an optional 60-90 minute cognitive interview for a subset of participants.",[382,383,384],"HIV Prevention","HIV Testing","Sexual and Reproductive Health",[386,387,388,389,390,382,391],"HIV selt-testing (HIVST)","Pre-exposure prophylaxis (PrEP)","African immigrants","Transnationalism","Relationship Typologies","Palava Hut Conversations","2026-06-24",{"date":394,"type":36},"2026-06-29",{"date":114,"type":21},{"date":364,"type":21},{"name":42,"class":43},{"id":399,"slug":400,"hasResults":12,"nctId":401,"briefTitle":402,"officialTitle":403,"acronym":4,"eligibilityCriteria":404,"healthyVolunteers":12,"sex":17,"minAge":281,"maxAge":405,"enrollmentInfo":406,"targetDuration":4,"studyType":22,"phases":408,"briefSummary":409,"conditions":410,"keywords":413,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":44},"100557530","project-asthma---aligning-with-schools-to-help-manage-asthma-and-improve-outcomes-100557530","NCT06539312","Project ASTHMA - Aligning With Schools To Help Manage Asthma and Improve Outcomes","Project ASTHMA - Aligning With Schools To Help Manage Asthma and Decrease Health Inequities","Inclusion Criteria:\n\n* uncontrolled asthma\n\nExclusion Criteria:\n\n* other chronic lung disease such as cystic fibrosis","13 Years",{"count":407,"type":21},400,[24],"Children with asthma from communities that experience health inequities frequently do not receive guideline-based asthma care, and as a result, account for a disproportionate percentage of asthma exacerbations, emergency department visits, and hospitalizations. Project ASTHMA (Aligning with Schools To Help Manage Asthma) tests the effectiveness of school-based health centers as a delivery model to improve health outcomes by providing children with guideline-based asthma assessments and preventive medication management, directly observed therapy of their preventive medication to support adherence, and self-management support. If successful, this multicomponent intervention will represent a cost effective and sustainable model to reduce asthma morbidity in historically marginalized communities, and has the potential to impact communities throughout the United States where over 2,500 school-based health centers operate.",[411,412],"Asthma in Children","Directly Observed Therapy",[414,312,415,416,417,412],"Asthma","School-based health center","NIH Guideline-based care","Controller medication","2026-06-22",{"date":420,"type":36},"2026-06-25",{"date":422,"type":36},"2024-09-27",{"date":424,"type":21},"2028-04-30",{"name":42,"class":43},{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":433,"targetDuration":4,"studyType":22,"phases":435,"briefSummary":436,"conditions":437,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":44},"100626744","comparison-of-root-canal-desinfection-protocols-100626744","NCT07439614","Comparison of Root Canal Desinfection Protocols","Comparison of Different Root Canal Disinfection Protocols for Bacterial Reduction in Teeth With Apical Periodontitis Using Two Analytical Microbiological Methods: a Randomized Clinical Study","Inclusion Criteria:\n\n* Adult patients able to give informed consent and willing\u002Fable to comply with study procedures and follow-up.\n* Molar teeth indicated for endodontic treatment.\n* Teeth with intact pulp-chamber walls (no extensive coronal destruction).\n* Necrotic pulp confirmed by pulp testing.\n* Clinical and radiographic evidence of asymptomatic apical periodontitis.\n\nExclusion Criteria:\n\n* Immature teeth\n* Teeth with calcified or obliterated canals\n* Teeth with extensive coronal destruction\n* Teeth with previous endodontic treatment\n* Symptomatic apical periodontitis\n* Teeth with periodontal pockets greater than 4 mm\n* Patients who have received systemic antibiotics in the last 3 months\n* Patients with a history of diabetes or immune impairment\n* Pregnant patients",{"count":434,"type":21},50,[24],"Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis",[438],"Periapical Periodontitis","2026-06-18",{"date":441,"type":36},"2026-06-23",{"date":443,"type":36},"2026-04-01",{"date":445,"type":21},"2027-06",{"name":42,"class":43},{"id":448,"slug":449,"hasResults":12,"nctId":450,"briefTitle":451,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":453,"targetDuration":455,"studyType":209,"phases":4,"briefSummary":456,"conditions":457,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":459,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":44},"100277944","non-invasive-liver-screening-using-fibroscan-device-for-liver-disease-patients-for-the-steatosisfibrosis-database-100277944","NCT02897908","Non-invasive Liver Screening Using FibroScan Device for Liver Disease Patients for the Steatosis\u002FFibrosis Database","Inclusion Criteria:\n\n* Subjects with known, or suspected risk factors for steatosis (fat) or hepatic fibrosis\n* Subjects who have been previously diagnosed with Non-Alcoholic Steatohepatitis (NASH) but who do not have current steatosis (fat) or fibrosis scoring\n* Subjects who have other known liver diseases ie: HCV\n\nExclusion Criteria:\n\n* Patients less than 18 years of age\n* Pregnancy\n* Patients that do not want to be contacted for consideration in future research studies.\n* Patients diagnosed with ascites or peritoneal dialysis\n* Body mass index (BMI) ≥40",{"count":454,"type":21},1000,"1 Day","The primary goal of this study is to establish a database of people with varying levels of hepatic fibrosis and various etiologies of liver disease for use in future research protocols.",[458],"Disease of Liver and Bile Duct",{"date":418,"type":36},{"date":461,"type":36},"2016-10-28",{"date":463,"type":21},"2027-04",{"name":42,"class":43},{"id":466,"slug":467,"hasResults":12,"nctId":468,"briefTitle":469,"officialTitle":469,"acronym":4,"eligibilityCriteria":470,"healthyVolunteers":52,"sex":154,"minAge":53,"maxAge":4,"enrollmentInfo":471,"targetDuration":4,"studyType":22,"phases":473,"briefSummary":474,"conditions":475,"keywords":478,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":44},"100641755","prevention-of-postpartum-smoking-relapse-and-related-health-consequences-by-breastfeeding-promotion-100641755","NCT07661550","Prevention of Postpartum Smoking Relapse and Related Health Consequences by Breastfeeding Promotion","Inclusion Criteria:\n\n* Be pregnant\n* Be 18 years or older\n* Have quit smoking cigarettes during this pregnancy\n* Be willing to receive infant care and breastfeeding education\n* Be able to read, listen, and talk in English\n\nExclusion Criteria:\n\n* Medical conditions contraindicating breastfeeding, such as HIV infection, active tuberculosis, and breast removal\n* Current heavy drinking (≥4 standard drinks on any day or ≥8 standard drinks per week)",{"count":472,"type":21},280,[24],"The objective of this randomized controlled trial is to examine the efficacy of a new intervention to prevent postpartum smoking relapse and related health consequences through breastfeeding promotion. After the pre-test, ex-smokers who are still abstinent from smoking will be randomized into either the breastfeeding intervention or the attention placebo control group. The outcomes are postpartum smoking relapse, breastfeeding practices, and maternal and child health.",[476,477],"Smoking ( Cigarette)","Breastfeeding",[162,479,480],"Postpartum","Relapse","2026-06-16",{"date":418,"type":36},{"date":484,"type":36},"2026-01-01",{"date":486,"type":21},"2031-07-31",{"name":42,"class":43},{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":4,"eligibilityCriteria":494,"healthyVolunteers":12,"sex":17,"minAge":495,"maxAge":496,"enrollmentInfo":497,"targetDuration":4,"studyType":22,"phases":498,"briefSummary":499,"conditions":500,"keywords":504,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":508,"lastUpdatePostDateStruct":509,"startDateStruct":511,"completionDateStruct":513,"leadSponsor":515,"locationsCount":44},"100642886","impact-of-vns-with-rehab-on-gait-post-stroke-100642886","NCT07643337","Impact of VNS With Rehab on Gait Post-Stroke","The Impact of Vagus Nerve Stimulation Paired With Rehabilitation on Lower Limb and Gait Functions After Ischemic Stroke","Inclusion Criteria:\n\n* Approved for Vagus Nerve Stimulation (VNS) and rehabilitation therapy\n* ≥22 years and ≤ 80 years\n* Only patients who elect to undergo VNS therapy for stroke-related upper limb deficits\n* Residual active movement in the affected limb's thumb and other 2 fingers\n* Stroke-related deficits in the lower limbs and gait with a Functional Ambulation Category (FAC) ≥3\n* Able to follow simple instructions and independently walk short distances with or without external support or leg orthoses, but without manual contact with another person\n\nExclusion Criteria:\n\n* Intact lower limb functions (Fugl-Meyer score=34)\n* Not a candidate for VNS therapy according to FDA guidelines\n* Pregnant patients","22 Years","80 Years",{"count":179,"type":21},[24],"This is a prospective, double-blinded, randomized controlled study to evaluate the impact of Vagus Nerve Stimulation (VNS) therapy on lower limb function.",[501,502,503],"Upper Limb Deficit","Stroke Gait Rehabilitation","Stroke",[505,506,507],"vagus nerve stimulation","stroke rehabilitation","stroke related upper limb deficit","2026-06-08",{"date":510,"type":36},"2026-06-11",{"date":512,"type":21},"2026-06",{"date":514,"type":21},"2028-02-23",{"name":42,"class":43},{"id":517,"slug":518,"hasResults":12,"nctId":519,"briefTitle":520,"officialTitle":521,"acronym":4,"eligibilityCriteria":522,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":232,"enrollmentInfo":523,"targetDuration":4,"studyType":22,"phases":524,"briefSummary":525,"conditions":526,"keywords":532,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":508,"lastUpdatePostDateStruct":538,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":543,"locationsCount":44},"100642861","hydration-intervention-to-decrease-side-effects-associated-with-glp---1-ra-therapy-100642861","NCT07641361","Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy","Hydration Intervention to Address Dehydration Associated With Use of GLP-1 Based Medications","Inclusion Criteria:\n\n* Adults aged 18-60\n* Recently prescribed a GLP-1RA (within one week of prescription)\n* Fluent in English\n* Willing to complete the study protocol\n\nExclusion Criteria:\n\n* Children and adults \\> 60 years of age\n* Those not taking a GLP-1RA\n* Those who have been on a GLP-1RA longer than one week\n* Not fluent in English\n* Those who are pregnant or planning on becoming pregnant during the duration of the study\n* Unwilling to comply with study protocol\n* People with cardiac implants",{"count":234,"type":21},[24],"This is a 17 - week study consisting of a one - week run - in period and a 16 - week intervention. The 16 - week pilot interventions aims to increase hydration in those beginning GLP - 1 RA therapy. Investigators aim to increase hydration to potentially decrease side effect severity, amount of side effects, and drug discontinuation associated with GLP - 1 RA therapy. The investigators are piloting to assess feasibility and preliminary efficacy of the intervention through examining participant retention, participant feedback, researcher and participant adherence to protocols, impact on hydration biomarkers, and participant reported GLP - 1 RA side effects.",[527,528,529,530,531],"Obesity & Overweight","Type 2 Diabetes","Type 2 Diabetes (Adult Onset)","Obesity Type 2 Diabetes Mellitus","Dehydration",[533,534,535,531,536,537],"Hydration","GLP - 1 RA","GLP - 1 RA therapy","Hydration biomarkers","GLP - 1 RA side effects",{"date":510,"type":36},{"date":540,"type":21},"2026-06-15",{"date":542,"type":21},"2027-02-01",{"name":42,"class":43},{"id":545,"slug":546,"hasResults":12,"nctId":547,"briefTitle":548,"officialTitle":548,"acronym":4,"eligibilityCriteria":549,"healthyVolunteers":52,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":550,"targetDuration":4,"studyType":22,"phases":552,"briefSummary":553,"conditions":554,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":557,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":561,"locationsCount":44},"100479487","comparison-of-intraocular-pressure-measurement-with-the-novel-tonovera-device-with-other-commonly-used-devices-100479487","NCT05523622","Comparison of Intraocular Pressure Measurement With the Novel TonoVera Device With Other Commonly Used Devices","Inclusion Criteria:\n\n* Ability to provide signed and dated informed consent form. Patients willing to comply with all study procedures and be available for the duration of the study.\n\nMale or female patients aged 18 to 99 Patients in good general health as evidenced by ability to come to their appointment on day of study.\n\nExclusion Criteria:\n\n* Patients age less than 18 years Patients unable or unwilling to provide informed consent to participate in the study Patients for which an accurate tonometry reading cannot be performed. This may include those with blepharospasm (lid squeezers), nystagmus, extensive corneal pathology, or contact lens wearers who cannot remove their contact lens.Patients with significant scleral thinning Patients with a known allergy to proparacaine or fluorescein as these are used to anesthetize and allow measurement respectively of the eye when used with the Goldmann tonometer.",{"count":551,"type":21},300,[24],"We are testing the accuracy of Reichert's Tono-Vera tonometer by comparing measurements of IOP with this device and measurements with other commonly-used tonometers, including Goldmann Applanation and iCare.",[555],"Glaucoma","2026-05-04",{"date":269,"type":36},{"date":559,"type":36},"2022-08-01",{"date":168,"type":21},{"name":42,"class":43},{"id":563,"slug":564,"hasResults":12,"nctId":565,"briefTitle":566,"officialTitle":567,"acronym":568,"eligibilityCriteria":569,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":570,"targetDuration":4,"studyType":22,"phases":571,"briefSummary":572,"conditions":573,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":44},"100603771","cgm-enhanced-dpp-to-prevent-type-2-diabetes-in-adults-with-prediabetes-100603771","NCT07140848","CGM-Enhanced DPP to Prevent Type 2 Diabetes in Adults With Prediabetes","A Novel Continuous Glucose Monitoring Enhanced DPP Intervention to Prevent Type 2 Diabetes in Adults With Prediabetes","CGM-DPP","Inclusion Criteria:\n\n1. adults aged 18 years or older,\n2. diagnosis of prediabetes, as defined by current clinical guidelines (HbA1c 5.7% to 6.4%, fasting plasma glucose 100-125 mg\u002FdL, or 2-hour plasma glucose 140-199 mg\u002FdL following a 75g oral glucose tolerance test),\n3. body mass index (BMI) of at least 24 kg\u002Fm² (or 22 kg\u002Fm² for Asian Americans),\n4. willingness to comply with all aspects of the study protocol, including attending coaching sessions and using CGM devices.\n\nExclusion Criteria:\n\nIndividuals will be excluded from the study if they\n\n1. have a diagnosis of type 1 or type 2 diabetes,\n2. are currently using CGMs or have medical contraindications to CGM use, such as severe skin allergies or implantable defibrillators, or\n3. are currently enrolled in another clinical trial for prediabetes. Additionally, using validated assessments, we will exclude participants with significant dementia, alcohol or drug abuse\u002Fdependency, active psychosis, or life expectancy less than 12 months as these conditions are likely to interfere with adherence to the intervention.",{"count":20,"type":21},[24],"Prediabetes affects over one-third of adults in the United States, placing them at a higher risk for developing type 2 diabetes and heart disease, which can lead to serious health complications and increased medical costs. Although a program called the Diabetes Prevention Program (DPP) has been shown to lower the risk of diabetes through healthy lifestyle changes, many people find it difficult to stick with these changes over the long term. This study seeks to find out if combining DPP coaching with continuous glucose monitoring (CGM) technology can help people stay on track with their health goals.",[574],"PreDiabetes","2026-04-21",{"date":577,"type":36},"2026-04-24",{"date":579,"type":36},"2026-04-13",{"date":581,"type":21},"2028-03",{"name":42,"class":43},{"id":584,"slug":585,"hasResults":12,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":4,"eligibilityCriteria":589,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":590,"enrollmentInfo":591,"targetDuration":4,"studyType":22,"phases":593,"briefSummary":594,"conditions":595,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":598,"startDateStruct":600,"completionDateStruct":601,"leadSponsor":602,"locationsCount":44},"100626309","neuromodulation-to-improve-grasping-function-after-sci-100626309","NCT07433959","Neuromodulation to Improve Grasping Function After SCI","Neuromodulation to Improve Grasping Function After Spinal Cord Injury","Inclusion Criteria:\n\nFor individuals with SCI:\n\n* Ages 18-75 years\n* Chronic SCI (≥1 year of injury)\n* Cervical injury at C8 or above\n* Individuals who have MEP responses in at least one FDI muscle\n\nExclusion Criteria:\n\n* Uncontrolled medical problems including pulmonary or cardiovascular disease\n* Premorbid, ongoing major depression or psychosis, altered cognitive status\n* History of head injury or stroke\n* Metal plate in skull\n* History of seizures\n* Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs\n* Pregnant females\n* Individuals who suffer from a spinal cord disease such as spinal stenosis, spinal bifida or herniated cervical","75 Years",{"count":592,"type":21},54,[24],"The goal of this study is to restore the activities of late descending signals with a noninvasive stimulation approach in combination with hand motor training to improve hand function in persons with cervical SCI. The main question it aims to answer is if the inputs to late descending signals above the level of injury and the output of residual late descending signals below the level of injury could be increased. Specifically, in the first part of the study, 30 participants will complete 2 randomized sessions to compare the effect of intermittent theta burst stimulation combined with paired corticospinal motoneuronal stimulation. In the second part of the study, 24 participants will complete either combined stimulation protocol or sham stimulation protocol with exercise training.",[596],"Spinal Cord Injury","2026-04-20",{"date":599,"type":36},"2026-04-23",{"date":443,"type":36},{"date":120,"type":21},{"name":42,"class":43},{"id":604,"slug":605,"hasResults":12,"nctId":606,"briefTitle":607,"officialTitle":608,"acronym":609,"eligibilityCriteria":610,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":257,"enrollmentInfo":611,"targetDuration":4,"studyType":22,"phases":613,"briefSummary":614,"conditions":615,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":618,"startDateStruct":619,"completionDateStruct":621,"leadSponsor":622,"locationsCount":44},"100613064","collaborative-opportunities-for-reducing-alcohol-and-sexual-violence-together-100613064","NCT07261722","Collaborative Opportunities for Reducing Alcohol and Sexual Violence Together","Harnessing the Power of Military Peers to Reduce Sexual Violence and Risky Drinking in Service Members","COAST","Inclusion Criteria:\n\n* Enlisted U.S. Navy service members on active duty status\n* Meet criteria for risky drinking (i.e. score of 4+ for men, 2+ for women according to the AUDIT-C)\n* Have an eligible peer and the pair must socialize together at least twice a month\n\nExclusion Criteria:\n\n* Individuals who endorse evidence of withdrawal (Item 6 on the AUDIT)",{"count":612,"type":21},132,[24],"The goal of this clinical trial is to test if a modified peer-based motivational intervention (the Military PAIRS; MPAIRS) is reasonable and practical for military contexts. The main questions it aims to answer are:\n\n* Does it works to reduce SV?\n* Does it works to reduce risky drinking? To test this, participants will answer questions about their SV history and risky drinking. Then they will be given MPAIRS. After 1 month, they will be asked about their SV history and risky drinking again.",[263,616,617],"Behavior Change","Military Training",{"date":599,"type":36},{"date":620,"type":36},"2025-10-10",{"date":463,"type":21},{"name":42,"class":43},""]