[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Stomatological Hospital Affiliated with Fujian Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":90},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100652952","thbccgf-for-alveolar-bone-regeneration-a-real-world-study-100652952",false,"NCT07779421","THBC\u002FCGF for Alveolar Bone Regeneration: A Real-World Study","A Real-World Study on Temperature-Sensitive Hydroxybutyl Chitosan-Loaded Concentrated Growth Factor for Alveolar Bone Defect Repair","* Inclusion Criteria:\n* Preoperative CBCT imaging confirming mandibular third molars (M3s) with low to moderate impaction according to the Pell and Gregory classification, and not in the acute inflammatory stage.\n* Ipsilateral mandibular second molars (M2s) with retention value and no indication for extraction.\n* Patients able to provide written informed consent and willing to comply with the scheduled follow-up visits.\n* Age between 18 and 60 years (inclusive).\n* Exclusion Criteria:\n* Presence of systemic diseases or other contraindications to tooth extraction surgery.\n* Known or suspected current malignancy.\n* History of radiation therapy to the head and neck region.\n* History of chemotherapy within 5 years prior to surgery.\n* Smoking \\> 15 cigarettes per day.\n* Subjects with mental or neurological disorders, or otherwise unable to provide informed consent.","ALL","18 Years","60 Years",{"count":20,"type":21},136,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to combine real-world research with relevant bone repair materials and techniques to improve alveolar bone resorption in extraction sockets following impacted wisdom tooth removal, while achieving effective bone preservation or promoting bone regeneration. All eligible cases within specified parameters will be included in the clinical study scope. Based on real-world clinical data, we will proactively collect postoperative clinical examination findings and imaging data. Statistical analysis will be performed on clinical outcomes and follow-up data from patients undergoing mandibular impacted M3 extraction. The study aims to clarify the therapeutic efficacy of the thermosensitive hydroxyethylchitosan-loaded concentrated growth factor group in repairing mesial bone defects of M2s following M3 extraction.",[27,28,29],"Alveolar Bone Loss","Alveolar Ridge Resorption After Extraction","Tooth, Impacted","RECRUITING","2026-08-19",{"date":33,"type":34},"2026-08-21","ACTUAL",{"date":36,"type":34},"2024-08-01",{"date":38,"type":21},"2027-07-31",{"name":40,"class":41},"Stomatological Hospital Affiliated with Fujian Medical University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":42},"100614399","spatiotemporal-single-cell-atlas-of-peri-implant-soft-tissue-healing-100614399","NCT07279090","Spatiotemporal Single-cell Atlas of Peri-implant Soft Tissue Healing","Inclusion Criteria:\n\n* Age: 18-65 years\n* Healthy individuals without chronic medical conditions or severe systemic diseases\n* Able to comply with study requirements (e.g., follow-up visits)\n* No history of periodontal disease or active infection\n* Already completed four or more implant placements in the posterior tooth region\n* Adequate gingival thickness to allow for sampling and proper healing\n\nExclusion Criteria:\n\n* Individuals with systemic conditions that affect wound healing (e.g., diabetes, immunosuppressive therapy)\n* Smoking or alcohol abuse\n* Pregnant or breastfeeding women\n* History of severe allergic reactions to implant materials\n* Participation in another clinical study at the same time",true,"65 Years",{"count":52,"type":21},5,[24],"This study aims to explore the dynamic changes in different cell types and their molecular regulatory mechanisms during the healing process of peri-implant soft tissues, using single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST).\n\nThe research will focus specifically on the healing of soft tissues around dental implants in human subjects with the use of a healing abutment. Participants in the healing abutment group will have a micro healing abutment placed immediately after implant placement.\n\nTissue samples will be collected at various time points (Day 4, Day 14, and Day 70) to construct a detailed single-cell map of the healing process.\n\nSpatial transcriptomics will be integrated to preserve tissue architecture, enabling the identification of the spatial distribution of different cell types and their interactions within the peri-implant microenvironment.\n\nThis combined approach will allow for a comprehensive characterization of cellular interactions, spatial gene expression patterns, and regulatory networks specific to healing abutments.\n\nThe goal is to identify key regulatory factors that could improve peri-implant soft tissue healing and help prevent peri-implantitis.",[56],"Peri-implant Soft Tissue Healing",[58,59],"Peri-implant soft tissue healing","scRNA-seq","NOT_YET_RECRUITING","2025-12-13",{"date":63,"type":34},"2025-12-16",{"date":65,"type":21},"2025-12-20",{"date":67,"type":21},"2026-12-31",{"name":40,"class":41},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":75,"maxAge":50,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":42},"100583025","research-on-the-development-and-clinical-evaluation-of-biomimetic-abutments-100583025","NCT06870955","Research on the Development and Clinical Evaluation of Biomimetic Abutments","Inclusion Criteria:\n\n* aged between 25 and 65 years old\n* had one single edentulous site\n* implant embedded healed and required secondary surgery to expose\n* good treatment compliance and could attend follow-up appointment regularly\n\nExclusion Criteria:\n\n* soft tissue grafting was needed\n* severe acute or chronic periodontitis\n* heavy smoking habit (\\> 10 cigarettes\u002Fday)\n* poor oral hygiene","25 Years",{"count":77,"type":21},30,[24],"This study aims to evaluate the clinical effectiveness of biomimetic abutments in implant restoration.",[81],"Tooth Loss","2025-03-06",{"date":84,"type":34},"2025-03-11",{"date":86,"type":34},"2023-11-23",{"date":88,"type":21},"2025-09-30",{"name":40,"class":41},""]