[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Summit Hyperbarics and Wellness\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":74},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100649203","phase-2-long-term-outcomes-following-hbot-100649203",false,"NCT07732374","Long-Term Outcomes Following HBOT","Assessing Follow-Up Effects Post-Discontinuation of Hyperbaric Oxygen Therapy on Cognitive Function, Mental Health, and Quality of Life in Veterans","Inclusion Criteria:\n\n1. At least 18 years of age.\n2. Veteran status\n3. Clinically diagnosed with a mTBI, PCS, PTSD, Anxiety, or Depression disorder.\n4. Successfully completed the parent Hyperbaric Oxygen Therapy (HBOT) intervention, consisting of the full study treatment protocol (40 HBOT sessions).\n5. Willing and able to read, understand, and provide written informed consent for participation in the 12-week follow-up study. Additionally, the Participant has clear consciousness and the ability to express self-feelings independently.\n6. Completed cognitive and psychological measurements.\n7. Clinical diagnoses cause significant impairment in social or occupational functioning or some other functional capacity.\n8. Stability on any current psychoactive medications (antidepressants, anti-anxiety medications, antipsychotics, stimulants, and mood stabilizers).\n\nExclusion Criteria:\n\n1. Acute medical illness or infection\n2. Severe or unstable physical disorders or major cognitive deficits\n3. Current manic, psychotic episodes, or serious suicidal ideations\n4. Non-English speakers\n5. Inability to attend scheduled follow-up visits\n6. Significant life events, new neurological injury, or new psychiatric diagnosis or hospitalization occurring after completion of the HBOT intervention that, in the opinion of the investigator, could confound cognitive, psychological, or quality-of-life outcomes.\n7. Participation in another interventional clinical study or receipt of a therapeutic intervention following completion of HBOT that could influence cognitive, psychological, or quality-of-life outcomes.","ALL","18 Years",{"count":19,"type":20},35,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear months after treatment has ended. We will evaluate changes in cognitive function, mental health, and daily functioning to help strengthen the scientific evidence supporting the use of HBOT and guide future treatment recommendations.",[26,27,28],"Traumatic Brain Injury","Post-Concussive Symptoms","Post-Traumatic Stress Disorder",[30,31,32,33,34,35,26,36],"Hyperbaric Oxygen Therapy","Treatment Durability","Cognitive Function","Mental Health","Quality of Life","Veterans","Persistent Post-Concussive Symptoms (PCS)","RECRUITING","2026-07-23",{"date":40,"type":41},"2026-07-28","ACTUAL",{"date":43,"type":41},"2026-06-18",{"date":45,"type":20},"2027-06-18",{"name":47,"class":48},"Summit Hyperbarics and Wellness","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":49},"100609425","phase-2-veterans-cognitive-function-mental-health-and-quality-of-life-after-hyperbaric-oxygen-therapy-100609425","NCT07214415","Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy","Evaluating the Effects of Hyperbaric Oxygen Therapy on Cognitive Function, Mental Health, and Quality of Life in Veterans","Inclusion Criteria:\n\n1. At least 18 years of age.\n2. Veteran status\n3. Clinically diagnosed with a mTBI, PTSD, Anxiety, or Depression disorder by meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and by a qualified and trained professional.\n4. The subject is willing and able to read, understand, and sign an informed consent. Additionally, the subject has clear consciousness and the ability to express self-feelings independently.\n5. Exposed to at least one trauma-focused therapy or evidence-based psychotherapeutic treatment, such as prolonged exposure therapy, EMDR, or CBT, to name a few.\n6. Completed cognitive and psychological measurements.\n7. Clinical diagnoses cause significant impairment in social or occupational functioning or some other functional capacity.\n8. Sexually active female participants of childbearing potential and sexually active male participants with female partners of childbearing potential must agree to use an acceptable method of contraception for the duration of the study and for 30 days following the final HBOT session.\n9. Stability on any current psychoactive medications (antidepressants, anti-anxiety medications, antipsychotics, stimulants, and mood stabilizers).\n\nExclusion Criteria:\n\n1. Untreated pneumothorax\n2. History of spontaneous pneumothorax\n3. Severe sinus infection\n4. Upper respiratory infection\n5. Asymptomatic pulmonary lesions on chest x-ray\n6. Uncontrollable high fever (greater than 39C)\n7. History of chest or ear surgery\n8. Congenital spherocytosis\n9. Any anemia or blood disorder\n10. Any convulsive disorder\n11. History of optic neuritis or sudden blindness\n12. Middle ear infection\n13. Diabetes mellitus (insulin therapy)\n14. The subject is pregnant or lactating\n15. Nicotine use\u002Fsubstance use\u002Faddiction\n16. Acute Hypoglycemia\n17. Diagnosed Chronic Obstructive Pulmonary Disease (COPD) and Emphysema\n18. Presenting with symptoms of cough, congestion, vomiting, diarrhea, or open wounds.\n19. Active malignancy\n20. Current manic, delusional, or psychotic episodes\n21. Serious\u002Fcurrent suicidal ideations\n22. Severe or unstable physical disorders or major cognitive deficits\n23. Inability to attend scheduled clinic visits or comply with study protocols.\n24. Treated with HBOT for any reason prior to study enrollment.\n25. Non-English speakers\n26. History of retinal repair, including laser photocoagulation or retinal detachment surgery.\n27. History of middle ear surgery, including tympanoplasty, mastoidectomy, or pressure equalization tube placement.\n28. Age greater than 75 years.\n29. Use of any of the following medications during the study period: Anti-metabolites (e.g., methotrexate, azathioprine); Chemotherapuetic agents (e.g., cyclophosphamide, cisplatin); Mafenide acetate e.g., Sulfamylon); Disulfiram (e.g, Antabuse); Peripheral vasodilators known to interact with oxygen exposure (e.g., nitroglycerin); and Antibacterial drugs with known HBOT interaction risks.","75 Years",{"count":59,"type":20},54,[23],"The purpose of this study is to evaluate how hyperbaric oxygen therapy (HBOT) may affect cognitive functioning, post-traumatic stress disorder (PTSD), depression, anxiety, and overall quality of life in veterans.\n\n1. Does Hyperbaric Oxygen Therapy improve cognitive functioning, psychological well-being, and quality of life among veterans, as measured by pre-and post-treatment scores?\n2. To what extent does Hyperbaric Oxygen Therapy improve cognitive functioning, psychological well-being, and qualify of life among veterans, after controlling for demographic characteristics.",[63,64,65],"TBI Traumatic Brain Injury","PTSD - Post Traumatic Stress Disorder","Post Concussive Syndrome","2025-10-06",{"date":68,"type":41},"2025-10-09",{"date":70,"type":41},"2025-10-01",{"date":72,"type":20},"2026-09-15",{"name":47,"class":48},""]