[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The Hong Kong Polytechnic University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":605},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,203,0,25,[9,46,71,97,120,147,174,197,221,240,260,293,318,335,350,382,404,432,450,471,497,518,539,557,583],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100652102","transcranial-direct-current-stimulation-for-neurogenic-overactive-bladder-symptoms-among-people-with-stroke-100652102",false,"NCT07768137","Transcranial Direct Current Stimulation for Neurogenic Overactive Bladder Symptoms Among People With Stroke","Transcranial Direct Current Stimulation for Neurogenic Overactive Bladder Symptoms Among People With Stroke: a Randomized Controlled Pilot Trial","Inclusion Criteria:\n\n* Aged between 18-80 years with onset of stroke within one and twelve months of enrollment and having overactive bladder (OAB) symptoms;\n* Experiencing moderate (scoring 6-11 points on the Overactive Bladder Symptom Score \\[OABSS\\]) to severe OAB (scoring ≥ 12 points on OABSS);\n* Obtaining a Mini-Mental State Examination (MMSE) score of ≥ 24.\n\nExclusion Criteria:\n\n* Presence of metallic implants in the cranium, intracardiac lines, increased intracranial pressure, cardiac pacemaker, cochlear implants, tumour, and skull abnormalities;\n* Family history of epilepsy\u002Fseizures;\n* Contraindications to transcranial magnetic stimulation.","ALL","18 Years","80 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Neurogenic overactive bladder (nOAB) is a common and distressing sequela following stroke, significantly impairing quality of life and imposing a substantial financial burden. Existing pharmacological options often present adverse effects, while standard non-pharmacological treatments, such as pelvic floor muscle training (PFMT), face compliance and efficacy limitations in individuals with functional impairments. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique capable of modulating neuronal excitability and cortical plasticity. Targeting the supplementary motor area (SMA) via tDCS may regulate pelvic floor muscle (PFM) and detrusor activities. However, clinical evidence evaluating tDCS as an adjuvant to PFMT for stroke survivors with nOAB is lacking. This randomized controlled pilot trial aims to evaluate the feasibility, preliminary effectiveness, and cost-utility of active tDCS combined with PFMT compared to sham tDCS plus PFMT in stroke survivors suffering from nOAB.",[28,29],"Stroke","Neurogenic Overactive Bladder",[31,32,28],"Transcranial direct current stimulation","Overactive bladder","NOT_YET_RECRUITING","2026-08-19",{"date":36,"type":37},"2026-08-21","ACTUAL",{"date":39,"type":22},"2026-09-14",{"date":41,"type":22},"2027-12-31",{"name":43,"class":44},"The Hong Kong Polytechnic University","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":19,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100590912","blood-flow-restriction-and-transcutaneous-electrical-nerve-stimulation-on-motor-function-in-stroke-100590912","NCT06973590","Blood Flow Restriction and Transcutaneous Electrical Nerve Stimulation on Motor Function in Stroke","Effects of Low-intensity Resistance Training With Blood Flow Restriction and Transcutaneous Electrical Nerve Stimulation on Lower Limb Motor Function in People With Stroke","Inclusion Criteria:\n\n1. are between 50 and 80 years of age;\n2. have had a single stroke more than 6 months and less than 15 years;\n3. have at least 5 degrees of active ankle dorsiflexion in the antigravity position;\n4. are able to walk 10 m independently, with or without a walking aid;\n5. are able to score 6 or higher out of 10 on the abbreviated mental test;\n6. have no skin allergies (e.g. redness or itchiness after application of the electrical stimulation pads) to electrical stimulation or electrodes;\n7. are able to follow instructions and give informed consent.\n\nExclusion Criteria:\n\n1. presence of other comorbidities like varicose veins, peripheral neuropathy, cancer, musculoskeletal injury, lower limb peripheral edema, post-surgical swelling, open wounds, or on a medication that increases blood clotting risk;\n2. resting blood pressure ≥ 160\u002F100 mmHg even after taking medications, cardiovascular comorbidity, heart failure, unstable angina, by-pass surgery, a pacemaker;\n3. administration of botulinum toxin in the lower limb at least 6 months prior to training;\n4. history of epilepsy, cochlear implants, any type of deep brain stimulator and metal implants in the head or neck;\n5. currently not participating in resistance training or high-intensity or long duration cardiovascular exercise;\n6. lack the ability to feel pain (because of paralysis), or other subjects who cannot complain of discomfort.","50 Years",{"count":21,"type":22},[25],"Stroke commonly results in persistent leg impairments that limit mobility and reduce quality of life. This study investigates whether combining low-intensity resistance training with blood flow restriction (LIRT-BFR) and transcutaneous electrical nerve stimulation (TENS) can effectively improve leg function in stroke survivors.\n\nParticipants with chronic stroke will be randomly assigned to one of four intervention groups: 1) LIRT with simulated BFR and simulated TENS; 2) LIRT with actual BFR and simulated TENS; 3) LIRT with simulated BFR and actual TENS; 4) LIRT with both actual BFR and actual TENS. The resistance training utilizes 20% of each participant's maximum lifting capacity. For blood flow restriction, an automated pressure cuff (SmartCuffs 4.0) will be placed on the upper portion of the affected leg, inflated to 50% of the individual's occlusion pressure during exercises and deflated during rest periods. TENS therapy delivers controlled electrical impulses through electrodes positioned on the anterior thigh.\n\nEach 60-minute session includes a 10-minute warm-up followed by 40 minutes of targeted resistance exercises (leg extensions, leg presses, and weight-bearing squats) and concludes with 10 minutes of stationary cycling. The resistance protocol involves 3 sets of 20 repetitions with standardized rest intervals between sets and exercises. Participants will attend three sessions weekly for six weeks.\n\nAssessments will be conducted at baseline, midpoint (3 weeks), completion (6 weeks), and follow-up (1 month post-intervention). The primary outcome measure is the Fugl-Meyer Assessment for Lower Extremity function, with secondary measures including muscle strength, stiffness, balance, mobility, walking capacity, and gait parameters. To understand the underlying mechanisms, we will measure muscle oxygenation using near-infrared spectroscopy, evaluate muscle structure via ultrasound, and monitor physiological responses including heart rate variability and perceived exertion for safety monitoring.",[58],"Chronic Stroke",[60,61,62,63],"blood flow restriction","transcutaneous electrical nerve stimulation","stroke","low-intensity resistance training","RECRUITING",{"date":36,"type":37},{"date":67,"type":37},"2024-09-01",{"date":69,"type":22},"2026-12-31",{"name":43,"class":44},{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":45},"100652137","cross-modal-neuromodulation-to-improve-balance-and-cognition-in-older-adults-with-glaucoma-a-randomized-trial-of-cerebellar-transcranial-electrical-stimulation-100652137","NCT07771699","Cross-modal Neuromodulation to Improve Balance and Cognition in Older Adults With Glaucoma: A Randomized Trial of Cerebellar Transcranial Electrical Stimulation","Inclusion Criteria:\n\n* Age over 55 years old;\n* Diagnosis of primary open-angle or normal-tension glaucoma with relative scotoma in both eyes;\n* Humphrey Field Analyzer visual field loss (mean deviation of ≤- 6 dB) using the 24-2 testing protocol for both eyes;\n* Best-corrected distance visual acuity of 6\u002F12 (equivalent to 0.3 logMAR) or better;\n* Cognitive functional score of 22 or above in the Montreal Cognitive Assessment -Hong Kong version (HK-MoCA).\n* Only the right-handed population will be recruited (screening by the Edinburgh Handedness Inventory).\n\nExclusion Criteria:\n\n* Have musculoskeletal disorders or neurological diseases that can affect the balance or nervous system.\n* Ocular diseases other than glaucoma (e.g., age-related macular degeneration, diabetic retinopathy, moderate to severe cataract) or severe hearing impairment (to ensure that participants can hear the instructions clearly during assessments and training)\n* Have any contraindications for tES","55 Years",{"count":79,"type":22},36,[25],"The goal of this clinical trial is to use different tES techniques to constantly stimulate the cerebellum in older glaucoma patients. The main questions aim to answer :\n\n1. If the different types of tES targeting the cerebellum can modulate glaucoma patients' balance function and visual-cognitive function?\n2. Which tES techniques among the two types can benefit most?\n\nParticipants will be required to receive the stimulation 15 times (3 sessions, 5 continuous days\u002Fsession, 1-week interval between each session), and complete the balance and visual-cognitive function outcome measurements before and after each session.",[83],"Glaucoma",[85,86,87,88],"balance","glaucoma","visual attention","transcranial electrical stimulation","2026-08-13",{"date":91,"type":37},"2026-08-18",{"date":93,"type":37},"2026-07-01",{"date":95,"type":22},"2029-11-01",{"name":43,"class":44},{"id":98,"slug":99,"hasResults":12,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":12,"sex":17,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":45},"100652078","musical-training-promoting-brain-function-in-children-who-have-survived-brain-tumours-100652078","NCT07769099","Musical Training: Promoting Brain Function in Children Who Have Survived Brain Tumours","Efficacy of a Musical Training Programme in Promoting Neuroplasticity in Children Who Have Survived Brain Tumours: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Completed cancer treatment at least 2 months previously,\n* Aged 7-16 years,\n* Able to speak Cantonese and read Chinese\n* Have had no musical training since their cancer diagnosis\n\nExclusion Criteria:\n\n* Have cancer recurrence or a second malignancy","7 Years","16 Years",{"count":107,"type":22},236,[25],"This study aims to understand whether learning music can help improve brain function and quality of life in children who have recovered from brain tumours. A total of 236 children will join the study. Some of them will receive regular medical care, while others will take part in a music training program using the ukulele. The music program will last for one year and includes both in-person group classes and online individual sessions. The investigators will assess how well the children can think, remember, and focus before and after the training. The investigators will also ask about their daily life and well-being. This study hopes to show that music training can be a fun and helpful way to support recovery in childhood brain tumour survivors.",[111,112],"Cancer Childhood","Brain Tumor",{"date":114,"type":37},"2026-08-17",{"date":116,"type":22},"2026-10-30",{"date":118,"type":22},"2029-10-30",{"name":43,"class":44},{"id":121,"slug":122,"hasResults":12,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":23,"phases":130,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":141,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":4},"100637971","telephone-based-acceptance-and-commitment-therapy-for-young-adult-hazardous-drinkers-100637971","NCT07621822","Telephone-Based Acceptance and Commitment Therapy for Young Adult Hazardous Drinkers","A Randomized Controlled Trial of Telephone-Based Acceptance and Commitment Therapy to Assist Young Adults With Hazardous or Harmful Alcohol Use to Quit Drinking","Inclusion Criteria:\n\n* (1) aged 18-35 years\n* (2) able to read Chinese and speak Cantonese\n* (3) have AUDIT scores ≥ 8\n\nExclusion Criteria:\n\n* (1) currently receiving other behavioural therapies for drinking\n* (2) has serious mental illnesses, defined as a Kessler Psychological Distress Scale score ≥ 13","35 Years",{"count":129,"type":22},288,[25],"The goal of this clinical trial is to learn if telephone-based Acceptance and Commitment Therapy (ACT) works to help young adults with hazardous or harmful alcohol use quit drinking. It will also learn about the psychological effects of ACT on participants.\n\nThe main questions it aims to answer are:\n\n1. Does telephone-based ACT increase the number of participants who quit drinking, as confirmed by a urine test?\n2. Does telephone-based ACT help participants reduce their alcohol consumption and improve their psychological flexibility?\n\nResearchers will compare telephone-based ACT to a telephone-based social support programme to see if ACT works to help young adults quit drinking.\n\nParticipants will:\n\n1. Receive telephone-based ACT or social support once a week for 6 weeks Complete questionnaires about their alcohol use and psychological flexibility.\n2. Keep a record of their daily alcohol consumption throughout the study using a standardised diary method.\n3. Provide a urine sample at the 6-month follow-up if they report having quit drinking",[133,134],"Hazardous Drinking","Harmful Alcohol Use",[136,137,138,139,140],"Acceptance and Commitment Therapy","Telephone-based intervention","Alcohol use","Psychological flexibility","Randomized controlled trial",{"date":114,"type":37},{"date":143,"type":22},"2026-08-01",{"date":145,"type":22},"2029-07-31",{"name":43,"class":44},{"id":148,"slug":149,"hasResults":12,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":154,"targetDuration":4,"studyType":23,"phases":156,"briefSummary":157,"conditions":158,"keywords":161,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":4},"100651198","pilot-rct-of-a-chinese-medicine-diabetes-education-programme-100651198","NCT07758413","Pilot RCT of a Chinese Medicine Diabetes Education Programme","Development and Pilot Test of a Chinese Medicine Diabetes Education Program 中醫糖尿病個人管理教育方案建構及初步試驗","Inclusion Criteria:\n\n* Adults aged 18 years or above\n* Diagnosed with type 2 diabetes mellitus\n* Able to understand and communicate in Cantonese, and able to read Chinese\n* Willing and able to provide written informed consent\n* Able to attend the education sessions at the designated venues\n\nExclusion Criteria:\n\n* Severe cognitive impairment that would prevent meaningful participation in group education\n* Acute or unstable medical conditions, or serious chronic illnesses currently under active treatment (e.g., ongoing cancer treatment), that may preclude safe participation in group activities\n* Currently participating in another structured diabetes education research programme\n* Pregnancy",{"count":155,"type":22},40,[25],"The goal of this clinical trial is to learn if a Chinese medicine diabetes education programme is feasible and acceptable, and to explore its preliminary effects on self-management, for adults with type 2 diabetes in Hong Kong. The main questions it aims to answer are:\n\n1. Is the Chinese medicine diabetes education programme feasible to deliver in a community setting (recruitment, retention and adherence)?\n2. Is the programme acceptable to participants?\n3. Does the programme show early signals of improving diabetes management self-efficacy and related outcomes?\n\nResearchers will compare the Chinese medicine education programme to usual care to see if the programme is feasible, acceptable and shows preliminary benefits.\n\nParticipants will:\n\n1. Be randomly assigned to either a 4-week Chinese medicine diabetes education programme (four group sessions, total 4-6 hours) or usual care\n2. Complete assessments at baseline, after the programme, and at 2-month follow-up.\n3. Attend a focus group interview at the end of the study (selected participants)\n\nOutcome assessors will be blinded to group allocation.",[159,160],"Diabetes (DM)","Medicine, Chinese Traditional",[162,163,164,165],"Diabetes Mellitus","patient education","self-management","medicine, chinese traditional","2026-08-06",{"date":168,"type":37},"2026-08-11",{"date":170,"type":22},"2026-07-30",{"date":172,"type":22},"2027-02-28",{"name":43,"class":44},{"id":175,"slug":176,"hasResults":12,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":23,"phases":184,"briefSummary":185,"conditions":186,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":45},"100650484","the-effect-of-combined-brain-stimulation-and-yoga-for-improving-cognitive-function-in-psychosis-100650484","NCT07747181","The Effect of Combined Brain Stimulation and Yoga for Improving Cognitive Function in Psychosis","Yoga and tDCS to Improve Cognitive Function in Individuals With Psychosis: A Pragmatic Controlled Trial","Inclusion Criteria:\n\n* (1) aged 18 to 65 years\n* (2) diagnosis based on SCID for schizophrenia and related disorders, psychosis, and delusional disorder with the positive symptom measured by CGI ≤ 3\n* (3) ability to understand the nature of the study and to give informed consent (The MacArthur Competence Assessment Tool for Clinical Research score ≥ 35)\n* (4) Chinese-speaking\n* (5) fewer than 10 hours of yoga and other mind-body intervention (e.g., Tai Chi, Qigong, Mindfulness) in the previous 3 months.\n\nExclusion Criteria:\n\n* (1) Severe physical diseases, such as myocardial infarction, uncontrollable severe hypertension, fracture, severe spinal problems, or contraindication for exercise\n* (2) comorbid substance dependence and seizure disorders\n* (3) pregnancy or other contraindication to fNIRS\n* (4) known history of intellectual disability or special school attendance, brain trauma, or organic brain disease\n* (5) Individuals taking Benzodiazepine will still be recruited in the project, and will be excluded from the fNIRS measure.","65 Years",{"count":183,"type":22},135,[25],"The study examines (1) the effects of active anodal (facilitatory) tDCS and yoga combined intervention on cognitive function, clinical symptoms, and quality of life domains (social function and physical wellbeing) in psychosis, and (2) the neurophysiological mechanisms underlying the effects induced by the combined intervention.",[187,188],"Cognitive Functioning","Psychosis","2026-08-04",{"date":191,"type":37},"2026-08-05",{"date":193,"type":37},"2026-01-01",{"date":195,"type":22},"2028-06-30",{"name":43,"class":44},{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":204,"sex":17,"minAge":205,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":23,"phases":209,"briefSummary":210,"conditions":211,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":45},"100650754","a-digitally-supported-outdoor-physical-activity-intervention-for-mildly-frail-older-adults-in-hong-kong-100650754","NCT07752615","A Digitally Supported Outdoor Physical Activity Intervention for Mildly Frail Older Adults in Hong Kong","A Digitally Supported Outdoor Physical Activity Intervention for Mildly Frail Older Adults: a Hybrid Type 1 Effectiveness-Implementation Cluster Randomized Controlled Trial (OUTDOOR-FIT)","Inclusion Criteria:\n\n* community-dwelling men or women aged 60 years or over\n* self-report of mild frailty as determined by a score of ≥ 1 and ≤ 3 on the Chinese version of the Fatigue, Resistance, Ambulation, Illness, and Loss of Weight (FRAIL) scale\n* passing the Physical Activity Readiness- Questionnaire (PAR-Q)\n* owning a smart phone for daily use\n* signing the informed consent documents\n\nExclusion Criteria:\n\n* older adult participants who achieved adequate level of daily physical activity, as defined as engaging in moderate-to-vigorous intensity physical activity (MVPA) for at least 150 minutes per week\n* scoring 0 or 4\u002F5 in the FRAIL scale\n* mildly frail older adults without cognitive ability to respond to self-reported questionnaires",true,"60 Years","100 Years",{"count":208,"type":22},240,[25],"The aging population in Hong Kong is projected to reach 36.6% by 2046, with roughly 16.6% of older adults estimated to be mildly frail-a condition linked to higher risks of falls, hospitalization, and mortality. While physical activity (PA) is a key modifiable determinant of frailty, a major service gap exists for mildly frail older adults, who lack tailored support, resources, and long-term self-management programs. Although Hong Kong features over 440 public open spaces equipped with senior-friendly outdoor exercise facilities (OEFs), older adults often lack awareness and knowledge on how to utilize them safely for aerobic, strength, and balance training. Furthermore, existing PA interventions often overlook social-ecological perspectives and fail to optimize built environment resources or address digital literacy barriers to sustain long-term behavior change.\n\nTo bridge these gaps, our team developed and preliminary-tested OUTDOOR-FIT, a complex, theory-driven, socio-ecological mHealth intervention. OUTDOOR-FIT synergizes Hong Kong's built environment (OEFs), social and volunteer support, individual goal-setting, and digital health technology (a contextually tailored mobile Application) to empower mildly frail older adults to self-manage their PA habits. Building upon promising preliminary findings and qualitative feedback from our initial pilot RCT, the intervention has been refined to incorporate neighborhood OEF environmental audits, supervised outdoor experiential practice sessions, and a train-the-trainer volunteer model to support digital literacy and engagement.\n\nThe main objective of this study is to evaluate the clinical effectiveness and real-world implementation of the refined OUTDOOR-FIT intervention using a hybrid type 1 effectiveness-implementation design. Primary effectiveness outcomes include physical activity levels, exercise self-efficacy, mental well-being, chronic pain, and social loneliness measured immediately post-intervention, as well as at 3-month and 6-month follow-ups. Guided by the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework, secondary implementation outcomes include Reach, Effectiveness, Adoption, Implementation fidelity, and Organizational Maintenance.\n\nThis study adopts a mixed-methods design embedded within a two-arm cluster randomized controlled trial (cluster RCT) involving community service units. Mildly frail older adults will be cluster-randomized into either (i) the OUTDOOR-FIT intervention group or (ii) a control group.\n\nQuantitative analysis will be conducted to evaluate the immediate and sustained effectiveness of the intervention across the primary health outcomes. The qualitative component will consist of semi-structured interviews with older adult participants and community stakeholders to evaluate intervention adoption, implementation barriers, and long-term organizational maintenance.",[212],"Physical Inactivity Frailty","2026-08-03",{"date":215,"type":37},"2026-08-07",{"date":217,"type":22},"2027-02-01",{"date":219,"type":22},"2029-03-03",{"name":43,"class":44},{"id":222,"slug":223,"hasResults":12,"nctId":224,"briefTitle":225,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":12,"sex":17,"minAge":227,"maxAge":228,"enrollmentInfo":229,"targetDuration":4,"studyType":23,"phases":231,"briefSummary":232,"conditions":233,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":239,"locationsCount":45},"100649530","closed-loop-sensorimotor-integrated-csmi-control-in-exoneuromusculoskeleton-enms-for-precise-wrist-hand-rehabilitation-after-stroke-100649530","NCT07737431","Closed-loop Sensorimotor Integrated (CSMI) Control in Exoneuromusculoskeleton (ENMS) for Precise Wrist-hand Rehabilitation After Stroke","Inclusion Criteria:\n\n1. at least 6 months after the onset of a unilateral lesion due to stroke;\n2. moderate to severe motor disability in the paretic wrist-hand joints (6\\\u003CFugl-Meyer Wrist-Hand Assessment (FMAWH)\\\u003C14) and spasticity in wrist-hand (Modified Ashworth Score (MAS) ≤3);\n3. sensory impairment on their affected forearm with a score of 1 measured by the sensation part of light touch in the FMA;\n4. maximal voluntary contraction (MVC) with detectable EMG (3 times of the standard deviation above the resting EMG baseline) in the muscle union of the flexor digitorum and flexor carpi radialis (FD-FCR) and that of the extensor digitorum and extensor carpi ulnaris (ED-ECU);\n5. sufficient cognition to follow experimental instructions (Mini-Mental State Examination score \\>21);\n6. aged from 30 to 70 years.\n\nExclusion Criteria:\n\n1. currently pregnant;\n2. dysphasia (language deficiency);\n3. skull implantation;\n4. post-stroke neglect;\n5. pacemaker implantation;\n6. involved in drug studies, other clinical trials, or concurrent medication\u002Foccupational\u002Fphysical treatments on the upper limb;\n7. the overall medical condition not suitable for the training (e.g., severe cardiac problem, unstable blood pressure, etc.).","30 Years","70 Years",{"count":230,"type":22},48,[25],"The goal of this randomized controlled trial is to determine whether using both brain and muscle signals to control a wrist-hand rehabilitation robot can improve recovery in people with chronic stroke.\n\nA total of 48 participants will be randomly assigned to one of two groups. Both groups will receive 20 sessions of wrist-hand rehabilitation using an exoneuromusculoskeleton rehabilitation robot.\n\nIn the closed-loop sensorimotor integrated group, the system will use information from both brain-muscle coordination and muscle activity to recognize the participant's movement intention and provide electrical stimulation and robotic assistance. In the electromyography-driven group, the system will use muscle activity alone to control the electrical stimulation and robotic assistance.\n\nThe main questions this study aims to answer are:\n\nDoes control using both brain and muscle signals improve wrist and hand motor function more than control using muscle signals alone? Does this approach produce greater changes in coordination between the brain and muscles? Participants will complete motor-function and brain-muscle assessments before training, immediately after the 20 training sessions, and 3 months after training.",[28],"2026-07-31",{"date":213,"type":37},{"date":237,"type":37},"2025-01-01",{"date":41,"type":22},{"name":43,"class":44},{"id":241,"slug":242,"hasResults":12,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":181,"enrollmentInfo":247,"targetDuration":4,"studyType":23,"phases":249,"briefSummary":250,"conditions":251,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":254,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":45},"100650214","the-effect-of-combined-brain-stimulation-and-exercise-for-improving-cognitive-function-in-schizophrenia-100650214","NCT07745140","The Effect of Combined Brain Stimulation and Exercise for Improving Cognitive Function in Schizophrenia","Feasibility of an Integrative Treatment of Brain Stimulation and Exercise on Cognitive Function in Schizophrenia: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Schizophrenia spectrum disorders;\n* Aged from 18 to 65.\n* Chinese-speaking (to enable cognitive testing).\n* Ability to understand the nature of the study and to give informed consent.\n* Fewer than 10 hours of physical exercise in the previous 3 months.\n\nExclusion Criteria:\n\n* Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise with mild-to-moderate intensity may be contraindicated).\n* Comorbid diagnoses of organic brain syndrome, substance misuse, history of epilepsy or seizure, intellectual disability, significant head trauma, active suicidal ideation or self-harm behaviors.\n* Known pregnancy, or other contraindication to tDCS or MRI (e.g., have a cardiac\u002Fheart pacemaker, brain aneurysm clips, any implanted metallic or electrical device, or any internal metal foreign objects).",{"count":248,"type":22},66,[25],"The study will investigate the (1) additive and synergistic effects of tDCS and aerobic exercise on cognitive function and clinical symptoms in schizophrenia, and (2) neurophysiological mechanisms (mediators) underlying these effects.",[252,253],"Schizophrenia","Cognitive Functions",{"date":189,"type":37},{"date":256,"type":22},"2026-09-01",{"date":258,"type":22},"2028-12-31",{"name":43,"class":44},{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":12,"sex":17,"minAge":268,"maxAge":18,"enrollmentInfo":269,"targetDuration":4,"studyType":23,"phases":271,"briefSummary":272,"conditions":273,"keywords":276,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":287,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":4},"100649662","dyadic-physical-activity-intervention-for-children-undergoing-cancer-treatment-100649662","NCT07737418","Dyadic Physical Activity Intervention for Children Undergoing Cancer Treatment","Dyadic-based Physical Activity Intervention for Children Who Are Undergoing Cancer Treatment: A Randomized Controlled Trial","DYAD-PA","Inclusion Criteria:\n\n* Children aged 9-18 years old\n* Diagnosed with leukaemia\n* Currently undergoing maintenance therapy\n* Have a parent willing to participate in the study\n* Both the child and participating parent speak Cantonese and read Chinese\n\nExclusion Criteria:\n\n* Children under palliative care with evidence of cancer recurrence or second malignancies\n* Children with medical contraindications for PA, such as thrombosis, as documented by physicians\n* Children or parents with physical impairment or cognitive and learning problems (identified from medical records)\n* Participants in the team's other interventional studies","9 Years",{"count":270,"type":22},198,[25],"The goal of this study is to learn if a parent-child dyadic physical activity (PA) intervention works to improve physical activity levels in children with leukaemia. It will also learn about the intervention's effects on children's self-confidence in doing physical activity and their quality of life. The main questions it aims to answer are:\n\nDoes the dyadic PA intervention increase the amount of physical activity children do, compared with an individual PA intervention or usual care? Does the dyadic PA intervention improve children's confidence in doing physical activity and their overall quality of life? What is the cost-effectiveness of the dyadic intervention relative to the individual intervention and psychological support control group?\n\nResearchers will compare three groups: children and parents doing physical activity together (dyadic intervention), children doing physical activity individually (individual intervention), and children receiving psychological support sessions only (control group), to see if involving parents makes a difference.\n\nParticipants will:\n\nAttend weekly sessions for 3 months (12 sessions total) Wear an activity tracker for 7 days and complete questionnaires at 5 different time points over 12 months Some participants will also be invited to take part in an interview about their experience",[274,275],"Leukemia","Physical Inactivity",[274,277,278,279,280,281,282,283,284,285,286],"Physical Activity","Self-Efficacy","Parent-Child Dyad","Quality of Life","Randomized Controlled Trial","Maintenance Therapy","Under treatment","Exercise","Dyadic intervention","Pediatric oncology",{"date":234,"type":37},{"date":289,"type":22},"2027-01-01",{"date":291,"type":22},"2030-01-01",{"name":43,"class":44},{"id":294,"slug":295,"hasResults":12,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":4,"eligibilityCriteria":299,"healthyVolunteers":12,"sex":300,"minAge":301,"maxAge":302,"enrollmentInfo":303,"targetDuration":4,"studyType":23,"phases":304,"briefSummary":305,"conditions":306,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":313,"completionDateStruct":314,"leadSponsor":316,"locationsCount":317},"100650098","effects-of-a-large-language-model-driven-chatbot-on-reproductive-concerns-after-cancer-100650098","NCT07741266","Effects of a Large Language Model-Driven Chatbot on Reproductive Concerns After Cancer","The Feasibility and Preliminary Effectiveness of a Large Language Model-Driven Chatbot in Addressing Reproductive Concerns Among Adolescent and Young Adult Cancer Survivors: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n(1) 15-39-year-old females; (2) cancer diagnosis between ages 15-39; (3) current or prior concerns regarding fertility; (4) proficiency in Mandarin Chinese; and (5) access to a mobile device for intervention delivery.\n\nExclusion Criteria:\n\n(1) Involvement in the chatbot co-design phases; (2) inability to provide informed consent; (3) significant sensory, cognitive, or psychological impairments precluding meaningful participation; and (4) acute illness at the time of recruitment.","FEMALE","15 Years","39 Years",{"count":21,"type":22},[25],"Reproductive health has emerged as a critical yet overlooked concern among Adolescent and Young Adult (AYA) cancer survivors, given their compromised potential for biological parenthood in prime childbearing years. Large language models (LLMs) offer a promising solution to bridge onco-fertility service gaps by integrating evidence-based knowledge and therapeutic frameworks. This pilot randomized controlled trial aims to assess the feasibility and preliminary effectiveness of an LLM-driven chatbot versus electronic brochure in addressing reproductive concerns among AYA cancer survivors.",[307,308,309,310],"Chatbot","Large Language Model","Adolescent and Young Adult Cancer Survivors","Reproductive Health","2026-07-28",{"date":213,"type":37},{"date":256,"type":22},{"date":315,"type":22},"2027-06-30",{"name":43,"class":44},2,{"id":319,"slug":320,"hasResults":12,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":181,"enrollmentInfo":325,"targetDuration":4,"studyType":23,"phases":326,"briefSummary":327,"conditions":328,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":330,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":334,"locationsCount":45},"100649970","electroacupuncture-on-neck-muscle-stiffness-in-chronic-neck-pain-100649970","NCT07741227","Electroacupuncture on Neck Muscle Stiffness in Chronic Neck Pain","The Immediate Effect of Electroacupuncture on Neck Muscle Stiffness in Individuals With Chronic Neck Pain","Inclusion Criteria:\n\n1. Aged 18-65 years\n2. Chronic non-specific neck pain persisting for ≥3 months\n3. Average pain intensity ≥3 on a 0-10 Numeric Rating Scale over the past week\n4. Pain primarily located in the posterior cervical region, which may radiate to the upper trapezius muscles\n5. Able to provide informed consent and sufficient language proficiency to complete questionnaires\n\nExclusion Criteria:\n\n1. Specific pathological causes for neck pain (cervical radiculopathy or myelopathy, fracture, infection, tumour, systemic rheumatic disease)\n2. History of neck or shoulder surgery\n3. Contraindications to acupuncture (severe needle phobia, bleeding disorders, pregnancy)\n4. Received acupuncture or other physical therapy for neck pain within the past 6 months",{"count":248,"type":22},[25],"This randomized, single-blind, placebo-controlled clinical trial aims to investigate the immediate physiological effects of a single session of electroacupuncture (EA) on neck muscle stiffness in individuals with chronic neck pain. While acupuncture is a widely used complementary therapy for musculoskeletal pain, high-quality, objective evidence demonstrating its immediate effects on muscle biomechanics remains limited. This study will utilize Shear Wave Elastography (SWE)-a non-invasive, objective ultrasound-based technology-to measure these changes.\n\nAdult participants aged 18 to 65 with non-specific chronic neck pain (lasting\n\n≥ 3 months) will be randomly allocated into one of two groups:\n\n1. True Electroacupuncture (EA) Group: Participants will receive a 20-minute session of active electroacupuncture with comfortable electrical stimulation at specific neck and tender points.\n2. Sham Acupuncture (Placebo) Group: Participants will receive a 20-minute session of non-penetrating sham acupuncture with a deactivated electroacupuncture device to ensure participant blinding.\n\nThe primary objective is to evaluate immediate changes in the stiffness of the upper trapezius muscle, measured objectively via SWE (as Young's Modulus in kPa) before and immediately after the intervention. Secondary objectives include assessing immediate post-treatment changes in subjective pain and stiffness (Visual Analogue Scale), Pressure Pain Threshold (PPT), and active Cervical Range of Motion (CROM), alongside a 7-day post-intervention follow-up questionnaire on neck function.",[329],"Chronic Neck Pain",{"date":213,"type":37},{"date":332,"type":37},"2026-05-01",{"date":116,"type":22},{"name":43,"class":44},{"id":336,"slug":337,"hasResults":12,"nctId":338,"briefTitle":339,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":12,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":341,"targetDuration":4,"studyType":23,"phases":342,"briefSummary":343,"conditions":344,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":346,"startDateStruct":347,"completionDateStruct":348,"leadSponsor":349,"locationsCount":4},"100649780","development-of-a-frailty-risk-prediction-model-and-preliminary-evaluation-of-a-risk-stratified-social-robot-assisted-intervention-in-middle-aged-and-older-spousal-caregivers-100649780","NCT07740031","Development of a Frailty Risk Prediction Model and Preliminary Evaluation of a Risk-stratified Social Robot-assisted Intervention in Middle-aged and Older Spousal Caregivers","Inclusion Criteria:\n\n* aged 50 years or older\n* currently being a spouse caregiver\n* assessed as being at high risk level frailty by the developed online risk calculator\n* being able to use the social robot through a smartphone or tablet, either independently or with necessary guidance\n* willing to sign informed consent and participate in study\n\nExclusion Criteria:\n\n* those with acute mental disorders or disabling diseases that may limit the practice of engaging with a robot\n* acute disease attack or acute medical condition\n* currently participating in another intervention or clinical trial\n* who have limited access to electricity, which would make it hard for them to use technology at home",{"count":21,"type":22},[25],"Background With population ageing accelerating worldwide, long-term care needs are rising, and family caregivers have become an essential yet often under-recognised component of care systems. Older family caregivers are particularly susceptible to frailty because they shoulder substantial caregiving responsibilities while simultaneously experiencing their own age-related decline in health and physiological reserve. Frailty is a clinically important state of heightened vulnerability to stressors and is associated with serious adverse outcomes, including disability, hospitalisation, and mortality. In family caregivers, frailty may compromise not only health and quality of life, but also their capacity to sustain caregiving, with wider implications for the sustainability of family-based long-term care.\n\nResearch gaps A scoping review conducted by this team indicated that middle-aged and older family caregivers, particularly spousal caregivers, are vulnerable to frailty, with caregiving-related, sociodemographic, physical, psychological, and social factors contributing to this condition. However, existing evidence remains fragmented. Caregiver-specific prognostic tools for estimating future frailty risk are lacking, and risk-stratified interventions among family caregivers are sparse.\n\nAim This study aims to develop and validate an incident frailty risk prediction model for middle-aged and older spousal caregivers, identify modifiable risk factors, as well as develop and preliminarily evaluate a risk-stratified, social robot-assisted intervention to reduce the risk of frailty.\n\nMethods This study comprises four phases. Phase 1 is a completed scoping review that mapped evidence on frailty among middle-aged and older family caregivers. Phase 2 will use longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS) to develop and validate an incident frailty risk prediction model for middle-aged and older spousal caregivers and to construct an online risk calculator. Phase 3 will develop social robot-assisted intervention based on the Capability, Opportunity, Motivation-Behavior (COM-B) model. Phase 4 will assess the feasibility, acceptability, and examine preliminary effects of the intervention.\n\nExpected outcomes This study is expected to provide a caregiver-specific tool for early frailty risk identification and risk stratification among middle-aged and older spousal caregivers. It will also generate a theoretically guided, risk-stratified social robot-assisted intervention targeting modifiable risk factors for frailty and provide evidence on its feasibility and acceptability, as well as preliminary effects. The findings will inform a future definitive large-scale trial and community-based caregiver support services.",[345],"Frailty",{"date":234,"type":37},{"date":143,"type":22},{"date":195,"type":22},{"name":43,"class":44},{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":12,"sex":17,"minAge":357,"maxAge":18,"enrollmentInfo":358,"targetDuration":4,"studyType":23,"phases":360,"briefSummary":361,"conditions":362,"keywords":366,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":381,"locationsCount":4},"100640447","digitalized-exercise-fit-tool-intervention-for-adolescents-with-blood-cancer-100640447","NCT07621887","Digitalized Exercise Fit Tool Intervention for Adolescents With Blood Cancer","Digitalised Exercise Fit Tool Intervention for Adolescents With Hematologic Cancer","Inclusion Criteria:\n\n* (1) they are 12-18 years old;\n* (2) they had been diagnosed with hematologic cancer such as leukaemia and lymphoma;\n* (3) they are regarded by the responsible physicians as stable, able to conduct PA, and without any PA restrictions,\n* (4) they completed all cancer treatment;\n* (5) they speak Cantonese and read Chinese.\n\nExclusion Criteria:\n\n* (1) Receiving palliative care\n* (2) Have physical or cognitive impairment and learning problems as identified from medical records\n* (3) Identified by physicians that no physical activity should be conducted at the time of recruitment","12 Years",{"count":359,"type":22},30,[25],"The goal of this clinical trial is to learn if a digitalised Exercise Fit Tool (EFT) mobile application can promote physical activity in adolescents aged 12-18 years who have completed treatment for hematologic cancer (e.g., leukaemia and lymphoma). The main questions it aims to answer are:\n\n1. Is it feasible to conduct a larger randomised controlled trial of the digitalised EFT intervention?\n2. Does the digitalised EFT intervention improve physical activity levels, physical activity self-efficacy, and quality of life at 6 months?\n\nResearchers will compare the digitalised EFT intervention group to a usual care group to see if the mobile application can promote physical activity levels, physical activity self-efficacy, and quality of life in adolescents with hematologic cancer.Participants will:\n\n1. Receive a 20-minute educational session on how to use the mobile application\n2. Use the mobile application to self-assess their appropriate physical activity level and exercise with a virtual coach\n3. Complete questionnaires and wear an accelerometer at 1, 3, and 6 months after enrollment\n4. Attend a 20-30-minute individual interview at 6 months (intervention group only, 10 participants)",[363,364,365,277],"Hematologic Cancer","Leukaemia","Lymphoma",[367,368,369,370,371,372,373,374],"Adolescents","Cancer","Physical activity","Mobile application","Feasibility randomised controlled trial","Exercise Fit Tool","Quality of life","Digital intervention","2026-07-24",{"date":377,"type":37},"2026-07-27",{"date":379,"type":22},"2026-07-20",{"date":41,"type":22},{"name":43,"class":44},{"id":383,"slug":384,"hasResults":12,"nctId":385,"briefTitle":386,"officialTitle":386,"acronym":4,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":388,"targetDuration":4,"studyType":23,"phases":390,"briefSummary":391,"conditions":392,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":45},"100649480","development-of-a-digital-acceptance-and-commitment-therapy-intervention-for-suicide-prevention-in-adults-through-co-design-100649480","NCT07733596","Development of a Digital Acceptance and Commitment Therapy Intervention for Suicide Prevention in Adults Through Co-design","* Inclusion Criteria Lived experience participants\n\n  1. Aged 18 years or older;\n  2. Have experienced suicidal thoughts and\u002For behaviors;\n  3. Able to read and communicate in Chinese; Professionals\n\n  \u003C!-- -->\n\n  1. Aged 18 years or older;\n  2. Professionals with experience relevant to suicide prevention, Acceptance and Commitment Therapy (ACT), digital mental health, or related fields;\n* Exclusion Criteria\n\n  1. Unable to provide informed consent or participate in study activities;\n  2. Currently experiencing acute suicide risk requiring immediate intervention;\n  3. Severe cognitive impairment or active psychotic symptoms that would prevent participation.",{"count":389,"type":22},80,[25],"Suicide is a major public health concern and there is a need for accessible and scalable interventions to support individuals experiencing suicidal thoughts. The aim of this study is to develop a digital Acceptance and Commitment Therapy (ACT) intervention for suicide prevention in Chinese adults through co-design. The study will involve literature review, interviews, and co-design activities to identify user needs, preferences, and contextual factors, and to develop the intervention. Following intervention development, a pilot study will be conducted to evaluate the feasibility, usability, acceptability, and user engagement of the intervention. Findings from this study will inform further refinement of the intervention and future evaluation studies.",[393,394,395],"Suicide","Co-design","Suicide Prevention","2026-07-23",{"date":398,"type":37},"2026-07-29",{"date":400,"type":22},"2026-07-15",{"date":402,"type":22},"2026-12-30",{"name":43,"class":44},{"id":405,"slug":406,"hasResults":12,"nctId":407,"briefTitle":408,"officialTitle":409,"acronym":4,"eligibilityCriteria":410,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":411,"targetDuration":413,"studyType":414,"phases":4,"briefSummary":415,"conditions":416,"keywords":418,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":425,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":430,"locationsCount":431},"100649454","ai-driven-iol-prediction-using-ss-oct-biometry-100649454","NCT07733154","AI-Driven IOL Prediction Using SS-OCT Biometry","International Multicenter Evaluation of a Novel SS-OCT Biometer and Development of an AI-Driven Intraocular Lens Power Prediction Model","Inclusion Criteria:\n\n1. Aged 18 years or above.\n2. Diagnosed with age-related cataract.\n3. Scheduled for routine phacoemulsification with posterior chamber intraocular lens implantation.\n4. Able to cooperate with preoperative ocular biometric measurements and postoperative assessments.\n5. Able to attend the planned 1-month postoperative follow-up visit.\n6. Able to understand the study information and provide written informed consent.\n\nExclusion Criteria:\n\n1. Ocular conditions that may significantly affect biometric measurements or postoperative refractive outcomes, including but not limited to severe corneal disease, severe ocular surface disease, advanced glaucoma, retinal detachment, severe maculopathy, significant optic nerve disease, or ocular trauma.\n2. History of previous intraocular surgery in the study eye, except minor superficial ocular procedures that are not expected to affect ocular biometry or refractive outcomes.\n3. Uncontrolled severe systemic disease that, in the opinion of the investigator or treating clinician, makes the patient unsuitable for routine cataract surgery or study participation.\n4. Cognitive impairment, severe mental disorder, or other condition that prevents the participant from understanding the study or providing valid informed consent.\n5. Poor cooperation that prevents reliable ocular biometric measurement or follow-up assessment.\n6. Current participation in another interventional clinical study that may affect the outcomes of this study.",{"count":412,"type":22},2500,"1 Month","OBSERVATIONAL","This prospective, multicenter, non-interventional observational study aims to evaluate the agreement between a novel swept-source optical coherence tomography (SS-OCT) biometer and the IOLMaster 700 for ocular biometric measurements and to develop and validate an artificial intelligence (AI)-driven intraocular lens (IOL) power prediction model.\n\nThe primary research questions are:\n\nDoes the novel SS-OCT biometer provide ocular biometric measurements that are comparable to those obtained using the IOLMaster 700? Can an AI-driven IOL power prediction model developed from multicenter biometric, imaging, surgical, and postoperative refractive data improve the accuracy of postoperative refractive prediction?\n\nAdult patients with age-related cataract who are scheduled to undergo routine phacoemulsification with posterior chamber IOL implantation will be consecutively recruited from participating study centers. Participants will undergo routine preoperative clinical assessments together with additional non-contact biometric measurements using the novel SS-OCT biometer before cataract surgery. Cataract surgery and postoperative care will follow standard clinical practice and will not be influenced by the study. Postoperative refractive and visual outcomes at approximately one month after surgery will be collected for analysis. The AI model and research device measurements will be used for research purposes only and will not be used to guide clinical decision-making during the study.",[417],"Cataract",[419,420,421,422,423,424],"Swept-source OCT","ocular biometry","intraocular lens power calculation","cataract surgery","axial length","IOLMaster comparison",{"date":398,"type":37},{"date":427,"type":22},"2026-08-20",{"date":429,"type":22},"2027-03-31",{"name":43,"class":44},3,{"id":433,"slug":434,"hasResults":12,"nctId":435,"briefTitle":436,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":12,"sex":17,"minAge":205,"maxAge":4,"enrollmentInfo":438,"targetDuration":4,"studyType":23,"phases":440,"briefSummary":441,"conditions":442,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":444,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":4},"100649078","strengthening-the-ear-to-brain-connection-in-older-adults-with-hearing-loss-through-engaging-web-based-gamified-auditory-cognitive-dual-task-training-a-randomized-controlled-trial-100649078","NCT07730775","Strengthening the Ear-to-brain Connection in Older Adults With Hearing Loss Through Engaging Web-based Gamified Auditory-cognitive Dual-task Training: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Ethnic Chinese aged 60 years and above, who speak Cantonese or Putonghua;\n2. Mild-to-moderate peripheral hearing loss diagnosed by a pure-tone average of 20-50 dB across octave frequencies of 0.5-4kHz in both ears;\n3. Not using hearing aids;\n4. Sensorineural hearing loss (defined as an air-bone gap across 0.5, 1, and 2 kHz\\\u003C15 dB); and 5) No cognitive impairment \\[score of ≦2 on the 5-item Abbreviated Memory Inventory for the Chinese (AMIC)\\].\n\nExclusion Criteria:\n\n1. Previously took part in a training intervention study;\n2. Diagnosed with a major neurocognitive disorder;\n3. A history of symptomatic stroke or other disease of the central nervous system; speech\u002F language disorders;\n4. A serious medical or psychiatric illness (e.g., severe depression, schizophrenia, bi-polar disorder) or a visual impairment that would interfere with engaging in web-based training.",{"count":439,"type":22},164,[25],"Abstract Objectives To assess the effectiveness of a web-based gamified auditory-cognitive dual-task training (ACDT) in improving the everyday listening abilities of older adults with hearing loss (HL), including speech perception performance, cognition, and self-reported hearing.\n\nHypothesis to be tested ACDT participants will show significantly greater improvements in 1) self-reported hearing; 2) speech perception-in-noise; 3) attention; 4) reasoning; and 5) dual-task of listening and working memory compared to the control group at week 6, immediately post-intervention, and week 24.\n\nDesign and subjects A prospective, single-blinded, two-arm parallel randomized controlled trial with individual semi-structured interviews. 164 Chinese adults aged 60 years or older, who speak Cantonese or Putonghua, and have mild-to-moderate HL with a pure-tone average of 20-50 dB across octave frequencies 0.5 to 4kHz in both ears.\n\nStudy instruments A web-based gamified auditory-cognitive dual-task training. Interventions This is a 12-week program conducted five times a week, with each session lasting 60 minutes, following a sequential dual-task training design. Each session includes auditory training in speech-in-noise, rapid speech, and competing speaker, and cognitive training focusing on executive function, perceptual-motor ability, memory, and complex attention.\n\nMain outcome measures Self-reported hearing (untrained); Speech perception in noise (trained), attention in listening and sustained selective attention (trained), reasoning (trained), and dual-task of listening and working memory; complex span working memory (trained).\n\nData analysis Descriptive statistics, an independent sample t-test or chi square test, generalized estimating equation and thematic analysis will be used.\n\nExpected results ACDT significantly improves the everyday listening abilities of older adults with HL.",[443],"Auditory-cognitive Dual-task Training",{"date":311,"type":37},{"date":446,"type":22},"2026-11-14",{"date":448,"type":22},"2029-11-13",{"name":43,"class":44},{"id":451,"slug":452,"hasResults":12,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":12,"sex":17,"minAge":457,"maxAge":458,"enrollmentInfo":459,"targetDuration":4,"studyType":23,"phases":461,"briefSummary":462,"conditions":463,"keywords":465,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":467,"startDateStruct":468,"completionDateStruct":469,"leadSponsor":470,"locationsCount":45},"100624228","dietary-supplement-for-myopia-control-100624228","NCT07406906","Dietary Supplement for Myopia Control","The Effect of Dietary Supplements on Choroidal Thickness and Vasculature in Myopic Children: A Randomized, Double-Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Age 8-13 years\n* Cycloplegic spherical equivalent refraction (SER) of -0.50 D to -5.00 D with astigmatism of 2.5 D or less and best-corrected visual acuity (BCVA) of 0.0 logarithm or more in either eye\n* Anisometropia of 1.50 D or less\n* Intraocular pressure of 10 mmHg to 21 mmHg in both eyes\n* Willing to give written consent to participate in the study and accept random allocation in grouping\n\nExclusion Criteria:\n\n* Ocular abnormalities leading to visual impairment\n* Severe physiological and psychological diseases affecting follow-up\n* Receiving previous myopia control treatment including but not limited to atropine therapy and orthokeratology in the past 3 months\n* Use of any other dietary supplements containing DHA\u002FEPA, Lutein, or Astaxanthin in the past 3 months\n* Known history of allergy to any of the components of the dietary supplement or placebo, or history of an allergic reaction that required emergency treatment\n* Children who had other contraindications identified by the investigators that made them unsuitable for participation","8 Years","13 Years",{"count":460,"type":22},156,[25],"The purpose of this clinical trial is to investigate the changes in choroidal thickness and vasculature in myopic children following oral supplementation.",[464],"Myopia",[466],"oral supplements, choroidal thickness, choroidal blood flow",{"date":375,"type":37},{"date":143,"type":22},{"date":402,"type":22},{"name":43,"class":44},{"id":472,"slug":473,"hasResults":12,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":4,"eligibilityCriteria":477,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":478,"enrollmentInfo":479,"targetDuration":4,"studyType":23,"phases":481,"briefSummary":482,"conditions":483,"keywords":485,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":490,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":496},"100602258","tele-group-cognitive-behavioural-family-intervention-for-individuals-with-schizophrenia-and-their-families-definitive-tgcbfi-100602258","NCT07121166","Tele-group Cognitive Behavioural Family Intervention for Individuals With Schizophrenia and Their Families (Definitive tgCBFI)","Effectiveness of a Tele-group Cognitive Behavioural Family Intervention (tgCBFI) for People With Schizophrenia and Their Families: a Mixed-method Study","I. Individuals with schizophrenia-spectrum disorders\n\nInclusion Criteria:\n\n* current diagnosis of schizophrenia-spectrum disorders, based on ICD-10 made by the treating clinicians,\n* aged 18-64, and\n* able to read and write Chinese\n\nExclusion Criteria:\n\n* having co-morbidity of learning disability, organic\u002Fneurological conditions, or substance use disorder, and\n* living in a hostel\n\nII. Family caregivers\n\nInclusion Criteria:\n\n* aged 18 or above,\n* able to read and write Chinese,\n* live with service users, and\n* nominated by the service users\n\nExclusion Criteria:\n\n* having active psychiatric conditions","64 Years",{"count":480,"type":22},200,[25],"This mixed-method study comprises a RCT with a twelve-week post-intervention follow-up and focus group interviews. The RCT study aims to examine the effectiveness of delivering the tgCBFI programme to dyads of people with schizophrenia and their family caregivers, while the focus group interviews aim to qualitatively study the benefits of the tgCBFI programme from the service users and their family caregivers to provide a more in-depth understanding and complement the quantitative data. The main questions it aims to answer are: Does this online tgCBFI programme reduce the expressed emotion experienced and positive and negative symptoms of individuals with schizophrenia? Does this online tgCBFI programme reduce the perceived care burden and level of mood disturbances of family caregivers?",[484],"Schizophrenia and Related Disorders",[486,487,488,489],"CBT","family intervention","schizophrenia","telehealth",{"date":375,"type":37},{"date":492,"type":37},"2025-09-01",{"date":494,"type":22},"2028-07-31",{"name":43,"class":44},6,{"id":498,"slug":499,"hasResults":12,"nctId":500,"briefTitle":501,"officialTitle":502,"acronym":4,"eligibilityCriteria":503,"healthyVolunteers":12,"sex":17,"minAge":205,"maxAge":4,"enrollmentInfo":504,"targetDuration":4,"studyType":23,"phases":505,"briefSummary":506,"conditions":507,"keywords":509,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":513,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":517,"locationsCount":45},"100575634","self-initiated-perturbation-based-training-in-older-adults-100575634","NCT06774833","Self-initiated Perturbation-based Training in Older Adults","Effect of Self-initiated Perturbation-based Balance Training on the Postural Stability of Community-dwelling Older Adults With An Increased Risk of Falling: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Community-dwelling adults aged 60 years old or older\n* Able to communicate effectively in Cantonese or Mandarin\n* Able to walk independently on level ground for at least 30 minutes\n* Abbreviated Mental Test (Hong Kong version) scores≥6\n* Have fallen in the preceding year, have concerns about falling, or feel unsteady while walking or standing.\n\nExclusion Criteria:\n\n* Uncorrected vision or hearing impairment\n* Osteoporosis\n* Have a historyof hip or knee replacement\n* Have musculoskeletal, cardiovascular, mental, or neurological disorders that preclude their participation in the assessment or intervention safety\n* Participating or planning to participate in another fall prevention program.",{"count":230,"type":22},[25],"This is a single-blinded study. Participants will be randomly assigned to self-initiated perturbation-based balance training (SePBT) group or control (conventional balance training) group. Kinematic and Kinetic changes following SePBT group compared to control will be investigated.",[508],"Healthy Subjects (HS)",[510,511,512],"Perturbation","Step training","Falls",{"date":375,"type":37},{"date":515,"type":37},"2024-11-06",{"date":69,"type":22},{"name":43,"class":44},{"id":519,"slug":520,"hasResults":12,"nctId":521,"briefTitle":522,"officialTitle":523,"acronym":4,"eligibilityCriteria":524,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":525,"targetDuration":4,"studyType":23,"phases":526,"briefSummary":527,"conditions":528,"keywords":530,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":533,"startDateStruct":534,"completionDateStruct":536,"leadSponsor":538,"locationsCount":45},"100649109","personalised-sleep-and-circadian-intervention-after-stroke-100649109","NCT07731516","Personalised Sleep and Circadian Intervention After Stroke","Feasibility, Efficacy, and Patient Experience of a Personalised Transdiagnostic Intervention for Sleep and Circadian Dysfunction Following Stroke: a Mixed-method Randomised Controlled Feasibility Trial","Inclusion Criteria:\n\n1. \\>6 months from last stroke\n2. aged ≥18 years\n3. Cantonese language fluency\n4. ≥1 self-reported sleep or circadian problem(s) for 3 months: ≥30 min to get to sleep on ≥3 nights per week, waking in the middle of night ≥30 min on ≥3 nights per week, \\\u003C6-hr sleep per night or ≥9-hr sleep per 24 hour period on ≥3 nights per week, ≥1.09 hours of variability in sleep-wake schedule across one week, and\u002For bedtime after 2:00 a.m. on ≥3 nights per week\n5. adequate opportunities for sleep.\n\nExclusion Criteria:\n\n1. presence of an active and progressive physical or neurocognitive illness or substance abuse making participation infeasible\n2. past or current involvement in psychological treatment for sleep issues\n3. night shift work\n4. pregnancy or breastfeeding.",{"count":155,"type":22},[25],"This is a two-arm, parallel-group randomized controlled feasibility trial involving 40 community-dwelling adults with chronic stroke and ongoing sleep or circadian difficulties. Participants will be randomly assigned in a 1:1 ratio to either an individualized behavioral sleep intervention or an attention-matched health education program.\n\nBefore randomization, participants will complete questionnaires assessing sleep and related health outcomes, maintain a sleep diary, and wear a wrist-worn activity monitor for seven days. Participants will then attend six weekly, individual, face-to-face sessions lasting approximately one hour each.\n\nThe behavioral sleep intervention will provide individualized education and behavioral strategies to support sleep and daily sleep-wake functioning following stroke. The comparison program will provide education about stroke, sleep, and general health. The two programs will be matched in session frequency and duration.\n\nFollowing the six-week program, participants will repeat the questionnaires, sleep diary, and seven-day wrist-monitoring assessment. Participants will also provide feedback about their experiences with the study and program.\n\nThe trial will evaluate recruitment, retention, attendance, intervention delivery, acceptability, fidelity, and safety. Preliminary changes in sleep and sleep-wake outcomes will also be examined.",[28,529],"Sleep",[28,529,531],"Circadian Rhythm","2026-07-22",{"date":311,"type":37},{"date":535,"type":22},"2026-08",{"date":537,"type":22},"2028-07",{"name":43,"class":44},{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":543,"acronym":4,"eligibilityCriteria":544,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":545,"targetDuration":4,"studyType":23,"phases":546,"briefSummary":547,"conditions":548,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":45},"100648217","morning-activation-to-improve-mood-after-stroke-100648217","NCT07719517","Morning Activation to Improve Mood After Stroke","Inclusion Criteria:\n\n* Age 18 years or older.\n* History of stroke at least 6 months before enrollment.\n* Patient Health Questionnaire-9 score of 10 or higher.\n* Difficulty getting started or engaging in activities in the morning.\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Conditions that would interfere with study participation.\n* Neurological condition other than stroke.\n* Currently receiving psychological therapy for depression.\n* Significant cognitive impairment or dementia.\n* Current or past diagnosis of psychosis, bipolar disorder, or mania.\n* Hospitalization that would interfere with study participation.\n* Acute or significant suicidal ideation\n* Alcohol or substance use problems within the past month.\n* Use of antidepressant or anti-anxiety medication unless the dosage has been stable for at least 4 weeks and no changes are planned during the study.",{"count":359,"type":22},[25],"This pilot randomized controlled trial will evaluate the feasibility and preliminary effects of a six-week behavioral intervention designed to improve mood and daily functioning in adults who have experienced a stroke and report depressive symptoms and difficulty becoming engaged in activities after waking.\n\nParticipants will be randomly assigned to either the behavioral intervention or a health education program. Assessments will be completed before and immediately after the six-week program and will include questionnaires and seven-day monitoring of sleep, activity, and mood. The study will also examine feasibility indices such as participant retention, intervention attendance, acceptability, and preliminary changes in mood.",[28,549],"Depressive Symptoms","2026-07-17",{"date":532,"type":37},{"date":553,"type":37},"2026-05-15",{"date":555,"type":22},"2026-12",{"name":43,"class":44},{"id":558,"slug":559,"hasResults":12,"nctId":560,"briefTitle":561,"officialTitle":562,"acronym":4,"eligibilityCriteria":563,"healthyVolunteers":12,"sex":17,"minAge":564,"maxAge":565,"enrollmentInfo":566,"targetDuration":4,"studyType":23,"phases":568,"briefSummary":569,"conditions":570,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":45},"100648084","ecological-momentary-intervention-e-breathing-to-reduce-psychological-distress-in-adolescents-100648084","NCT07717112","Ecological Momentary Intervention (E-Breathing) to Reduce Psychological Distress in Adolescents","Effect of Slow-Paced Breathing Via Ecological Momentary Intervention on Reducing Psychological Distress in Adolescents: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged between 11 to17 years;\n2. With at least one mild mental health state as reported by Depression, Anxiety, and Stress Scale-21;\n3. Able to read and understand Chinese;\n4. Have access to a mobile phone and data plan.\n\nExclusion Criteria:\n\n1. With a diagnosis of hearing, visual, or physical impairments that may hinder study participation;\n2. With a diagnosed history of major mental illnesses or other diagnosed medical conditions that may affect study participation.","11 Years","17 Years",{"count":567,"type":22},100,[25],"A two-arm randomized controlled trial (RCT) will be conducted to test a mobile-based intervention, E-breathing, for early detection and intervention to address psychological distress in at-risk adolescents in Hong Kong. E-breathing harnesses the science of real-time, in-situ assessment approach - Ecological Momentary Assessment (EMA) - to capture the psychological symptoms and needs of adolescents. Based on the real-time data collected via smartphone, the mobile application prompts the practice of slow-paced breathing as an Ecological Momentary Intervention (EMI) to reduce psychological distress. This RCT will recruit a total of 100 participants who will be randomly allocated to either (1) an intervention group (EMI group), where they will receive a feedback prompt when they score high on negative affect (i.e., E-breathing) or (2) the control group (EMA group), where they will only complete EMAs without feedback. This project aims to investigate the feasibility and effectiveness of E-breathing in improving psychological symptoms in Hong Kong adolescents. This project also examine the underlying physio-mechanisms of the effects of E-breathing on psychological outcomes in this target population.",[571,572,573,574],"Psychological Distress","Depressed Mood","Anxiety","Stress","2026-07-16",{"date":577,"type":37},"2026-07-21",{"date":579,"type":22},"2026-10-01",{"date":581,"type":22},"2027-05-31",{"name":43,"class":44},{"id":584,"slug":585,"hasResults":12,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":4,"eligibilityCriteria":589,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":19,"enrollmentInfo":590,"targetDuration":4,"studyType":23,"phases":591,"briefSummary":592,"conditions":593,"keywords":596,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":601,"completionDateStruct":602,"leadSponsor":604,"locationsCount":4},"100645778","effect-of-inspiratory-muscle-training-on-knee-osteoarthritis-pain-100645778","NCT07698418","Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain","Effect of Inspiratory Muscle Training on Pain in Patients With Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 55 years or older.\n* Knee osteoarthritis (Kellgren-Lawrence grade ≥ 2).\n* Knee pain (Visual Analogue Scale, VAS ≥ 3) on the most days in the past month.\n* Able to walk independently without assitive devices.\n\nExclusion Criteria:\n\n* History of knee replacement surgery, meniscus surgery, or ligament surgery.\n* Received corticosteroid injection within the previous three weeks.\n* Diagnosed with rheumatoid arthritis.\n* Unstable angina, recent myocardial infarction, uncontrolled cardiac arrhythmia, or severe heart failure.\n* History of stroke.\n* Currently receiving steroid therapy, hormonal therapy, or cancer chemotherapy.\n* Pneumothorax, pulmonary bullae, lung surgery within the past 12 months, unstable asthma, or severe dyspnea at rest.\n* Unable to understand the study procedures and potential risks.",{"count":389,"type":22},[25],"Knee osteoarthritis (KOA) is a common joint disease that causes chronic pain and limits daily activities. Current treatments, such as painkillers or surgery, have limitations like side effects or high costs. This study will test whether a safe, non-drug intervention-inspiratory muscle training (breathing exercises against resistance)-can reduce knee pain in people with KOA. The training may work by lowering inflammation and improving the brain's modulation of pain.\n\nEighty patients aged ≥55 years with confirmed KOA and frequent knee pain will be enrolled. Participants will be randomly assigned to either an 8-week inspiratory muscle training program (5 sessions per week, with gradually increasing resistance) or a sham (very low resistance) training program. Neither the patients nor the researchers assessing the outcomes will know who is in which group.\n\nThe main outcome is change in knee pain measured by a visual analog scale (VAS). Secondary outcomes include blood markers of inflammation (TNF-α, IL-6, IL1β), physical function, the Knee injury and Osteoarthritis Outcome Score (KOOS), inspiratory muscle strength, activity level, sleep quality, and quality of life. To explore underlying mechanisms, outcomes included heart rate variability (HRV) as an indicator of autonomic nervous system function, and brain functional connectivity in the prefrontal cortex using functional near-infrared spectroscopy (fNIRS) are collected. These mechanistic assessments will be performed at baseline and at the end of 8-week intervention. Additional follow-up assessments for clinical outcomes will be done at 3 and 6 months after the training ends. Any side effects or adverse events will be recorded.\n\nThis study will provide high-quality evidence on whether inspiratory muscle training is an effective and safe complementary treatment for knee pain in people with knee OA, and will offer new insights into the mechanisms underlying its analgesic effects.",[594,595],"Knee Osteoarthritis","Knee Osteoarthritis (Knee OA)",[594,597,598],"Inspiratory Muscle Training","Chronic Pain","2026-07-14",{"date":575,"type":37},{"date":256,"type":22},{"date":603,"type":22},"2030-09-01",{"name":43,"class":44},""]