[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"The University of Tennessee, Knoxville\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":162},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,55,79,110,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100652087","ai-based-personalized-exercise-prescription-through-mobile-health-on-physical-activity-and-health-outcomes-in-older-adults-a-feasibility-study-100652087",false,"NCT07768670","AI-Based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study","Artificial Intelligence-based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study","Inclusion Criteria:\n\n* Be aged 65 years or older.\n* Own a smartphone (Android or iOS) compatible with study applications.\n* Have reliable access to the internet or Wi-Fi.\n* Demonstrate basic digital literacy sufficient to operate a smartphone (e.g., ability to open applications, navigate simple interfaces, and follow on-screen instructions), with or without initial guidance from the research staff.\n* Be able to safely engage in physical activity, as determined by the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) or physician approval if indicated.\n* Report engaging in less than 150 minutes of moderate-to-vigorous physical activity (MVPA) per week.\n* Be able to communicate in English sufficiently to complete study procedures and assessments.\n\nExclusion Criteria:\n\n* Are younger than 65 years of age.\n* Do not own a compatible smartphone (Android or iOS) or do not have reliable internet\u002FWi-Fi access.\n* Are deemed unable to safely participate in physical activity based on the screening process (including PAR-Q+, STEADI, and research staff assessment), or do not obtain required physician clearance when indicated.\n* Currently meet or exceed 150 minutes of moderate-to-vigorous physical activity (MVPA) per week.\n* Are unable to communicate in English sufficiently to understand study procedures, provide informed consent, or complete study-related assessments.\n* Have any medical, physical, or cognitive condition that, in the judgment of the research team, would make participation unsafe or prevent completion of study procedures.",true,"ALL","65 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this research is to investigate the feasibility, acceptability, appropriateness, and preliminary efficacy of a wearable and artificial intelligence-driven mobile application-based exercise prescription grounded in self-determination theory (SDT) and behavioral change techniques (BCTs) among older adults. As no data exists on the feasibility of AI-driven exercise programs grounded in SDT and multiple BCTs specifically for older adults, this will be a pioneering study to explore the feasibility of wearable and AI-driven exercise program protocols and the rates of acceptance and appropriateness of the exercise prescription intervention among older adults. In addition, this study will test the preliminary efficacy of the intervention on physical activity (PA), mental health, and quality of life. This study follows the National Institute of Health (NIH) stage model, and it represents stage 1b of the NIH stage model, which emphasizes the feasibility and actionable processes for delivering a new health intervention. Specifically, this study will: 1.Evaluate the research protocol feasibility of a wearable and AI-driven mobile application-based exercise prescription grounded in SDT and BCTs (of goal setting, self-monitoring, graded task, and demonstration) on older adults over 8 weeks 2. Evaluate the acceptability and appropriateness of a wearable, AI-driven, mobile application-based exercise prescription grounded in SDT and BCTs among older adults over 8 weeks. 3. Evaluate the preliminary impact of a wearable and AI-driven mobile application-based exercise prescription grounded in SDT and BCTs on older adult PA (steps per day and daily duration of light PA and Moderate-vigorous PA), sedentary time, sleep, mental health (depression and anxiety), and quality of life.",[27,28,29,30,31],"Feasibility Studies","Physical Activity","Mental Health (Depression)","Anxiety","Quality of Life",[33,34,35,36,37,38,39,40,41],"AI-based intervention","mobile health technology","wearable","fitness app","feasibility study","study acceptability and appropriateness","older adult","age 65 years","60 years","RECRUITING","2026-08-18",{"date":45,"type":46},"2026-08-20","ACTUAL",{"date":48,"type":21},"2026-10-01",{"date":50,"type":21},"2026-12-31",{"name":52,"class":53},"The University of Tennessee, Knoxville","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":54},"100551123","daily-eating-patterns-for-total-health-study-100551123","NCT06455995","Daily Eating Patterns for Total Health Study","Effect of Time-based Energy Intake Goals on Weight Loss During Obesity Treatment","DEPTH","Inclusion Criteria:\n\n* Body mass index (BMI) between 27 and 45 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Report not regularly (\\>\u002F= 5 days\u002Fwk) consuming energy (\\>\u002F= 100 kcal) prior to 12 pm, and not being able to consume energy every day (\\>\u002F= 50 kcal) within one hour of awakening.\n* Report taking sleep medication or not regularly (\\>\u002F= 5 nights\u002Fwk) getting at least 6 hrs of total sleep.\n* Report being a shift workers\u002Falternative shift workers that work outside of 7 am and 7 pm.\n* Report being diagnosed with type 1, or type 2 diabetes and taking medication that requires eating to occur at certain time periods.\n* Report a heart condition, chest pain during periods of activity or rest, or loss of consciousness on the Physical Activity Readiness Questionnaire (PAR-Q). Individuals reporting joint problems, prescription medication usage, or other medical conditions that could limit exercise will be required to obtain written physician consent to participate.\n* Report being unable to walk for 2 blocks (1\u002F4 mile) without stopping.\n* Report major psychiatric diseases or organic brain syndromes.\n* Report currently participating in a weight loss program and\u002For taking weight loss or appetite regulation medication or lost \\>\u002F= 5% of body weight during the past 6 months.\n* Report having bariatric surgery for weight loss\u002Fplanning to have bariatric surgery in the next 12 months.\n* Report being pregnant, lactating, \\\u003C 6 months post-partum or plan to become pregnant (next 12 months).\n* Report planning to move outside of the metropolitan area within the time frame of the investigation.\n* Do not have daily access to PC with internet or smartphones (needed for self-monitoring).","25 Years","60 Years",{"count":66,"type":21},174,[24],"The goal of this randomized controlled trial is to learn how the time of day when calories are eaten affects weight loss in the long-term (12 months). The main aims are to learn:\n\n1. The influence of time-based energy intake goals on longer-term weight loss.\n2. The influence of time-based energy intake goals on eating temporal patterns, sleep regularity, and appetite regulation.\n\nResearchers will compare whether goals to eat most of a person's calories in the morning or evening work to treat obesity.\n\nParticipants will:\n\n1. Eat a reduced-calorie, low-fat diet (some participants will have goals to eat their calories at certain times of day based on their group)\n2. Be physically active at least 200 minutes\n3. Receive a cognitive behavioral intervention",[70],"Obesity","2026-06-12",{"date":73,"type":46},"2026-06-15",{"date":75,"type":46},"2024-07-16",{"date":77,"type":21},"2028-12",{"name":52,"class":53},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":96,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},"100608933","evaluating-health-outcomes-of-ai-based-fitness-wearables-and-app-programs-in-older-adults-living-alone-with-cognitive-decline-100608933","NCT07207993","Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline","Inclusion Criteria:\n\n* Participant must be at least 65 years of age older\n* Participant must be living alone in the U.S. for the next 6 months\n* Participant must have report mild cognitive decline \\[We will use a short self-report AD8 measure of cognitive concerns. Those scoring positive on the AD8 (≥2) will qualify as mild cognitive decline\\];\n* Participant must own an Android\u002FApple smartphone\n* Participant must have access to internet or Wi-Fi access\n* Participant must be capable of engaging in some PA as determined by the PA Readiness Questionnaire or physician approval\n* Participant must currently participate in weekly moderate-to-vigorous PA (MVPA) or less than 150 minutes\n* Participant must have basic English communication skills.\n\nExclusion Criteria:\n\n* Foreign residents or visitors",{"count":86,"type":21},64,[24],"The overarching goal of our research is to develop personalized and accessible healthy aging lifestyle interventions aimed at promoting physical activity (PA) and improving health among community-dwelling older adults living alone with cognitive decline (LACD). To achieve this goal, the purpose of this project is to determine whether wearable and app-based mHealth intervention component(s) will contribute to increased PA and improved health outcomes in older adults LACD. Our specific aims are to: identify and evaluate mHealth intervention components that practically and significantly contribute to enhanced mechanistic outcomes (e.g., self-efficacy, outcome expectations) and increased PA (primary outcome) in older adults LACD over a 6-month period; determine the optimal combinations of intervention components for future efficacy testing; elucidate the mechanism of behavioral change (MoBC) and potential outcomes of these intervention components, namely, the mediating effects of MoBC variables (e.g., self-efficacy, outcome expectations) on the relationship between intervention components and change in PA. The first two aims are primary and fully-powered. The third aim is exploratory. The aims will support a refined, data-driven intervention design for a subsequent larger trial.",[90,91,92,93,94,28,95],"Older Adults With Cognitive Decline","Older Adults","AI-Based Fitness","Wearables","Cognitive Decline","Physical Inactivity",[97,98,92,28,95,99,100,101],"Older adults","Cognitive decline","Living alone with cognitive decline","LACD","U.S Older adults","2026-06-10",{"date":73,"type":46},{"date":105,"type":46},"2026-06-08",{"date":107,"type":21},"2028-06-08",{"name":52,"class":53},2,{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":16,"sex":17,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":122,"briefSummary":123,"conditions":124,"keywords":126,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":54},"100610414","early-childhood-dietary-assessment-study-100610414","NCT07227272","Early Childhood Dietary Assessment Study","Enhancing the Accuracy of Self-Reported Dietary Intake in Young Children: Development of Two Proxy Reporting Protocols for Self-Reported Dietary Assessment","ECDAS","Inclusion Criteria:\n\n* Adult caregiver ≥ 18 years old\n* Absence of food allergies or dietary restrictions for medical reasons (for the child)\n* Caregiver reports child likes at least 70% of the study-provided foods from the pre-defined list of food options\n* Caregiver has access to a smartphone device compatible with the EMA platform\n* Caregiver can identify a second adult caregiver with access to a smartphone device compatible with the EMA platform and willing to provide the child with study-provided foods for at least two eating occasions.\n\nExclusion Criteria:\n\n* Caregiver unwilling to feed study-provided foods to their child\n* Caregiver unwilling to take pre-and-post photos of child's eating occasions\n* Caregiver unwilling or unable to identify a second adult caregiver meeting the eligibility criteria\n* Caregiver and child reside in a separate household for \\> 2 days per week\n* Family resides \\>25 miles outside of the Knoxville, Tennessee, metropolitan area.","2 Years","5 Years",{"count":121,"type":21},40,[24],"The goal of this crossover randomized controlled trial is to develop a proxy reporting protocol for a traditional 24-hour dietary recall (24HR) and an ecological momentary assessment (EMA) assisted 24-HR for use among children between the ages of 2 and 5 years. The main aims are to:\n\n1. Assess the usability and feasibility of each proxy-reporting protocol and dietary assessment methodology.\n2. Describe the dietary misreporting captured using each proxy-reporting protocol, and\n3. Explore the accuracy of energy intake estimation of the 24HR and EMA+24HR methods, compared to objectively measured food intake.\n\nDuring the research study, participants will:\n\n1. Be provided with one meal and two snacks each day to provide to their child on three consecutive days. Foods can be offered to their child at times of their choosing, and leftovers will be placed back into reusable food storage containers to be picked up by research study staff. Uneaten foods will be weighed for an objective measure of intake.\n2. The day after study-provided foods are given to the child, the adult caregiver will complete a proxy-reported 24HR phone call with a trained research assistant.\n3. In the EMA+24HR condition, caregivers will be provided access to an online platform where they will upload pre- and post-photographs of all of their child's eating occasions across the three days that study-provided foods are eaten.",[125],"Dietary Assessment",[125,127,128,129],"Assessment","Nutrition","Children","2026-06-05",{"date":105,"type":46},{"date":133,"type":46},"2025-07-15",{"date":135,"type":21},"2026-12",{"name":52,"class":53},{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":16,"sex":17,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":22,"phases":148,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":109},"100441426","ebt-fruit-and-vegetable-prescription-100441426","NCT05028205","EBT Fruit and Vegetable Prescription","Eating Better Together: A Pilot Study","Inclusion Criteria:\n\n* Patients at the Cherokee Health Systems clinic in Cherokee Mills\n* Child age between 4 to 10 years old\n* Child BMI \\> 85th percentile\n* Child must have an adult caregiver (\\> 18 years) living in the household and be willing to participate in the program\n* Adult caregivers need to be able to read and speak English\n\nExclusion Criteria:\n\n* Not patients at the CHS Knox County Pediatric Clinic\n* A child not within the 4 to 10 years age range\n* Child BMI at or below the 85 percentile\n* Child without an adult caregiver (\\> 18 years) living in the household and not willing to participate in the program\n* Adult caregivers that are not able to read and speak English","4 Years","10 Years",{"count":147,"type":21},30,[24],"Eating Better Together is a 6-month pilot program that teaches families about healthy eating and activity and provides home deliveries of fresh fruits and vegetables from a local retail partner.",[151,70],"Childhood Obesity",[153,154],"Fruit and Vegetable Prescription","Food Security",{"date":156,"type":46},"2026-06-09",{"date":158,"type":46},"2021-08-16",{"date":160,"type":21},"2026-12-28",{"name":52,"class":53},""]