[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Tufts University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":439},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,48,71,100,131,158,186,207,229,249,275,302,323,344,364,394,414],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100652074","elucidating-the-effect-of-dietary-stearic-acid-on-the-regional-heterogeneity-of-the-gut-microbiome-and-metabolome-focus-on-bile-acid-metabolism-sampill-study-100652074",false,"NCT07766915","Elucidating the Effect of Dietary Stearic Acid on the Regional Heterogeneity of the Gut Microbiome and Metabolome: Focus on Bile Acid Metabolism (SAMPill Study)","Elucidating the Effect of Dietary Stearic Acid on the Regional Heterogeneity of the Gut Microbiome and Metabolome: Focus on Bile Acid Metabolism","SAMPill","Inclusion Criteria:\n\n1. Postmenopausal women (defined as complete natural cessation of menses for \\>12 months or a bilateral oophorectomy), who are not currently using hormone replacement therapy (HRT) or gender-affirming hormone treatments\n2. Age \\>50 years\n3. BMI \\>20 to \\\u003C35 kg\u002Fm2, inclusive\n4. Non-smoker or former smoker who quit \\> 6 months\n5. Normotensive with or without medication\n6. Normal gastrointestinal function with regular bowel movements at least once every other day\n7. Willingness to swallow the mini-pills\n8. Willingness to collect and return multiple stool samples\n9. Adequate refrigerator and freezer space to store study meals\n10. Intent to remain in the greater Boston area during the intervention periods\n\nExclusion Criteria:\n\n1. Allergy\u002Fintolerance\u002Freligious reasons to avoid study meals or food ingredients\n2. Regular use of dietary supplements, pre\u002Fprobiotics, laxatives or fiber supplements (except multivitamins) within the past 3 months\n3. Use of steroids (excluding topical) within the past 3 months\n4. Regular use of aspirin (except baby aspirin), NSAIDS, or anti diarrheal medication\n5. Current smokers or former smokers who quit \\\u003C 6 months ago, and use of nicotine replacement products within the last 6 months\n6. Chronic constipation\n7. Use of oral antibiotics within the past 3 months.\n8. Use of dental prophylaxis within the past 3 months\n9. Regular use of stomach acid lowering and weight loss medications such as GLP-1 agonists\n10. Planned colonoscopy 3 months prior to or during the study period\n11. Swallowing disorder or inability or difficulty taking pills\n12. Malabsorptive and inflammatory bowel disease, diverticulosis, and history of diverticulitis, gastric esophageal\u002Fintestinal surgery, including lap banding or bariatric surgery.\n13. History of bowel obstruction, gallstones, gastroparesis, pancreas and liver\u002Fgallbaldder disorders.\n14. Any form of active substance abuse or dependence (including drug or alcohol abuse).\n15. Established major chronic diseases such as CVD, diabetes, active cancer within the last 5 years, or any significant medical condition at the study MD's discretion\n16. A clinical condition that, in the judgment of the study MD or PI, could potentially pose a health risk to the subject while involved in the study.\n17. Unwillingness to adhere to study protocol\n18. Intent to increase or decrease body weight during the study period\n19. No Social Security number (for payment and IRS forms).\n20. Individuals who directly report to any member of the research team.","FEMALE","50 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","Stearic acid and palmitic acid are two common consumed saturated fatty acids found in foods. Palmitic acid is associated with increases in blood cholesterol, whereas stearic acid is generally considered neutral with respect to blood cholesterol. However, the mechanisms underlying these different effects are not fully understood. The goal of this clinical trial is to determine how replacing dietary palmitic acid with stearic acid affects microorganisms living in the gastrointestinal tract (gut microbiome) and the metabolites they produce, including secondary bile acids, and whether these changes influence heart and metabolic health in postmenopausal women. The main question it aims to answer is whether the cholesterol lowering effect of dietary stearic acid, compared to dietary palmitic acid is due to changes in the composition and function of the gut microbiome and bile acid metabolism. Participants will consume a controlled diet high in palmitic acid for a 10-day run-in period, followed by a controlled diet high in stearic acid for 28 days. During the study, participants will provide biological samples, including blood samples collected in both fasting and non-fasting states, for assessment of cardiometabolic outcomes. Participants will also swallow mini-pills designed to collect samples from different regions of the gastrointestinal tract to assess the gut microbiome and related metabolites. Results will contribute to understanding the relationship between stearic acid mediated microbiota effects on cardiometabolic heath.",[27],"CVD Risk",[29,30,31,32,33,34],"stearic acid","bile acid metabolism","post-menopausal women","dietary intervention","saturated fatty acids","gut microbiome","NOT_YET_RECRUITING","2026-08-11",{"date":38,"type":39},"2026-08-17","ACTUAL",{"date":41,"type":21},"2026-09",{"date":43,"type":21},"2029-08",{"name":45,"class":46},"Tufts University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":4,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":47},"100649282","sjogrens-mini-pill-oral-and-gut-microbiome-study-100649282","NCT07732582","Sjogren's Mini-Pill Oral and Gut Microbiome Study","Exploratory Study on Characterizing Region-Specific Gastrointestinal and Oral Microbiomes in Sjögren's Disease Using Novel Ingestible Mini-Pill Sampling Technology","Inclusion Criteria:\n\nGroup 1: Control\n\n1. Currently enrolled in and willing to share data from the parent study of \"Evaluation of Ingestible Mini-pill for Gastrointestinal Regional Luminal Content Sampling\" at Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.\n2. Willing to provide saliva and periodontal plaque from the deepest periodontal pocket.\n3. Able to understand study requirements and procedures, and willing to sign informed consent prior to participation.\n\nGroup 2: Sjogren's Cohort\n\n1. Adult Sjogren's Disease participants diagnosed according to the 2016 American European criteria\n2. Willing to donate saliva and periodontal plaque from the deepest periodontal pocket.\n3. Able and willing to perform home stool collection and recovery of GI sampling capsules.\n\nExclusion Criteria\n\nControl Group:\n\n1. Those not participating in parent study, \"Evaluation of Ingestible Mini-pill for Gastrointestinal Regional Luminal Content Sampling\" at HNRCA.\n2. Unable to understand or unwilling to sign the informed consent form.\n3. Any medical conditions requiring antibiotic prophylaxis prior to dental procedures (e.g., certain cardiac conditions, prosthetic joints). Upon interviewing the potential subject, no periodontal sample will be taken. Only saliva samples will be taken in these cases.\n4. Presence of active disease of the hard or soft oral tissues.\n5. History of salivary gland disorders, such as Sjögren's syndrome, sarcoidosis, or prior head and neck radiation therapy.\n6. If a subject needs to undergo new dental or periodontal treatment (including scaling, root planing, or antibiotic irrigation) while enrolled in our study\n\nSjogren's Cohort:\n\n1. Pregnant or breast feeding\n2. Requiring antibiotic prophylaxis before dental procedures\n3. HIV\u002FAIDS, sarcoidosis, or prior head and neck radiation therapy.",true,"ALL",{"count":58,"type":21},90,[24],"The goal of this observational study is to characterize and compare region-specific gastrointestinal, stool, oral, and periodontal microbiomes in adults with Sjögren's disease and healthy controls using ingestible mini-pill sampling technology. The study will include adults with Sjögren's disease and healthy control participants enrolled in a parent gastrointestinal microbiome study",[62],"Sjogren's Syndrome","2026-07-23",{"date":65,"type":39},"2026-07-29",{"date":67,"type":21},"2026-08-31",{"date":69,"type":21},"2028-08-31",{"name":45,"class":46},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":56,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},"100648149","family-based-weight-wellness-treatment-through-food-is-medicine-and-group-medical-visits-in-pediatric-and-adult-primary-care-100648149","NCT07717658","Family-Based Weight Wellness Treatment Through Food is Medicine and Group Medical Visits in Pediatric and Adult Primary Care","Inclusion Criteria:\n\nFor children:\n\n* Child aged 12-17 years at time of enrollment (inclusive)\n* BMI ≥ 95% for age and sex based on CDC growth charts\n* Comfortable speaking and reading English (due to limitations in intervention materials and qualitative data collection tools)\n* Child is an active patient at Tufts Medical Center\n* Child can provide assent, Willing and able to participate in the 18-month study, including attendance at scheduled in-person or telehealth sessions\n* Access to a device with internet capability (e.g., computer, tablet, or smartphone) to engage with online intervention\n\nFor parents or guardians:\n\n* Age 18+ at time of enrollment\n* Primary caregiver is the legal guardian of the child\n* Comfortable speaking and reading English (due to limitations in intervention materials and qualitative data collection tools)\n* Can provide consent, Willing and able to participate in the 12-month study, including attendance at scheduled in-person or telehealth sessions\n* Access to a device with internet capability (e.g., computer, tablet, or smartphone) to engage with online intervention components.\n\nExclusion Criteria:\n\nFor Children:\n\n* Participation is medically or developmentally inappropriate, including but not limited to: Severe intellectual disability or cognitive impairment preventing meaningful participation, Active eating disorder diagnosis or concerning disordered eating behaviors, Severe physical limitations or mobility impairments that would limit participation in lifestyle activities, Active unmanaged psychiatric condition (e.g., acute suicidality or psychosis) that may interfere with participation or consent\n* Planned bariatric surgery or other weight loss procedures during the 12-month study period\n* Child is currently pregnant or plans to become so in the next 12 months\n* Plans to relocate or transfer care away from the participating clinic during the 12-month study period\n* Concurrent participation in another weight management clinical trial that could confound results or interfere with study activities\n* Parent is unwilling or unable to participate in the study\n* Child is a parent (has their own child), is in the armed forces, or lives independently and manages their own affairs (emancipated)\n* Child is a foster child, in state custody, or has an open DCF case pending as identified in the electronic medical record or disclosed verbally by child or guardian.\n\nFor parent:\n\n* Severe intellectual disability or cognitive impairment preventing meaningful participation\n* Plans to relocate or transfer care away from the participating clinic during the 12-month study period\n* Unwilling or unable to participate in the study.","12 Years","17 Years",{"count":80,"type":21},60,[24],"The proposed project aims to implement and evaluate a novel, family-based lifestyle medicine intervention integrating group Shared Medical Appointments (SMAs) for parents and adolescents with a twelve-month medically tailored groceries (MTG) and six-month culinary medicine Food is Medicine program. The intervention provides adolescent weight wellness treatment through a holistic, community engaged approach leveraging family connection, clinical care, and nutrition support. Monthly SMAs will include time for parents and adolescents to meet independently and conclude together. These visits will be co-led by physicians, dietitians, and health professionals. Parents will receive the Ardmore Institute's Full Plate Living program while adolescents receive Tufts Pediatrics Strong, Positive and Resilient Kids (SPARK) Weight Wellness program. The SMA format is reimbursable, fosters peer support, enhances patient-provider interaction, and allows efficient delivery of education and care. Each session will include nutrition and lifestyle education, review of individualized weight care plans, and proactive goal setting tailored to adults, adolescents, and families.",[84,85],"Obesity & Overweight","Weight Management",[87,88,89],"culinary medicine","medically tailored groceries","weight management","RECRUITING","2026-07-16",{"date":93,"type":39},"2026-07-21",{"date":95,"type":39},"2025-02-05",{"date":97,"type":21},"2027-12",{"name":45,"class":46},2,{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":56,"minAge":108,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":117,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":47},"100647974","nutrition-intervention-optimization-to-better-utilize-resources-and-support-health-100647974","NCT07713836","Nutrition Intervention Optimization to Better Utilize Resources and Support Health","Optimizing Interventions to Improve Nutrition Security and Reduce Diabetes Risk Among Food Pantry Clients","NOURISH","Inclusion Criteria:\n\n* Aged 18+,\n* Body mass index (BMI)≥ 25;\n* Access to a device with SMS and MMS (picture) text and Wi-Fi capabilities (e.g., phone, tablet, computer) and willingness to use the device regularly during the study;\n* Willingness to complete four in-person data collection appointments;\n* Willing and able to consent.\n\nExclusion Criteria:\n\n* Presence of a condition or dietary restriction precluding eating study meals or weight loss (e.g., condition requiring liquid diet, pregnancy);\n* Another member of the household participating;\n* Planning to move within the next 12 months;\n* Unwilling to participate.","18 Years",{"count":110,"type":21},400,[24],"Not having enough food for each person in a household, also called food insecurity, makes it hard to eat a nutritious diet, maintain a healthy weight, and manage diabetes risk. Food banks and pantries provide direct food assistance that can mitigate food insecurity among people with lower income, however, people that utilize these organizations face time, resource, and physical constraints that limit their ability to consistently select and cook healthier meals and the organizations face budget constraints that limit their bandwidth for implementing nutrition programs. This research will test four innovative nutrition programs (nutritious prepared meals, medically tailored groceries in the form of meal kits, culinary medicine, motivational text messages) to identify which are the most effective for supporting healthy eating and food security and the most cost effective for organizations to implement, as an effort to reduce diabetes risk, improve diabetes self-management, and diminish health disparities.",[114,84,115,116],"Diabete Type 2","Nutritional Intervention","Food Insecurity",[118,119,120,121,122],"Food is Medicine","Medically tailored meals","Medically tailored groceries","Type 2 Diabetes","Culinary medicine","2026-07-14",{"date":125,"type":39},"2026-07-20",{"date":127,"type":21},"2027-01",{"date":129,"type":21},"2031-02",{"name":45,"class":46},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":56,"minAge":108,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":152,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":47},"100645574","assessing-follow-up-trajectories-in-eating-routines-and-weight-after-glp-1-100645574","NCT07701460","Assessing Follow up Trajectories in Eating, Routines, and Weight After GLP-1","AFTER-GLP","Inclusion Criteria:\n\n* 18 years of age or older (no upper limit);\n* ability to read, write, and speak English and\u002For Spanish;\n* ability to provide informed consent;\n* less than 30-days since GLP-1 RA cessation;\n* willing to participate.\n\nExclusion Criteria:\n\n* No clinically significant weight loss (e.g., \\\u003C 5% body weight) while taking GLP medication;\n* major psychiatric illness, cognitive impairment, or substance misuse that could impair ability to participate;\n* medical conditions that significantly affect weight or make participation unsafe (e.g., pregnancy or breastfeeding, recent bariatric surgery, current use of GLP 1 or other anti-obesity medications, or endocrine disorders that alter weight regulation);\n* inability to use a smartphone or complete remote study procedures;\n* participation in another weight loss or maintenance program or clinical trial judged by investigators to interfere with study involvement;\n* Adults unable to consent (cognitively impaired);\n* Wards of the state;\n* Anyone under age 18.",{"count":139,"type":21},200,[24],"Many people who use GLP-1 medications (such as semaglutide or tirzepatide) achieve meaningful weight loss, but maintaining that weight loss off after stopping the medication can be very challenging. Researchers at Tufts University are conducting a study to learn whether a digital lifestyle program can help people maintain their weight loss after they stop taking a GLP-1 medication.\n\nAdults who have recently stopped a GLP-1 medication may be eligible to participate. Participants will be randomly assigned to either receive access to a digital program or to continue with usual care. The study lasts 12 months and is fully remote. All participants will receive a Bluetooth scale to track weight from home and will complete short online questionnaires several times over the year.\n\nBy taking part, participants can help researchers better understand how to support long-term weight maintenance in a way that is affordable, accessible, and sustainable. Participants are compensated for their time, and involvement may help improve care for others with similar experiences.",[143],"Weight Maintenance",[145,146,147,148,149,150,143,151],"Obesity","Overweight","Glucagon-Like Peptide-1 Receptor Agonists","Digital Health","Lifestyle Intervention","Mobile Applications","Eating Behavior",{"date":91,"type":39},{"date":154,"type":21},"2026-08-01",{"date":156,"type":21},"2028-07-31",{"name":45,"class":46},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":55,"sex":56,"minAge":18,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":167,"phases":4,"briefSummary":168,"conditions":169,"keywords":171,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":47},"100639730","teaching-kitchens-intervention-for-older-adults-in-a-senior-center-in-new-england-100639730","NCT07609368","Teaching Kitchens Intervention for Older Adults in a Senior Center in New England","A Pilot Teaching Kitchens Intervention Protocol to Improve the Dietary Quality of Congregate Meals for Older Adults","Inclusion Criteria:\n\n1. Age 50 years or older\n2. Regularly visits the Senior Center either for lunch meals or other center-based programming\n3. Willing and able to participate in a 6-month intervention, which includes consistent involvement in the lunch program\n4. Willing and able to participate in multiple focus group discussions centered around meal preferences, health perceptions, and dietary habits (full study participation is 7 months)\n5. Capable of providing informed consent and completing an eligibility screening\n\nExclusion Criteria:\n\n1. History of moderate to severe neurological condition(s) that may impact cognitive ability (e.g., dementia, major stroke)\n2. Known severe food allergies that may interfere with participation. (with study MD approval, participants with mild allergies or intolerances may be included and notified not to consume any known allergens)\n3. Recent changes in health status that affect the ability to assess foods (e.g., altered appetite, smell, vision, hearing, and\u002For taste)\n4. Any disorder, unwillingness, or inability, not covered by any of the other exclusion criteria, which, in either the investigator's or study MD's opinion, might jeopardize the subject's compliance with the protocol. This includes impaired vision requiring assistance or aid from another person, impaired smell, or impaired taste perception. Given the number of written surveys and visual support materials, the study would place a large burden on participation for individuals with visual impairment requiring assistance.\n5. Individuals who have a cognitive, sensory, or physical impairment that prevents them from understanding the consent information or completing the required consent documentation will be excluded from participation.",{"count":166,"type":21},30,"OBSERVATIONAL","This study will evaluate a culinary nutrition intervention designed to improve the quality of meals served to older adults participating in a senior center. Many meals currently provided in these settings do not meet recommended dietary guidelines, which negatively impact health outcomes among older adults. In this pilot study, participants will receive improved lunch meals that are designed to be more nutritious, culturally appropriate, and acceptable, along with nutrition education sessions over a 6-month period. This intervention will also include training for food service staff to support implementation of the improved meals. The study will assess changes in dietary quality, physical health measures, and social and behavioral outcomes among participants at baseline, 3 months, and 6 months. Findings from this study will help determine the feasibility and effectiveness of this approach and inform future efforts to improve nutrition and health outcomes in Congregate Meal Program for older adults.",[170],"Dietary Quality",[172,173,174,175,176,177],"Teaching Kitchen","Nutrition Literacy","Older Adults","Social Engagement","Congregate Meal Programs","Healthy Eating Index","2026-05-19",{"date":180,"type":39},"2026-05-27",{"date":182,"type":21},"2026-07-01",{"date":184,"type":21},"2027-06-01",{"name":45,"class":46},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":56,"minAge":108,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":22,"phases":195,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":47},"100487930","changes-of-soft-tissue-grafting-a-randomized-study-100487930","NCT05633511","Changes of Soft Tissue Grafting: A Randomized Study","Volumetric Changes of Soft Tissue Grafting. Comparison of Autologous PRF (Platelet-rich Fibrin ) & Autogenous CTG (Connective Tissue Grafts) . A Split-mouth Randomized Design","Inclusion Criteria:\n\n1. Adults 18yrs or older\n2. Need of MG-tx for 2 or more sites for root coverage RT I and II (Cairo classification)\n3. Class A +\u002F-\n4. No class V restoration present\n\nExclusion Criteria:\n\n1. Patients who do not consent to recommended therapy\n2. Patients who smoke\n3. Patients who will not be able to comply with follow up protocols\n4. Those who self report that they are pregnant.",{"count":194,"type":21},50,[24],"To correct gum recession, patient's own tissue from the roof of the mouth is harvested and placed where there is root exposed. This is considered gold standard of treatment. Sometimes patient don't want to have second surgical site in their mouth and at the same time do not want to use alternative tissue from human or animal donor. Using patients' blood and preparing it as a membrane is the next best thing to correct gum recession.",[198],"Gingival Recession","2026-04-23",{"date":201,"type":39},"2026-04-29",{"date":203,"type":39},"2023-01-11",{"date":205,"type":21},"2036-12-30",{"name":45,"class":46},{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":11,"sex":56,"minAge":108,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":47},"100543190","evaluation-of-safety-and-efficacy-of-bixdo-ultra-compact-water-flosser-100543190","NCT06352645","Evaluation of Safety and Efficacy of Bixdo Ultra Compact Water Flosser","Evaluation of Safety and Efficacy of Bixdo Ultra Compact Water Flosser in Addition to Toothbrushing-A 8-week Randomized Controlled Trial","Inclusion Criteria:\n\n1. Participants between the age of 18 - 70 years old.\n2. Having at least 20 natural teeth in their dentition - excluding third molars.\n3. In good overall systemic health, in the opinion of the investigator.\n4. In good dental health with no visible carious lesions, periodontitis, orthodontic appliances, or removable partial dentures.\n5. No hard or soft tissue lesions.\n6. Subjects with moderate or severe plaque-induced gingivitis: a minimum of 50% BOP, 1.75 modified gingival index (MGI), and 0.60 Rustogi Modification of the Navy Plaque Index (RMNPI) and PPD ≤5 mm.\n7. Subjects who agree to delay dental prophylaxis, elective dental treatment, and cosmetic procedures (i.e. tooth whitening, crowns) for the duration of the study\n8. For the main study only: Subjects who agree to refrain from using any non-study dental device or oral care products for the duration of the study, return for scheduled visits, and comply with all study procedures.\n\nExclusion Criteria:\n\n1. Systemic disease self-reported that has an impact on periodontal status (e.g., diabetes mellitus, HIV\u002FAIDS, rheumatoid arthritis).\n2. History of any autoimmune disease (e.g., pSS, SLE, psoriasis, IBS).\n3. History of immunosuppressive chemotherapy or history of any disease known to severely compromise immune function (e.g., cytomegalovirus infection) within the last 5 years.\n4. Any acute intraoral infection (e.g., herpetic gingivostomatitis, herpangina, abscesses).\n5. Patients with visible carious lesions, periodontitis, orthodontic appliances, or removable partial dentures.\n6. Patients with mild plaque-induced gingivitis: \\\u003C 50% BOP, \\\u003C1.75 modified gingival index (MGI), and \\\u003C0.60 Rustogi Modification of the Navy Plaque Index (RMNPI) and PPD ≤5 mm.\n7. Patients with PPD \\>5 mm.\n8. Need for antibiotic premedication for routine dental procedures.\n9. Use of antibiotics within the last 3 months.\n10. Daily use of steroids or non-steroid anti-inflammatory therapy within the last 3-months.\n11. Patients who self-report pregnancy or lactation (hormonal changes that can affect periodontal health and aggravate existing periodontal disease).\n12. Current smokers.\n13. Inability or unwillingness to sign informed consent form.\n14. Patients who do not agree to delay dental prophylaxis, elective dental treatment, and cosmetic procedures (i.e. tooth whitening, crowns).\n15. For the main study only: Patients who do not agree to refrain from using any non-study dental device or oral care products, return for scheduled visits, and comply with all study procedures.\n16. Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study at the discretion of the investigators.\n17. For the main study only: Patients who need assistance from others to perform their daily oral hygiene practices or read the manual of instructions that come with the at-home product.\n18. Those not fluent in English","70 Years",{"count":216,"type":21},165,[24],"The objective of the present randomized controlled trial is to evaluate the safety and efficacy of the use of Bixdo A30 Pro Ultra Compact Water Flosser (also referred to as the \"Bixdo A30 Portable Water Flosser Travel Set\") in addition to a manual toothbrush on clinical parameters of inflammation and bacterial plaque removal.",[220],"Plaque Induced Gingivitis","2026-04-02",{"date":223,"type":39},"2026-04-08",{"date":225,"type":39},"2025-03-04",{"date":227,"type":21},"2027-12-31",{"name":45,"class":46},{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":56,"minAge":108,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":22,"phases":238,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":246,"leadSponsor":248,"locationsCount":47},"100612104","healing-outcomes-of-peri-implant-soft-tissues-with-different-healing-abutments-100612104","NCT07249242","Healing Outcomes of Peri-implant Soft Tissues With Different Healing Abutments","Healing Outcomes of Peri-implant Soft Tissues With Customized Healing Abutments in Immediate and Delayed Implant Placement Protocols: a Pilot Study","Inclusion Criteria:\n\n1. Patients of record at TUSDM who are over 18 years of age\n2. Implants placed as immediate or delayed with a torque of ≥ 35 Ncm eligible to receive a healing abutment left exposed to heal;\n3. Site of implant placement not requiring soft tissue augmentation at the time of healing abutment placement\n4. Sufficient mesial, distal space (7mm for anterior teeth and premolar and 8-9mm for molars) and interocclusal space (7-8mm for screw and cement retained crowns) for definitive restorations (12).\n\nExclusion Criteria:\n\n1. Unable to give consent\n2. active periodontal disease\n3. Heavy smoker\n4. Pregnant\n5. Active infection at implant site",{"count":237,"type":21},48,[24],"The purpose of this study is to compare how well our research participants heal with two different kind of healing abutments used. One is pre-fabricated, meaning it is made to fit anyone, and the other is customized to fit the subject specifically. Much of what will occur is 'standard of care' meaning it is part of a subject's typical dental treatment and the research team wants to just look at the data for this research study, as well.",[241],"Implant","2026-01-21",{"date":244,"type":39},"2026-01-22",{"date":244,"type":39},{"date":247,"type":21},"2028-01-01",{"name":45,"class":46},{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":55,"sex":56,"minAge":18,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":22,"phases":258,"briefSummary":259,"conditions":260,"keywords":262,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":47},"100609883","gut-mini-pill-study-100609883","NCT07220369","Gut Mini-Pill Study","Evaluation of Ingestible Mini-pill for Gastrointestinal Regional Luminal Content Sampling","Inclusion Criteria:\n\n* Men and postmenopausal women\n* Age \\>50 to \\\u003C75 years\n* BMI \\>20 to \\\u003C35 kg\u002Fm2\n* Normotensive with or without medication\n* Normal gastrointestinal function with regular bowel movements at least once every other day\n* Normal kidney and liver function\n* Willingness to swallow the mini-pills\n* Willingness to collect and return multiple stool samples\n* Adequate refrigerator and freezer space to store study entrées\n* Intent to remain in the greater Boston area during the intervention periods\n\nExclusion Criteria:\n\n* Individuals self-reporting adhering to any type of vegetarian diet\n* Lack of willingness to restrict fish intake to less than once per week during the dietary intervention phases\n* Allergy\u002Fintolerance\u002Freligious reasons to avoid study foods or food ingredients, including known hypersensitivity to Blue 1 food coloring and wheat gluten.\n* Regular use of prebiotics or probiotics within the past 3 months\n* Regular use of laxatives or fiber supplements\n* Chronic constipation\n* Chronic use of antibiotics (except topical)\n* Regular use of stomach acid lowering and weight loss medications such as GLP-1 agonists\n* Use of dental prophylaxis\n* Planned colonoscopy 2 months prior to or during the study period\n* Gastroparesis\n* Swallowing disorder, or inability or difficulty taking pills\n* Malabsorptive and inflammatory bowel disease, diverticulosis, and history of diverticulitis, gastric\u002F esophageal\u002Fintestinal surgery, including lap banding or bariatric surgery.\n* History of bowel obstruction, pancreas and liver disorders.\n* Any form of active substance abuse or dependence (including drug or alcohol abuse). This information will be stored in REDCAP in a subsection that has no identifiers.\n* Established major chronic diseases such as cardiovascular disease, diabetes, active cancer within the last 5 years, or any significant medical condition at the study MD's discretion\n* A clinical condition that, in the judgment of the study MD or principal investigator, could potentially pose a health risk to the subject while involved in the study.\n* Unwillingness to adhere to study protocol\n* Intent to increase or decrease body weight during the study period\n* No Social Security number (for payment and IRS forms).\n* Individuals who directly report to any member of the research team.","75 Years",{"count":166,"type":21},[24],"The purpose of this proof-of-concept study in humans is to determine if a noninvasive, ingestible device, called a \"mini-pill\", can collect gastrointestinal (GI) luminal content samples from 2 different locations along the GI tract after consumption of diets differing in protein source (meat and plant-based meat alternatives). The mini-pills will be recovered in the stool. We will analyze the microbial profile of the mini-pill contents and in stool, and also measure blood biomarkers related to cardiometabolic risk, to better understand the relationship between diet, microbiota and health.",[261],"Gut Microbiota",[263,264,265,266],"gut","mini-pill","gut sampling","gut microbiota","2025-10-28",{"date":269,"type":39},"2025-10-30",{"date":271,"type":39},"2025-09-08",{"date":273,"type":21},"2028-08",{"name":45,"class":46},{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":55,"sex":56,"minAge":281,"maxAge":4,"enrollmentInfo":282,"targetDuration":4,"studyType":167,"phases":4,"briefSummary":283,"conditions":284,"keywords":288,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":47},"100609697","assessing-the-feasibility-of-multi-modal-biosensing-for-monitoring-mobility-and-cognition-in-older-adults-100609697","NCT07217951","Assessing the Feasibility of Multi-modal Biosensing for Monitoring Mobility and Cognition in Older Adults","Inclusion Criteria:\n\n1. Aged 65 or older\n2. Expressed willingness to participate.\n3. Able to give written informed consent\n4. Able to operate a smartphone and complete surveys\n\nExclusion Criteria:\n\n1. Reliance on assistive walking devices\n2. Inability to operate a smartphone\n3. Unable to complete surveys\n4. Unable to give written informed consent\n5. Younger than 65 years old\n6. Known skin allergies to kinesiology tape (KT tape)","65 Years",{"count":20,"type":21},"Current health devices often overlook older users, who may face both health challenges and technology barriers. We are investigating the feasibility of wearable sensors to track posture, heart rate, and breathing, alongside a microneedle patch that collect body fluids to measure stress and inflammation markers. By combining this data, we aim to create an easy to use system that supports personalized, at home health monitoring for older adults.",[285,286,287],"Chronic Stress","Systemic Inflammation","Mobility and Independence",[289,290,291,292,293],"wearable sensors","older adults","aging","mobility","inflammation","2025-10-16",{"date":296,"type":39},"2025-10-20",{"date":298,"type":21},"2025-12",{"date":300,"type":21},"2028-09",{"name":45,"class":46},{"id":303,"slug":304,"hasResults":11,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":55,"sex":56,"minAge":309,"maxAge":4,"enrollmentInfo":310,"targetDuration":4,"studyType":22,"phases":311,"briefSummary":312,"conditions":313,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":47},"100527770","caries-detection-with-two-different-caries-detecting-devices-100527770","NCT06152081","Caries Detection With Two Different Caries Detecting Devices","A Pilot Clinical Trial Comparing the Efficacy of Caries Detection With a Novel Caries Detecting Rinse and Existing Diagnostic Tools","Inclusion Criteria:\n\n* Patients of TUSDM Comprehensive Care Clinic\n* Adult patients over the age of 21\n* Extreme\u002FHigh Caries Risk classification per TUSDM Caries Management by Risk Assessment (CAMBRA) form\n* Presence of 2 or more initial active primary carious lesions on a free coronal surface of any tooth by visual assessment, QLF, and LumiCare™\n* Presence of at least 1 cavitated lesion\n* Updated (no more than 6 months old) bite wing radiographs available.\n* Patients who responded either yes\u002Fno to use of e-cigarettes\u002Fvapes\n* 1 active caries, 1 inactive caries and 1 sound tooth surface.\n\nExclusion Criteria:\n\n* Low or moderate caries risk classification per TUSDM CAMBRA form\n* No clinically detectable carious lesions on free coronal surfaces\n* No cavitated caries lesions\n* Carious teeth with caries lesions concomitant with extrinsic stains, fluorosis, or developmental defects.\n* Patients who responded yes to the use of conventional cigarettes or smokeless tobacco","21 Years",{"count":80,"type":21},[24],"The primary aim of this study will be to compare the effectiveness of the novel LumiCare™ rinse and with QLF in determining caries progression. The secondary aim is to compare the progression of carious lesions between patients who reported use of e-cigarettes\u002Fvapes and those who did not.",[314],"Caries,Dental","2025-08-04",{"date":317,"type":39},"2025-08-05",{"date":319,"type":39},"2025-04-01",{"date":321,"type":21},"2027-10",{"name":45,"class":46},{"id":324,"slug":325,"hasResults":11,"nctId":326,"briefTitle":327,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":55,"sex":56,"minAge":108,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":22,"phases":331,"briefSummary":333,"conditions":334,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":47},"100600564","early-phase-1-effective-interventions-to-overcome-severe-gag-reflex-100600564","NCT07099131","Effective Interventions to Overcome Severe Gag Reflex","Inclusion Criteria:\n\n* 18 years or older (individuals below 18 years will be excluded from the study as the study procedures might not be well tolerated by them, and they are not the primary population on which these procedures are used).\n* Students, faculty, or staff of Tufts SDM\n* Subjects who score a 2 or higher on the Gagging Severity Index (GSI)7 and have a positive gag reflex response when stimulated with a cotton swab at the base of the tongue\u002Fuvula\u002Ftonsil region.\n\nExclusion Criteria:\n\n* Adults unable to consent (cognitively impaired adults)\n* Wards of the state\n* Pregnant women (those that are self-reported)\n* Current use of anticoagulants\n* Allergy to xylocaine\n* Those with bleeding disorders\n* Those who participated in the Calibration phase of this study",{"count":330,"type":21},45,[332],"EARLY_PHASE1","The purpose of this study is to evaluate the use of various techniques in alleviating gag reflex following gag reflex stimulation.\n\nPrimary aim: To compare if there is any reduction in gag reflex from each of the following interventions\n\n* Acupuncture (CV-24)\n* Tape\n* Anesthetic spray Secondary aim: to compare the degree of gag reduction",[335],"Gagging","2025-07-24",{"date":338,"type":39},"2025-08-01",{"date":340,"type":21},"2025-12-07",{"date":342,"type":21},"2028-12-07",{"name":45,"class":46},{"id":345,"slug":346,"hasResults":11,"nctId":347,"briefTitle":348,"officialTitle":348,"acronym":4,"eligibilityCriteria":349,"healthyVolunteers":55,"sex":56,"minAge":350,"maxAge":77,"enrollmentInfo":351,"targetDuration":4,"studyType":22,"phases":352,"briefSummary":353,"conditions":354,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":99},"100511142","intervention-inc-an-interactive-family-centered-mhealth-tool-to-reduce-obesity-risk-in-urban-minority-preadolescents-100511142","NCT05935592","Intervention INC: An Interactive Family-centered mHealth Tool to Reduce Obesity Risk in Urban Minority Preadolescents","Inclusion Criteria (child):\n\n* self-identifies as Black\u002FAfrican-American and\u002For Latino\n* between ages 8 and 12 years (preadolescents) at time of scheduled baseline visits\n* reads and speaks in English\n* has a Body Mass Index percentile at or above 5% at baseline (categorized as healthy, overweight, or obese)\n* has regular internet access via a tablet device, smartphone, or computer\u002Flaptop\n* has regular access to a phone with texting capability\n* is comfortable reading\u002Fviewing material on electronic devices\n* is comfortable speaking with study staff about thoughts\u002Fexperiences while participating in study\n* has a legal parent\u002Fguardian willing to participate in study\n\nInclusion Criteria (parent):\n\n* legal parent\u002Fguardian of child willing to participate in study\n* reads and speaks in English or Spanish\n* primarily responsible for preparing\u002Fpurchasing food for child\n* has regular internet access via a tablet device, smartphone, or computer\u002Flaptop\n* has regular access to a phone with texting capability\n* comfortable reading\u002Fviewing material on electronic devices\n* able to attend in-person study visits and complete online questionnaires with their child over the full duration of study\n\nExclusion Criteria (child):\n\n* has allergies, food aversions, food disorders, or medications with side-effects that may impact participation in study\n* has a pacemaker or heart condition\n* in foster care","8 Years",{"count":139,"type":21},[24],"Using a two-group randomized study design, this study aims to evaluate the effectiveness of the adapted family-centered mHealth tool on child BMI z-score (primary outcome), child dietary behaviors, and parental feeding practices, from baseline to 12-month follow-up, among 200 child-parent dyads. It is hypothesized that children in the experimental group will demonstrate larger BMI-z score improvements between baseline and 12-month follow-up compared to children in the comparison group.",[355],"Obesity, Childhood","2025-04-07",{"date":358,"type":39},"2025-04-10",{"date":360,"type":39},"2025-02-27",{"date":362,"type":21},"2027-06",{"name":45,"class":46},{"id":365,"slug":366,"hasResults":11,"nctId":367,"briefTitle":368,"officialTitle":369,"acronym":370,"eligibilityCriteria":371,"healthyVolunteers":11,"sex":56,"minAge":108,"maxAge":4,"enrollmentInfo":372,"targetDuration":4,"studyType":22,"phases":374,"briefSummary":375,"conditions":376,"keywords":379,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":387,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":4},"100586820","community-pharmacy-produce-prescriptions-100586820","NCT06920355","Community Pharmacy Produce Prescriptions","Community Pharmacy Produce Prescriptions (CP3): Design, Implementation, and Evaluation of a Produce Prescription Program in Community Pharmacies","CP3","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Age 18 years or older\n* Presence of one or more of the following conditions: type 2 diabetes or hypertension. (Type 2 diabetes and hypertension will be defined by the combination of a self-reported physician diagnosis of one of the conditions and at least one pharmacy prescription for one of the conditions.)\n* Able to converse, and complete the research surveys in English or Spanish, based on self-report.\n* Positive screening for food or nutrition insecurity by:\n\n  1. Hunger Vital Sign™ screening and,\n  2. Nutrition Security Screener\n\nExclusion Criteria:\n\n* Unable to provide informed consent.\n* Unable to read and write.\n* Self-reported serious medical conditions that may be expected to shorten life expectancy to less than one year\n* A condition that limits participant's ability to grocery shop or choose food for themselves\n* Plans to move to a new home in the next 6 months that would require use of a different pharmacy\n* Currently pregnant or pregnancy planned within the next 6 months\n* Currently using or planning to start an insulin pump or other automated insulin delivery device within the next 6 months\n* Currently on a GLP-1 agonist or planning to start a GLP-1 agonist within the next 6 months\n* Currently receiving or planning to receive within the next 6 months another Food is Medicine program, like PRx, Grocery Rx, or Medically Tailored Meals",{"count":373,"type":21},610,[24],"The goal of this clinical trial is to generate evidence on the feasibility and effectiveness of community pharmacies as the implementers of a produce prescription program for adults with diabetes and\u002For hypertension. The main question this study plans to answer is if using community pharmacies as a point-of-service for improving nutrition and health is feasible and effective. The trial also explores the impact of the program on food security, nutrition security, diet quality and health and patient centered outcomes.\n\nParticipants will be enrolled in a produce prescription program to purchase healthy foods at the grocery store where they are currently receiving their pharmacy services. Participants will be asked to attend pharmacy visits to collect biometrics at two different time points and complete electronic surveys at three different time points.",[377,378],"Diabetes Mellitus Type 2","Hypertension",[118,380,381,382,383,384,385,386],"Produce Prescriptions","Produce Rx","Community Pharmacy","Nutrition Security","Food Security","Nutrition Intervention","Food as Medicine",{"date":388,"type":39},"2025-04-09",{"date":390,"type":21},"2025-04",{"date":392,"type":21},"2026-06",{"name":45,"class":46},{"id":395,"slug":396,"hasResults":11,"nctId":397,"briefTitle":398,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":11,"sex":56,"minAge":108,"maxAge":256,"enrollmentInfo":401,"targetDuration":4,"studyType":167,"phases":4,"briefSummary":403,"conditions":404,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":47},"100434211","3d-dynamic-and-patient-centered-outcomes-of-facial-reanimation-surgery-in-patients-with-facial-paralysis-100434211","NCT04934176","3D Dynamic and Patient-Centered Outcomes of Facial Reanimation Surgery in Patients With Facial Paralysis","3D Dynamic and Patient-Centered Outcomes of Facial Reanimation","Inclusion Criteria:\n\n* Patients with unilateral facial paralysis scheduled for smile reconstruction using free gracilis muscle transfer driven by one of four neuronal inputs, specifically, the trigeminal nerve (nV), a cross-face nerve graft (nVII), dual innervation combining the trigeminal nerve, a cross face nerve graft, and patients who have midfacial modifications that involve performing direct coaptation between the trigeminal nerve and a branch to the native zygomaticus major muscle (5-7 transfer) and selective neurolysis in which several facial nerve branches that innervate muscles antagonistic to the smile animation are transected.\n* Patient\u002Fparent interest\u002Fwillingness to participate in the study\n* An ability to comprehend verbal instructions\n* An age range of 18 to 75 years\n\nExclusion Criteria:\n\n* Presence of a major facial deformity\u002Fcondition either congenital or acquired e.g. hemifacial microsomia, cancer\n* Facial movement disorders due to primary muscular dysfunction or hemifacial spasm in the absence of synkinesis\n* Mental or hearing impairment to the extent that comprehension or ability to perform the tests is hampered",{"count":402,"type":21},125,"In this study, patients who have undergone facial paralysis surgery will be asked to participate. The goal of this study is to compare the facial disability and perception outcomes of facial reanimation surgeries in patients with extensive and permanent, unilateral paralysis using 3D analysis, and compare patient-centered outcomes of facial appearance, well-being, and satisfaction using validated questionnaires. The focus point of this study will be on outcomes of mid-facial reanimation surgeries in patients with more extensive and permanent, unilateral, paralysis of varied etiology and presentation.\n\nThe specific aims of the study are as follows. Specific Aim 1. To quantitatively determine the surgical effects\u002Fimpact on facial disability (facial impairment and disfigurement) among four surgically treated groups of patients with unilateral facial paralysis who undergo free gracilis muscle transfer driven by (1) a trigeminal nerve (nV) graft, (2) a crossface nerve graft (nVII), (3) dual innervation comprising both nerves, and (4) midfacial modification.\n\n1. We will compare the changes in facial disability among the groups before and after surgery, and the differences in facial disability between each surgery group and the controls before and after surgery.\n2. Specific Aim 2. To compare among the surgery groups the changes in self-perceptions of facial appearance and well-being that occur due to facial reanimation surgery, and to compare the surgery groups before and at 18 months to historical controls recruited during the tenure of the R21 grant.\n3. Specific Aim 3. In patients with facial paralysis, to compare surgeons' current qualitative assessment and 2D, quantitative assessment of facial impairment and disfigurement with the objective, 3D, quantitative assessments in order to determine the clinical utility of the 3D assessment approach as an outcome measure and relevance for dissemination to the surgical community.",[405],"Facial Paralysis","2024-12-20",{"date":408,"type":39},"2024-12-27",{"date":410,"type":39},"2021-06-03",{"date":412,"type":21},"2026-06-03",{"name":45,"class":46},{"id":415,"slug":416,"hasResults":11,"nctId":417,"briefTitle":418,"officialTitle":418,"acronym":419,"eligibilityCriteria":420,"healthyVolunteers":55,"sex":56,"minAge":108,"maxAge":4,"enrollmentInfo":421,"targetDuration":423,"studyType":167,"phases":4,"briefSummary":424,"conditions":425,"keywords":427,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":438},"100432152","international-weight-control-registry-100432152","NCT04907396","International Weight Control Registry","IWCR","Inclusion Criteria:\n\n* The IWCR is open to anyone 18 years or older who is considering weight loss, is actively engaged in weight loss, or has previously attempted weight loss (including successful and unsuccessful attempts)\n\nExclusion Criteria:\n\n1. Minors, below the age of 18\n2. Adults who are not able to give informed consent online and complete online surveys",{"count":422,"type":21},100000,"5 Years","The IWCR is a global scientific study aimed at better understanding the opportunities and barriers for reducing the prevalence of obesity by collecting information from people who have experience with weight management in their everyday lives. The investigators seek to gather information on a wide range of weight management experiences, ranging from weight loss and weight loss maintenance to weight gain and inability to lose weight.",[426,146,145],"Weight Loss",[428,429],"Weight Loss Maintenance","Obesity Management","2024-09-03",{"date":432,"type":39},"2024-09-19",{"date":434,"type":39},"2020-12-10",{"date":436,"type":21},"2025-12-01",{"name":45,"class":46},7,""]