[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ukrainian Society of Regional Anesthesia and Pain Therapy\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":369},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,54,82,111,142,174,203,230,257,288,312,339],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":50,"locationsCount":53},"100647332","drone-wound-study-severe-infection-after-drone-related-combat-trauma-100647332",false,"NCT07706608","DRONE-WOUND Study: Severe Infection After Drone-Related Combat Trauma","DRONE-WOUND Study: Tissue Devitalization and Severe Infection Following Drone-Related Combat Trauma: A Prospective Multicenter Observational Cohort Study","DRONE-WOUND","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Combat-related injury caused by a confirmed drone-related mechanism, including first-person view (FPV) drones, drone-delivered explosive munitions, or other unmanned aerial vehicle (UAV)-associated injuries.\n* Open extremity injury requiring operative surgical debridement.\n* Hospital admission within 24 hours after injury.\n* Written informed consent provided by the participant or legally authorized representative, in accordance with local regulations.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Isolated superficial soft tissue injuries not requiring operative treatment. Injuries requiring immediate primary amputation before initial surgical assessment.\n* Patients transferred more than 24 hours after injury.\n* Pre-existing active infection involving the injured limb before the combat injury.\n* Patients who die before completion of the initial surgical debridement.\n* Prisoners or other individuals unable to provide informed consent when no legally authorized representative is available.","ALL","18 Years","60 Years",{"count":21,"type":22},500,"ESTIMATED","OBSERVATIONAL","Drone-related combat injuries have become one of the most devastating mechanisms of injury in modern warfare. These injuries often cause extensive tissue devitalization, contamination, open fractures, vascular injuries, and complex soft tissue damage, which may substantially increase the risk of severe wound infection, multidrug-resistant bacterial infection, repeated surgical procedures, limb loss, and sepsis. However, the relationship between the extent of tissue devitalization and the development of severe infection has not been systematically investigated.\n\nThe DRONE-WOUND Study is a prospective observational cohort study designed to evaluate the association between tissue devitalization and severe wound infection in patients with drone-related combat trauma. The study will collect detailed clinical, surgical, microbiological, and radiological data from injured patients treated at participating trauma centers. Measures of tissue injury, contamination, surgical management, microbiological findings, and infection outcomes will be analyzed to identify factors associated with severe infection and poor clinical outcomes.\n\nThe findings of this study are expected to improve understanding of the mechanisms leading to infection after drone-related injuries, support early identification of high-risk patients, and inform future strategies for surgical management, antimicrobial therapy, and infection prevention in combat trauma. Ultimately, the study aims to improve limb salvage, reduce infectious complications, and enhance outcomes for patients with severe drone-related injuries.",[26,27,28,29,30,31,32],"Combat Related Symptoms","Combat Trauma","Infection","Infection Complication","Wound - in Medical Care","Wound Infection Post-Traumatic","Surgical Site Infection (SSI)",[34,27,35,36,37,38,39,40,41],"Drone-Related Injury","Tissue Devitalization","Wound Infection","Severe Wound Infection","Surgical Site Infection","Multidrug-Resistant Organisms","Antimicrobial Resistance","Soft Tissue Injury","NOT_YET_RECRUITING","2026-07-11",{"date":45,"type":46},"2026-07-16","ACTUAL",{"date":48,"type":22},"2026-10-23",{"date":48,"type":22},{"name":51,"class":52},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":81,"locationsCount":53},"100645688","block-trauma-study-100645688","NCT07702071","BLOCK-TRAUMA Study","Regional Anesthesia Burden and Clinical Outcomes in Polytrauma Patients: A Prospective Cohort Study","BLOCK-TRAUMA","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Diagnosis of polytrauma, defined as traumatic injuries involving two or more anatomical regions.\n* Injury Severity Score (ISS) ≥16.\n* Hospital admission within 48 hours after injury.\n* Requirement for acute pain management during hospital treatment.\n* Receipt of at least one ultrasound-guided peripheral nerve block and\u002For continuous peripheral nerve catheter as part of routine clinical care.\n* Ability to collect clinical data on regional anesthesia procedures, analgesic use, pain assessment, and early recovery outcomes.\n* Written informed consent provided by the patient or legally authorized representative, according to local regulations.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Isolated single-system injury without polytrauma. ISS \\\u003C16.\n* Expected survival less than 24 hours after admission.\n* Severe traumatic brain injury or impaired consciousness preventing reliable pain and functional assessment, unless validated behavioral pain scales can be used.\n* Known allergy or contraindication to local anesthetics.\n* Pre-existing severe neuromuscular disease affecting motor function assessment.\n* Chronic opioid therapy before injury.\n* Pregnancy.\n* Enrollment in another interventional trial that may affect pain management or functional recovery outcomes.\n* Missing essential data required for assessment of Regional Anesthesia Burden.","50 Years",{"count":21,"type":22},"This prospective cohort study will evaluate the association between the overall burden of regional anesthesia and early clinical outcomes in adult patients with polytrauma.\n\nPatients with severe trauma often experience pain from multiple injury sites and may require more than one peripheral nerve block or continuous regional anesthesia catheter. While regional anesthesia can improve pain control and reduce opioid use, multiple blocks and catheters may also increase treatment complexity, local anesthetic exposure, motor weakness, and monitoring challenges.\n\nThe study will prospectively collect data on the number and type of regional anesthesia procedures, local anesthetic exposure, catheter use, pain intensity, opioid consumption, mobility, complications, and early recovery outcomes. The goal is to determine whether increasing regional anesthesia burden is associated with improved analgesia, functional recovery, or increased risk in polytrauma patients.",[66,67,68,69,27],"Polytrauma","Regional Anaesthesia","Nerve Block","Acute Pain",[66,71,72,69,73,74],"Regional Anesthesia","Peripheral Nerve Block","Local Anesthetics","Combat Injury","2026-07-09",{"date":77,"type":46},"2026-07-14",{"date":79,"type":22},"2026-07-23",{"date":48,"type":22},{"name":51,"class":52},{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":90,"targetDuration":92,"studyType":23,"phases":4,"briefSummary":93,"conditions":94,"keywords":99,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":110,"locationsCount":53},"100646441","asv-and-targeted-fluid-resuscitation-in-severe-burns-100646441","NCT07689097","ASV and Targeted Fluid Resuscitation in Severe Burns","Adaptive Support Ventilation and Targeted Fluid Resuscitation in Patients With Severe Burn Injury: A Prospective Cohort Study","BURN-ASV\u002FTFR","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Hospital admission with severe burn injury involving ≥20% total body surface area (TBSA).\n* Requirement for invasive mechanical ventilation within 24 hours after admission to the intensive care unit.\n* Expected need for mechanical ventilation for at least 48 hours.\n* Treatment with Adaptive Support Ventilation (ASV) and targeted fluid resuscitation according to institutional protocols.\n* Written informed consent provided by the patient or legally authorized representative, in accordance with local regulations.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Burn injury involving \\\u003C20% TBSA.\n* Mechanical ventilation initiated more than 24 hours after ICU admission.\n* Pregnancy.\n* Pre-existing chronic dependence on invasive mechanical ventilation.\n* Severe traumatic brain injury requiring a specific ventilation strategy.\n* Terminal illness with an expected survival of less than 24 hours.\n* Enrollment in another interventional clinical trial that may influence study outcomes.\n* Inability to obtain essential clinical data required for study analysis.",{"count":91,"type":22},100,"7 Days","This prospective cohort study will evaluate the use of Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation in adult patients with severe burn injuries requiring mechanical ventilation in the intensive care unit.\n\nPatients with extensive burns often develop respiratory failure and require both invasive mechanical ventilation and large-volume fluid resuscitation during the first days after injury. The study will assess whether the combination of ASV and targeted fluid resuscitation is associated with improved oxygenation, respiratory mechanics, fluid balance, and early clinical outcomes during the first 72 hours of intensive care.\n\nClinical data, ventilatory parameters, laboratory results, hemodynamic variables, and fluid resuscitation characteristics will be collected as part of routine clinical care. The findings may help optimize early intensive care management for patients with severe burn injuries and improve future treatment strategies.",[95,96,97,98],"Burn","War-Related Injuries","Mechanical Ventilation","Infusion Fluid",[100,101,102,103],"burns","war - ralated injury","addaptive support ventilation","fluid therapy","2026-07-04",{"date":106,"type":46},"2026-07-08",{"date":108,"type":22},"2026-09-23",{"date":108,"type":22},{"name":51,"class":52},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":119,"targetDuration":4,"studyType":120,"phases":121,"briefSummary":123,"conditions":124,"keywords":131,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":139,"leadSponsor":141,"locationsCount":4},"100644682","burn-asv-trial-adaptive-support-ventilation-in-severe-burn-injury-100644682","NCT07674563","BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury","Adaptive Support Ventilation Versus Conventional Lung-Protective Ventilation in Severe Burn Injury Including Thermobaric and Drone-Related Burns: The BURN-ASV Randomized Controlled Trial","BURN-ASV","Inclusion Criteria:\n\n* Age 18 years or older.\n* Thermal burn injury involving ≥20% total body surface area (TBSA).\n* Requirement for invasive mechanical ventilation expected to exceed 24 hours.\n* Admission to a participating intensive care unit within 48 hours of injury.\n* Burn injury resulting from conventional flame burns, explosion-related burns, drone-related burns, or thermobaric blast burns.\n* Written informed consent provided by the patient or a legally authorized representative.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Pregnancy or breastfeeding.\n* Pre-existing chronic respiratory failure requiring home oxygen therapy or long-term mechanical ventilation.\n* Severe chronic obstructive pulmonary disease (COPD GOLD IV) or other end-stage pulmonary disease.\n* Extracorporeal membrane oxygenation (ECMO) at the time of enrollment.\n* Severe traumatic brain injury requiring controlled hyperventilation.\n* Expected death within 24 hours of ICU admission.\n* Do-not-resuscitate (DNR) order or limitations of life-sustaining treatment.\n* Previous enrollment in the current study.\n* Participation in another interventional trial that may interfere with study outcomes.",{"count":91,"type":22},"INTERVENTIONAL",[122],"NA","Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures. Patients with extensive burns are at high risk of ventilator-associated complications, prolonged intensive care unit (ICU) stay, and death.\n\nAdaptive Support Ventilation (ASV) is an automated mode of mechanical ventilation that continuously adjusts breathing support according to the patient's respiratory needs and lung mechanics. Although ASV has shown potential benefits in general ICU populations, its effectiveness in patients with severe burn injuries has not been adequately studied.\n\nThe purpose of this randomized controlled trial is to compare Adaptive Support Ventilation with conventional lung-protective mechanical ventilation in critically ill adult burn patients, including those with inhalation injury, drone-related burns, and thermobaric blast burns. Participants will be randomly assigned to receive either ASV or conventional ventilation. The study will evaluate whether ASV improves ventilator-free days, reduces duration of mechanical ventilation, decreases ventilator-associated complications, and improves clinical outcomes.\n\nThe results of this study may help identify optimal ventilation strategies for patients with severe burn injuries and improve critical care management in both civilian and military burn centers.",[95,97,125,126,127,128,129,130],"Mechanical Ventilation Complication","ICU","ICU Hospitalization","Critical Care, Intensive Care","Military Activity","Combat-Related Burn Injury",[132,130,133,134],"burn","adaptive support mechanical ventilation","mechanical ventilation","2026-06-24",{"date":137,"type":46},"2026-06-29",{"date":108,"type":22},{"date":140,"type":22},"2026-11-23",{"name":51,"class":52},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":149,"targetDuration":151,"studyType":23,"phases":4,"briefSummary":152,"conditions":153,"keywords":158,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":4},"100626681","post-amputation-stump-infection-as-a-predictor-of-persistent-residual-limb-pain-a-prospective-cohort-study-100626681","NCT07438795","Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study","INF-STUMP-PAIN","Inclusion Criteria:\n\n* Traumatic upper or lower limb amputation\n* Enrollment within 4 weeks after surgery\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Pre-existing chronic pain in the affected limb\n* Severe cognitive impairment\n* Terminal illness limiting follow-up\n* Refusal or inability to complete follow-up assessments",{"count":150,"type":22},150,"6 Months","Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and long-term pain persistence. This prospective cohort study aims to determine whether early post-amputation stump infection independently predicts persistent clinically significant residual limb pain at 3 and 6 months after surgery.",[154,155,156,38,157],"Residual Limb Pain","Stump Pain","Post-Amputation Pain","Phantom Limb Pain (PLP)",[159,160,161,162,163,164,165],"Traumatic amputation","stump infection","residual limb pain","chronic pain","surgical site infection","blast injury","neuropathic pain","2026-06-01",{"date":168,"type":46},"2026-06-03",{"date":170,"type":22},"2026-06-23",{"date":172,"type":22},"2026-12-23",{"name":51,"class":52},{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":181,"targetDuration":151,"studyType":23,"phases":4,"briefSummary":183,"conditions":184,"keywords":187,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":202,"locationsCount":53},"100640874","the-association-between-amputation-level-and-chronic-low-back-pain-after-combat-related-amputation-100640874","NCT07626294","The Association Between Amputation Level and Chronic Low Back Pain After Combat-Related Amputation","LEVEL-BACK","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related lower limb amputation\n* Transtibial, transfemoral, or bilateral lower limb amputation\n* Time since amputation ≥3 months\n* Current or planned prosthesis use\n* Ability to participate in rehabilitation assessment\n* Ability to report low back pain intensity\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Traumatic spinal injury related to the initial combat trauma\n* Previous spinal surgery before amputation\n* Known severe spinal deformity\n* Active spinal infection or malignancy\n* Severe neurological disorder affecting mobility\n* Non-combat-related amputation\n* Inability to complete follow-up assessments\n* Refusal or inability to provide informed consent",{"count":182,"type":22},300,"Patients with combat-related lower limb amputations frequently experience chronic low back pain during long-term rehabilitation and prosthetic use. Altered biomechanics, asymmetric loading, gait disturbances, and changes in spinal alignment after limb loss may contribute to the development of persistent back pain. The severity and characteristics of low back pain may vary according to the level of amputation.\n\nThe LEVEL-BACK Study is a prospective observational study designed to evaluate the relationship between amputation level and chronic low back pain after combat-related amputation.\n\nParticipants with different levels of lower limb amputation will undergo clinical assessment of low back pain intensity, functional limitations, prosthesis use, and rehabilitation outcomes during follow-up.\n\nThe goal of the study is to improve understanding of how amputation level influences chronic low back pain after combat-related limb loss and to identify patients at increased risk for persistent spinal pain during rehabilitation.",[185,186],"Low Back Pain","Amputation",[188,189,190,191,192,193,194,195],"Chronic low back pain","Combat-related amputation","Amputation level","Transtibial amputation","Transfemoral amputation","Bilateral amputation","Prosthesis use","Rehabilitation","2026-05-30",{"date":198,"type":46},"2026-06-04",{"date":200,"type":22},"2026-09-15",{"date":200,"type":22},{"name":51,"class":52},{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":209,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":211,"targetDuration":4,"studyType":120,"phases":212,"briefSummary":213,"conditions":214,"keywords":218,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":224,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":228,"locationsCount":229},"100640546","ultrasound-guided-platelet-rich-plasma-versus-local-anesthetic-injection-for-chronic-neuroma-pain-after-combat-related-amputation-100640546","NCT07624890","Ultrasound-Guided Platelet-Rich Plasma Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation","Ultrasound-Guided Platelet-Rich Plasma Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation: A Prospective Multicenter Controlled Study","PRP-NEUROMA","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related limb amputation\n* Chronic neuroma pain lasting ≥3 months\n* Ultrasound-confirmed painful neuroma\n* Average neuroma pain intensity ≥4\u002F10 on the Numeric Rating Scale\n* Persistent pain interfering with rehabilitation, prosthesis use, or daily activities\n* Ability to undergo ultrasound-guided injection\n* Stable analgesic regimen for at least 14 days before enrollment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Active infection at or near the injection site\n* Open wound preventing safe injection\n* Previous PRP injection for neuroma pain within 6 months\n* Previous neuroma surgery within 3 months\n* Severe coagulopathy or platelet disorder\n* Anticoagulant therapy contraindicating injection\n* Active malignancy\n* Severe uncontrolled systemic disease\n* Known allergy to local anesthetics\n* Inability to complete follow-up assessments",{"count":91,"type":22},[122],"Patients with combat-related amputations frequently experience chronic neuroma pain that may interfere with rehabilitation, prosthesis use, mobility, sleep, and quality of life. Current treatment approaches often provide only temporary pain relief.\n\nPlatelet-rich plasma (PRP) has emerged as a potential regenerative treatment option because of its possible effects on tissue healing, neuroinflammation, and peripheral nerve irritation. However, its role in the treatment of chronic neuroma pain after amputation remains unclear.\n\nThis prospective multicenter controlled study aims to compare ultrasound-guided PRP injection around the neuroma with ultrasound-guided local anesthetic injection in patients with chronic neuroma pain after combat-related amputation.\n\nParticipants will undergo one of the two injection treatments and will be followed over time to evaluate changes in pain intensity, neuropathic pain symptoms, phantom limb pain, prosthesis tolerance, and functional outcomes.\n\nThe goal of the study is to evaluate the safety, feasibility, and potential clinical effectiveness of PRP injection for chronic neuroma pain following combat-related amputation.",[215,216,155,217],"Neuroma","Phantom Limb Pain After Amputation","Platelet-rich Plasma (PRP)",[219,154,220,221,222,223],"Chronic Neuroma Pain","Combat-Related Amputation","Post-Amputation Pain Syndrome","Painful Stump Neuroma","Platelet-rich plasma",{"date":168,"type":46},{"date":226,"type":22},"2026-12-15",{"date":226,"type":22},{"name":51,"class":52},2,{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":234,"acronym":235,"eligibilityCriteria":236,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":237,"targetDuration":4,"studyType":120,"phases":239,"briefSummary":240,"conditions":241,"keywords":243,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":256,"locationsCount":53},"100640513","proximal-nerve-cryoablation-versus-perineuroma-cryoablation-for-chronic-neuroma-pain-after-combat-related-amputation-100640513","NCT07618689","Proximal Nerve Cryoablation Versus Perineuroma Cryoablation for Chronic Neuroma Pain After Combat-Related Amputation","AXON-FREEZE","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related limb amputation\n* Chronic neuroma pain lasting ≥3 months\n* Ultrasound-confirmed painful neuroma\n* Average pain intensity ≥4\u002F10 on Numeric Rating Scale\n* Positive Tinel sign\n* Ability to undergo ultrasound-guided cryoablation\n* Stable analgesic regimen for at least 14 days\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Active infection at the treatment site\n* Open wound preventing safe procedure\n* Previous cryoablation of the target nerve within 6 months\n* Neuroma surgery within 3 months\n* Severe coagulopathy or anticoagulation contraindicating procedure\n* Pregnancy or breastfeeding\n* Severe uncontrolled systemic disease\n* Inability to complete follow-up assessments",{"count":238,"type":22},50,[122],"atients with combat-related amputations frequently develop chronic neuroma pain that interferes with rehabilitation, prosthesis use, mobility, sleep, and quality of life. Cryoablation is a minimally invasive treatment that produces controlled nerve injury using extreme cold. Although the freezing effect is localized around the cryoprobe, axonal interruption followed by distal Wallerian degeneration may extend functional denervation distal to the ablation site.\n\nThis study aims to compare two ultrasound-guided cryoablation strategies for chronic neuroma pain after combat-related amputation: cryoablation performed directly near the neuroma and cryoablation performed proximal to the neuroma along the affected nerve.\n\nThe study will evaluate whether proximal nerve cryoablation produces greater or longer-lasting analgesic effects compared with perineuroma cryoablation.",[215,242],"Cryoablation",[242,244,245,246,161,247,248,249,250],"neuroma pain","combat-related amputation","phantom limb pain","peripheral nerve injury","Wallerian degeneration","ultrasound-guided intervention","military trauma",{"date":252,"type":46},"2026-06-02",{"date":254,"type":22},"2026-10-15",{"date":254,"type":22},{"name":51,"class":52},{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":265,"targetDuration":4,"studyType":120,"phases":266,"briefSummary":267,"conditions":268,"keywords":273,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":284,"startDateStruct":285,"completionDateStruct":286,"leadSponsor":287,"locationsCount":229},"100640278","botulinum-toxin-type-a-versus-local-anesthetic-injection-for-chronic-neuroma-pain-after-combat-related-amputation-100640278","NCT07626983","Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation","Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation: A Multicenter Randomized Double-Blind Trial","NEUROQUIET","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related limb amputation\n* Persistent neuroma pain lasting ≥3 months\n* Ultrasound-confirmed neuroma\n* Positive Tinel sign over the neuroma\n* Average pain intensity ≥4\u002F10 on the Numeric Rating Scale (NRS)\n* Stable analgesic regimen for at least 14 days before enrollment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Active infection at the injection site\n* Previous botulinum toxin injection within 6 months\n* Previous neuroma surgery within 3 months\n* Severe uncontrolled psychiatric disorder\n* Coagulopathy or anticoagulant therapy contraindicating injection\n* Known allergy to botulinum toxin or local anesthetics\n* Severe uncontrolled systemic disease\n* Inability to complete study follow-up or questionnaires",{"count":91,"type":22},[122],"Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life. Current treatment options often provide only temporary relief. This study aims to compare two ultrasound-guided injection approaches for chronic neuroma pain after combat-related amputation: botulinum toxin type A and local anesthetic injection.\n\nParticipants will be randomly assigned to receive one of the two treatments. Pain intensity, neuropathic pain symptoms, phantom limb pain, prosthesis tolerance, and functional outcomes will be evaluated during follow-up visits over a 24-week period.\n\nThe goal of the study is to determine whether botulinum toxin type A provides longer-lasting pain reduction and improved functional recovery compared with local anesthetic injection in patients with chronic neuroma pain after combat-related amputation.",[269,270,271,272,26],"Chronic Pain Due to Injury","Neuroma of Lower Limb","Neural Injury","Neuroma of Upper Limb",[274,189,275,276,277,278,279,280,281,282,283],"Neuroma pain","Botulinum toxin type A","Local anesthetic injection","Ultrasound-guided injection","Phantom limb pain","Residual limb pain","Neuropathic pain","Military trauma","Chronic post-amputation pain","Ultrasound-guided pain intervention",{"date":198,"type":46},{"date":196,"type":22},{"date":226,"type":22},{"name":51,"class":52},{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":294,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":296,"targetDuration":4,"studyType":120,"phases":297,"briefSummary":298,"conditions":299,"keywords":302,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":307,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":311,"locationsCount":229},"100640078","comparative-evaluation-of-intraneuroma-and-perineuroma-botulinum-toxin-type-a-injection-techniques-for-chronic-neuroma-pain-after-combat-related-amputation-100640078","NCT07624877","Comparative Evaluation of Intraneuroma and Perineuroma Botulinum Toxin Type A Injection Techniques for Chronic Neuroma Pain After Combat-Related Amputation","Comparative Evaluation of Intraneuroma and Perineuroma Botulinum Toxin Type A Injection Techniques for Chronic Neuroma Pain After Combat-Related Amputation: A Prospective Multicenter Study","IN-PERI NEUROM","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related limb amputation\n* Chronic neuroma pain lasting ≥3 months\n* Ultrasound-confirmed painful neuroma\n* Average neuroma pain intensity ≥4\u002F10 on the Numeric Rating Scale\n* Ability to undergo ultrasound-guided injection\n* Stable analgesic regimen for at least 14 days before enrollment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Active infection at or near the injection site\n* Open wound preventing safe injection\n* Previous botulinum toxin injection for neuroma pain within 6 months\n* Previous neuroma surgery within 3 months\n* Known allergy to botulinum toxin type A\n* Coagulopathy or anticoagulation contraindicating injection\n* Severe uncontrolled systemic disease\n* Inability to complete follow-up assessments",{"count":91,"type":22},[122],"Patients with combat-related amputations frequently experience chronic neuroma pain that may interfere with rehabilitation, prosthesis use, mobility, sleep, and quality of life. Ultrasound-guided botulinum toxin type A injection has emerged as a potential treatment option for persistent neuroma pain; however, the optimal injection technique remains unclear.\n\nThis prospective multicenter study aims to compare two ultrasound-guided botulinum toxin injection techniques for chronic neuroma pain after combat-related amputation: intraneuroma injection and perineuroma injection.\n\nParticipants with ultrasound-confirmed painful neuromas will undergo one of the two injection approaches based on the treating physician's clinical decision and local practice. Pain intensity, neuropathic pain characteristics, phantom limb pain, prosthesis tolerance, functional outcomes, and adverse events will be evaluated during follow-up.\n\nThe goal of the study is to evaluate the feasibility, safety, and potential clinical effectiveness of intraneuroma and perineuroma botulinum toxin type A injection techniques in patients with chronic neuroma pain following combat-related amputation.",[300,215,301,27],"Chronic Pain","Botulinium Toxin-A",[303,189,275,304,305,277,279,306],"Chronic neuroma pain","Intraneuroma injection","Perineuroma injection","Painful neuroma",{"date":168,"type":46},{"date":309,"type":22},"2026-05-27",{"date":226,"type":22},{"name":51,"class":52},{"id":313,"slug":314,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":319,"targetDuration":151,"studyType":23,"phases":4,"briefSummary":320,"conditions":321,"keywords":325,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":53},"100626679","ultrasound-predictors-of-persistent-burn-scar-pain-after-blast-and-drone-related-injuries-a-prospective-cohort-study-100626679","NCT07438769","Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study","US-SCAR-PAIN","Inclusion Criteria:\n\n* Age ≥18 years\n* Burn injury with clinically formed scar\n* Enrollment 2-12 weeks after injury\n* Scar located on extremities, chest wall, or neck\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment preventing valid questionnaires\n* Hemodynamic instability or inability to complete baseline evaluation\n* Active systemic infection (enrollment deferred until stable)\n* Pre-existing chronic pain condition unrelated to burn scar that would confound outcomes (investigator judgment)",{"count":150,"type":22},"Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue. This prospective cohort study aims to determine whether early ultrasound features of scars and nerves predict persistent clinically significant scar pain at 3 and 6 months. Ultrasound measures include scar thickness, echogenicity, Power Doppler vascularity, dynamic adhesion (gliding) assessment, and ultrasound signs of nerve involvement (\"US-nerve positive\"). Clinical outcomes include pain intensity (NRS), neuropathic pain screening (DN4), and functional interference.",[322,323,130,324],"Burn Scar Pain","Neuropathic Pain","Scar-Related Pain",[326,327,328,164,329,165,330],"Burn scar pain","ultrasound","nerve entrapment","drone injury","chronic pain prediction","2026-02-22",{"date":333,"type":46},"2026-02-27",{"date":335,"type":22},"2026-03-24",{"date":337,"type":22},"2026-05-23",{"name":51,"class":52},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":345,"eligibilityCriteria":346,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":120,"phases":348,"briefSummary":349,"conditions":350,"keywords":356,"overallStatus":360,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":368,"locationsCount":53},"100624962","neuroma-associated-pain-management-after-combat-related-trauma-in-ukraine-100624962","NCT07416448","Neuroma-Associated Pain Management After Combat-Related Trauma in Ukraine","Comprehensive Multicenter Study on the Management of Neuroma-Associated Pain Following Combat-Related Trauma in Ukraine","NAP-C\u002FR","Inclusion Criteria:\n\n* Age 18 years or older\n* Sustained combat-related trauma\n* Clinically significant neuroma-associated pain localized to a peripheral nerve or neuroma\n* Moderate to severe pain (score ≥ 4 on a standardized numeric pain rating scale)\n* Medically stable and able to undergo a percutaneous interventional procedure\n* Able to understand and provide written informed consent\n* Willing and able to comply with study procedures, including follow-up assessments and patient-reported outcome measures\n* May be receiving standard analgesic therapy, including opioids, if usage can be monitored\n* No planned surgical intervention at the neuroma site during the study period that could interfere with pain assessment\n\nExclusion Criteria:\n\n* Age under 18 years\n* Pregnant or breastfeeding\n* Severe uncontrolled medical comorbidities that preclude safe participation\n* Active infection at or near the proposed intervention site\n* Known coagulopathy or use of anticoagulants that cannot be safely withheld\n* Previous cryoablation or radiofrequency ablation at the target neuroma within the past 6 months\n* Inability to provide informed consent or comply with study procedures\n* Participation in another interventional clinical trial that could interfere with study outcomes\n* Known allergy or intolerance to materials used during the procedures",{"count":238,"type":22},[122],"This multicenter interventional study in Ukraine is designed to compare the effectiveness of cryoablation and radiofrequency ablation in managing neuroma-associated pain following combat-related trauma. Adult patients with clinically significant neuropathic pain caused by neuromas will be randomly assigned to receive either image-guided cryoablation or radiofrequency ablation of the affected nerve. Cryoablation uses controlled cold temperatures to temporarily disrupt nerve conduction, while radiofrequency ablation uses thermal energy to modulate nerve function. Both interventions are minimally invasive and performed under image guidance. The study will evaluate changes in pain intensity, opioid consumption, functional outcomes, and patient-reported measures at predefined time points following the procedure. This research aims to provide evidence on which intervention is more effective in reducing pain, improving function, and minimizing the need for opioid medications in patients with combat-related neuroma pain.",[351,352,215,353,354,323,355],"Pain Management","Quality of Life","Functional Outcome","Depression in Adults","Hypoesthesia",[357,358,242,359,323],"Neuroma Pain","Combat-Related Trauma","Radiofrequency Ablation","RECRUITING","2026-02-14",{"date":363,"type":46},"2026-02-18",{"date":365,"type":46},"2026-02-05",{"date":367,"type":22},"2027-02-05",{"name":51,"class":52},""]